CN113230362A

CN113230362A - Stomach medicine and preparation method thereof

Info

Publication number: CN113230362A
Application number: CN202110616587.9A
Authority: CN
Inventors: 李纪文
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-06-02
Filing date: 2021-06-02
Publication date: 2021-08-10

Abstract

The invention provides a stomach medicine and a preparation method thereof, relating to the technical field of traditional Chinese medicines. The stomach medicine is prepared from rhizoma Atractylodis, radix Angelicae Dahuricae, fructus Gardeniae preparata, rhizoma Ligustici Chuanxiong, rhizoma Cyperi, Massa Medicata Fermentata, Pumex, fructus Hordei Germinatus, fructus crataegi preparata, rhizoma arisaematis preparata, semen Persicae, radix aucklandiae, Carthami flos, Atractylodis rhizoma, radix Sophorae Flavescentis, fructus evodiae, pericarpium Citri Reticulatae viride, indigo naturalis and semen Trichosanthis. The raw materials are reasonably compatible, and have better synergistic effect, so that the traditional Chinese medicine composition has better curative effects on symptoms such as stomach fullness, gastrectasia, hyperacidity and the like. In addition, the preparation method of the stomach medicine can be used for preparing pills by uniformly mixing the paste containing the effective components, the dried powder and the pill forming matrix, is convenient to take, take and carry, and has longer storage life and stronger practicability.

Description

Stomach medicine and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a stomach medicine and a preparation method thereof.

Background

Gastropathy is the general term for many stomach related diseases. The common stomach diseases clinically include acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastric calculus, acute gastric dilatation, pyloric obstruction and the like. The stomach diseases are caused by a plurality of reasons, such as helicobacter pylori infection, improper eating habits, excessive smoking, a plurality of medicinal factors and the like. Especially, chronic gastropathy has no obvious symptoms and has some dyspepsia manifestations, so that patients with gastropathy often neglect stomach diseases, and the stomach diseases are aggravated, and the health problems of the patients are serious.

Disclosure of Invention

The invention aims to provide a stomach medicine which has good effects on symptoms such as stomach fullness, gastrectasia, hyperacidity and the like, and also has good effects of strengthening spleen and stomach, eliminating stagnation and removing food retention and treating stomach diseases.

The invention also aims to provide a preparation method of the stomach medicine, which can extract the effective components in the raw materials by a simple and convenient method, can prepare the effective components into a stomach medicine pill, is convenient for being taken in mouth and swallowed and has better using effect.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The invention provides a stomach medicine which comprises the following raw materials in parts by weight: 8-9 parts of rhizoma atractylodis, 8-9 parts of angelica dahurica, 8-9 parts of fructus gardeniae, 5-6 parts of ligusticum wallichii, 8-9 parts of cyperus rotundus, 5-6 parts of medicated leaven, 8-9 parts of bryozoatum, 8-9 parts of malt, 8-9 parts of scorched hawthorn fruit, 8-9 parts of processed rhizoma arisaematis, 8-9 parts of peach kernel, 8-9 parts of elecampane, 3-4 parts of safflower, 8-9 parts of bighead atractylodes rhizome, 8-9 parts of sophora flavescens, 8-9 parts of fructus evodiae, 8-9 parts of green tangerine peel, 2-3 parts of indigo naturalis and 8-9 parts of semen trichosanthis.

The invention provides a preparation method of a stomach medicine, which mainly comprises the following steps:

pulverizing raw materials, soaking in water for 1-2 h, performing microwave treatment under vacuum condition, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain unguent;

drying the residue, grinding, sieving to obtain powder, mixing the powder, paste and matrix, making pill, drying, sterilizing, and making into stomach medicine.

The stomach medicine and the preparation method thereof provided by the embodiment of the invention have at least the following beneficial effects:

the invention provides a stomach medicine, which has reasonable compatibility of raw materials and better synergistic effect, thereby having better curative effect on gastropathy, in particular chronic gastropathy. Specifically, the combination of the rhizoma atractylodis and the fructus evodiae can inhibit or reduce the secretion of gastric acid, so that the stomach medicine has a good treatment effect on stomach diseases caused by hyperacidity. When the atractylodes rhizome and the angelica dahurica are used together, cold-dampness and indigestion can be effectively treated. The combination of the charred hawthorn fruit, the fructus evodiae and the medicated leaven can effectively treat indigestion, and the stomach medicament has better curative effects on symptoms such as indigestion, meat food stagnation, gastral cavity fullness and the like. The malt, the ligusticum wallichii, the costustoot, the safflower, the bighead atractylodes rhizome and the cyperus rotundus are used in a compatibility manner, so that the stomach medicine not only has a good effect of promoting blood circulation and invigorating pulse, but also has good effects of promoting qi circulation and helping digestion, tonifying spleen and promoting appetite and tonifying qi, and therefore, the stomach medicine can play a good role in conditioning while treating stomach diseases, and has a good treatment effect. When the fructus gardeniae preparata and the natural indigo are used in a matching way, the traditional Chinese medicine has better effect of cooling blood and has better curative effect on symptoms such as blood heat caused by stomach diseases. In addition, the pumice and the snakegourd seed can also effectively treat the cough with dry phlegm, and the effect is better. In conclusion, the stomach medicine has good curative effect on stomach diseases, can strengthen the spleen and stomach and harmonize stomach qi, has good conditioning effect, has small stimulation effect on the stomach and has higher use value.

