CN113233963A - 一种苯酚与甲醇制备苯甲醚的方法 - Google Patents
一种苯酚与甲醇制备苯甲醚的方法 Download PDFInfo
- Publication number
- CN113233963A CN113233963A CN202110586953.0A CN202110586953A CN113233963A CN 113233963 A CN113233963 A CN 113233963A CN 202110586953 A CN202110586953 A CN 202110586953A CN 113233963 A CN113233963 A CN 113233963A
- Authority
- CN
- China
- Prior art keywords
- fluoride
- phenol
- anisole
- powder
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title claims abstract description 94
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 title claims abstract description 90
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title claims abstract description 47
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 34
- 239000003054 catalyst Substances 0.000 claims abstract description 65
- 238000006243 chemical reaction Methods 0.000 claims abstract description 43
- 229910003158 γ-Al2O3 Inorganic materials 0.000 claims abstract description 12
- 229910002651 NO3 Inorganic materials 0.000 claims abstract description 11
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000005470 impregnation Methods 0.000 claims abstract description 11
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000005695 Ammonium acetate Substances 0.000 claims abstract description 9
- 235000019257 ammonium acetate Nutrition 0.000 claims abstract description 9
- 229940043376 ammonium acetate Drugs 0.000 claims abstract description 9
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims abstract description 8
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims abstract description 8
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims abstract description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims abstract description 8
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims abstract description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims abstract description 4
- 239000001639 calcium acetate Substances 0.000 claims abstract description 4
- 235000011092 calcium acetate Nutrition 0.000 claims abstract description 4
- 229960005147 calcium acetate Drugs 0.000 claims abstract description 4
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims abstract description 4
- 235000011285 magnesium acetate Nutrition 0.000 claims abstract description 4
- 239000011654 magnesium acetate Substances 0.000 claims abstract description 4
- 229940069446 magnesium acetate Drugs 0.000 claims abstract description 4
- 235000011056 potassium acetate Nutrition 0.000 claims abstract description 4
- 235000003270 potassium fluoride Nutrition 0.000 claims abstract description 4
