CN113244131A - Refreshing and refreshing chewing gum composition, chewing gum toothpaste and preparation method thereof - Google Patents
Refreshing and refreshing chewing gum composition, chewing gum toothpaste and preparation method thereof Download PDFInfo
- Publication number
- CN113244131A CN113244131A CN202110547383.4A CN202110547383A CN113244131A CN 113244131 A CN113244131 A CN 113244131A CN 202110547383 A CN202110547383 A CN 202110547383A CN 113244131 A CN113244131 A CN 113244131A
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- China
- Prior art keywords
- chewing gum
- refreshing
- parts
- toothpaste
- gum composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a refreshing and refreshing chewing gum composition, a chewing gum toothpaste and a preparation method thereof, and belongs to the technical field of toothpaste. The refreshing and refreshing chewing gum composition and the chewing gum toothpaste provided by the invention have the advantages that the yeast fermentation product is utilized to destroy and strip microbial membranes on teeth and mucous membranes in the oral cavity, the micro-ecological balance of the oral cavity is kept, the catechin active monomer epigallocatechin gallate is utilized to remove the peculiar smell in the oral cavity, Evercool190 is used for lasting cooling, the Optaflow promotes the saliva secretion, and the pleasant feeling of the chewing gum is improved. The synergistic effect of the chewing gum composition can effectively remove microorganisms overgrowing in the oral cavity, remove peculiar smell in the oral cavity, bring lasting cool feeling after the whole using process and tooth brushing and bring healthy and smooth experience in taste.
Description
Technical Field
The invention belongs to the technical field of toothpaste, and particularly relates to a refreshing and refreshing chewing gum composition, a chewing gum toothpaste and a preparation method thereof. The present invention has been developed primarily for use in oral care compositions. It will be appreciated, however, that the invention is not limited to this particular field of application.
Background
The oral environment is the most daily one in human life, and oral problems can affect the whole body health. With the continuous development of science and technology, the continuous improvement and perfection of technological equipment, various types of toothpastes come out in succession, and the quality and the grade of products are continuously improved. At present, the variety of the toothpaste is developed from single clean toothpaste into multifunctional toothpaste with various varieties, complete efficacies and hundreds of brands, and the requirements of consumption levels at different levels are met.
Halitosis is odor and peculiar smell emitted from oral cavity or other air-filled cavities such as nose, nasal sinuses and pharynx, which affects normal interaction and communication of people and affects social image and mental health of people. A recent survey shows that the incidence rate of halitosis in Chinese people reaches 27.5%, and the incidence causes of halitosis belong to 80-90% of patients with intra-oral factors. Oral halitosis is mainly caused by substances such as sulfur-containing amino acids, polypeptides and proteins, which are decomposed by bacteria in oral cavity, and volatile sulfides and fatty acids with peculiar smell are generated. Therefore, refreshing breath has become the most desirable oral experience for consumers.
For halitosis of oral origin, it can inhibit halitosis and refresh breath by eliminating pathogenic microorganisms and toxins produced thereby and rapidly and directly eliminating odor compounds in oral cavity.
The exhaled gas of a person contains a plurality of trace Volatile Sulfides (VSCs), and the amounts of hydrogen sulfide, methyl mercaptan and dimethyl sulfide in the VSCs are directly related to the intensity of halitosis. These VSCs are generally associated with human health and metabolic processes and are generally classified as oral and non-oral, with 90% of them originating from the oral cavity. Data related to prevalence of halitosis in some countries or regions of recent years. Research reports that when oral microecology is out of balance, the proportion of anaerobes producing halitosis in oral cavity is increased, and the ozone decomposes sulfur-containing protein to generate VSCs (including hydrogen sulfide, methyl mercaptan, dimethyl mercaptan and the like). For example, patent application No. CN931060702 discloses synergistic cooling effects of menthol, menthylamide, menthone glycerol ketal, etc. and its simple application. The invention patent with the publication number of CN 102512337B mentions that the use of polyvinylpyrrolidone, polypropylene copolymer and the like with chlorohexidine, dodecyl dimethyl benzyl ammonium chloride and cetyl pyridinium chloride prolongs the bacteriostasis time.
In the above-disclosed techniques, the use of bacteriostatic agents is not considered in terms of the microecological balance in the oral cavity, and in the use of cooling agents, it has been studied that the combined use of cooling agents can produce a synergistic effect to enhance the cooling effect, but is deficient in the duration of cooling and the degree of moistening of the oral cavity.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a refreshing and refreshing chewing gum composition.