In addition, the invention also provides a preparation method of the stomach medicine, which can extract the effective components in the raw materials under the condition of vacuum microwave, has better extraction efficiency and is simple and convenient. Then the paste containing the active ingredients, the dried powder and the pelleting matrix are uniformly mixed to prepare the pellets, so that the pellets are convenient to take, take and carry, and have longer storage life and stronger practicability. Therefore, the preparation method of the stomach medicine not only can keep the effective components in the raw materials, but also can enable the effective components to play a role more quickly and easily, and has strong practicability.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

Specifically, the raw materials in the prescription are reasonably compatible and have better synergistic effect, so that the traditional Chinese medicine has better curative effect on gastropathy, especially chronic gastropathy. In detail, the combination of atractylodes rhizome and evodia fruit can inhibit or reduce the secretion of gastric acid, so that the stomach medicine has a better treatment effect on stomach diseases caused by hyperacidity. When the atractylodes rhizome and the angelica dahurica are used together, cold-dampness and indigestion can be effectively treated. The combination of the charred hawthorn fruit, the fructus evodiae and the medicated leaven can effectively treat indigestion, and the stomach medicament has better curative effects on symptoms such as indigestion, meat food stagnation, gastral cavity fullness and the like. The malt, the ligusticum wallichii, the costustoot, the safflower, the bighead atractylodes rhizome and the cyperus rotundus are used in a compatibility manner, so that the stomach medicine not only has a good effect of promoting blood circulation and invigorating pulse, but also has good effects of promoting qi circulation and helping digestion, tonifying spleen and promoting appetite and tonifying qi, and therefore, the stomach medicine can play a good role in conditioning while treating stomach diseases, and has a good treatment effect. When the fructus gardeniae preparata and the natural indigo are used in a matching way, the traditional Chinese medicine has better effect of cooling blood and has better curative effect on symptoms such as blood heat caused by stomach diseases. In addition, the pumice and the snakegourd seed can also effectively treat the cough with dry phlegm, and the effect is better. In conclusion, the stomach medicine has good curative effect on stomach diseases, can strengthen the spleen and stomach and harmonize stomach qi, has good conditioning effect, has small stimulation effect on the stomach and has higher use value. In addition, the efficacy and the effect of each raw material are as follows:

rhizoma atractylodis: pungent and bitter in flavor and warm in nature, can eliminate dampness, invigorate spleen, expel wind and cold and improve eyesight, and can be used for treating damp obstruction of middle energizer, abdominal distention, diarrhea, edema, night blindness and blurred vision. Its pungent flavor can ascend and disperse, while bitter flavor can dredge and descend, so it can make the pathogens (including qi, dampness, phlegm, heat, cold and mutual combination) blocking the middle energizer disperse from the top to the bottom, so it can promote qi circulation and strengthen the spleen and stomach. Therefore, the rhizoma atractylodis can enable the stomach medicine to have a good treatment effect on stomach diseases. In addition, when the rhizoma atractylodis and the fructus evodiae are used together, the secretion of gastric acid can be effectively inhibited or reduced, and the traditional Chinese medicine has a good curative effect on gastric diseases caused by excessive gastric acid secretion.

Radix angelicae: has pungent taste and warm nature, and has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, eliminating dampness, stopping leukorrhagia, dispelling pathogenic wind and relieving itching. For stomach diseases, radix angelicae can eliminate swelling, repair and heal ulcers, and has a good treatment effect. And the angelica dahurica can relieve pain, widen the stomach and promote intestines circulation, relax the middle energizer, promote intestinal tract circulation, regulate the middle warmer, relax the collaterals and relieve depression, dissipate stagnation and eliminate mass, is in accordance with the pathological characteristics of the stomach diseases correspondingly, and has better stomach invigorating and treating effects. In addition, the angelica dahurica has thick fragrance, and the qi fragrance of the angelica dahurica has the effects of regulating qi to reduce phlegm, ventilating the qi, relieving stuffiness and fullness, regulating the middle warmer and invigorating the stomach, so that the stomach medicine has fragrance, and a patient feels more joyful when taking the stomach medicine and has better taking effect. It should be noted that when the dahurian angelica root is combined with the atractylodes rhizome, the effect of curing the symptoms of cold-dampness, indigestion and the like is better.

Charred masts: bitter taste and cold nature, it can cool blood and stop bleeding. Especially has better effect on the symptoms of stomach heat pain (the stomach heat pain is easy to cause by frequently eating spicy and pungent food), epigastric pain, burning sensation, intolerance of spicy and pungent food and the like.

