CN107007482A - A kind of oral care implement for removing implication and preparation method thereof - Google Patents
A kind of oral care implement for removing implication and preparation method thereof Download PDFInfo
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- CN107007482A CN107007482A CN201710146398.3A CN201710146398A CN107007482A CN 107007482 A CN107007482 A CN 107007482A CN 201710146398 A CN201710146398 A CN 201710146398A CN 107007482 A CN107007482 A CN 107007482A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The invention discloses a kind of oral care implement for removing implication and preparation method thereof, including the methylphenol of 4 isopropyl 3, zinc citrate and citrate；The citrate is one or more of potassium citrate or sodium citrate；In terms of parts by weight, 0.5~2.0 part of zinc citrate；0.01~0.1 part of 4 isopropyl, 3 methylphenol；The weight ratio of the zinc citrate and potassium citrate is 1:(1.3~1.5)；The weight ratio of the zinc citrate and sodium citrate is 1:(1.2~1.35).Oral care implement of the present invention can suppress/reduce to produce the quantity of volatile sulfur compounds bacterium in oral cavity, so that reaching improves the purpose of the bad implication of mouth source property.
Description
Technical field
Belong to oral care techniques field the present invention relates to the technology, specifically related to a kind of oral care for removing implication is used
Product and preparation method thereof.
Background technology
Implication is also known as halitosis, refers to breathing or a kind of symptom of peculiar smell is given out when dehiscing.Halitosis is quite general in adult
Time, epidemiology survey shows that the incidence of disease of halitosis is higher.Liu etc. has investigated the Chinese that 2000 ages are 15-64 Sui, mouth
Smelly illness rate is 27.5% (Xue N L, Shinada K, Xiao C C, et al.Oral malodor-related
parameters in the Chinese general population[J].Journal of Clinical
Periodontology,2006,33(1):31-6).The adult's private prosecution in more than 30 years old for having 24% in Japan has halitosis symptom；In U.S.
State, 92% dentist ran into the patient sought medical advice by halitosis；Nearly 50% dentist can all run into weekly 6 with
Upper halitosis patient (the international oral cavity equipment exhibition of the Ye Wei halitosis causes of disease and new development [A] the 14th of diagnosis China and
Scientific seminar's collection of thesis, 2010:2).
Halitosis is divided into true property halitosis (Genuine Halitosis), false halitosis (Pseudo Halitosis) and probably smelly
Disease (Halitophobia).True property halitosis refers to the obvious peculiar smell from oral cavity that other people can feel.True property halitosis is divided into
Physiological halitosis (Physiologic Halitosis) and pathologic halitosis (Pathologic Halitosis).Physiological mouthful
It is smelly to result from oral cavity corruption process, it can not cause the special disease or pathological condition of halitosis to exist.Halitosis main source is tongue
The rear of the back of the body.Temporary halitosis caused by food factor (garlic onion etc.) is also attributed to such.Pathologic halitosis is divided into a mouthful source property
Halitosis and non-mouth source property halitosis.Mouthful source property halitosis due to dental health is poor or some mouth diseases caused by, such as tooth
Halitosis caused by all diseases, carious tooth, the xerostomia do not cured etc..Non- mouth source property halitosis is by nasal cavity, throat, lung or upper digestive system
The systemic disease disease halitosis that for example uremia, hepatic sclerosis etc. are caused.False halitosis refers to sufferers themselves and has felt oral peculiar smell,
Inspection result is feminine gender.This symptom can obtain improver by illustrating with psychological consultation.Probably smelly disease refers to by true property or vacation
After the treatment of property halitosis, patient still adheres to oneself there is halitosis, exists on inspection without any factor that can cause halitosis.
Triggering the cause of disease of halitosis has oral cavity intrinsic factor, oral cavity other factor and spiritual sexual factor.In three kinds of factors, oral cavity internal cause
Element is main pathogenic.Once there are some researches show the pathogenic factor of 87% halitosis patient come from oral cavity (Delanghe G,
Ghyselen J,Bollen C,et al.An inventory of patients’response to treatment at a
multi-disciplinary breath odor clinic[J].Quintessence Int,1999,30:307-310.)。
In addition, some mental illnesses and systemic disease can also trigger halitosis.
