CN103505690A - Medicament for treating chronic gastrointestinal tract diseases and preparation method of medicament - Google Patents
Medicament for treating chronic gastrointestinal tract diseases and preparation method of medicament Download PDFInfo
- Publication number
- CN103505690A CN103505690A CN201310485573.3A CN201310485573A CN103505690A CN 103505690 A CN103505690 A CN 103505690A CN 201310485573 A CN201310485573 A CN 201310485573A CN 103505690 A CN103505690 A CN 103505690A
- Authority
- CN
- China
- Prior art keywords
- parched
- parts
- brown
- bran
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a medicament for treating chronic gastrointestinal tract diseases and a preparation method of the medicament. The medicament comprises vinegar-processed corydalis yanhusuo, vinegar-processed cyperus rotundus, dried tangerine peel, bran-parched atractylodes macrocephala, aucklandia lappa, fructus amomi, parched endothelium corneae gigeriae galli, bran-parched atractylodes lancea, parched hawthorn fruit, charred medicated leaven, dark malt, astragalus membranaceus, codonopsis pilosula, cuttlefish bone, calcined concha ostreae, roasted fructus aurantii immaturus, coptis chinensis and honey-fried licorice root. The preparation method is simple. With the compatibility of the above medicinal materials, the whole formulation has the effects of promoting Qi circulation to relieve pain, invigorating the spleen and stomach and promoting digestion to eliminate food stagnation, is used for relieving the syndrome of weakness of the spleen and stomach, manifested by the symptoms of gastric distention, pain of the chest, hypochondrium and belly, poor appetite, nausea and vomiting, is suitable for treating gastritis, gastric ulcer, duodenal ulcer and the like, achieves the effect of treating both symptoms and root causes of a disease, and can not only effectively relieve the patient's discomforts but also eliminate pathogenic causes by invigorating the spleen and stomach, with no recurrence.
Description
Technical field
The present invention relates to a kind of medicine, specifically, relate to a kind of medicine for the treatment of Chronic gastrointestinal diseases and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Along with current rhythm of life is accelerated day by day, it is irregular that people have a meal and become, hungry after a full meal, eating and drinking too much at one meal, in the face of the pressure in life and work, the bad life habits of formed smoking, drinking, these all cause increasing people to suffer from Chronic gastrointestinal diseases, and gastroenteropathy has become the key factor of the present quality of social life of impact.
The digestive tract of supply is large with Western medicine side effect in the market, is not suitable for long-term taking, often cures the symptoms, not the disease, and Chinese patent medicine mainly be take the watered pill as main, and dosage form is more single, and taking dose is excessive, and therapeutic effect is undesirable.
Summary of the invention
Technical problem to be solved by this invention is for above problem, and a kind of medicine for the treatment of Chronic gastrointestinal diseases is provided, and adopts medicine of the present invention, and therapeutic effect is good.
Another object of the present invention is to provide a kind of preparation method for the treatment of Chronic gastrointestinal diseases medicine.
For addressing the above problem, the present invention takes following technical scheme: a kind of medicine for the treatment of Chronic gastrointestinal diseases, is characterized in that: the active ingredient of described medicine comprises: vinegar Rhizoma Corydalis, Rhizoma Cyperi (processed with vinegar), Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Aucklandiae, Fructus Amomi, Endothelium Corneum Gigeriae Galli (parched), parched with bran Rhizoma Atractylodis, Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Radix Codonopsis, Endoconcha Sepiae, Concha Ostreae (calcined), Fructus Aurantii Immaturus (parched), Rhizoma Coptidis and Radix Glycyrrhizae Preparata.
, the active ingredient of described medicine comprises by weight: vinegar Rhizoma Corydalis 10-22 part, Rhizoma Cyperi (processed with vinegar) 9-19 part, Pericarpium Citri Reticulatae 10-23 part, Rhizoma Atractylodis Macrocephalae (parched with bran) 7-16 part, Radix Aucklandiae 5-13 part, Fructus Amomi 5-13 part, Endothelium Corneum Gigeriae Galli (parched) 9-19 part, parched with bran Rhizoma Atractylodis 7-17 part, Fructus Crataegi (parched to brown) 7-16 part, Massa Medicata Fermentata (parched to brown) 7-16 part, Fructus Hordei Germinatus (parched to brown) 7-16 part, Radix Astragali 9-19 part, Radix Codonopsis 8-16 part, Endoconcha Sepiae 10-19 part, Concha Ostreae (calcined) 9-19 part, Fructus Aurantii Immaturus (parched) 7-16 part, Rhizoma Coptidis 3-10 part and Radix Glycyrrhizae Preparata 8-16 part.
Another kind of prioritization scheme, the active ingredient of described medicine comprises by weight: 12 parts of 18 parts of vinegar Rhizoma Corydalis, 15 parts of Rhizoma Cyperi (processed with vinegar), 18 parts of Pericarpium Citri Reticulataes, 12 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 9 parts of the Radix Aucklandiae, 9 parts of Fructus Amomis, 15 parts of Endothelium Corneum Gigeriae Galli (parched)s, 12 parts of parched with bran Rhizoma Atractylodis, 12 parts of Fructus Crataegi (parched to brown)s, 12 parts of Massa Medicata Fermentata (parched to brown), 12 parts of Fructus Hordei Germinatus (parched to brown)s, 15 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 15 parts of Endoconcha Sepiaes, 15 parts of Concha Ostreae (calcined)s, 12 parts of Fructus Aurantii Immaturus (parched), 6 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
Another prioritization scheme, is characterized in that: described preparation method comprises:
According to aforementioned proportion weighting raw materials;
Get Fructus Crataegi (parched to brown), vinegar Rhizoma Corydalis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Codonopsis four tastes dry after, be ground into fine powder, sieve, mix;
Residue medical material decocts with water secondary, and each 2 hours, decocting liquid filtered, and filtrate merges, and is condensed into thick paste shape, mixes with above-mentioned fine powder, through pill, dry, polishing, obtains concentrated pill.