Ligusticum wallichii: warm in nature and pungent in flavor, enter liver meridian, gallbladder meridian and pericardium meridian, and have the effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Moreover, the composition can protect gastric mucosa, reduce the stimulation of the medicament to the gastric mucosa and has better use effect.

Cyperus rotundus: it is pungent, slightly bitter and slightly sweet, enters liver, spleen and triple energizer meridians, can soothe liver, relieve depression, regulate qi, and relieve epigastric distention, and can be used for treating liver depression, qi stagnation of spleen and stomach, abdominal fullness and distention, and pain. Moreover, the cyperus rotundus has a good treatment effect on dyspepsia. Therefore, the cyperus rotundus can not only make the stomach medicine have a good conditioning effect, but also quickly relieve dyspepsia, and has a good treatment effect.

Medicated leaven: has effects in invigorating spleen, regulating stomach function, promoting digestion, and relieving food stagnation, and can be used for treating food stagnation, dyspepsia, abdominal distention, anorexia, emesis, and dysentery. When the traditional Chinese medicine composition is used with the rhizoma atractylodis, the traditional Chinese medicine composition can strengthen the spleen and strengthen the stomach, can effectively relieve stomach injury caused by improper diet, and has a good treatment effect.

Pumice stone: has effects in clearing lung-heat, eliminating phlegm, softening hard masses, and resolving hard mass, and can be used for treating cough due to lung heat, thick and yellow phlegm, and hemoptysis. Besides the above effects, the pumice can promote blood circulation and stimulate local channels and collaterals of a human body, so that the drug effect of the stomach drug is enhanced, the absorption effect of the stomach drug is improved, and the drug effect is stronger.

Malt: it has effects of activating qi-flowing, resolving food stagnation, invigorating spleen and promoting appetite, and can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, liver depression, hypochondriac pain, and liver and stomach pain. When it is used with Shen Qu, it can be used for fast diaphragma intake. Furthermore, the raw malt can strengthen the spleen and stomach, soothe the liver and promote the circulation of qi, the stir-fried malt can promote the circulation of qi and promote digestion, the curative effect on the symptoms of indigestion is better, and the scorched malt can promote digestion and resolve stagnation and is used for indigestion and abdominal distending pain.

Charring the hawthorn: it is slightly warm in nature, and can promote digestion, resolve food stagnation, promote digestion and stop diarrhea, and is used for treating food stagnation, gastric distention, diarrhea, abdominal pain, dyspepsia, etc. When the charred Hawthorn fruit is used in combination with Massa Medicata Fermentata, it has a better effect of treating dyspepsia.

Preparing the rhizoma arisaematis: enters lung, liver and spleen meridians, has the effects of eliminating dampness and phlegm, dispelling wind and relieving spasm, and also has the effects of relieving swelling and resolving masses.

Peach kernel: the Chinese medicinal composition belongs to heart channel, liver channel and large intestine channel, has the effects of promoting blood circulation, eliminating phlegm, moistening the intestines and relaxing the bowels, and can be used for treating constipation caused by intestinal dryness and the like. According to the pharmacological action research of peach kernels, the peach kernels have better anticoagulation, antitrystanic, blood flow improving, anti-inflammatory, analgesic and antiallergic effects, and have better cough and asthma relieving effects.

Costustoot: it is dried root of Aucklandia lappa Decne of Compositae, and has effects of activating qi-flowing, relieving pain, invigorating spleen, and resolving food stagnation, and can be used for treating chest and hypochondrium, abdominal distention and pain, diarrhea, dyspepsia, anorexia, etc. According to Ben Cao gang mu, mu Xiang is indicated for qi stagnation and discomfort due to stomach qi harmonizing, lung qi releasing and liver qi moving.

Safflower: it has effects of promoting blood circulation, dredging channels, removing blood stasis, and relieving pain, and can be used for treating abdominal pain due to blood stasis, pain in chest and hypochondrium, sore and ulcer, and swelling and pain. Moreover, the efficacy of activating blood circulation and stimulating the menstrual flow can ensure that the stomach medicine has better efficacy and achieves the effect of further promoting the absorption of effective components.

White atractylodes rhizome: it has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis and arresting sweating, and can be used for treating spleen and stomach qi weakness, anorexia, listlessness, qi deficiency, asthenia distention, diarrhea, phlegm retention, edema and spontaneous perspiration. Pharmacological research shows that the bighead atractylodes rhizome has a bidirectional regulating effect on gastrointestinal systems and has a good gastric ulcer resisting effect. Moreover, the bighead atractylodes rhizome not only has better spasmolysis, liver protection, antibacterial and other effects, but also can promote gastrointestinal peristalsis, cholagogue, antioxidation, blood sugar reduction, anticoagulation, antibiosis, blood vessel dilatation, sedation and other effects.

Flavescent sophora root: it has effects of clearing heat, eliminating dampness, killing parasite and promoting urination, and can be used for treating hematochezia, eczema and leprosy. Because the sophora flavescens has better antibacterial and bacteriostatic properties, the gastric drug can be stored for a longer time, the addition of preservatives is reduced, the expected effects of avoiding mildew and insects and the like are achieved, and the use value is higher.