Another object of the present invention is to provide a refreshing toothpaste with a pleasant smell.
The invention also aims to provide a preparation method of the refreshing and refreshing toothpaste.
The chewing gum composition and the chewing gum toothpaste have the functions of destroying and stripping microbial membranes on teeth and mucous membranes in the oral cavity, keeping the micro-ecological balance of the oral cavity, removing the peculiar smell of the oral cavity, assisting in lasting cooling, promoting the secretion of saliva and enhancing the pleasant feeling of the chewing gum.
The purpose of the invention is realized by the following technical scheme:
the invention discloses a refreshing and refreshing chewing gum composition, which comprises the following main components: BioTolife, EGCg, Evercool190, Optaflow; may also contain glycerol and poloxamer.
In order to achieve the purpose, the invention adopts the technical scheme that: a refreshing and refreshing chewing gum composition comprises the following main raw materials in parts by weight: 5-15 parts of BioTolife, 10-30 parts of EGCg, 1901-3 parts of Evercool, 0.5-2 parts of Optaflow, 50-85 parts of glycerol and 0.5-2 parts of poloxamer.
Further, the refreshing and refreshing chewing gum composition comprises the following main raw materials in parts by weight: 8-15 parts of BioTolife, 20-30 parts of EGCg, 1901-2 parts of Evercool, 0.5-1 part of Optaflow, 50-85 parts of glycerol and 0.5-2 parts of poloxamer.
Still further, the refreshing and refreshing chewing gum composition comprises the following main raw materials in parts by weight: 8-10 parts of BioTolife, 20-25 parts of EGCg, 1.5-2 parts of Evercool190, 0.5-1 part of Optaflow, 60-68 parts of glycerol and 2 parts of poloxamer.
Furthermore, the refreshing and refreshing chewing gum composition comprises the following main raw materials in parts by weight: BioTolife 10 parts, EGCg 25 parts, Evercool 1902 parts, Optaflow 1 parts, glycerol 60 parts and poloxamer 2 parts.
The preparation method of the refreshing chewing gum composition comprises the following steps:
a, adding Evercool190 and Optaflow into glycerol, and stirring to dissolve;
b, poloxamer is dissolved in BioTolife;
c, adding the A into the B and uniformly stirring;
and D, adding EGCg and stirring uniformly.
The invention also discloses application of the refreshing and refreshing chewing gum composition in preparing an oral care product.
The oral care product is toothpaste, mouthwash, oral spray, tooth powder or chewing gum.
The invention also discloses a refreshing and refreshing chewing gum toothpaste, which contains the refreshing and refreshing chewing gum composition; further comprises 3-8% (preferably 5%) by mass of a refreshing chewing gum composition.
Specifically, the chewing gum toothpaste is prepared from an abrasive, a humectant, a thickening agent, a foaming agent, a chewing gum composition (Biotolife, EGCg, Evercool190, Optaflow), essence, an auxiliary agent and water.
In order to achieve the purpose, the invention adopts the technical scheme that: the cool and fresh chewing gum toothpaste comprises the following main raw materials in parts by weight: 20-40 parts of an abrasive, 30-55 parts of a humectant, 0.5-1.5 parts of a thickening agent, 0.5-2.5 parts of a foaming agent, 3-8 parts of a chewing gum composition, 1-1.2 parts of essence, 0.3-1 part of an auxiliary agent and 15-40 parts of water.
Further, the cool and refreshing toothpaste with the mouth fragrance comprises the following main raw materials in parts by weight: 20-40 parts of an abrasive, 30-55 parts of a humectant, 0.5-1.5 parts of a thickening agent, 0.5-2.5 parts of a foaming agent, 5 parts of a chewing gum composition, 1-1.2 parts of essence, 0.3-1 part of an auxiliary agent and 15-40 parts of water.
Still further, the cool and refreshing toothpaste with the mouth fragrance comprises the following main raw materials in parts by weight: 20-40 parts of an abrasive, 30-35 parts of a humectant, 0.8-1.2 parts of a thickening agent, 1.5-2 parts of a foaming agent, 5 parts of a chewing gum composition, 1 part of mint essence, 0.5-0.8 part of an auxiliary agent and 17.2-36.1 parts of water.