Based on above treatment Chronic gastrointestinal diseases medicine, the preparation method of described medicine comprises:
According to aforementioned proportion weighting raw materials;
Get Fructus Crataegi (parched to brown), vinegar Rhizoma Corydalis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Codonopsis four tastes dry after, be ground into coarse powder, mix; Residue medical material decocts with water secondary, and each 2 hours, decocting liquid filtered, and filtrate merges, and is condensed into thick paste shape, mixes, is dried, is ground into fine powder with above-mentioned coarse powder, incapsulates, and obtains hard capsule.
Based on above treatment Chronic gastrointestinal diseases medicine, the preparation method of described medicine comprises:
According to aforementioned proportion weighting raw materials;
Decoct with water three times, each 2 hours, decocting liquid filtered, and filtrate merges, concentrated, adds dextrin and starch, granulation, and dry, screening, obtains granule.
Based on above treatment Chronic gastrointestinal diseases medicine, the preparation method of described medicine comprises:
According to aforementioned proportion weighting raw materials;
Decoct with water three times, each 2 hours, decocting liquid filtered, and filtrate merges, be concentrated into relative density 1.06, add ethanol, ethanol accounts for 70%, standing 24 hours, filter filtrate recycling ethanol, cold preservation 24 hours, filter, filtrate adds 8 parts of polyoxyethylene sorbitan monoleates, 20 parts of glycerol, 2 parts of saccharin sodium and 2 parts of sorbic acid, and the sodium hydroxide solution with 1% is adjusted PH to 7.0, mix, boil, fill, sealing, sterilizing, obtains oral liquid.
Vinegar Rhizoma Corydalis: this product is the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W.T.Wang.Acrid in the mouth, hardship, warm in nature, return liver, spleen channel.Have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving, for the breast side of body, epigastric pain, amenorrhea dysmenorrhea, the diseases such as injury from falling down.After processed with vinegar, increase the effect of its promoting the circulation of QI to relieve pain.
Rhizoma Cyperi (processed with vinegar): this product is the dry rhizome of sedge dried tuber Cuperus rarundui L..Acrid in the mouth, micro-hardship, property is flat, returns liver, spleen, tri-jiao channel.There are promoting QI circulation for relieving depression, the effect of menstruction regulating and pain relieving, for stagnation of QI due to depression of the liver, abdominal distention, dyspepsia, the disease such as breast gastral cavity painful abdominal mass is vexed, colic of cold type stomachache.After processed with vinegar, increase its analgesic effect.
Pericarpium Citri Reticulatae: this product is the dry mature skin of rutaceae orange Citrus reticulate Blanco and variety thereof, bitter in the mouth, pungent is warm in nature, returns lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm, for distension and fullness in the abdomen, lack of appetite vomiting, the diseases such as cough with copious phlegm.
Rhizoma Atractylodis Macrocephalae (parched with bran): this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylades macrocephala Koldz..Bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, the abdominal distention disease such as have loose bowels, strengthens its drying damp and strengthening spleen effect after parched with bran.
The Radix Aucklandiae: this product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Ddcne..Acrid in the mouth, hardship, warm in nature, return spleen, stomach, large intestine, three warmers, gallbladder meridian.There are promoting the circulation of QI to relieve pain, the effect of strengthening the spleen to promote digestion, for breast gastral cavity distending pain, heavy after dysentery, the disease such as food stagnation does not disappear, anorexia.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomuni villosum Lour..Acrid in the mouth, warm in nature, return spleen, stomach, kidney channel.Have removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy, hinders for stone table, and gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, the vomiting disease such as have loose bowels.
Endothelium Corneum Gigeriae Galli (parched): this product is the dry gizzard inwall of the chicken Gallus gallus domesticus Brisson of Phasianidae animal man.Sweet in the mouth, property is flat, returns spleen, stomach, small intestinal, urinary bladder channel.There is invigorating the stomach and promoting digestion, arresting seminal emission, the effect for the treatment of stranguria fossil, does not disappear for food stagnation, the diseases such as vomiting dysentery.
Parched with bran Rhizoma Atractylodis: this product is the dry rhizome of feverfew lance Rhizoma Atractylodis Atractylodes lancea (Thunb.) DC..Acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, expelling wind and cold, the effect of improving eyesight, for retention of dampness in middle-JIAO, Han distention and fullness in the abdomen, has loose bowels, the diseases such as edema.After parched with bran, strengthen its drying damp and strengthening spleen effect.
Fructus Crataegi (parched to brown): this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Cratacgus pinnatiflda Bge.var.mojor N.E.Br..Sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel.Have promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, changes the effect of turbid blood fat reducing, for meat stagnation, and gastral cavilty distension, the diseases such as dysentery stomachache.After parching to brown, dyspepsia and intestinal stasis relieving effect strengthens.
Massa Medicata Fermentata (parched to brown): this product is after flour, wheat bran and multi-medicament mix, the herbal leaven forming through fermentation.Sweet in the mouth, pungent, warm in nature, return spleen, stomach warp.The effect with the stomach function regulating that helps digestion, for eating accumulation, distension and fullness in the abdomen, lack of appetite is indigestion and loss of appetite.After parching to brown, strengthen the effect of its strengthening the spleen to promote digestion.