Evodia fruit: warming heat, dispersing cold to alleviate pain, soothing liver to descend qi, warming middle energizer and drying dampness, and has good curative effects on abdominal psychroalgia, vomiting and acid regurgitation, cold-dampness diarrhea and other diseases.

Green tangerine peel: warm in nature, entering liver, gallbladder and stomach meridians, can soothe liver, break qi, resolve stagnation, and relieve stagnation, and can be used for treating distending pain in chest and hypochondrium, hernia pain, food stagnation and qi stagnation, and abdominal distention and pain with good therapeutic effect.

Indigo naturalis: it is cold in nature, enters liver meridian, has effects of clearing heat and toxic materials, cooling blood, resolving macula, clearing pathogenic fire, and arresting convulsion, and can be used for treating warm toxic macula, blood heat, hematemesis, epistaxis, chest pain, hemoptysis, and aphtha.

Semen trichosanthis: the cold in nature, which enters lung and large intestine channels, has the effects of relaxing bowel, clearing lung and eliminating phlegm, and has better curative effects on constipation due to dryness accumulation, cough due to dryness-phlegm and other diseases.

In the invention, the stomach medicine comprises the following raw materials in parts by weight: 9 parts of rhizoma atractylodis, 9 parts of angelica dahurica, 9 parts of charred gardenia, 6 parts of ligusticum wallichii, 9 parts of cyperus rotundus, 6 parts of medicated leaven, 9 parts of bryozoatum, 9 parts of malt, 9 parts of charred hawthorn, 9 parts of processed arisaema tuber, 9 parts of peach kernel, 9 parts of elecampane, 3 parts of safflower, 9 parts of bighead atractylodes rhizome, 9 parts of radix sophorae flavescentis, 9 parts of fructus evodiae, 9 parts of pericarpium citri reticulatae viride, 3 parts of indigo naturalis and 9 parts of semen. The prescription has reasonable compatibility, is suitable for being taken by patients with gastropathy with more constitutions, and has better treatment effect.

In addition, the invention also provides a preparation method of the stomach medicine, which mainly comprises the following steps:

pulverizing raw materials, soaking in water for 1-2 hr, performing microwave treatment under vacuum condition, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain unguent. Specifically, smash the raw materials and can make the area of contact between raw materials and water bigger, the water logging is gone into the inside time of raw materials shorter, soaks the effect better. After soaking for 1-2 h, the water can fully soak the interior of the structure of each raw material, so as to achieve the expected soaking effect. After soaking, performing microwave under vacuum condition, wherein microwave energy can accelerate the dissolution process of effective components in the raw materials, so that the water-soluble effective components can be dissolved in water to achieve the desired extraction effect. In addition, the penetrability of microwave energy is stronger, can effectual promotion extraction efficiency to make the drug effect better. It should be noted here that the vacuum microwave extraction can be performed at low temperature, so as to avoid the damage of high temperature to the effective components and reduce the drug effect.

Vacuum microwave extracting, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain unguent. The filtrate is concentrated, so that the volume of the liquid medicine can be effectively reduced, the occupied area of the liquid medicine during storage is saved, the liquid medicine can be conveniently transported and transferred, and the practicability is high. In addition, the paste prepared by concentration is convenient to prepare into pills, the drug effect is ensured, the preparation difficulty is reduced, and the yield is higher. It should be noted that when the stomach medicine prepared from the paste acts, the contained effective components can permeate into tissues and a blood circulation system more quickly, so that the treatment effect is quickly achieved, the pain feeling of a patient is effectively relieved, and the use effect is better.

In the invention, the power of the microwave is 280w-300w, and the microwave time is 15min-30min, so that the extraction efficiency of the water-soluble active ingredients in the raw materials is higher, the extraction time is shorter, the preparation time of the stomach medicine is greatly shortened, and the effect of saving time and cost is better. When the microwave power is lower, the energy of the microwave is not enough to achieve the expected extraction effect, and when the microwave power is continuously increased, the extraction efficiency tends to be stable and does not continuously increase, so that the energy consumption is larger, the cost is higher, and the cost of the stomach medicine is higher and the cost performance is lower. Under the condition of the microwave power, the expected extraction effect can be achieved in a short time, and the use value is high. Moreover, the microwave extraction is carried out under the vacuum condition, and according to the dynamic principle of the diffusion of the active ingredients, the diffusion speed of the active ingredients into water can be increased, so that the dissolution speed is high, more active ingredients are dissolved, and the drug effect is better. In the invention, the filtrate can be concentrated by adopting a reduced pressure low-temperature concentration method, and the concentration multiple is 13-15 times, so that the filtrate is prepared into paste, and the paste is convenient to store, use, transport and the like and has stronger practicability. If the concentration multiple is smaller, the moisture content in the paste is larger, the drying difficulty of the stomach medicine is greatly improved at the moment, the cost is higher, and when the concentration multiple is larger, the paste has overlarge viscosity and is difficult to be uniformly mixed with powder and a pill matrix, so that the quality of the stomach medicine is seriously influenced, and the effect is poorer.