In the invention, the friction agent is selected from one or more of calcium hydrophosphate dihydrate, silicon dioxide and calcite powder; the humectant is one or more selected from polyethylene glycol, glycerol, propylene glycol and sorbitol; the thickener is one or more of sodium carboxymethylcellulose (CMC), guar gum, xanthan gum and carrageenan; the foaming agent is one or more of sodium lauryl sulfate, sodium lauroyl sarcosinate, alkyl glycoside and cocamidopropyl betaine; the essence is mint essence; the auxiliary agent is one or more of sodium pyrophosphate and sodium citrate.
The preparation method of the refreshing and refreshing chewing gum toothpaste comprises the following steps:
(1) preparation of the chewing gum composition: a, adding Evercool190 and Optaflow into glycerol, and stirring to dissolve; b, poloxamer is dissolved in BioTolife; c, adding the A into the B and uniformly stirring; d, adding EGCg, and uniformly stirring;
(2) according to the formula of the chewing gum toothpaste, the humectant and the auxiliary agent are put into a premixing pot, water is added, the mixture is stirred and mixed uniformly, and the stirring is continued to obtain a mixture;
(3) adding an abrasive, a thickening agent and a foaming agent into the mixture obtained in the step (2), vacuumizing, homogenizing and stirring to obtain a paste;
(4) adding essence and the chewing gum composition into the paste, stirring thoroughly, degassing, aging, and aging to obtain the final product.
Preferably, in the step (2), the stirring is continued for 5-10 min.
Preferably, in the step (3), the vacuumizing condition is that the vacuum degree is kept at-0.095 Mpa;
preferably, in the step (3), the time for homogenizing and stirring is 25-30 min;
preferably, in the step (4), the degassing time is 10-15 min;
preferably, in the step (4), the aging time is 6-12 h, and further 12 h.
The functional components of the invention have the following functions:
BioTolife: microbial biofilms (biofilms) are aggregates of various bacteria, usually attached to the surface of a solid body and secreting a polysaccharide matrix, and bacterial colony membranes formed by enclosing bacterial colonies therein are more resistant to antibacterial agents and other environmental factors than free bacteria, and are mostly attached to teeth, often referred to as dental plaque. BioTolife is a plant fermentation extract produced by Pasteur company by adopting a Japanese advanced innovative fermentation technology, natural vegetable oil and sophorose are used for producing high-lactone glycolipid under the fermentation of a special yeast strain, microbial membranes on teeth and mucous membranes in oral cavities can be damaged and peeled, and in vitro tests show that the minimum bacteriostatic concentration and the minimum bactericidal mass concentration of BioTolife are respectively 0.1mg/mL and 1mg/mL, so that overgrowth microorganisms are effectively removed.
EGCg (epigallocatechin gallate), which is the main component of green tea polyphenol, is a catechin monomer separated from tea leaves, and epigallocatechin gallate (EGCg) is the only catechin with Gallo body and Galleto body, and the structure endows the tea polyphenol with antibacterial, antioxidant and deodorizing performances, is the most active component in tea polyphenol, and has antibacterial, antiviral, antioxidant and antiinflammatory effects. In the field of oral care, the research on the in-vitro antibacterial effect of the porphyromonas gingivalis at a lower concentration [ J ] medicine front, 2012(20): 182-.
Evercool 190: coolshot (cooling shock) based on the cooling component of the latest patent technology of Qiwashington company (WO2012/113873), with the chemical name of 2-isopropyl-5-methyl-N- (2- (pyridin-4-yl) ethyl) cyclohexanecarboxamide, has a strongly enhanced cooling sensation after gargling compared with other cooling agents including menthol, menthyl lactate, menthylamide, menthyl acetate, menthone glycerol ketal, WS-23, WS-5, etc., and the maximum intensity thereof is reached at 7 minutes. Very slow decay arcs, and with a stable high strength. The lasting freshness sensation of the mouth after rinsing is not associated with a lasting fragrance for the consumer. After oral care the aroma should fade away and leave only a fresh sensation. This sensation can be achieved by a cooling agent that only supports a clean feeling in the mouth, which in use results in a higher product and fragrance preference that is acceptable to consumers, resulting in a better lasting cooling throughout the entire use and after brushing.
The Optaflow, Dezhixin developed oral product additive capable of promoting salivation can remarkably improve 140-150% of the basic level of normal salivation, improves the natural moisturizing feeling in the oral cavity, and is a safe guard of oral flora. Rejuvenating and strengthening gums and teeth, bringing a healthy silky experience on teeth and taste.