According to statistics, 80%-90% halitosis comes from oral cavity, such as dental caries, periodontosis, tongue fur, food impaction, bad reparation
Body, diseases of oral mucosa etc., wherein carious tooth and periodontosis are most common relevant disease.Contain substantial amounts of microorganism in oral cavity, its profit
With swill catabolism such as amino acid, the protein of residual in the oral cavity, offensive odour is produced --- volatilization
Property cured compound (Volatile sulfur compounds, VSCs).Sulfide main component is hydrogen sulfide, methyl mercaptan
With diethyl sulfide (Scully C, el-Maaytah M, Porter SR, et al.Breath odor:
etippatheogenesis,assessment and management[J].Eur J Oral Sci,1997,105:287-
293).Clinical trial certificate VSCs levels and halitosis degree are into positive correlation (NakanoY, Yoshimura M, Koga
T.Correlation between oral malodor and periodontal bacteria[J].Microbes
Infect,2002,4(6):67)。
At present, most of researchs are thought to trigger microorganism (mainly Grain-negative anaerobic bacteria) main collection of halitosis in oral cavity
In in gingival sulcus (oral pocket) and tongue fur (Tonzetich J, McBride B C.Characterization of volatile
sulphur production by pathogenic and non-pathogenic strains of oral
Bacteroides[J].Arch Oral Biol,1981,26:963–969).This with research report (classification of Liu Bing's red halitosis and
Related etiological analysis [J] continuing medial educations, 2007,34:72-74) VSCs oral cavity source is mainly gingival sulcus (oral pocket)
And back is consistent with.
Patent ZL 03809346 is added in composition for oral cavity using zinc citrate as anti-calculus material, zinc salt
Addition is 0.001%-20%.Patent ZL 200510026049.5 is referred to a kind of proportioning of whitening toothpaste, and zinc citrate is
0.5%-3.5%, this patent thinks that zinc citrate can dissolve calculus and suppress bacterial plaque calcified deposits, so as to prevent bacterial plaque calculus dentalis
Formation.Patent ZL 200580026141.X are mentioned to a kind of dentifrice composition comprising zinc salt, and zinc salt is to be dissolved in the citric acid of water
Zinc form is present, and zinc citrate is used as a kind of antilithic.Attapulgite double fluorine toothpaste described in patent ZL 200810018916.4 into
Divide and be related to zinc citrate, addition is 0.05%-1.0%, the prevention dental calculus that act as of zinc citrate is formed, and suppresses korron, tea
Attachment of the pigments such as spot in dental surface.Patent ZL 200810018908.X refer to the addition of zinc citrate with acting on before
One patent is identical.Toothpaste described in patent ZL 201010135299.3 contains zinc citrate, and addition is 0.5%-2%, still
Do not refer to that it is acted on.Toothpaste described in patent ZL 20101047150.7 includes zinc citrate composition, and addition is 1%-2%,
This invention thinks that the compositions such as aurantiin, zinc citrate, cineole are added in toothpaste can remove oral peculiar smell, kill oral cavity
Harmful bacteria, zinc citrate has effects that except halitosis, prevents gingivitis, calculus dentalis, dental hemorrhage.Patent ZL
Dentifrice described in 200980162304.5 includes a clock zinc ion source, and the zinc salt comprising organic acid includes zinc citrate.Patent
Toothpaste described in ZL 201180018204.2 is slightly water-soluble citrate, this citrate comprising a kind of source of citrate ion
For zinc citrate.The source of citrate ion at least accounts for more than the 0.6% of formula total amount.The reason for selecting zinc citrate is offer
Extra opaque effect further improves the aesthetic property of product.This patent thinks zinc ion to this composition antiplaque and anti-tooth
Dirt is also valuable.Composition described in patent ZL 201180018162.2 includes one or more zinc ion sources, the zinc from
Component is zinc citrate, helps to increase the aesthetic property and stability of product.Composition described in patent ZL 201080070593.9
Antimicrobial include zinc compound, zinc citrate is one of which.Composition described in patent ZL 201180067627.3
It is used to cover oral peculiar smell containing a series of fragrance components, wherein containing metal salt, metal salt is zinc citrate.Patent ZL
201080015215.0 describe a kind of antimicrobial system, zinc ion source including containing 4- isopropyl -3- methylphenols (IPMP)
With the composition of anion surfactant.