In the invention, the filter residue obtained by filtering and separating is dried for 10 to 12 hours at the temperature of between 45 and 60 ℃, so that the moisture in the filter residue can be removed on the premise of not damaging the medicinal components of the filter residue (raw material), and the expected effect can be achieved while the medicinal effect is good. If the drying temperature of filter residue is higher, active ingredient will be destroyed in the filter residue to cause the drug effect of stomach medicine to reduce, influence treatment, and when dry temperature was lower, not only can increase the drying time of filter residue, drying effect is relatively poor moreover, influences the quality of stomach medicine, and the effect is relatively poor. Therefore, the drying temperature of the filter residue adopted in the invention can ensure that the drying time is shortest and the effect is better on the premise of not losing the drug effect. And then, grinding the dried filter residue into fine powder, and sieving the fine powder through a 100-mesh and 200-mesh sieve to prepare powder. The filter residue after grinding and sieving can make the stomach medicine more delicate in texture and better in quality. In addition, the materials with higher hardness and larger particle size can be removed by sieving, so that the mixture of the paste and the pelleting matrix is facilitated, and the quality of the gastric medicine for pelleting is better. When the powder contains harder and/or larger substances, gaps are easy to appear in the stomach medicine after pills are formed, so that the moisture absorption phenomenon is easy to occur, the quality guarantee period is short, and when the gaps and cracks appear in the pills, the appearance and the quality of the pills are poor, and the use feeling of patients is influenced. And when the aperture of the screen is small (the mesh number is large), the screening difficulty is large, the time is long, and the preparation cost is high.

In the invention, the prepared paste, powder and pelleting matrix are mixed, and are subjected to pelleting and pelleting, drying and sterilization to prepare the stomach medicine. Wherein the matrix for making pill comprises one of beeswax, polyoxyethylene glyceryl monostearate, poloxamer or gelatin. In the present invention, the mass ratio of the pelleting matrix to the powder is (1-1.5): 1. The pelleting matrix can not only mix the paste and the powder more uniformly to prepare pills with higher quality, but also improve the taking taste to a certain extent, so that the stomach medicine has better effect of entering the mouth. The specific effects of the pelleting matrix are as follows:

beeswax: beeswax has the effects of removing toxic substances, promoting granulation, stopping bleeding and relieving pain, and can further enhance the medicinal effect of stomach medicine. When the beeswax is used as a pelleting matrix, the beeswax can play a better role in adhesion and relieve the irritation of the medicament, so that the stomach medicament has a better slow-release effect and is weaker in irritation. And the water content of the beeswax is lower, so that the drying process of the stomach medicine is simpler and easier, and the cost is lower.

Polyoxyethylene glyceryl monostearate: the powder and paste agent has good thickening, wetting, stabilizing and emulsifying effects, can be used for more closely mixing powder and paste agent, and has good effect. And the stomach medicine has better sensory characteristics, so that the stomach medicine formed into pills has better luster and better visual perception. In addition, the antibacterial activity of the gastric drug is strong, the antibacterial spectrum is wide, so that the antibacterial property of the gastric drug is better, the possibility of mildew or insect growth of the gastric drug is greatly reduced, the service and storage life is longer, and the practicability is stronger.

Gelatin: the gelatin is used as a gel matrix, so that the powder and the paste can be bonded uniformly, the taste of the stomach pill can be improved, and the use value is high. Moreover, the gelatin has better biocompatibility and lower irritation.

It should be noted that poloxamer can also be added into the matrix of the pill to enhance the stability and absorption effect of the pill. Specifically, poloxamer can promote the intestinal peristalsis to slow down, prolong the retention time of the drug in intestines and stomach, and improve the utilization rate of the drug. In addition, the adhesive has better adhesive effect and controlled release function, thereby achieving the effects of slowly releasing the medicine and reducing the stimulation of the medicine. In addition, the mass ratio of the poloxamer to the powder is 1 (15-17), so that the expected slow-release effect can be achieved, the cost is low, and the cost performance is high.

Mixing the matrix, paste and powder, and making into pill. In view of the fact that the pill rolling process can enable the quality of the pills to be better, for example, the phenomena of hollowness, cracks, wrinkles and the like of the pills can be effectively avoided. Therefore, rubbing pills is also one of the important factors for guaranteeing the quality of pills. Then preparing pills after pelleting, drying and sterilizing the pills to prepare the stomach medicine. After the stomach medicine is dried, the water content is less than 8 percent. Therefore, after the stomach medicine is stored for a certain time, the phenomenon of crinkle does not occur, and the storage effect is better. When the moisture content of the stomach medicine is high, moisture on the surface of the stomach medicine is easily lost in the storage stage, so that the epidermis is wrinkled and the appearance is poor. In addition, sterilization can effectively remove microorganisms on the surface of the stomach medicine, thereby avoiding the generation of mildewing and/or vermination. It should be noted that both the paste and the powder need to be sterilized, so that the stomach medicine can be stored for a longer time, the stomach medicine pills can be superior in quality, and the curative effect is better. It should be noted that the sterilization may be performed by ethanol spraying, or may be performed by infrared sterilization, which is not limited herein.

In the invention, in order to enhance the oxidation resistance, the moisture absorption resistance and the stability of the stomach medicine, a coating is coated on the surface of the stomach medicine, and a finished product is prepared after defoaming. The deaeration process not only can make the coating shell more even fine and smooth, when the gloss is good, the aesthetic property is stronger, can also effectively strengthen the oxidation resistance and the moisture absorption resistance of the stomach medicine, and the preservation effect is better. In addition, the coating is formed by mixing the hydroxymethyl cellulose, the lac and the glycerol, and has good surface activity, so that the coating can be more attached to the surface of the stomach medicine, and the coating is prevented from falling off. And the glycerol has slightly sweet taste, so that the mouthfeel of the stomach medicine is further improved, and the feeling of taking the stomach medicine is better. It should be noted here that the defoaming process is realized by a vacuum pump, the pressure of the vacuum pump is 0.1MPa-0.2MPa, and the defoaming time is 2h-3 h. In addition, the coating can cover the taste of the stomach medicine to a certain degree, reduce the rejection feeling of taking, improve the taking feeling and achieve better effect.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a stomach medicine which comprises the following raw materials in parts by weight: 9g of rhizoma atractylodis, 9g of angelica dahurica, 9g of charred gardenia, 6g of ligusticum wallichii, 9g of cyperus rotundus, 6g of medicated leaven, 9g of bryozoatum, 9g of malt, 9g of charred hawthorn, 9g of prepared arisaema tuber, 9g of peach kernel, 9g of elecampane, 3g of safflower, 9g of bighead atractylodes rhizome, 9g of radix sophorae flavescentis, 9g of fructus evodiae, 9g of pericarpium citri reticulatae viride, 3g of indigo naturalis and 9g of semen trichosanthis.

The preparation method of the stomach medicine comprises the following steps:

pulverizing the raw materials, soaking in water for 2 hr, performing microwave treatment under vacuum with microwave power of 300w for 20min, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain unguent with concentration multiple of 14.

Drying the filter residue at 55 deg.C for 11h, grinding, sieving with 120 mesh sieve to obtain powder, mixing the powder, paste and Cera flava, making into pill, drying and sterilizing to obtain the stomach medicine, wherein the mass ratio of Cera flava and powder is 1.5: 1.

Example 2

The embodiment provides a stomach medicine which comprises the following raw materials in parts by weight: 8g of rhizoma atractylodis, 8g of angelica dahurica, 8g of charred gardenia, 5g of ligusticum wallichii, 8g of cyperus rotundus, 5g of medicated leaven, 8g of bryozoatum, 8g of malt, 8g of charred hawthorn, 8g of prepared arisaema tuber, 8g of peach kernel, 8g of elecampane, 4g of safflower, 8g of bighead atractylodes rhizome, 8g of sophora flavescens, 8g of fructus evodiae, 8g of pericarpium citri reticulatae viride, 2g of indigo naturalis and 8g of semen trichosanthis.

The preparation method of the stomach medicine comprises the following steps:

pulverizing raw materials, soaking in water for 1h, performing microwave treatment under vacuum with microwave power of 280w for 15min, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain unguent with concentration multiple of 13.

Drying the filter residue at the temperature of 45 ℃ for 12h, grinding, sieving with a 160-mesh sieve to obtain powder, mixing the powder, paste and polyoxyethylene glyceryl monostearate, rolling and pelleting, drying and sterilizing to obtain the stomach medicine, wherein the mass ratio of the polyoxyethylene glyceryl monostearate to the powder is 1.0: 1.

Example 3

The embodiment provides a stomach medicine which comprises the following raw materials in parts by weight: 8.5g of rhizoma atractylodis, 8.5g of angelica dahurica, 8.5g of fructus gardeniae preparata, 5.5g of rhizoma ligustici wallichii, 8.5g of rhizoma cyperi, 5.5g of medicated leaven, 8.5g of bryozoatum, 8.5g of malt, 8.5g of fructus crataegi preparata, 8.5g of rhizoma arisaematis preparata, 8.5g of peach kernel, 8.5g of elecampane, 3.5g of safflower carthamus, 8.5g of rhizoma atractylodis macrocephalae, 8.5g of radix sophorae flavescentis, 8.5g of fructus evodiae, 8.5g of green tangerine peel, 2.5g of indigo naturalis and 8.5g of semen trichosanthis.

The preparation method of the stomach medicine comprises the following steps:

pulverizing the raw materials, soaking in water for 1.5 hr, performing microwave under vacuum with microwave power of 290w for 25min, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain paste with concentration multiple of 14 times.