Fructus Hordei Germinatus (parched to brown): this product is that the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. is dried and obtains through germinateing.Sweet in the mouth, property is flat, returns spleen, stomach, Liver Channel.Have promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back the effect of newborn relieving distension, for food stagnation, do not disappear, and abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, women's ablactation.After parching to brown, strengthen the effect of its strengthening the spleen to promote digestion.
The Radix Astragali: this product is the root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.).Sweet in the mouth, slightly warm in nature, returns liver,spleen,kidney warp.Have benefiting QI for strengthening the superficies, arresting sweating is admittedly de-, holder skin ulcer granulation promoting, and the effect of inducing diuresis to remove edema, weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, the diseases such as deficiency of vital energy edema.
Radix Codonopsis: this product is the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf..Sweet in the mouth, property is flat, returns spleen, lung meridian.There is invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting, for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, the interior-heat disease such as quench one's thirst.
Endoconcha Sepiae: this product is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindroni de Rochebrune or golden cuttlefish Sepia esculenta Hoyle.Salty in the mouth, puckery, warm in nature, return spleen, kidney channel.There is astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, the effect of sore, for the acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, the diseases such as ulcer.
Concha Ostreae (calcined): this product is the shell of the long Concha Ostreae Ostra of Ostreidae animal gigas Thunberg.Salty in the mouth, cold nature, returns liver, gallbladder, kidney channel.The effect of Concha Ostreae (calcined) is astringent or styptic treatment for spontaneous sweating for restraining, for spontaneous sweating, and seminal emission metrorrhagia and leukorrhagia, the diseases such as stomachache acid regurgitation.
Fructus Aurantii Immaturus (parched): this product is the dry young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.Bitter in the mouth, pungent, sour, warm in nature, returns spleen, stomach warp.Effect is dispelling the stagnated QI removing food stagnancy, and the loose painful abdominal mass of reducing phlegm is stopped in stagnant, and feeling of fullness distending pain is heavy after dysentery, constipation, gastroptosis, proctoptosis, the diseases such as uterine prolapse.After parch, strengthen the effect of its relieving dyspepsia.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Cotis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall COPTIS TEETA Wall..Bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Effect is heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told the diseases such as nosebleed.
Radix Glycyrrhizae Preparata: this product is the dry root of glycyrrhizic legume Glycyrrhizauralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Sweet in the mouth, property is flat, GUIXIN, lung, spleen, stomach warp.Effect is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, and expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, cushion toxicity, strong.After processed with honey, strengthen the effect of invigorating the spleen and replenishing QI.
Adopt above technical scheme, compared with prior art, have the following advantages: above-mentioned 18 herbal medicine monarch reasonable compatibilities, in side vinegar Rhizoma Corydalis invigorate blood circulation, circulation of qi promoting, pain relieving, Rhizoma Atractylodis Macrocephalae (parched with bran) invigorating the spleen and benefiting QI, Endothelium Corneum Gigeriae Galli (parched) strengthening the spleen to promote digestion is monarch drug; Minister is with Rhizoma Cyperi (processed with vinegar), Radix Aucklandiae promoting the circulation of QI to relieve pain, and parched with bran Rhizoma Atractylodis, Fructus Aurantii Immaturus (parched), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), Fructus Hordei Germinatus (parched to brown) is drying damp and strengthening spleen, and stomach function regulating helps digestion; Assistant is with Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, the Radix Astragali, Radix Codonopsis invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, Fructus Amomi, Endoconcha Sepiae, Concha Ostreae (calcined), Rhizoma Coptidis relieving gastric hyperacidity to alleviate stomachache, astringing to arrest diarrhea; The Radix Glycyrrhizae Preparata invigorating the spleen and replenishing QI coordinating the actions of various ingredients in a prescription of holding concurrently is adjuvant.After above compatibility of drugs, whole prescription has the effect of promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, for weakness of the spleen and stomach gastral cavilty distension, breast flank pain, inappetence, nausea and vomiting, be suitable for the diseases such as gastritis, gastric ulcer, duodenal ulcer, treating both the principal and secondary aspects of a disease, the effective malaise symptoms of reduction of patient, function of spleen and stomach regulating fundamentally, eradicates the root of curing the disease again, avoids recurrence.
The specific embodiment
The present embodiment is for the ease of understanding the present invention, and the claim not limiting the present invention in any way and core content.