Above-mentioned patent has the composition for referring to zinc citrate as its oral care composition, and most of patent thinks that it has
Play the role of anti-calculus dentalis, partial monopoly think its have except halitosis, prevent gingivitis, calculus dentalis, dental hemorrhage the effects such as.But,
It is reported above that any explanation and illustration is not made to its mechanism of action, supported while also not providing basic experimental data.
Zinc citrate is only a kind of its numerous composition played in effect material in its composition.The reason for disadvantage mentioned above occurs
For above-mentioned all units of patent or the personal mechanism not to composition components are analysed in depth, and are not tested accordingly
It is more to judge certain material or many from the information in other reports verifying effect of the composition or single component
Plant the effect of combinations of substances.
The content of the invention
Present invention aims at provide a kind of oral care implement for removing implication and preparation method thereof, suppression/reduction mouthful
The quantity of volatile sulfur compounds bacterium is produced in chamber, so that reaching improves the purpose of the bad implication of mouth source property.Effect of the present invention
Composition is verified by clinical test can significantly reduce the quantity that volatile sulfur compounds bacterium is produced in oral cavity, improve bad mouth
Gas.
A kind of oral care implement for removing implication includes 4- isopropyl -3- methylphenols, zinc citrate and citrate；
The citrate is one or more of potassium citrate or sodium citrate；
In terms of parts by weight, 0.5~2.0 part of zinc citrate；0.01~0.1 part of 4- isopropyl -3- methylphenols；
The weight ratio of the zinc citrate and potassium citrate is 1: (1.3~1.5)；
The weight ratio of the zinc citrate and sodium citrate is 1: (1.2~1.35).
Further, the oral care implement also includes 0.1~1.0 part of overlord's flower extract.
Overlord's flower extract is that Hylocereus undatus is added into cold soaking 30min in the water of 15 times of quality, is heated in a water bath
Flow back 1h, filtering, reserved filtrate；The water of 15 times of quality, then the 1h that flows back are added in the dregs of a decoction, filtering, merging filtrate is concentrated to give.
On the other hand, oral care implement of the present invention is that toothpaste, tooth powder, mouthwash or mouth are pure and fresh.
It is preferred that, the oral care implement is toothpaste, and in terms of parts by weight, the component of the toothpaste includes：
Also include citrate, the citrate is one or more of potassium citrate or sodium citrate；The lemon
The weight ratio of sour zinc and potassium citrate is 1: (1.3~1.5)；The weight ratio of the zinc citrate and sodium citrate is 1: (1.2~
1.35), all components total amount is 100 parts.
The preferred sorbierite of NMF, glycerine, polyethylene glycol；
The preferred hydrated silica of rubbing agent, calcium carbonate, calcium monohydrogen phosphate；
The thickener preferably carboxymethyl cellulose sodium, xanthans, HPMC, carragheen, guar gum；
Further, the toothpaste also includes 0.1~1.0 part of overlord's flower extract.
On the other hand, the invention provides the preparation method of the toothpaste, comprise the following steps：
(1) citrate and the sweetener stirring and dissolving that is added to the water are obtained into solution；
(2) thickener is added in NMF, is uniformly dispersed and obtains homogeneous solution；
(3) homogeneous solution of step (2) is added in the solution of step (1), stirred；
(4) zinc citrate is added in the solution of step (3) and stirred；
(5) surfactant is added in rubbing agent and is uniformly mixing to obtain uniform powder；
(6) uniform powder of step (5) is added in the solution of step (4), is uniformly mixing to obtain uniform lotion；
(7) 4- isopropyl -3- methylphenols and preservative are added in essence, heating water bath makes dissolving, obtain uniform
Solution；
(8) homogeneous solution of step (7) is added in the uniform lotion of step (6) and stirred, is evacuated；
The preservative is oil-solvent preservative.