Compared with the prior art, the invention has the following advantages and effects:
(1) the refreshing and refreshing chewing gum composition and the chewing gum toothpaste are the initiatives in the oral cavity industry, the yeast fermentation product is utilized to destroy and strip microbial membranes on teeth and mucous membranes in the oral cavity, the microecological balance of the oral cavity is kept, the catechin active monomer epigallocatechin gallate is utilized to remove the peculiar smell in the oral cavity, Evercool190 is used for lasting cooling, and Optaflow promotes the promotion of salivary secretion and the pleasant feeling of the chewing gum.
(2) The synergistic effect of the chewing gum composition can effectively remove microorganisms overgrowing in the oral cavity, remove peculiar smell in the oral cavity, bring lasting cool feeling after the whole using process and tooth brushing and bring healthy and smooth experience in taste.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1-2A Cool-refreshing chewing gum composition
A cooling and refreshing chewing gum composition formula is shown in Table 1.
TABLE 1 chewing gum composition recipe (parts by weight)
The preparation method comprises the following steps: a, adding Evercool190 and Optaflow into glycerol, and stirring to dissolve; b, poloxamer is dissolved in BioTolife; c, adding the A into the B and uniformly stirring; and D, adding EGCg and stirring uniformly.
Application example 1
The refreshing and refreshing chewing gum comprises the following substances in parts by weight: 40 parts of calcite powder, 30 parts of sorbitol, 1.2 parts of sodium carboxymethylcellulose, 2 parts of sodium lauryl sulfate, 5 parts of the chewing gum composition of example 1, 1 part of mint essence, 0.5 part of sodium pyrophosphate and 20.3 parts of water.
The preparation method comprises the following steps:
(1) preparation of the chewing gum composition: a, adding Evercool190 and Optaflow into glycerol, and stirring to dissolve; b, poloxamer is dissolved in BioTolife; c, adding the A into the B and uniformly stirring; d, adding EGCg, and uniformly stirring;
(2) according to the formula of the chewing gum toothpaste, putting sorbitol and an auxiliary agent into a premixing pot, adding water, stirring and mixing uniformly, and continuously stirring for 15min to obtain a mixture;
(3) adding calcite powder, sodium carboxymethylcellulose and sodium lauryl sulfate into the mixture obtained in the step (2), vacuumizing a paste making pot, keeping the vacuum degree at-0.095 Mpa, and homogenizing and stirring for 25min to obtain paste;
(4) adding the mint essence and the chewing gum composition into the paste, stirring uniformly, degassing the paste for 15min, then transferring the paste into a paste storage tank for aging for 12h, and obtaining the chewing gum toothpaste after aging, wherein the toothpaste is marked as chewing gum toothpaste 1.
Application example 2
The refreshing and refreshing chewing gum comprises the following substances in parts by weight: 38 parts of calcium hydrophosphate dihydrate, 5 parts of polyethylene glycol 4005 parts of sorbitol, 30 parts of hydroxypropyl guar gum, 0.5 part of CMC, 2 parts of sodium lauroyl sarcosinate, 5 parts of the chewing gum composition of example 2, 1 part of mint essence, 0.8 part of sodium pyrophosphate and 17.2 parts of water.
The preparation method comprises the following steps:
(1) preparation of the chewing gum composition: a, adding Evercool190 into glycerol, and stirring to dissolve; b, poloxamer is dissolved in BioTolife; c, adding the A into the B and uniformly stirring; d, adding EGCg, and uniformly stirring;
(2) according to the formula of the chewing gum toothpaste, putting polyethylene glycol 400, sorbitol and an auxiliary agent into a premixing pot, adding water, stirring and mixing uniformly, and continuing stirring for 5min to obtain a mixture;
(3) adding calcium hydrophosphate dihydrate, hydroxypropyl guar gum, CMC and sodium lauroyl sarcosinate into the mixture obtained in the step (2), vacuumizing a paste making pot, keeping the vacuum degree at-0.095 Mpa, and homogenizing and stirring for 25-30 min to obtain a paste material;
(4) adding the mint essence and the chewing gum composition into the paste, stirring the paste fully and uniformly, degassing the paste for 10-15 min, then transferring the paste into a paste storage tank, and aging the paste for 12h to obtain the chewing gum toothpaste, and marking the toothpaste as the chewing gum toothpaste 2 after the aging is finished.