Drying the filter residue at 60 deg.C for 10 hr, grinding, sieving with 100 mesh sieve to obtain powder, mixing the powder, paste and gelatin, making into pill, drying and sterilizing to obtain the final product, wherein the mass ratio of gelatin to powder is 1.1: 1.

Example 4

The embodiment provides a stomach medicine which comprises the following raw materials in parts by weight: 8g of rhizoma atractylodis, 9g of angelica dahurica, 9g of charred gardenia, 6g of ligusticum wallichii, 9g of cyperus rotundus, 6g of medicated leaven, 9g of bryozoatum, 9g of malt, 9g of charred hawthorn, 9g of prepared arisaema tuber, 9g of peach kernel, 9g of elecampane, 3g of safflower, 9g of bighead atractylodes rhizome, 9g of radix sophorae flavescentis, 9g of fructus evodiae, 9g of pericarpium citri reticulatae viride, 3g of indigo naturalis and 9g of semen trichosanthis.

The preparation method of the stomach medicine comprises the following steps:

pulverizing raw materials, soaking in water for 1.8 hr, performing microwave treatment under vacuum with microwave power of 285w for 30min, filtering to obtain filtrate and residue, and concentrating the filtrate to obtain paste with concentration of 15 times.

Drying the filter residue at 50 deg.C for 11.5h, grinding, sieving with 200 mesh sieve to obtain powder, mixing the powder, paste and Cera flava, making into pill, drying and sterilizing to obtain the stomach medicine, wherein the mass ratio of Cera flava and powder is 1.4: 1.

Coating a layer of coating on the surface of the stomach medicine, and defoaming to obtain the finished product, wherein the coating is prepared by mixing 10g of hydroxymethyl cellulose, 20g of lac and 3g of glycerol.

Example 5

The preparation method of the stomach medicine comprises the following steps:

Coating a layer of coating on the surface of the stomach medicine, and defoaming to obtain the finished product, wherein the coating is prepared by mixing 20g of hydroxymethyl cellulose, 25g of lac and 5g of glycerol.

Effect example 1

The gastric drugs prepared in examples 1 to 5 were subjected to the performance test, and the test results are shown in Table 1. The performance test method specifically comprises the following steps:

and (3) stability testing: 10g of the stomach medicine prepared in examples 1 to 5 was taken, and then it was left to stand under the conditions of a temperature of 20 ℃ to 30 ℃ and a relative humidity of 70 to 85%, and the surface and oxidation state thereof were observed after 15d, 30d and 90 d.

And (3) appearance observation: the appearance of the stomach medicine was observed by placing it under normal light conditions, and it was noted that the observer was a normal color vision observer without color weakness and color blindness.

TABLE 1 gastric drug Performance test results

As can be seen from the above table, the products prepared in examples 1-5 have glossy appearance, fine and smooth surface and good visual perception, and the taste of the coated product is covered to a certain extent, so that the feeling of taking the stomach medicine is improved, and the using effect is better. And after the stability test of 15d, 30d and 90d, the appearance is still smooth and glossy, and the surface has no wrinkles, so that the moisture absorption resistance is better. In addition, the product is still as original after being placed for 90 days, the oxidation resistance of the product is good, and the interior of the stomach medicine is complete without gaps, sand return and the like. It can be seen that the stomach medicine prepared by the preparation methods provided in examples 1-5 has good stability, is beneficial to storage and interval administration, and has strong practicability.

Effect example 2

50 volunteers of patients with stomach diseases are collected, wherein 28 men and 22 women have the disease course of 14-17 days, and the effective rate and the cure rate are shown in table 2 after the product is taken regularly and quantitatively. Statistical analysis of gender revealed that the difference between the two was not statistically significant (P > 0.05). The stomach medicine is taken by the following method: the medicine is taken with warm boiled water on an empty stomach every morning, and is taken after two hours every day, and the taking frequency is once a day. It should be noted that pregnant women, enteritis patients, children, patients with severe heart disease and patients with high blood pressure need to take the medicine with caution, and wine, spicy food and uncooked food are forbidden during taking. In addition, volunteers are grouped according to their symptoms and severity, as follows:

a first group: the effective rate and the cure rate of 25 patients with gastrectasia and gastrectasia, wherein 16 men and 9 women respectively use the products prepared in the example 5 are shown in the table 2;

second group: the effective rate and the cure rate of 15 patients with hyperchlorhydria, 7 men and 8 women, respectively using the products prepared in example 5 are shown in table 2;

third group: the effective rate and cure rate of 10 patients with duodenal ulcer, 5 men and 5 women, after using the product prepared in example 5 respectively, are shown in table 2.

It is noted here that symptoms, changes in signs and adverse reactions were recorded at each visit, with follow-up observations at 7 and 14 days before and after treatment, respectively.