- 239000011698 potassium fluoride Substances 0.000 claims abstract description 4
- 239000001632 sodium acetate Substances 0.000 claims abstract description 4
- 235000017281 sodium acetate Nutrition 0.000 claims abstract description 4
- 235000013024 sodium fluoride Nutrition 0.000 claims abstract description 4
- 239000011775 sodium fluoride Substances 0.000 claims abstract description 4
- 229960004109 potassium acetate Drugs 0.000 claims abstract description 3
- 229960004249 sodium acetate Drugs 0.000 claims abstract description 3
- 239000000843 powder Substances 0.000 claims description 46
- 239000008367 deionised water Substances 0.000 claims description 35
- 229910021641 deionized water Inorganic materials 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 238000000227 grinding Methods 0.000 claims description 31
- 238000003756 stirring Methods 0.000 claims description 31
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 28
- 238000001035 drying Methods 0.000 claims description 26
- 230000032683 aging Effects 0.000 claims description 21
- 238000009210 therapy by ultrasound Methods 0.000 claims description 21
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 18
- 229910052786 argon Inorganic materials 0.000 claims description 14
- 239000012300 argon atmosphere Substances 0.000 claims description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 6
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 claims description 6
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 claims description 6
- 238000010574 gas phase reaction Methods 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 4
- 238000000465 moulding Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 229910052593 corundum Inorganic materials 0.000 claims 1
- 229910001845 yogo sapphire Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 7
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 abstract 2
- 229910001634 calcium fluoride Inorganic materials 0.000 abstract 2
- SHXXPRJOPFJRHA-UHFFFAOYSA-K iron(iii) fluoride Chemical compound F[Fe](F)F SHXXPRJOPFJRHA-UHFFFAOYSA-K 0.000 abstract 2
- ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 abstract 2
- 229910001635 magnesium fluoride Inorganic materials 0.000 abstract 2
- 238000005804 alkylation reaction Methods 0.000 description 7
- 238000010934 O-alkylation reaction Methods 0.000 description 6
- 238000001354 calcination Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 6
- 238000000643 oven drying Methods 0.000 description 5