Or, the preparation method of the toothpaste comprises the following steps：
(1) citrate, sweetener and the preservative stirring and dissolving that is added to the water are obtained into solution；
(2) thickener is added in NMF, is uniformly dispersed and obtains homogeneous solution；
(3) homogeneous solution of step (2) is added in the solution of step (1), stirred；
(4) zinc citrate is added in the solution of step (3) and stirred；
(5) surfactant is added in rubbing agent and is uniformly mixing to obtain uniform powder；
(6) uniform powder of step (5) is added in the solution of step (4), is uniformly mixing to obtain uniform lotion；
(7) 4- isopropyl -3- methylphenols are added in essence, heating water bath makes dissolving, obtains homogeneous solution；
(8) homogeneous solution of step (7) is added in the uniform lotion of step (6) and stirred, is evacuated；
The preservative is waterborne-type preservation.
Further, the preparation method is additionally included in the step of adding overlord's flower extract in step (1).
The present invention is by zinc citrate, 4- isopropyl -3- methylphenols (IPMP), potassium citrate or sodium citrate, several things
Matter combine, can apply to toothpaste, mouthwash, mouth it is pure and fresh including oral care implement in, by suppressing oral cavity for a long time
Pathogenic bacteria, especially produce the bacterium of bad implication (volatile sulfur compounds), reach removal implication, maintain the work of oral health
With.
At present, declare with suppression/killing oral bacteria or remove the oral care product of implication, substantially useization
Learn bactericide and carry out antibacterial.Such product antibacterial action time is short, and being used for a long time can even trigger oral cavity flora to lack of proper care, and cause mouth
Chamber conditioned pathogen ratio is raised, and further triggers more oral problems.The present invention uses the member of naturally occurring in body
Element or material suppress to produce the bacterium of bad implication in oral cavity.Specific composition and mechanism are explained as follows：
Zinc citrate can effectively suppress to produce volatility vulcanization in oral cavity in the composition as main antibacterial material
The growth of thing bacterium.Zinc ion suppresses following (treatment [J] foreign countries doctor of the flat mouthfuls of source property halitosis of Chen Xi, Feng Xi of mechanism of halitosis
Learn dentistry fascicles, 2004,06:481-482+485.)：(1)Zn2+Sulfydryl in oxidable glycolytic ferment, bacterium is reduced with this
The metabolic activity of bacterium in spot, reaches the effect for suppressing bacterial plaque.(2), Zn2+Affinity, voloxidation vulcanization can be produced with sulphur
Thing (Volatile sulfur compounds, VSCs) can produce the sulfydryl in VSCs material, make non-volatile
Product.Zinc ion can by with newly salivate in Ca2+Ion exchange is carried out, is combined, is able to the material such as carboxyl, phosphate radical
It is detained for a long time in oral cavity, obtains slow lasting release, so that the effect for playing its suppression VSCs of continuation.
In addition, zinc is the indispensable one kind trace element of human body, form of the zinc in human body is widely studied.Except with auxiliary
Outside the form of enzyme is combined with protein, zinc exists also in the form of small molecule complex compound, by zinc in human milk and prostatic fluid
Research, find zinc citrate be a kind of naturally occurring form of the zinc in human body.As can be seen here, zinc citrate is for human body
With very high security.
Bacterium in human oral cavity exists in the form of bacterial plaque mostly, and bacterial plaque is to be present in tooth or other oral cavities are hard
In institutional framework, the microbial film being flush with water is difficult, it is considered to be cause the Etiological of some oral cavity common diseases.Perhaps
Many researchs show bacterium in biomembrane to the sensitiveness of bacteriostatic agent than it in floating state when it is much lower.IPMP is Moschus
The isomer of careless phenol, it is permeable in Dental plaque biofilm and sterilized, and possesses outstanding biocidal efficacies.The same zinc of IPMP
Ion compounding can play a part of Synergistic antimicrobial.
Potassium citrate and sodium citrate are in the composition as solubilized material, when the proportioning of zinc citrate and potassium citrate is
1:When (1.3~1.5), zinc citrate can be completely dissolved.When the proportioning of zinc citrate and sodium citrate is 1:(1.2~
1.35) when, zinc citrate can be completely dissolved.Both materials can apply to toothpaste with zinc citrate compounding use, gargle
In the product such as saliva, mouth be pure and fresh, increase the concentration of zinc ion, improve anti-microbial property.