Application example 3
The refreshing and refreshing chewing gum comprises the following substances in parts by weight: 20 parts of silicon dioxide, 5 parts of glycerol, 30 parts of sorbitol, 0.4 part of xanthan gum, 0.4 part of carrageenan, 1.5 parts of lauryl sodium sulfate, 5 parts of the chewing gum composition of example 2, 1 part of mint essence, 0.6 part of sodium citrate and 36.1 parts of water.
The preparation method comprises the following steps:
(1) preparation of the chewing gum composition: a, adding Evercool190 and Optaflow into glycerol, and stirring to dissolve; b, poloxamer is dissolved in BioTolife; c, adding the A into the B and uniformly stirring; d, adding EGCg, and uniformly stirring;
(2) according to the formula of the chewing gum toothpaste, putting glycerol, sorbitol and an auxiliary agent into a premixing pot, adding water, stirring and mixing uniformly, and continuously stirring for 5-10 min to obtain a mixture;
(3) adding silicon dioxide, sodium lauryl sulfate, xanthan gum and carrageenan into the mixture obtained in the step (2), vacuumizing a paste preparation pot, keeping the vacuum degree at-0.095 Mpa, and homogenizing and stirring for 25-30 min to obtain a paste;
(4) adding the mint essence and the chewing gum composition into the paste, stirring the paste fully and uniformly, degassing the paste for 10-15 min, then transferring the paste into a paste storage tank, and aging the paste for 12h to obtain the chewing gum toothpaste, and marking the toothpaste as the chewing gum toothpaste 3 after the aging is finished.
Referring to the preparation method of application example 3 and table 1, control toothpastes were obtained, designated as control toothpaste 1 (blank EGCg composition of mouth), control toothpaste 2 (blank BioTolife composition of mouth), control toothpaste 3 (blank Optaflow composition of mouth), and control toothpaste 4 (blank Evercool190 composition of mouth), respectively.
Effect example 1
A cooling durability test was performed on the toothpaste 3 obtained in application example 3, the toothpaste obtained from the bare Optaflow chewing gum composition (control toothpaste 3) (the rest of the composition was the same as in application example 3), and the toothpaste obtained from the bare Evercool190 chewing gum composition (control toothpaste 4) (the rest of the composition was the same as in application example 3). The test method is to select 60 people who are sensitive to coolness, divide the people into three groups randomly, and score the cool and refreshing mouth fragrance persistence of the toothpaste according to the following standard (table 2).
The toothpaste prepared in application example 3 and a blank sample (except that no chewing gum composition is contained, the mixture ratio is the same as that in example 2, and the small amount is added to water) are subjected to a cooling degree lasting test, the test method is that 60 people sensitive to cooling degree are selected, the groups are divided into three groups randomly, and the cooling degree lasting degree of the toothpaste is scored according to the following standard.
TABLE 2 evaluation criteria for refreshing chewing gum
| Evaluation criteria | Score of |
| The cooling degree lasts for 10-20 minutes after tooth brushing | 2 to 3 points |
| The cooling degree lasts for 20-40 minutes after tooth brushing | 4 to 5 points |
| The cooling degree lasts for 40-60 minutes after tooth brushing | 6 to 7 points |
| The cooling degree lasts for 60-120 minutes after tooth brushing | 8 to 9 points |
| The cooling degree lasts for more than 120 minutes after tooth brushing | 10 minutes |
TABLE 3 Cool and refreshing Gum aroma Effect data
| Serial number | Group of | Average score |
| 1 | Chewing gum toothpaste 3 | 9.4 |
| 2 | Control toothpaste 3 | 8.5 |
| 3 | Control toothpaste 4 | 3.2 |
As can be seen from the data of the effect of the cool mouth degree in the table 3, the application example of the composition containing the mouth fragrance has obvious improvement on the cool mouth fragrance durability compared with the mouth fragrance toothpaste prepared by the Optaflow blank, which indicates that the Optaflow has great improvement effect on the cool and fresh mouth feeling.
Effect example 2
The experiment of the inhibition ring of the chewing gum toothpaste prepared in application example 3 on Porphyromonas gingivalis
The experimental principle is as follows: according to the sterilization ring inhibition test of 2002 edition 'Disinfection technical Specification' 2.1.8.2 of Ministry of public health, the negative control product is the matrix toothpaste without the chewing gum component. And judging the bacteriostatic ability according to the size of the bacteriostatic ring.