- 230000003197 catalytic effect Effects 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000011987 methylation Effects 0.000 description 2
- 238000007069 methylation reaction Methods 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000003254 gasoline additive Substances 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- -1 methyl halide Chemical class 0.000 description 1
- 239000012022 methylating agents Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000003016 pheromone Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000010660 tarragon oil Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/09—Preparation of ethers by dehydration of compounds containing hydroxy groups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/24—Nitrogen compounds
- B01J27/25—Nitrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J35/00—Catalysts, in general, characterised by their form or physical properties
- B01J35/40—Catalysts, in general, characterised by their form or physical properties characterised by dimensions, e.g. grain size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J35/00—Catalysts, in general, characterised by their form or physical properties
- B01J35/50—Catalysts, in general, characterised by their form or physical properties characterised by their shape or configuration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/02—Impregnation, coating or precipitation
- B01J37/0201—Impregnation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/08—Heat treatment
- B01J37/082—Decomposition and pyrolysis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
本发明公开了一种苯酚与甲醇制备苯甲醚的方法,该方法采用固定床反应器,以乙酸钠、乙酸钾、乙酸钙、乙酸镁或乙酸铵改性γ‑Al2O3负载氟化铵、氟化钠、氟化钾、氟化铁、氟化镁、氟化钙等活性组分作为催化剂,催化苯酚与甲醇制备苯甲醚,其中氟化铁、氟化镁、氟化钙改性均为对应硝酸盐和氟化铵在γ‑Al2O3上二次浸渍制备而成。本发明实现了苯甲醚的高效合成,不但苯酚转化率高、苯甲醚选择性高,且催化剂制备流程简单、成本低、稳定性高、使用寿命长,达到了工业催化剂的应用要求。
Description
技术领域
本发明属于苯甲醚的制备技术领域,具体涉及一种采用苯酚与甲醇制备苯甲醚的方法。
背景技术
苯甲醚又称茴香醚、甲氧基苯,天然发现存在于龙蒿油中。由于苯甲醚具有独特的香味,广泛用于香水、昆虫信息素、酚醛树脂、肥皂、驱虫剂和添加剂等。由于其具有活泼的醚键,可作为工业有机合成的原料。而且,苯甲醚能提高汽油的辛烷值,可作汽油添加剂代替甲基叔丁基醚。由于它具有高的介电常数和高沸点,可作为引发剂、恒温器填料等,是一种重要的有机化工原料及中间体。近年来,市场对苯甲醚的需求量急剧增长。苯甲醚在印刷工业和油漆颜料工业中作溶剂,亦可用于催化剂的生产,合成树脂和燃料的添加剂。
合成苯甲醚的主要方法是苯酚的烷基化反应。在苯酚的烷基化反应中,苯甲醚通常在碱性环境下通过液相法合成,如苯酚与硫酸二甲酯的反应、苯酚与卤代烃的反应。然而所用碱对环境有害,以及硫酸二甲酯、溴代苯等剧毒原料使用过程中会对人和设备环境造成损害,近年来这些工艺受到了严格的限制,一个绿色高效的制备工艺就显得尤为重要。碳酸二甲酯(DMC)和甲醇都是烷基化反应中对硫酸二甲酯和甲基卤化物的环保替代品,二者毒性较低,无污染,是绿色环保的甲基化试剂。采用DMC作为烷基化剂,在温和条件下实现了酚类化合物转化为相应的醚类。但不可否认的是DMC在反应过程中活性较低,需在较高温度和催化剂的共同作用才能发生反应,增加了苯甲醚合成过程的复杂性和成本。
采用甲醇直接烷基化取代DMC的方法,以甲醇作为甲基化试剂与苯酚反应合成苯甲醚,相较DMC法具有原材料成本低和后处理简单等优点。Samolada等(Journal ofCatalysis,1995,152(1):52-62)研究了γ-Al2O3负载硫酸盐催化苯酚与甲醇的选择性O-烷基化反应,在290~330℃及常压条件下,苯酚转化率约为65%,苯甲醚选择性达90%。党丹等(Chinese Journal of Catalysis,2016,37(5):720-726.)研究了γ-Al2O3(AA)负载型催化剂上甲醇与苯酚气相甲基化反应。在700℃、焙烧8h后,KH2PO4/AA催化性能最佳。在400-450℃的最佳反应条件下,苯酚转化率约为72.34%,苯甲醚选择性达98%。