It is compared with the prior art, the present invention passes through zinc citrate and 4- isopropyl -3- methylphenols (IPMP), potassium citrate
Or sodium citrate compounding plays a part of Synergistic, potassium citrate or sodium citrate can increase lemon with zinc citrate compounding
The solubility of sour zinc, discharges more zinc ions, and the dissolution of substantial amounts of zinc ion can extend zinc citrate or zinc ion in mouth
Retention time in chamber mucous membrane and saliva, strengthens antibacterial effect.IPMP can be infiltrated into be sterilized in Dental plaque biofilm, together
When, play prolonged antibacterial effect.
Had the advantage that relative to prior art and beneficial effect：
(1) present invention plays a part of Synergistic, lemon by zinc citrate and potassium citrate or sodium citrate compounding
Sour potassium or sodium citrate can increase the solubility of zinc citrate with zinc citrate compounding, discharge more zinc ions, and enhancing is anti-
Bacterium effect.Meanwhile, the dissolution of substantial amounts of zinc ion can extend the guarantor of zinc citrate or zinc ion in mucous membrane of mouth and saliva
The time is stayed, prolonged antibacterial effect is played.
(2) present invention can be infiltrated into by 4- isopropyl -3- methylphenols (IPMP) and killed in Dental plaque biofilm
Bacterium, can further enhance the anti-microbial property of composition.
(3) using zinc citrate as bacteriostatic agent, zinc citrate is a kind of naturally occurring form of the zinc in human body, to people
Body has important physiological action, and zinc citrate is added in the composition, while microbial balance in not influenceing oral cavity, energy
Enough bacteriums for effectively suppressing to produce bad implication.
(4) extract of present invention addition Hylocereus undatus has heat-clearing effect, can eliminate gingival swelling and pain, further promotes anti-
Bacterium effect.
Embodiment
Embodiment 1
A kind of toothpaste for removing implication, the parts by weight of each composition：
It is as follows using preparation method：
(1) potassium citrate, saccharin sodium and sodium benzoate are added to the water stirring and dissolving；
(2) sodium carboxymethylcellulose is added and stirred in sorbierite, added PEG-400 and stir；
(3) solution that the homogeneous solution of step (2) is added into step (1) stirs；
(4) stirred in the solution that zinc citrate is added to step (3)；
(5) laruyl alcohol sodium sulfovinate is added and stirred in hydrated silica；
(6) uniform powder of step (5) is added in the solution of step (4), stirred；
(7) 4- isopropyl -3- methylphenols are added in fragrance solution, heating water bath dissolving；
(8) stir, be evacuated in the uniform lotion that the homogeneous solution of step (7) is added to step (6).
Comparative example 1
The parts by weight of each composition of toothpaste：(individually addition 4- isopropyl -3- methylphenols (IPMP))
Method be the same as Example 1
Comparative example 2
The parts by weight of each composition of toothpaste：(individually adding zinc citrate)
Method be the same as Example 1
1 removing foul breath toothpaste efficiency clinical trial
1.1 test object
Subject be meet include and exclusion standard the masculinity and femininity with mouth source property halitosis.
1.2 testing process
Test is carried out using chemical analysis and bacterial analysis method simultaneously.
Flow：Elution → base line measurement → toothpaste efficiency test → detection → interpretation of result
(1) elute：Subject is continuously brushed teeth 7 days using the toothpaste of comparative example 2, is respectively brushed teeth 1 time sooner or later daily, and 1- is squeezed every time
2cm length toothpaste is brushed teeth 2-3 minutes.
(2) base line measurement：
Chemical analysis：Respectively at the 2nd day, the 4th day, the 6th day morning 9, do not brushed teeth the condition do not fed in subject
Under, determine its numerical value using Halimeter halimeters；
Bacterial analysis method：At the 8th day morning 9, under conditions of subject does not brush teeth and not fed, using sterile test tube and
Cotton swab collects subjects saliva and tongue fur bacterium respectively, and carries out Anaerobic culturel counting to production vulcanization hydrogen bacteria.
(3) toothpaste efficiency is tested：The toothpaste of embodiment 1 was begun to use continuously to brush teeth from the 9th day 7 days, it is sooner or later each daily to brush
Tooth 1 time, squeezes 1-2cm length toothpaste and brushes teeth 2-3 minutes every time.
(4) detect：
Chemical analysis：Respectively at the 10th day, the 12nd day, the 14th day morning 9, do not brushed teeth the bar do not fed in subject
Under part, its implication value is determined using Halimeter halimeters；
Bacterial analysis method：At the 16th day morning 9, under conditions of subject does not brush teeth and do not fed, sterile test tube is used
Collect subjects saliva and tongue fur bacterium respectively with cotton swab, and Anaerobic culturel counting is carried out to production vulcanization hydrogen bacteria.
1.3 test result
1.3.1 chemical analysis test result
As shown in Table 1, when the toothpaste that zinc citrate is individually added using comparative example 2 is eluted, the mouth of each subject
Gas measured value maintains an of a relatively high and stable level.When beginning to use effect toothpaste of embodiment 1 to be brushed teeth, mouth
Gas measured value starts slow decline, until the implication measured value of the 14th day each subject reaches a relatively low level (table 1).By
This proves that the present invention plays a part of Synergistic by zinc citrate and 4- isopropyl -3- methylphenols, potassium citrate compounding,
Potassium citrate or sodium citrate can increase the solubility of zinc citrate with zinc citrate compounding, discharge more zinc ions, increase
Strong antimicrobial effect.Meanwhile, the dissolution of substantial amounts of zinc ion can extend zinc citrate or zinc ion in mucous membrane of mouth and saliva
Retention time, play prolonged antibacterial effect.
The Halimeter implications instrument of table 1 detects data
1.3.2 bacterial analysis method test result
Using producing H in subjects saliva after the toothpaste of embodiment 12S bacterial number variation tendencies are shown in Table 2.Test result table
The bright toothpaste containing the present composition produces H to reducing in saliva2S bacteriums have the effect of highly significant, and (bacterial reduction reaches
99.99%).This shows the present composition to producing H in saliva2S bacteriums have good inhibiting effect.
H is produced in the subjects saliva of table 22S bacterial numbers change
To producing H in subject's tongue fur2S bacteriums carry out detection discovery, although it produces H2S bacteriums reduce quantity and are not so good as in saliva
Reduce much, but its slip has still reached 89.38% (table 3).Because the area at back rear portion is larger, the nipple on surface
Shape structure, surface can adhere to substantial amounts of microorganism, and microorganism easily forms mycoderm on its surface and improves bacteria thing
The resistance of matter, this may is that saliva produces H with tongue fur2S bacterial numbers reduce the reason for difference is big.
The subject's tongue fur of table 3 produces H2S bacterial numbers change
Use production in subject's tongue fur after the toothpaste of comparative example 1 (individually addition 4- isopropyl -3- methylphenols (IPMP))
H2S bacteriums carry out detection discovery, produce H2S bacterial numbers are reduced not as producing H after the toothpaste using embodiment 12S bacteriums are reduced much,
But its slip has still reached 79.0% (table 4).This be due to back rear portion area it is larger, the mamillary knot on surface
Structure, surface can adhere to substantial amounts of microorganism, and microorganism easily forms mycoderm on its surface and improves bacteria material
Resistance, plays synergy after the present composition is compounded, and 4- isopropyl -3- methylphenols (IPMP) infiltrate into bacterial plaque
The ability sterilized in biomembrane is greatly enhanced, and produces H2S bacterial reductions have reached 89.38%, considerably beyond independent addition
IPMP effect.
The subject's tongue fur of table 4 produces H2S bacterial numbers change
Embodiment 2
A kind of toothpaste for removing implication of the present invention, can also add overlord's flower extract, the parts by weight of each composition are as follows：
Overlord's flower extract is that Hylocereus undatus is added into cold soaking 30min in the water of 15 times of quality, is heated in a water bath
Flow back 1h, filtering, reserved filtrate；The water of 15 times of quality, then the 1h that flows back are added in the dregs of a decoction, filtering, merging filtrate is concentrated to give.