Preparing a bacterial suspension: 3 turbidity bottles were prepared, and 4mL, 8mL, and 10mL of phosphate buffered saline PBS (0.03mol/L, pH7.2) were added for further use. Taking out the well-grown porphyromonas gingivalis plate from the culture bag, scraping half of the strain into a 4mL PBS turbidity tube, shaking uniformly, adding liquid paraffin for sealing, and taking the liquid as mother liquid. Using a pipette to transfer 100 mu L of mother liquor to 8mL of PBS for shaking up each time, adjusting the concentration of the bacterial liquid on a turbidimeter, firstly using a turbidity bottle containing 10mL of PBS for zero calibration, and then measuring the turbidity until the turbidity is 0.5MCF (1.5 multiplied by 10) and the concentration is lower than the original value8cfu/mL)。
Wherein the Porphyromonas gingivalis is Porphyromonas gingivalis ATCC33277, which is purchased from Shenzhen Asekeridae Biotech Ltd.
Bacterial liquid coating: marking on a blood agar plate, sucking 100 mu L of 0.5MCF bacterial suspension onto the blood agar plate by using a pipette, uniformly coating by using a sterile cotton swab, and drying at room temperature for 5min for later use.
Preparing a toothpaste flat plate to be tested: a small hole of about 6mm in diameter was dug out in a triangle on a blood agar plate, toothpaste was evenly squeezed into a sterile syringe, 50mg of toothpaste was injected into the small hole through a needle, and three different samples were injected on each plate. Three plates were repeated. Placing the flat plate in an anaerobic culture bag, placing an aerogenic bag and an oxygen indicator in a constant-temperature incubator at 37 ℃, measuring the diameter of an antibacterial ring by using a vernier caliper after 48-72 hours, wherein the larger the diameter of the antibacterial ring is, the stronger the antibacterial effect is, and the diameter of the antibacterial ring is larger than 7mm, so that the plate is judged to have the antibacterial effect; if the diameter of the antibacterial ring is less than or equal to 7mm, the product is judged to have no antibacterial effect.
Number 1 is a chewing gum toothpaste 3 made by the formula of the chewing gum of application example 3 of the present invention; number 2 is control toothpaste 1 (blank EGCg chewing gum composition, the rest proportion is the same as application example 3) prepared in application example 3, number 3 is control toothpaste 2 (blank biotoli chewing gum composition, the rest proportion is application example 3) prepared in the chewing gum formulation of application example 3 of the present invention; no. 4 is negative control toothpaste, no chewing gum composition is contained, and the rest proportion is the same as that of application example 3.
TABLE 4 antibacterial ring of chewing gum for Porphyromonas gingivalis
| Group of | Parallel sample 1 | Parallel sample 2 | Parallel sample 3 | Average |
| No. 1 chewing gum toothpaste 3 inhibiting bacteria ring mm | 25 | 26.5 | 26 | 25.8 |
| Number 2 control toothpaste 1 antibacterial ring mm | 20 | 19.5 | 18 | 19.2 |
| Number 3 control toothpaste 2 bacteriostatic ring mm | 15.6 | 16.1 | 15.3 | 15.7 |
| Number 4 negative control toothpaste antibacterial ring mm | 4.2 | 3.5 | 4 | 3.9 |
The results are shown in table 4, where the antibacterial ring of the toothpaste was greater than that of the toothpaste without EGCg (control toothpaste 1) and also greater than that of the toothpaste without biotilefe (control toothpaste 2). According to the judgment of sterilization technical specification, the antibacterial ring larger than 7mm has the antibacterial effect, so the test sample toothpaste has the obvious antibacterial effect on the porphyromonas gingivalis.
Effect example 3
BioTolife and EGCg minimum inhibitory concentration determination
Taking one sterile microporous plate, taking rows A, B and C as three repeated tests of BioTolife, taking rows E, F and G as three repeated tests of EGCg, adding 180 mu L of prepared diluted bacteria liquid (10 multiplied by 5CFU/mL of Gum phanthin unicellular bacteria cultured by BHI culture medium) into each row of first holes, adding 100 mu L of prepared detection liquid into each other row of first holes, adding 20 mu L of prepared detection liquid into each row of first holes (the concentration of BioTolife or EGCg is respectively 80G/L), uniformly mixing, sucking 100 mu L, and adding into a second hole. Diluting to 12 th well in sequence by the same method, discarding 100 μ L, making the concentration of the detection solution in each well 8000, 4000, 2000, 1000, 500, 250, 125, 62.5, 31.25, 15.625, 7.8125, 3.906mg/L, adding 100 μ L diluted bacteria solution in each well of row D as growth control; row H100 μ L of sterilized BHI medium was added to each well as a blank. And (3) placing the microporous plate at 37 ℃ for anaerobic culture for 48 hours, and observing the result. The lowest drug concentration without bacterial growth was the MIC and the specific results are shown in table 5.