但在苯酚-甲醇反应中,甲醇反应活性低,易分解,且C-烷基化与O-烷基化反应同时进行,产物组成更为复杂。相较于C-烷基化,苯酚的O-烷基化的产物更难获得。Balasubramanian等(Proceedings of the Indian Academy of Sciences-ChemicalSciences,1998,110(5):453-460.)在Y分子筛上进行离子交换生成FeY、ZnY、CdY分子筛进行苯酚与甲醇的烷基化反应,但生成O-烷基化产物的选择性均小于10%。Rajaram等(Applied Catalysis A General,2003,246(2):373-382)以浸渍碱金属氧化物后的气相SiO2为催化剂研究苯酚的烷基化反应,当673K、酚醇比为5时,苯酚转化率达91%,O烷基化反应选择性为100%。
虽然上述研究中获得了一部分突破,催化剂都表现出较高的催化活性,但大部分催化剂存在着生C-烷基化和O-烷基化同时发生,且存在随着反应的进行催化剂活性逐渐衰减、催化剂使用寿命较低等缺陷,势必造成生产成本较高,能耗较大,难以具有市场竞争力等问题。由此,选择合适的催化剂是决定苯酚O-烷基化工艺合成苯甲醚工业化的关键。
发明内容
本发明的目的在于针对现有技术中存在的缺陷或不足,提供一种制备工艺简单、无污染、转化率高、催化剂制备工艺简单、使用寿命长的苯酚与甲醇制备苯甲醚的方法。
针对上述目的,本发明采取的技术方案由下述步骤组成:
1、将γ-Al2O3和乙酸盐加入到去离子水中,在40~80℃下搅拌3~8h,过滤,洗涤,60~100℃烘干,研磨成粉,在管式炉氩气气氛下400℃~600℃焙烧3~6h,得到催化剂载体;其中,所述γ-Al2O3与乙酸盐、去离子水的质量比为1:0.01~0.1:5~15,所述乙酸盐为乙酸钠、乙酸钾、乙酸钙、乙酸镁、乙酸铵中任意一种或多种。
2、采用等体积浸渍法,将催化剂载体和硝酸盐加入到去离子水中,搅拌均匀,超声3~30min,常温静置陈化8~12h,60~100℃烘干,研磨成粉,再将其与氟化物加入到去离子水中,搅拌均匀,超声3~30min,常温静置陈化8~12h,60~100℃烘干,研磨成粉后置于管式炉中,在氩气气氛下400~600℃焙烧3~20h,制得催化剂;其中,所述催化剂载体与氟化物、硝酸盐的质量比为1:0.005~0.05:0.01~0.1。或者采用等体积浸渍法,将催化剂载体和氟化物加入到去离子水中,搅拌均匀,超声3~30min,常温静置陈化8~12h,60~100℃烘干,研磨成粉后置于管式炉中,在氩气气氛下400~600℃焙烧3~20h,制得催化剂;其中,所述催化剂载体与氟化物的质量比为1:0.001~0.02。
上述的硝酸盐为硝酸铁、硝酸镁、硝酸钙中任意一种或多种,氟化物为氟化铵、氟化钠、氟化钾中任意一种或多种。
3、将催化剂经造粒、成型为直径3~6mm、高3~6mm的圆柱状粒子,装填入固定床反应器;将苯酚和甲醇预热后连续通过固定床反应器,在反应温度280~350℃、反应压力为0.1~3MPa、物料停留时间为20~40s反应条件下,进行气相反应生成苯甲醚,其中所述苯酚与甲醇的摩尔比为1:2~10。
上述步骤1中,优选将γ-Al2O3和乙酸盐加入到去离子水中,在60~70℃下搅拌5~6h,过滤,洗涤,60~80℃烘干,研磨成粉,在管式炉氩气气氛下450~550℃焙烧4~5h,得到催化剂载体;其中,优选所述γ-Al2O3与乙酸盐、去离子水的质量比为1:0.03~0.05:8~12。
上述步骤2中,采用等体积浸渍法,将催化剂载体和硝酸盐加入到去离子水中,搅拌均匀,优选超声10~30min,常温静置陈化10~12h,60~80℃烘干,研磨成粉,再将其与氟化物加入到去离子水中,搅拌均匀,超声10~30min,常温静置陈化10~12h,60~80℃烘干,研磨成粉后置于管式炉中,在氩气气氛下450~550℃焙烧4~5h;其中,所述催化剂载体与氟化物、硝酸盐的质量比优选为1:0.01~0.03:0.03~0.08。
上述步骤2中,采用等体积浸渍法,将催化剂载体和氟化物加入到去离子水中,搅拌均匀,优选超声10~30min,常温静置陈化10~12h,60~80℃烘干,研磨成粉后置于管式炉中,在氩气气氛下450~550℃焙烧4~5h;其中,所述催化剂载体与氟化物的质量比优选为1:0.005~0.012。
上述步骤1和2中,所述氩气优选以50~100mL/min通入管式炉。
上述步骤3中,优选将催化剂经造粒、成型为直径4~5mm、高4~5mm的圆柱状粒子,装填入固定床反应器;将苯酚和甲醇预热后连续通过固定床反应器,在反应温度300~330℃、反应压力为0.1~1MPa、物料停留时间为25~35s反应条件下,进行气相反应生成苯甲醚,其中所述苯酚与甲醇的摩尔比为1:3~5。
本发明的有益效果如下:
本发明具有催化剂制备流程简单、成本低的特点,催化使用具有转化率高、选择性好、副产物少、使用寿命长的特点,反应200h后,苯酚的转化率仍可达到76.8%~90.7%、苯甲醚选择性仍可达到90.7%~98.3%,继续延长反应至2000h,催化剂的活性基本不变,达到了工业催化剂的应用要求。
具体实施方式
下面结合实施例对本发明进一步详细说明,但本发明的保护范围不仅限于这些实施例。
下面实施例中苯酚转化率和苯甲醚选择性采用气相色谱检测,气相色谱条件为:检测器为FID,汽化室240℃,检测器温度为240℃,柱温为60℃恒温2min,10℃/min升至220℃,恒温1min,色谱柱为HP-5。
实施例1
1、将100gγ-Al2O3加入到1000g去离子水中,加入3g乙酸铵,在70℃下搅拌6h,过滤,洗涤,70℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂载体。