The preparation method of the toothpaste is as follows：
(1) sodium citrate, saccharin sodium, sodium benzoate and overlord's flower extract are added to the water stirring and dissolving；
(2) sodium carboxymethylcellulose is added and stirred in sorbierite, added PEG-400 and stir；
(3) solution that the homogeneous solution of step (2) is added into step (1) stirs；
(4) stirred in the solution that zinc citrate is added to step (3)；
(5) laruyl alcohol sodium sulfovinate is added and stirred in hydrated silica；
(6) uniform powder of step (5) is added in the solution of step (4), stirred；
(7) 4- isopropyl -3- methylphenols are added in fragrance solution, heating water bath dissolving；
(8) stir, be evacuated in the uniform lotion that the homogeneous solution of step (7) is added to step (6).
Toothpaste removing foul breath measure of merit is tested
1 removing foul breath toothpaste efficiency clinical trial
1.1 test object
Subject be meet include and exclusion standard the masculinity and femininity with mouth source property halitosis.
1.2 testing process
Test is carried out using chemical analysis and bacterial analysis method simultaneously.
Flow：Elution → base line measurement → toothpaste efficiency test → detection → interpretation of result
(1) elute：Subject is continuously brushed teeth 7 days using the toothpaste of embodiment 2, is respectively brushed teeth 1 time sooner or later daily, and 1- is squeezed every time
2cm length toothpaste is brushed teeth 2-3 minutes.
(2) base line measurement：
Chemical analysis：Respectively at the 2nd day, the 4th day, the 6th day morning 9, do not brushed teeth the condition do not fed in subject
Under, determine its numerical value using Halimeter halimeters；
(3) toothpaste efficiency is tested：The toothpaste of embodiment 1 was begun to use continuously to brush teeth from the 9th day 7 days, it is sooner or later each daily to brush
Tooth 1 time, squeezes 1-2cm length toothpaste and brushes teeth 2-3 minutes every time.
(4) detect：
Chemical analysis：Respectively at the 10th day, the 12nd day, the 14th day morning 9, do not brushed teeth the bar do not fed in subject
Under part, its implication value is determined using Halimeter halimeters；
1.3 test result
1.3.1 chemical analysis test result
The Halimeter implications instrument of table 5 detects data
Test result (table 5) shows mouth of toothpaste of the embodiment 2 containing zinc citrate and overlord's flower extract to subject
Gas measured value has significant decline, illustrates to reduce and H is produced in saliva2S bacteriums, this shows that zinc citrate is answered with overlord's flower extract
Timing in saliva to producing H2S bacteriums have more preferable inhibitory action.
Embodiment 3
1.3.2 zinc citrate solubility experiment result
The zinc citrate solubility experiment result of table 6
Note：+ to represent liquid muddy, ++ liquid slight haziness is represented, +++ liquid relatively clarification is represented, ++++to represent liquid complete
Full clarification
Test result shows to play a part of Synergistic, lemon by zinc citrate and potassium citrate or sodium citrate compounding
Lemon acid potassium or sodium citrate can increase the solubility of zinc citrate with zinc citrate compounding, discharge more zinc ions, enhancing
Antibacterial effect.Meanwhile, the dissolution of substantial amounts of zinc ion can extend zinc citrate or zinc ion in mucous membrane of mouth and saliva
Retention time, plays prolonged antibacterial effect.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in embodiment disclosed and described above, to the present invention's
Some modifications and changes should also be as falling into the scope of the claims of the present invention.Although in addition, being used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any limitation to the present invention.
Claims (10)
1. a kind of oral care implement for removing implication, it is characterised in that including 4- isopropyl -3- methylphenols, zinc citrate
And citrate；The citrate is one or more of potassium citrate or sodium citrate；
In terms of parts by weight, 0.5~2.0 part of zinc citrate；0.01~0.1 part of 4- isopropyl -3- methylphenols；
The weight ratio of the zinc citrate and potassium citrate is 1:(1.3~1.5)；
The weight ratio of the zinc citrate and sodium citrate is 1:(1.2~1.35).
2. oral care implement according to claim 1, it is characterised in that also extracted including 0.1~1.0 part of Hylocereus undatus
Thing.
3. oral care implement according to claim 2, it is characterised in that overlord's flower extract is to add Hylocereus undatus
Enter the cold soaking 30min into the water of 15 times of quality, 1h is heated to reflux in a water bath, filter, reserved filtrate；15 times of quality are added in the dregs of a decoction
Water, then the 1h that flows back, filtering, merging filtrate is concentrated to give.
4. the oral care implement according to one of claim 1-3, it is characterised in that the oral care implement is tooth
Cream, tooth powder, mouthwash or mouth are pure and fresh.
5. oral care implement according to claim 4, it is characterised in that the oral care implement is toothpaste, with weight
Number meter is measured, the component of the toothpaste includes：
Also include citrate, the citrate is one or more of potassium citrate or sodium citrate；The zinc citrate
Weight ratio with potassium citrate is 1: (1.3~1.5)；The weight ratio of the zinc citrate and sodium citrate is 1: (1.2~
1.35), all components total amount is 100 parts.
6. oral care implement according to claim 5, it is characterised in that the toothpaste also includes 0.1~1.0 part of despot
King blossom extract.
7. oral care implement according to claim 6, it is characterised in that overlord's flower extract is to add Hylocereus undatus
Enter the cold soaking 30min into the water of 15 times of quality, 1h is heated to reflux in a water bath, filter, reserved filtrate；15 times of quality are added in the dregs of a decoction
Water, then the 1h that flows back, filtering, merging filtrate is concentrated to give.
8. the preparation method of the oral care implement of a kind of removal implication described in claim 5, it is characterised in that including following
Step：
(1) citrate and the sweetener stirring and dissolving that is added to the water are obtained into solution；
(2) thickener is added in NMF, is uniformly dispersed and obtains homogeneous solution；
(3) homogeneous solution of step (2) is added in the solution of step (1), stirred；
(4) zinc citrate is added in the solution of step (3) and stirred；
(5) surfactant is added in rubbing agent and is uniformly mixing to obtain uniform powder；
(6) uniform powder of step (5) is added in the solution of step (4), is uniformly mixing to obtain uniform lotion；
(7) 4- isopropyl -3- methylphenols and preservative are added in essence, heating water bath makes dissolving, obtains homogeneous solution；
(8) homogeneous solution of step (7) is added in the uniform lotion of step (6) and stirred, is evacuated；
The preservative is oil-solvent preservative.
9. the preparation method of the oral care implement of a kind of removal implication described in claim 5, it is characterised in that including following
Step：
(1) citrate, sweetener and the preservative stirring and dissolving that is added to the water are obtained into solution；
(2) thickener is added in NMF, is uniformly dispersed and obtains homogeneous solution；
(3) homogeneous solution of step (2) is added in the solution of step (1), stirred；
(4) zinc citrate is added in the solution of step (3) and stirred；
(5) surfactant is added in rubbing agent and is uniformly mixing to obtain uniform powder；
(6) uniform powder of step (5) is added in the solution of step (4), is uniformly mixing to obtain uniform lotion；
(7) 4- isopropyl -3- methylphenols are added in essence, heating water bath makes dissolving, obtains homogeneous solution；
(8) homogeneous solution of step (7) is added in the uniform lotion of step (6) and stirred, is evacuated；
The preservative is waterborne-type preservation.
10. preparation method according to claim 8 or claim 9, it is characterised in that be additionally included in step (1) and add Hylocereus undatus
The step of extract.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710146398.3A CN107007482A (en) | 2017-03-13 | 2017-03-13 | A kind of oral care implement for removing implication and preparation method thereof |
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| CN201710146398.3A CN107007482A (en) | 2017-03-13 | 2017-03-13 | A kind of oral care implement for removing implication and preparation method thereof |
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| CN111057622A (en) * | 2019-10-21 | 2020-04-24 | 广东莱雅新化工科技有限公司 | Cleaning agent |
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Application publication date: 20170804 |