Wherein the Porphyromonas gingivalis is Porphyromonas gingivalis ATCC33277, which is purchased from Shenzhen Asekeridae Biotech Ltd.
TABLE 5 BioTolife and minimum inhibitory concentration MIC of EGCg
| Detecting the component | MIC |
| BioTolife | 100mg/L |
| EGCg | 250mg/L |
BioTolife and EGCg combined bacteriostasis test
Biotolife was diluted in a 2-fold tube dilution to: 200. 100, 50, 25, 12.5 and 6.25 mg/L. EGCg was diluted in the same way to: 500. 250, 125, 62.5, 31.25 and 15.625 mg/L. The highest concentrations were 2 times the MIC, respectively.
36 groups of formulas are formed by matching by a chessboard method, prepared diluted bacteria liquid (the P.gingivalis cultured by BHI culture medium, 10 multiplied by 5CFU/mL) is respectively added, and the mixture is placed at 37 ℃ for anaerobic culture for 48 hours, and then the results are observed, and the results are shown in table 6.
TABLE 6 Combined bacteriostasis test of BioTolife with EGCg
Note: + means sterile, -means aseptic. A represents the Biotolife concentration (mg/L) and B represents the EGCg concentration (mg/L).
The FIC index is the MIC of the combination A/the MIC of the combination A alone + the MIC of the combination B/the MIC of the combination B alone, and the FIC index is less than or equal to 0.5, which indicates that the synergistic effect is achieved. FIC index in the experiment is 0.375, which shows that Biotolife and EGCg have synergistic effect.
Effect example 4
Test for efficacy of oral malodor reduction using the chewing gum prepared in example 3.
The test method comprises the following steps: 60 subjects suffering from oral halitosis who met the inclusion and non-exclusion criteria were selected and randomly divided into two groups, 30 persons each for the test group and the control group, with the test sample being a breath toothpaste 3 produced according to the invention using the breath toothpaste formulation of example 3, and the negative control toothpaste being a toothpaste without a breath composition.
During the test, the corresponding toothpaste is squeezed on a unified standard toothbrush for 2cm respectively, and the tooth brushing time is guaranteed for 3 min. The subject tested the concentration of VSCs in the oral cavity on the 1 st time prior to brushing the teeth in mouth; testing the concentration of VSCs in the oral cavity at time 2 min post brushing; testing the concentration of VSCs in the oral cavity at 60min post-brushing 3 rd time; testing the concentration of VSCs in the oral cavity at the 4 th time 120min after brushing; the following day the concentration of VSCs in the oral cavity was tested at 5 th 60min post brushing. The concentration of VSCs in the oral cavity was tested 60min 6 th time after brushing on day three; the concentration of VSCs in the oral cavity was tested 60min after brushing on day four, at time 7. Fifth day VSCs concentration in the oral cavity was tested 60min post brushing at 8 th time.
The testing instrument uses a Halimeter breath measuring instrument. The method adopts an electrochemical principle to measure the concentration of Volatile Sulfides (VSCs) in oral gas as an index for measuring the oral gas level of a patient. Before use, the zero setting is carried out by using ambient air, during measurement, a subject breathes with the nose, slightly opens the mouth, places the gas collecting pipe mouth at the position 0.5cm above the junction of the middle and the rear third of the tongue, and reads the numerical value on the display screen. Each examination was repeated 3 times and the results averaged and the results are shown in table 7.
TABLE 7 results of the measurement of halitosis-alleviating effect of the toothpaste
| Group of | Test group | Control group |
| Breath value ppb before tooth brushing | 502 | 512 |
| Breath value ppb at 10 minutes after tooth brushing | 383 | 467 |
| Breath value ppb at 60 minutes after tooth brushing | 402 | 471 |
| Breath value ppb at 120 minutes after tooth brushing | 454 | 513 |
| The second day of breath value ppb | 380 | 460 |
| Third day breath value ppb | 370 | 450 |
| Fourth day breath value ppb | 356 | 440 |
| Fifth day breath value ppb | 350 | 454 |
Results and discussion: as can be seen from Table 7, after the toothpaste is used, the breath value of each group is reduced to a certain extent, which indicates that the breath can be kept fresh to a certain extent after the toothpaste is used for brushing teeth, but the breath value of the test sample toothpaste is reduced to a large extent, the mouth can still keep fresh after 2h, the breath value of the common toothpaste is reduced to a small extent, and the breath value of the mouth is basically restored to the original state after 2 h. The breath value of the tested toothpaste is obviously reduced after five consecutive days, while the common toothpaste is basically kept at the same level.
The cool and refreshing chewing gum provided by the invention can effectively remove the peculiar smell in the oral cavity and refresh the breath after being used by a testee. Remarkably reduces halitosis, and maintains the clinical curative effect of the chewing gum. Repeated experiments show that the oral cavity odor-eliminating ointment has obvious effects on gingival inflammation, red swelling and bleeding and oral cavity odor.
It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. A cooling and refreshing chewing gum composition characterized by: the chewing gum composition comprises the following main components: BioTolife, EGCg, Evercool190, Optaflow.
2. A cooling refreshing chewing gum composition according to claim 1, characterised in that:
the chewing gum composition further comprises glycerin and poloxamer.
3. A cooling refreshing chewing gum composition according to claim 2, characterised in that:
the refreshing and refreshing chewing gum composition comprises the following main raw materials in parts by weight: 5-15 parts of BioTolife, 10-30 parts of EGCg, 1901-3 parts of Evercool, 0.5-2 parts of Optaflow, 50-85 parts of glycerol and 0.5-2 parts of poloxamer.
4. Use of a cooling freshening chewing gum composition according to any one of claims 1 to 3 in the manufacture of an oral care product.
5. Use according to claim 4, characterized in that:
the oral care product is toothpaste, mouthwash, oral spray, tooth powder or chewing gum.
6. A cool and fresh chewing gum toothpaste is characterized in that: a refreshing chewing gum composition comprising the composition according to any one of claims 1 to 3.
7. The refreshing breath toothpaste according to claim 6, wherein:
the chewing gum toothpaste is prepared from an abrasive, a humectant, a thickening agent, a foaming agent, a chewing gum composition, essence, an auxiliary agent and water.
8. A cooling and refreshing chewing gum according to claim 7, wherein:
the cool and refreshing toothpaste with the chewing gum comprises the following main raw materials in parts by weight: 20-40 parts of an abrasive, 30-55 parts of a humectant, 0.5-1.5 parts of a thickening agent, 0.5-2.5 parts of a foaming agent, 3-8 parts of a chewing gum composition, 1-1.2 parts of essence, 0.3-1 part of an auxiliary agent and 15-40 parts of water.
9. A cooling refreshing chewing gum according to claim 7 or 8, characterised in that:
the friction agent is selected from one or more of calcium hydrophosphate dihydrate, silicon dioxide and calcite powder; the humectant is one or more selected from polyethylene glycol, glycerol, propylene glycol and sorbitol; the thickener is one or more of sodium carboxymethylcellulose, guar gum, xanthan gum and carrageenan; the foaming agent is one or more of sodium lauryl sulfate, sodium lauroyl sarcosinate, alkyl glycoside and cocamidopropyl betaine; the essence is mint essence; the auxiliary agent is one or more of sodium pyrophosphate and sodium citrate.
10. A method of preparing a refreshing breath toothpaste according to any of claims 6 to 9 wherein: the method comprises the following steps:
(1) preparation of the chewing gum composition: a, adding Evercool190 and Optaflow into glycerol, and stirring to dissolve;
b, poloxamer is dissolved in BioTolife; c, adding the A into the B and uniformly stirring; d, adding EGCg, and uniformly stirring;
(2) according to the formula of the chewing gum toothpaste, the humectant and the auxiliary agent are put into a premixing pot, water is added, the mixture is stirred and mixed uniformly, and the stirring is continued to obtain a mixture;
(3) adding an abrasive, a thickening agent and a foaming agent into the mixture obtained in the step (2), vacuumizing, homogenizing and stirring to obtain a paste;
(4) adding essence and the chewing gum composition into the paste, stirring thoroughly, degassing, aging, and aging to obtain the final product.
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| CN115211486A (en) * | 2022-07-26 | 2022-10-21 | 山东大学 | Chewing gum capable of promoting breath freshening and preparation method thereof |
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