2、将7.2g硝酸铁加入72g去离子水中,再加入100g催化剂载体,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉,再将其与1.98g氟化铵加入到78g去离子水中,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂。
3、将步骤2所得催化剂经造粒、成型为直径4mm、高4mm的圆柱状粒子,装填入固定床反应器,催化剂装填量为5mL,反应管内径为28mm,材质为316L不锈钢;将苯酚与甲醇预热后按摩尔比为1:5连续通过固定床反应器,在反应温度310℃、反应压力0.1MPa、物料停留时间为30s反应条件下,进行气相反应生成苯甲醚。经检测,反应200h,苯酚转化率为90.7%,苯甲醚选择性为90.6%。
实施例2
1、将100gγ-Al2O3加入到1000g去离子水中,加入2g乙酸铵和2.78g乙酸镁,在70℃下搅拌6h,过滤,洗涤,70℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂载体。
2、将4.58g硝酸镁加入72g去离子水中,再加入100g催化剂载体,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉,再将其与1.32g氟化铵加入到78g去离子水中,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂。
3、该步骤与实施例1相同,经检测,反应200h,苯酚转化率为88.9%,苯甲醚选择性为91.4%。
实施例3
1、将100gγ-Al2O3加入到1000g去离子水中,加入2g乙酸铵和2.06g乙酸钙,在70℃下搅拌6h,过滤,洗涤,70℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂载体。
2、将4.22g硝酸钙加入72g去离子水中,再加入100g催化剂载体,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉,再将其与1.32g氟化铵加入到78g去离子水中,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂。
3、该步骤与实施例1相同,经检测,反应200h,苯酚转化率为86.6%,苯甲醚选择性为93.4%。
实施例4
1、将100gγ-Al2O3加入到1000g去离子水中,加入2g乙酸铵和1.78g乙酸钠,在70℃下搅拌6h,过滤,洗涤,70℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂载体。
2、将0.75g氟化钠加入80g去离子水中,再加入100g催化剂载体,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂。
3、该步骤与实施例1相同,经检测,反应200h,苯酚转化率为76.8%,苯甲醚选择性为98.3%。
实施例5
1、将100gγ-Al2O3加入到1000g去离子水中,加入3g乙酸铵,在70℃下搅拌6h,过滤,洗涤,70℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂载体。
2、将0.66g氟化铵加入80g去离子水中,再加入100g催化剂载体,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂。
3、该步骤与实施例1相同,经检测,反应200h,苯酚转化率为86.5%,苯甲醚选择性为90.78%。
实施例6
1、将100gγ-Al2O3加入到1000g去离子水中,加入2g乙酸铵和1.27g乙酸钾,在70℃下搅拌6h,过滤,洗涤,70℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂载体。
2、将1.04g氟化钾加入80g去离子水中,再加入100g催化剂载体,搅拌均匀,超声20min,常温静置陈化10h,60℃烘干,研磨成粉后置于管式炉中,以50mL/min通入氩气,在500℃下焙烧4h,制得催化剂。
3、该步骤与实施例1相同,经检测,反应200h,苯酚转化率为80.3%,苯甲醚选择性为94.5%。
Claims (9)
1.一种苯酚与甲醇制备苯甲醚的方法,其特征在于该方法由下述步骤组成:
(1)将γ-Al2O3和乙酸盐加入到去离子水中,在40~80℃下搅拌3~8h,过滤,洗涤,60~100℃烘干,研磨成粉,在管式炉氩气气氛下400~600℃焙烧3~6h,得到催化剂载体;其中,所述γ-Al2O3与乙酸盐、去离子水的质量比为1:0.01~0.1:5~15,所述乙酸盐为乙酸钠、乙酸钾、乙酸钙、乙酸镁、乙酸铵中任意一种或多种;
(2)采用等体积浸渍法,将催化剂载体和硝酸盐加入到去离子水中,搅拌均匀,超声3~30min,常温静置陈化8~12h,60~100℃烘干,研磨成粉,再将其与氟化物加入到去离子水中,搅拌均匀,超声3~30min,常温静置陈化8~12h,60~100℃烘干,研磨成粉后置于管式炉中,在氩气气氛下400~600℃焙烧3~20h,制得催化剂;其中,所述催化剂载体与氟化物、硝酸盐的质量比为1:0.005~0.05:0.01~0.1;
或者采用等体积浸渍法,将催化剂载体和氟化物加入到去离子水中,搅拌均匀,超声3~30min,常温静置陈化8~12h,60~100℃烘干,研磨成粉后置于管式炉中,在氩气气氛下400~600℃焙烧3~20h,制得催化剂;其中,所述催化剂载体与氟化物的质量比为1:0.001~0.02;
上述的硝酸盐为硝酸铁、硝酸镁、硝酸钙中任意一种或多种,氟化物为氟化铵、氟化钠、氟化钾中任意一种或多种;
(3)将催化剂经造粒、成型为直径3~6mm、高3~6mm的圆柱状粒子,装填入固定床反应器;将苯酚和甲醇预热后连续通过固定床反应器,在反应温度280~350℃、反应压力为0.1~3MPa、物料停留时间为20~40s反应条件下,进行气相反应生成苯甲醚,其中所述苯酚与甲醇的摩尔比为1:2~10。