TABLE 2 therapeutic results for gastric drug prepared in example 5

As can be seen from table 2, after a course of treatment, the stomach medicine prepared in example 5 has a good curative effect on symptoms such as gastrectasia, gastric hyperacidity, duodenal ulcer and the like, and has a significant curative effect. Moreover, according to the return visit record, the patients can more smoothly swallow the medicine, and the medicine taste is lighter and the feeling is better. In addition, statistical analysis of the data after 7d and 14d of administration revealed significant differences (see specifically X in table 2)²) Therefore, after the traditional Chinese medicine is taken for one treatment course, the effective rate is obviously increased, and the effect is better.

In conclusion, the invention provides a stomach medicine which has reasonable compatibility of raw materials and better synergistic effect, thereby having better curative effect on gastropathy, in particular chronic gastropathy. Specifically, the combination of the rhizoma atractylodis and the fructus evodiae can inhibit or reduce the secretion of gastric acid, so that the stomach medicine has a good treatment effect on stomach diseases caused by hyperacidity. When the atractylodes rhizome and the angelica dahurica are used together, cold-dampness and indigestion can be effectively treated. The combination of the charred hawthorn fruit, the fructus evodiae and the medicated leaven can effectively treat indigestion, and the stomach medicament has better curative effects on symptoms such as indigestion, meat food stagnation, gastral cavity fullness and the like. The malt, the ligusticum wallichii, the costustoot, the safflower, the bighead atractylodes rhizome and the cyperus rotundus are used in a compatibility manner, so that the stomach medicine not only has a good effect of promoting blood circulation and invigorating pulse, but also has good effects of promoting qi circulation and helping digestion, tonifying spleen and promoting appetite and tonifying qi, and therefore, the stomach medicine can play a good role in conditioning while treating stomach diseases, and has a good treatment effect. When the fructus gardeniae preparata and the natural indigo are used in a matching way, the traditional Chinese medicine has better effect of cooling blood and has better curative effect on symptoms such as blood heat caused by stomach diseases.

In addition, the invention also provides a preparation method of the stomach medicine, which can extract the effective components in the raw materials under the condition of vacuum microwave and has better extraction efficiency. Then the paste containing the active ingredients, the dried powder and the pelleting matrix are uniformly mixed to prepare the pellets, so that the pellets are convenient to take, take and carry, and have longer storage life and stronger practicability.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The stomach medicine is characterized by comprising the following raw materials in parts by weight: 8-9 parts of rhizoma atractylodis, 8-9 parts of angelica dahurica, 8-9 parts of fructus gardeniae, 5-6 parts of ligusticum wallichii, 8-9 parts of cyperus rotundus, 5-6 parts of medicated leaven, 8-9 parts of bryozoatum, 8-9 parts of malt, 8-9 parts of scorched hawthorn fruit, 8-9 parts of processed rhizoma arisaematis, 8-9 parts of peach kernel, 8-9 parts of elecampane, 3-4 parts of safflower, 8-9 parts of bighead atractylodes rhizome, 8-9 parts of sophora flavescens, 8-9 parts of fructus evodiae, 8-9 parts of green tangerine peel, 2-3 parts of indigo naturalis and 8-9 parts of semen trichosanthis.

2. The gastric drug according to claim 1, comprising the following raw materials in parts by weight: 9 parts of rhizoma atractylodis, 9 parts of angelica dahurica, 9 parts of charred gardenia, 6 parts of ligusticum wallichii, 9 parts of cyperus rotundus, 6 parts of medicated leaven, 9 parts of bryozoatum, 9 parts of malt, 9 parts of charred hawthorn, 9 parts of processed arisaema tuber, 9 parts of peach kernel, 9 parts of elecampane, 3 parts of safflower, 9 parts of bighead atractylodes rhizome, 9 parts of radix sophorae flavescentis, 9 parts of fructus evodiae, 9 parts of pericarpium citri reticulatae viride, 3 parts of indigo naturalis and 9 parts of semen trichosanthis.

3. A process for the preparation of a gastric drug according to claim 1 or 2, characterized in that it comprises the following steps:

drying the filter residue, grinding, sieving to obtain powder, mixing the powder, the paste and the pill matrix, making pills, drying, sterilizing, and making into the stomach medicine.

4. The method of claim 3, wherein the granulation base comprises one of beeswax, polyoxyethylene glyceryl monostearate or gelatin.

5. The method for preparing a gastric drug according to claim 4, wherein the microwave power is 280w-300w, and the microwave time is 15min-30 min.

6. The method for preparing a gastric drug according to claim 5, wherein the concentration factor is 13 to 15.

7. The method for preparing a gastric drug according to claim 6, wherein the drying temperature of the filter residue is 45 ℃ to 60 ℃, and the drying time of the filter residue is 10h to 12 h.

8. The process for preparing a gastric drug according to claim 7, wherein the gastric drug has a water content of less than 8% after drying.

9. The method for preparing a gastric drug according to claim 8, wherein the mass ratio of the pelleting matrix to the powder is (1-1.5): 1.

10. The process for preparing a gastric drug according to any one of claims 4 to 9, wherein a coating is applied to the surface of the gastric drug, and the coating is made by mixing hydroxymethylcellulose, shellac and glycerin, and deaerating the mixture to obtain the final product.