Embodiment 1, a medicine for the treatment of Chronic gastrointestinal diseases, active ingredient comprises by weight: 12 parts of 18 parts of vinegar Rhizoma Corydalis, 15 parts of Rhizoma Cyperi (processed with vinegar), 18 parts of Pericarpium Citri Reticulataes, 12 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 9 parts of the Radix Aucklandiae, 9 parts of Fructus Amomis, 15 parts of Endothelium Corneum Gigeriae Galli (parched)s, 12 parts of parched with bran Rhizoma Atractylodis, 12 parts of Fructus Crataegi (parched to brown)s, 12 parts of Massa Medicata Fermentata (parched to brown), 12 parts of Fructus Hordei Germinatus (parched to brown)s, 15 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 15 parts of Endoconcha Sepiaes, 15 parts of Concha Ostreae (calcined)s, 12 parts of Fructus Aurantii Immaturus (parched), 6 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
Embodiment 2, a medicine for the treatment of Chronic gastrointestinal diseases, active ingredient comprises by weight: 8 parts of 10 parts of vinegar Rhizoma Corydalis, 9 parts of Rhizoma Cyperi (processed with vinegar), 10 parts of Pericarpium Citri Reticulataes, 7 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 5 parts of the Radix Aucklandiae, 5 parts of Fructus Amomis, 9 parts of Endothelium Corneum Gigeriae Galli (parched)s, 7 parts of parched with bran Rhizoma Atractylodis, 7 parts of Fructus Crataegi (parched to brown)s, 7 parts of Massa Medicata Fermentata (parched to brown), 7 parts of Fructus Hordei Germinatus (parched to brown)s, 9 parts of the Radixs Astragali, 8 parts of Radix Codonopsis, 10 parts of Endoconcha Sepiaes, 9 parts of Concha Ostreae (calcined)s, 7 parts of Fructus Aurantii Immaturus (parched), 3 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
Embodiment 3, a medicine for the treatment of Chronic gastrointestinal diseases, active ingredient comprises by weight: 16 parts of 22 parts of vinegar Rhizoma Corydalis, 19 parts of Rhizoma Cyperi (processed with vinegar), 23 parts of Pericarpium Citri Reticulataes, 16 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 13 parts of the Radix Aucklandiae, 13 parts of Fructus Amomis, 19 parts of Endothelium Corneum Gigeriae Galli (parched)s, 17 parts of parched with bran Rhizoma Atractylodis, 16 parts of Fructus Crataegi (parched to brown)s, 16 parts of Massa Medicata Fermentata (parched to brown), 16 parts of Fructus Hordei Germinatus (parched to brown)s, 19 parts of the Radixs Astragali, 16 parts of Radix Codonopsis, 19 parts of Endoconcha Sepiaes, 19 parts of Concha Ostreae (calcined)s, 16 parts of Fructus Aurantii Immaturus (parched), 10 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
Embodiment 4, a medicine for the treatment of Chronic gastrointestinal diseases, active ingredient comprises by weight: 14 parts of 14 parts of vinegar Rhizoma Corydalis, 17 parts of Rhizoma Cyperi (processed with vinegar), 14 parts of Pericarpium Citri Reticulataes, 9 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 11 parts of the Radix Aucklandiae, 11 parts of Fructus Amomis, 12 parts of Endothelium Corneum Gigeriae Galli (parched)s, 9 parts of parched with bran Rhizoma Atractylodis, 14 parts of Fructus Crataegi (parched to brown)s, 9 parts of Massa Medicata Fermentata (parched to brown), 14 parts of Fructus Hordei Germinatus (parched to brown)s, 12 parts of the Radixs Astragali, 10 parts of Radix Codonopsis, 13 parts of Endoconcha Sepiaes, 12 parts of Concha Ostreae (calcined)s, 9 parts of Fructus Aurantii Immaturus (parched), 7 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
Embodiment 5, a medicine for the treatment of Chronic gastrointestinal diseases, active ingredient comprises by weight: 10 parts of 20 parts of vinegar Rhizoma Corydalis, 12 parts of Rhizoma Cyperi (processed with vinegar), 13 parts of Pericarpium Citri Reticulataes, 14 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 7 parts of the Radix Aucklandiae, 7 parts of Fructus Amomis, 17 parts of Endothelium Corneum Gigeriae Galli (parched)s, 15 parts of parched with bran Rhizoma Atractylodis, 10 parts of Fructus Crataegi (parched to brown)s, 14 parts of Massa Medicata Fermentata (parched to brown), 9 parts of Fructus Hordei Germinatus (parched to brown)s, 17 parts of the Radixs Astragali, 14 parts of Radix Codonopsis, 17 parts of Endoconcha Sepiaes, 17 parts of Concha Ostreae (calcined)s, 14 parts of Fructus Aurantii Immaturus (parched), 8 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
The preparation of concentrated pill:
According to aforementioned proportion weighting raw materials;
Get Fructus Crataegi (parched to brown), vinegar Rhizoma Corydalis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Codonopsis four tastes dry after, be ground into fine powder, sieve, mix.Residue medical material decocts with water secondary, and each 2 hours, decocting liquid filtered, and filtrate merges, and is condensed into thick paste shape, mixes with above-mentioned fine powder, adopts traditional method pill, and dry, polishing, obtains.
[function cures mainly] promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, the disease such as gastral cavilty distension, inappetence, nausea and vomiting and the chronic gastritis that is mainly used in causing because of weakness of the spleen and stomach, gastric ulcer, duodenal ulcer.
[usage and dosage] boiled water is taken after mixing it with water, a 5g, and one day twice, or follow the doctor's advice.
[specification] every packed 5g.
[storage] sealing.
The preparation of hard capsule:
According to aforementioned proportion weighting raw materials;
Get Fructus Crataegi (parched to brown), vinegar Rhizoma Corydalis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Codonopsis four tastes dry after, be ground into coarse powder, mix.Residue medical material decocts with water secondary, and each 2 hours, decocting liquid filtered, and filtrate merges, and is condensed into thick paste shape, mixes with above-mentioned coarse powder, dry, pulverize into fine powder, mixes, and incapsulates, and makes 1000, obtains.
[function cures mainly] promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, the disease such as gastral cavilty distension, inappetence, nausea and vomiting and the chronic gastritis that is mainly used in causing because of weakness of the spleen and stomach, gastric ulcer, duodenal ulcer.
[usage and dosage] is oral, one time 2 ~ 4, one day twice, or follow the doctor's advice.
[specification] every dress 0.5g.
[storage] sealing.
The preparation of granule:
According to aforementioned proportion weighting raw materials; Decoct with water three times, each 2 hours, decocting liquid filtered, and filtrate merges, and was concentrated in right amount, adopted traditional method to add dextrin and starch, granulation, and dry, screening, makes 1000g, obtains.
[function cures mainly] promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, the disease such as gastral cavilty distension, inappetence, nausea and vomiting and the chronic gastritis that is mainly used in causing because of weakness of the spleen and stomach, gastric ulcer, duodenal ulcer
[usage and dosage] boiled water is taken after mixing it with water, a 6 ~ 9g, and one day twice, or follow the doctor's advice.
[specification] every packed 6g.
[storage] sealing.
The preparation of oral liquid:
According to aforementioned proportion weighting raw materials; Decoct with water three times, each 2 hours, decocting liquid filtered, and filtrate merges, be concentrated into relative density 1.06(20 ℃), add ethanol, ethanol accounts for 70%, standing 24 hours, filter, filtrate recycling ethanol, cold preservation 24 hours, filters, filtrate adds 8 parts of polyoxyethylene sorbitan monoleates, 20 parts of glycerol, 2 parts of saccharin sodium and 2 parts of sorbic acid, and the sodium hydroxide solution with 1% is adjusted PH to 7.0, adds water to 1000ml, mix, boil, fill, sealing, sterilizing, obtains.
[function cures mainly] promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, the disease such as gastral cavilty distension, inappetence, nausea and vomiting and the chronic gastritis that is mainly used in causing because of weakness of the spleen and stomach, gastric ulcer, duodenal ulcer.
[usage and dosage] is oral, a 10ml, and one day twice, or follow the doctor's advice.
[specification] every dress 10ml.
[storage] sealing.
The method of quality control of medicine is as follows:
According to high performance liquid chromatography (" Chinese Pharmacopoeia " appendix VI D), measure the content of Hesperidin in compositions:
Chromatographic condition and system suitability test: take octadecylsilane chemically bonded silica as filler, the methanol-water (40:60) of take is mobile phase, detect wavelength 284nm, and theoretical cam curve is calculated and should be not less than 2000 by Hesperidin peak.
The preparation of reference substance solution: get Hesperidin reference substance appropriate, accurately weighed, add methanol and make every 1ml containing the solution of 0.2mg, obtain.
The preparation of need testing solution: precision measures the extractum 1ml after extract drugs of the present invention concentrates, and puts in 25ml volumetric flask, is diluted with water to scale, precision measures diluent 1ml to evaporating dish, and water bath method turns molten to 10ml volumetric flask with methanol, by methanol constant volume, to scale, obtain.
Algoscopy: precision is drawn reference substance solution and need testing solution 10 μ l respectively, injects high performance liquid chromatograph, measures.
Result is judged: the every 1ml of this product, contains Pericarpium Citri Reticulatae and Fructus Aurantii Immaturus (parched) with Hesperidin (C
28h
34o
15) meter, must not be less than 5mg.
Through test, above embodiment gained medicine is used for the treatment of Chronic gastrointestinal diseases, and the effect of embodiment 1 is best, and below test is carried out with embodiment 1 gained medicine.
Results of pharmacodynamic test:
By pharmacodynamics test, verify the beneficial effect of Chinese medicine composition of the present invention, choose this medicine on the impact of the digestive tract indexs such as Mouse Stomach Emptying Rate, alvine pushing rate, motilin (MTL) content, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP) content, somatostatin (SS) content as measure the item.(test be take this Chinese medicine composition oral liquid as test specimen)
1, the impact of medicine of the present invention on Mouse Stomach Emptying Rate
(1), process of the test:
36 of Kunming mouses, 18～22g, male and female half and half, be divided at random 3 groups, be respectively heavy dose of group, small dose group, matched group, gavage is given this medicine oral liquid (heavy dose), one times (low dose) of oral administration solution dilution of same volume respectively, distilled water (contrast), successive administration 5 days.Fasting 24h before experiment, removes the bedding and padding in mouse cage, and drinking-water is not limit.During experiment, lh after administration, gives semi-solid nutrition and sticks with paste, and 0.4mL/ only, after 10min, put to death by de-cervical vertebra.Ligation stomach cardia and pylorus, get stomach and weigh, and then along greater gastric curvature, cuts off body of stomach, wipes away dry weighing after washing away gastric content.The difference of stomach full weight stomach function regulating net weight of take is gastric residue weight, gastric residue account for to fill with the semi-solid percentage by weight of sticking with paste be gastric residual rate.
Gastric residual rate=(stomach gross weight-stomach net weight)/the nutrition of filling with stick with paste heavy * 100%
(2), result of the test:
The emptying experimental data of table 1 Mouse Stomach
| Group | n | Stomach gross weight (g) | Stomach net weight (g) | Stomach residue rate (%) |
| Heavy dose of group | 12 | 0.6626±0.1474 | 0.2107±0.0203 | 123.83±37.60 ** |
| Small dose group | 12 | 0.6569±0.2134 | 0.2090±0.0420 | 152.30±42.18 * |
| Matched group | 12 | 0.8281±0.1313 | 0.1834±0.0261 | 192.65±35.14 |
Note: * represents and matched group comparison, significant difference P < 0.05
* represents and matched group comparison, significant difference P < 0.01
Experimental result shows, heavy dose of group and matched group comparison, this medicine can obviously improve the gastric emptying of mice, and significant difference (P < 0.01), small dose group and matched group comparison, also can embody the facilitation emptying to Mouse Stomach, significant difference (0 < 0.05), by above result, can be drawn, it has the emptying effect of obvious promotion Mouse Stomach this medicine oral liquid.
2, the impact of medicine of the present invention on mice alvine pushing rate
(1), process of the test:
36 of Kunming mouses, 18～22g, male and female half and half, be divided at random 3 groups, be respectively heavy dose of group, small dose group, matched group, gavage is given this medicine oral liquid (heavy dose), 3 times (low dose) of oral administration solution dilution of same volume respectively, distilled water (contrast), successive administration 5 days.Fasting 24h before experiment, removes the bedding and padding in mouse cage, and drinking-water is not limit.During experiment, lh after administration, gives semi-solid nutrition and sticks with paste, and 0.4mL/ only, after 10min, put to death, and takes out rapidly small intestinal, peels off gently rear being directly laid on blank sheet of paper by de-cervical vertebra, measures pylorus to ileocecum portion total length and pylorus and to black semisolid, sticks with paste the distance in forward position.It is intestinal propulsion rate that the distance (propelling length) that pylorus to the black semisolid of take is stuck with paste forward position accounts for pylorus to the percentage ratio of ileocecus total length (small intestinal overall length).
Intestinal propulsion rate=propelling length/small intestinal overall length * 100%
(2), result of the test:
Table 2 mice intestinal Promoting Experiment data
| Group | n | Small intestinal total length (cm) | Advance distance (cm) | Propelling rate (%) |
| Heavy dose of group | 12 | 52.08±4.75 | 40.00±12.70 | 78.52±21.38 ** |
| Small dose group | 12 | 56.58±4.77 | 40.00±15.06 | 63.12±21.23 * |
| Matched group | 12 | 51.17±5.34 | 28.50±7.38 | 42.75±12.59 |
Note: * represents and matched group comparison, significant difference P < 0.05
* represents and matched group comparison, significant difference P < 0.01
Experimental result shows, heavy dose of group and matched group comparison, this medicine can obviously promote the intestinal of high mice to advance, and significant difference (P < 0.01), small dose group and matched group comparison, also can embody the facilitation that mice intestinal is advanced, significant difference (0 < 0.05), by above result, can be drawn its effect that has obvious promotion mice intestinal to advance of this medicine oral liquid.
3, the impact of medicine of the present invention on gut hormones such as Mouse Stomach therbligs (MTL), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), somatostatin (SS)
(1), process of the test:
The grouping of a, animal and administration: Kunming mouse is equally divided into blank, low dose, heavy dose of three groups, every group of 14 male and female half and half, conventional raising one week, makes its body weight in 25g left and right; Medicine oral liquid of the present invention, as heavy dose, dilutes 3 times as low dose of, and distilled water is as blank, and each treated animal fasting 18h before administration, can't help water, respectively with 0.25ml/ gastric infusion.
B, specimen collection: 1h after administration, mice is plucked eyeball and gets blood, about amount for taking blood 1ml, get blood after the de-cervical vertebra of mice put to death, dissect rapidly, under small intestinal and duodenum junction, 0.5cm Chang small intestine is got at 0.5cm place ,-70 ℃ of Refrigerator stores after weighing.
The preparation of c, testing sample:
Blood serum sample preparation: avoid any cytositimulation in operating process.Use not containing pyrogen and endotoxic test tube.Collect after blood 1000rmin
-1centrifugal 10min, gets supernatant 0.200ml ,-70 ℃ of Refrigerator stores, and before measuring, room temperature is thawed.
Small intestine's sample preparation: small intestine adds the homogenate in homogenizer of 1.5ml sodium chloride injection, 2000rmin
-1centrifugal 10min, gets the supernatant.
MTL, SP, SS assay in 2.4 samples
D, measurement result: adopt euzymelinked immunosorbent assay (ELISA) (ELISA) to measure, strictly press the operation of test kit description.
(2), experimental result:
Average ± standard deviation for data acquisition (n=10) represents, the results are shown in Table 3, table 4.
The impact (n=10) of table 3 on MTL, SP, SS content in mice serum
Note: * and matched group be P < 0.05 relatively
The impact (n=10) of MTL, SP, SS content in table 4 mouse small intestine tissue
Note: * and matched group be P < 0.05 relatively
Adopt SPSS mathematical statistics software to be analyzed each group data, analysis result is as follows:
In blood serum sample, the heavy dose of group of this medicine can significantly improve the content of motilin and Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 in mice serum, significantly reduce the content of somatostatin, this medicine low dose is to motilin in mice serum, the trend that the impact of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, Somatostatin is improved and reduces, but there is no significant difference.
In small intestine's sample, the heavy dose of group of this medicine can significantly improve the content of motilin and Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 in mice serum, significantly reduce the content of somatostatin, this medicine low dose is to motilin in mice serum, the trend that the impact of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, Somatostatin is improved and reduces, but there is no significant difference.
As can be seen from the above results, in the suitable situation of drug dose of the present invention, can effectively regulate the level of gut hormone, thereby promote pipe intestinal digesting function.
4, pharmacodynamic experiment is summed up:
By above experimental result, shown, Chinese medicine composition of the present invention can effectively promote gastrointestinal motility, improve gastrointestinal function, can effectively regulate the level of gut hormone simultaneously, make the functional rehabilitation of disorderly gastrointestinal normal, therefore Chinese medicine composition of the present invention can fundamentally improve human intestines and stomach's digestive function, can alleviate rapidly malaise symptoms again, really accomplish treating both the principal and secondary aspects of a disease.
Unless there is specified otherwise, above percentage composition is quality percentage composition.
Those skilled in the art will recognize that; the above-mentioned specific embodiment is exemplary; in order to make those skilled in the art can better understand content of the present invention; should not be understood as limiting the scope of the invention; so long as the improvement of doing according to technical solution of the present invention; and realization and identical effect of the present invention, all fall into protection scope of the present invention.
Claims (7)
1. a medicine for the treatment of Chronic gastrointestinal diseases, is characterized in that: the active ingredient of described medicine comprises: vinegar Rhizoma Corydalis, Rhizoma Cyperi (processed with vinegar), Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Aucklandiae, Fructus Amomi, Endothelium Corneum Gigeriae Galli (parched), parched with bran Rhizoma Atractylodis, Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Radix Codonopsis, Endoconcha Sepiae, Concha Ostreae (calcined), Fructus Aurantii Immaturus (parched), Rhizoma Coptidis and Radix Glycyrrhizae Preparata.
2. medicine according to claim 1, is characterized in that: the active ingredient of described medicine comprises by weight: vinegar Rhizoma Corydalis 10-22 part, Rhizoma Cyperi (processed with vinegar) 9-19 part, Pericarpium Citri Reticulatae 10-23 part, Rhizoma Atractylodis Macrocephalae (parched with bran) 7-16 part, Radix Aucklandiae 5-13 part, Fructus Amomi 5-13 part, Endothelium Corneum Gigeriae Galli (parched) 9-19 part, parched with bran Rhizoma Atractylodis 7-17 part, Fructus Crataegi (parched to brown) 7-16 part, Massa Medicata Fermentata (parched to brown) 7-16 part, Fructus Hordei Germinatus (parched to brown) 7-16 part, Radix Astragali 9-19 part, Radix Codonopsis 8-16 part, Endoconcha Sepiae 10-19 part, Concha Ostreae (calcined) 9-19 part, Fructus Aurantii Immaturus (parched) 7-16 part, Rhizoma Coptidis 3-10 part and Radix Glycyrrhizae Preparata 8-16 part.
3. medicine according to claim 1, is characterized in that: the active ingredient of described medicine comprises by weight: 12 parts of 18 parts of vinegar Rhizoma Corydalis, 15 parts of Rhizoma Cyperi (processed with vinegar), 18 parts of Pericarpium Citri Reticulataes, 12 parts of Rhizoma Atractylodis Macrocephalae (parched with bran), 9 parts of the Radix Aucklandiae, 9 parts of Fructus Amomis, 15 parts of Endothelium Corneum Gigeriae Galli (parched)s, 12 parts of parched with bran Rhizoma Atractylodis, 12 parts of Fructus Crataegi (parched to brown)s, 12 parts of Massa Medicata Fermentata (parched to brown), 12 parts of Fructus Hordei Germinatus (parched to brown)s, 15 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 15 parts of Endoconcha Sepiaes, 15 parts of Concha Ostreae (calcined)s, 12 parts of Fructus Aurantii Immaturus (parched), 6 parts of Rhizoma Coptidis and Radix Glycyrrhizae Preparatas.
4. according to the preparation method for the treatment of Chronic gastrointestinal diseases medicine described in claim 1,2 or 3, it is characterized in that: described preparation method comprises:
According to aforementioned proportion weighting raw materials;
Get Fructus Crataegi (parched to brown), vinegar Rhizoma Corydalis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Codonopsis four tastes dry after, be ground into fine powder, sieve, mix;
Residue medical material decocts with water secondary, and each 2 hours, decocting liquid filtered, and filtrate merges, and is condensed into thick paste shape, mixes with above-mentioned fine powder, through pill, dry, polishing, obtains concentrated pill.
5. according to the preparation method for the treatment of Chronic gastrointestinal diseases medicine described in claim 1,2 or 3, it is characterized in that: described preparation method comprises:
According to aforementioned proportion weighting raw materials;
Get Fructus Crataegi (parched to brown), vinegar Rhizoma Corydalis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Codonopsis four tastes dry after, be ground into coarse powder, mix; Residue medical material decocts with water secondary, and each 2 hours, decocting liquid filtered, and filtrate merges, and is condensed into thick paste shape, mixes, is dried, is ground into fine powder with above-mentioned coarse powder, incapsulates, and obtains hard capsule.
6. according to the preparation method for the treatment of Chronic gastrointestinal diseases medicine described in claim 1,2 or 3, it is characterized in that: described preparation method comprises:
According to aforementioned proportion weighting raw materials;
Decoct with water three times, each 2 hours, decocting liquid filtered, and filtrate merges, concentrated, adds dextrin and starch, granulation, and dry, screening, obtains granule.
7. according to the preparation method for the treatment of Chronic gastrointestinal diseases medicine described in claim 1,2 or 3, it is characterized in that: described preparation method comprises:
According to aforementioned proportion weighting raw materials;
Decoct with water three times, each 2 hours, decocting liquid filtered, and filtrate merges, be concentrated into relative density 1.06, add ethanol, ethanol accounts for 70%, standing 24 hours, filter filtrate recycling ethanol, cold preservation 24 hours, filter, filtrate adds 8 parts of polyoxyethylene sorbitan monoleates, 20 parts of glycerol, 2 parts of saccharin sodium and 2 parts of sorbic acid, and the sodium hydroxide solution with 1% is adjusted PH to 7.0, mix, boil, fill, sealing, sterilizing, obtains oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310485573.3A CN103505690A (en) | 2013-10-17 | 2013-10-17 | Medicament for treating chronic gastrointestinal tract diseases and preparation method of medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310485573.3A CN103505690A (en) | 2013-10-17 | 2013-10-17 | Medicament for treating chronic gastrointestinal tract diseases and preparation method of medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103505690A true CN103505690A (en) | 2014-01-15 |
Family
ID=49889464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310485573.3A Pending CN103505690A (en) | 2013-10-17 | 2013-10-17 | Medicament for treating chronic gastrointestinal tract diseases and preparation method of medicament |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103505690A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524414A (en) * | 2014-12-26 | 2015-04-22 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine preparation for treating chronic gastritis |
| CN105597012A (en) * | 2016-02-03 | 2016-05-25 | 河南省南山菇业有限公司 | Traditional Chinese medicine composition for nourishing spleen and enriching stomach and preparation method of traditional Chinese medicine composition |
| CN106421053A (en) * | 2016-11-30 | 2017-02-22 | 河南中医药大学 | Traditional Chinese medicine capable of tonifying spleen and warming stomach |
| CN111000962A (en) * | 2019-12-05 | 2020-04-14 | 佛山市禅城区中心医院有限公司 | Chinese patent medicine for treating functional dyspepsia of spleen deficiency and damp stagnation syndrome and preparation method thereof |
| CN112870309A (en) * | 2021-04-16 | 2021-06-01 | 扬子江药业集团江苏龙凤堂中药有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating or improving gastrointestinal diseases |
| CN113230362A (en) * | 2021-06-02 | 2021-08-10 | 李纪文 | Stomach medicine and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615944A (en) * | 2004-09-07 | 2005-05-18 | 马占风 | Chinese medicine recipe for treating gastric disease |
| CN101002904A (en) * | 2007-01-19 | 2007-07-25 | 马学荣 | Medicine for treating gastric ulcer and duodenal ulcer |
-
2013
- 2013-10-17 CN CN201310485573.3A patent/CN103505690A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615944A (en) * | 2004-09-07 | 2005-05-18 | 马占风 | Chinese medicine recipe for treating gastric disease |
| CN101002904A (en) * | 2007-01-19 | 2007-07-25 | 马学荣 | Medicine for treating gastric ulcer and duodenal ulcer |
Non-Patent Citations (2)
| Title |
|---|
| 李秀英: "香砂六君子汤治疗胃脘痛68例疗效观察", 《中国民康医学》 * |
| 高玉玮: "香砂六君子汤加减治疗慢性胃炎86例", 《中医临床研究》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524414A (en) * | 2014-12-26 | 2015-04-22 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine preparation for treating chronic gastritis |
| CN105597012A (en) * | 2016-02-03 | 2016-05-25 | 河南省南山菇业有限公司 | Traditional Chinese medicine composition for nourishing spleen and enriching stomach and preparation method of traditional Chinese medicine composition |
| CN106421053A (en) * | 2016-11-30 | 2017-02-22 | 河南中医药大学 | Traditional Chinese medicine capable of tonifying spleen and warming stomach |
| CN111000962A (en) * | 2019-12-05 | 2020-04-14 | 佛山市禅城区中心医院有限公司 | Chinese patent medicine for treating functional dyspepsia of spleen deficiency and damp stagnation syndrome and preparation method thereof |
| CN112870309A (en) * | 2021-04-16 | 2021-06-01 | 扬子江药业集团江苏龙凤堂中药有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating or improving gastrointestinal diseases |
| CN113230362A (en) * | 2021-06-02 | 2021-08-10 | 李纪文 | Stomach medicine and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103505690A (en) | Medicament for treating chronic gastrointestinal tract diseases and preparation method of medicament | |
| CN104338043B (en) | A kind of medicine for improving immunity and preparation method thereof | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN103110762A (en) | Traditional Chinese medicine composition for treating old fracture | |
| CN102670966A (en) | Chinese medicinal composition for treating dilated cardiomyopathy | |
| CN103316317A (en) | Traditional Chinese medicine composition for treating superficial gastritis | |
| CN103432412B (en) | Medicament for treating hyperplasia of mammary glands and preparation method thereof | |
| CN104940596A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof | |
| CN103463406B (en) | Traditional Chinese medicine for treating sweating sickness of disharmony of heart and kidney | |
| CN104800771A (en) | Traditional Chinese medicine preparation for treating children sleep terror disorder and preparation method thereof | |
| CN104958536A (en) | Chinese medicinal composition for treating diabetes and preparation method thereof | |
| CN108576341A (en) | A kind of coffee and preparation method improving male's sexual | |
| CN103721237A (en) | Traditional Chinese medicine composition for treating hypomenorrhea | |
| CN103690869B (en) | Chinese medicine for the treatment of irritable bowel syndrome and preparation method thereof | |
| CN101983699A (en) | Traditional Chinese medicine composition for treating kidney disease and preparation method thereof | |
| CN112569291A (en) | Pharmaceutical composition for polycystic ovarian syndrome and preparation method thereof | |
| CN104906511A (en) | Traditional Chinese medicine preparation for reflux esophagitis and preparation method of traditional Chinese medicine preparation | |
| CN105412424A (en) | Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation | |
| CN104888132A (en) | Traditional Chinese medicine composition for treatment of chronic gastritis | |
| CN105056170A (en) | Application of traditional Chinese medicine composition in preparing drug for treating acute gastritis | |
| CN101095938A (en) | Chinese traditional medicine for treating diabetic ischemic muscular atrophy | |
| CN104623544A (en) | Traditional Chinese medicine preparation capable of tonifying spleen and eliminating dampness for treating moderate fatty liver and preparation method of traditional Chinese medicine preparation | |
| CN103705831B (en) | A kind of pharmaceutical composition treating menopausal syndrome and preparation method thereof | |
| CN104161971A (en) | Traditional Chinese medicine composition for treating preceded menorrhea | |
| CN106581176A (en) | Traditional Chinese medicine composition for treating infertility and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140115 |