2.根据权利要求1所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(1)中,将γ-Al2O3和乙酸盐加入到去离子水中,在60~70℃下搅拌5~6h,过滤,洗涤,60~80℃烘干,研磨成粉,在管式炉氩气气氛下450~550℃焙烧4~5h,得到催化剂载体。
3.根据权利要求1或2所述的苯酚与甲醇制备苯甲醚的方法,步骤(1)中,所述的γ-Al2O3与乙酸盐、去离子水的质量比为1:0.03~0.05:8~12。
4.根据权利要求1所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(2)中,采用等体积浸渍法,将催化剂载体和硝酸盐加入到去离子水中,搅拌均匀,超声10~30min,常温静置陈化10~12h,60~80℃烘干,研磨成粉,再将其和氟化物加入到去离子水中,搅拌均匀,超声10~30min,常温静置陈化10~12h,60~80℃烘干,研磨成粉后置于管式炉中,在氩气气氛下450~550℃焙烧4~5h,制得催化剂。
5.根据权利要求4所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(2)中,所述催化剂载体与氟化物、硝酸盐的质量比为1:0.01~0.03:0.03~0.08。
6.根据权利要求1所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(2)中,采用等体积浸渍法,将催化剂载体和氟化物加入到去离子水中,搅拌均匀,超声10~30min,常温静置陈化10~12h,60~80℃烘干,研磨成粉后置于管式炉中,在氩气气氛下450~550℃焙烧4~5h,制得催化剂。
7.根据权利要求6所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(2)中,所述催化剂载体与氟化物的质量比为1:0.005~0.012。
8.根据权利要求1所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(1)和(2)中,所述氩气以50~200mL/min通入管式炉。
9.根据权利要求1所述的苯酚与甲醇制备苯甲醚的方法,其特征在于:步骤(3)中,将催化剂经造粒、成型为直径4~5mm、高4~5mm的圆柱状粒子,装填入固定床反应器;将苯酚和甲醇预热后连续通过固定床反应器,在反应温度300~330℃、反应压力为0.1~1MPa、物料停留时间为25~35s反应条件下,进行气相反应生成苯甲醚,其中所述苯酚与甲醇的摩尔比为1:3~5。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110586953.0A CN113233963A (zh) | 2021-05-27 | 2021-05-27 | 一种苯酚与甲醇制备苯甲醚的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110586953.0A CN113233963A (zh) | 2021-05-27 | 2021-05-27 | 一种苯酚与甲醇制备苯甲醚的方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113233963A true CN113233963A (zh) | 2021-08-10 |
Family
ID=77139224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110586953.0A Pending CN113233963A (zh) | 2021-05-27 | 2021-05-27 | 一种苯酚与甲醇制备苯甲醚的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113233963A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115448820A (zh) * | 2022-10-13 | 2022-12-09 | 南京工业大学 | 一种由酚和甲醇制备芳基甲醚的温和方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109809970A (zh) * | 2019-02-01 | 2019-05-28 | 宝鸡文理学院 | 一种催化苯酚与甲醇生产苯甲醚的方法 |
CN109879728A (zh) * | 2019-02-01 | 2019-06-14 | 宝鸡文理学院 | 一种催化苯酚与甲醇合成苯甲醚的方法 |
CN109879730A (zh) * | 2019-02-01 | 2019-06-14 | 宝鸡文理学院 | 一种苯酚与甲醇生产苯甲醚的方法 |
CN109879727A (zh) * | 2019-02-01 | 2019-06-14 | 宝鸡文理学院 | 一种苯酚与甲醇合成苯甲醚的方法 |
-
2021
- 2021-05-27 CN CN202110586953.0A patent/CN113233963A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109809970A (zh) * | 2019-02-01 | 2019-05-28 | 宝鸡文理学院 | 一种催化苯酚与甲醇生产苯甲醚的方法 |
CN109879728A (zh) * | 2019-02-01 | 2019-06-14 | 宝鸡文理学院 | 一种催化苯酚与甲醇合成苯甲醚的方法 |
CN109879730A (zh) * | 2019-02-01 | 2019-06-14 | 宝鸡文理学院 | 一种苯酚与甲醇生产苯甲醚的方法 |
CN109879727A (zh) * | 2019-02-01 | 2019-06-14 | 宝鸡文理学院 | 一种苯酚与甲醇合成苯甲醚的方法 |
Non-Patent Citations (3)
Title |
---|
DAN DANG等: "Synthesis of anisole by vapor phase methylation of phenol with methanol over catalysts supported on activated alumina", CHINESE JOURNAL OF CATALYSIS, vol. 37, no. 5, pages 721 * |
SAMOLADA M.C.等: "Selective O-Alkylation of Phenol with Methanol over Sulfates Supported on γ-Al2O3", JOURNAL OF CATALYSIS, vol. 152, no. 1, pages 52 - 62 * |
WANG ZE等: "Catalytic Upgrading of Phenolic Oil by Etherification with Methanol", CHEMICAL ENGINEERING & TECHNOLOGY, vol. 39, no. 10, pages 1797 - 1803, XP071792526, DOI: 10.1002/ceat.201600252 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115448820A (zh) * | 2022-10-13 | 2022-12-09 | 南京工业大学 | 一种由酚和甲醇制备芳基甲醚的温和方法 |
CN115448820B (zh) * | 2022-10-13 | 2023-12-05 | 南京工业大学 | 一种由酚和甲醇制备芳基甲醚的温和方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109879730B (zh) | 一种苯酚与甲醇生产苯甲醚的方法 | |
Wilson et al. | Novel heterogeneous zinc triflate catalysts for the rearrangement of α-pinene oxide | |
CN109879727B (zh) | 一种苯酚与甲醇合成苯甲醚的方法 | |
CN109809970B (zh) | 一种催化苯酚与甲醇生产苯甲醚的方法 | |
Mirkhani et al. | Efficient regio-and stereoselective ring opening of epoxides with alcohols, acetic acid and water catalyzed by ammonium decatungstocerate (IV) | |
Climent et al. | Synthesis of methylpseudoionones by activated hydrotalcites as solid base catalysts | |
Seki et al. | Palladium supported on an acidic resin: a unique bifunctional catalyst for the continuous catalytic hydrogenation of organic compounds in supercritical carbon dioxide | |
Hensen et al. | Alkoxylation of limonene and alpha-pinene over beta zeolite as heterogeneous catalyst | |
CN106866331A (zh) | 一种由糠醇制备环戊二烯或双环戊二烯的方法 | |
CN113233963A (zh) | 一种苯酚与甲醇制备苯甲醚的方法 | |
CN109879728B (zh) | 一种催化苯酚与甲醇合成苯甲醚的方法 | |
CN110038576B (zh) | 一种负载型金属催化剂及其制备方法和应用 | |
CN107537526B (zh) | 一种流化床异构化催化剂及其制备方法和应用 | |
Yadav et al. | InCl3 immobilized in ionic liquids: a novel and recyclable catalytic system for tetrahydropyranylation and furanylation of alcohols | |
CN115745751B (zh) | 在固定床反应器上用苯酚和甲醇原料连续生产苯甲醚的液固相反应方法 | |
CN109970514B (zh) | 一种催化精制甲醇法合成苯甲醚工艺中苯酚的方法 | |
CN115739080B (zh) | 一种Pt基催化剂的制备及其在氯代硝基苯选择性加氢制氯代苯胺中的应用 | |
CN114870837B (zh) | 一种碱金属修饰的负载型金属催化剂及其制备方法和应用 | |
CN114956963B (zh) | 一种呋喃2,5-二甲醛二肟制备2,6-二叔丁基对甲酚的方法 | |
CN113559935B (zh) | 一种香茅醛环氧化物制备羟基香茅醛的催化剂体系和方法 | |
CN113372306B (zh) | 一种2,5-呋喃二甲醇二叔丁基醚的制备方法 | |
CN110496628B (zh) | 一种3-甲基-3-丁烯-1-醇的固体催化剂及其制备方法 | |
CN108927171B (zh) | 一种乙酸异戊烯酯转酯化制异戊烯醇的催化剂及其应用 | |
CN107827723B (zh) | 一种长链二酮合成方法 | |
CN104672069B (zh) | 一种环己酮或取代环己酮的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |