CN113209263A - Antibacterial gynecological gel and preparation method thereof - Google Patents
Antibacterial gynecological gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an antibacterial gynecological gel which comprises the following components in parts by weight: 1-3 parts of solubilizer, 2-3 parts of bactericide, 80-92 parts of purified water, 0.8-1.5 parts of ginger root extract, 0.8-1.5 parts of clausena lansium extract, 0.8-1.5 parts of hypericum perforatum extract, 0.8-1.5 parts of artemisia capillaris extract, 0.8-1.5 parts of radix stemonae erecta extract, 0.8-1.5 parts of sophora flavescens root extract, 0.8-1.5 parts of fructus cnidii extract and 0.8-1.5 parts of scutellaria baicalensis root extract; the bactericide is one or a composition of more than two of cationic bactericide, silver ion bactericide or ozone bactericide. The gel has good antibacterial effect by adopting the synergistic antibacterial effect of a plurality of bactericides, simultaneously has the effect of killing staphylococcus aureus, candida albicans, escherichia coli and the like, has the highest antibacterial efficiency of 96 percent, simultaneously has good viscosity, humidity and comfort level, and has good effect on keeping the vagina healthy.
Description
Technical Field
The invention belongs to the field of medicines, and relates to an antibacterial gynecological gel and a preparation method thereof.
Background
The gynecological gel is a gel, has antiinflammatory, antibacterial, and antipruritic effects, and can be used for treating various gynecological vaginitis and cervicitis, such as bacterial vaginitis, trichomonas vaginitis, mixed vaginitis, gonococcal infection, chronic cervicitis, and cervical erosion. The gynecological gel has obvious inhibition effect on the growth of pathogenic microorganisms such as staphylococcus aureus, escherichia coli, gonococcus, candida albicans, fungi, saccharomycetes and the like.
The prior patent application with publication number CN110151684A describes an antibacterial gynecological gel, a preparation method and applications thereof, wherein the antibacterial gynecological gel comprises the following components in parts by weight: 1-4 parts of gel, 5-30 parts of solubilizer, 0.7-1 part of buffering agent, 2-20 parts of antibacterial agent, 0.1-0.4 part of activity promoter and 60-80 parts of water; the product has antibacterial and bactericidal effects through the action of povidone iodine and radix Puerariae polysaccharide.
In addition, the patent application document with the publication number of CN111840516A describes an antibacterial gel for gynecology and a preparation method thereof, which is prepared from the following raw materials in percentage by weight: 1-5% of cecropin antibacterial peptide, 1-5% of gastrodia elata polypeptide, 1-5% of luteolin, 10-30% of thickening agent, 2-6% of wetting agent, 1-5% of tocopherol, 1-3% of sodium hyaluronate, 0.5-2% of menthol, a proper amount of pH regulator and the balance of purified water; the cecropin B and the gastrodia elata polypeptide are used as active ingredients of the antimicrobial peptide, and have synergistic antibacterial effect.
Although the existing gynecological gel has a certain antibacterial and bactericidal capacity, the bactericidal effect is still slightly insufficient, the improvement needs to be realized, and the humidity and the comfort degree of the existing product in the use process are not good, so that the improvement needs to be further realized.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides an antibacterial gynecological gel and a preparation method thereof, which have the effect of killing staphylococcus aureus, candida albicans, escherichia coli and the like, have the highest antibacterial efficiency of 96 percent and have stable performance.
The invention adopts the following specific technical scheme:
an antibacterial gynecological gel comprises the following components in parts by weight:
1-3 parts of solubilizer, 2-3 parts of bactericide, 80-90 parts of purified water, 0.8-1.5 parts of ginger root extract, 0.8-1.5 parts of clausena lansium extract, 0.8-1.5 parts of hypericum perforatum extract, 0.8-1.5 parts of artemisia capillaris extract, 0.8-1.5 parts of radix stemonae erecta extract, 0.8-1.5 parts of sophora flavescens root extract, 0.8-1.5 parts of fructus cnidii extract and 0.8-1.5 parts of scutellaria baicalensis root extract;
the bactericide is one or a composition of more than two of cationic bactericide, silver ion bactericide or ozone bactericide.
The product of the invention is added with various plant extracts, and the ginger root extract can enhance the activity of skin and activate skin, and has the functions of oxidation resistance and anti-aging. The extract of cortex Phellodendri is also called as cortex Phellodendri extract, and has effects of clearing heat, eliminating dampness, clearing pathogenic fire, removing toxic substance, and treating sore. Hypericin extracted from Hypericum perforatum has obvious DNA and RNA virus resisting effect, and can interfere virus replication and propagation and inhibit virus. The Artemisia capillaris Thunb extract has strong antitumor activity and antioxidant effect, and can inhibit or kill fungus causing dermatosis, and its antifungal effective component is capillone. The stemona sessilifolia extract has an inhibiting effect on most pathogenic bacteria and dermatophytes, can transiently inhibit the activity of nerve cells, calms and relieves the skin, and improves the trial comfort level of products. The sophora flavescens root extract has a good relieving effect on skin itch, promotes the growth and repair of damaged vascular nerve cells, restores the activity of subcutaneous capillary cells, and makes skin compact and smooth. Fructus Cnidii extract has antifungal effect, can eliminate dampness, kill parasites and relieve itching, and can be used for treating trichomonas vaginitis. The Scutellariae radix extract has wide antibacterial spectrum, and has inhibitory effect on Staphylococcus aureus, Candida albicans, Escherichia coli, etc.
The invention combines the bactericide with various plant extracts, reduces the side effect of the product by increasing the dosage of the plant extracts and properly using the bactericide, and improves the use comfort of the product while improving the sterilizing effect.
Preferably, the solubilizer comprises any one or a combination of at least two of glycerol, propylene glycol, pentanediol or hydrogenated castor oil.
Preferably, the solubilizer is glycerol. Glycerol, glycerol, is colorless, transparent, odorless, and has clear and viscous liquid appearance, and can enhance dissolution of plant extract and bactericide.
In order to obtain better sterilization effect, the sterilization agent preferably comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
Preferably, the bactericide is a cationic bactericide, and specifically is one of a biguanide bactericide and a quaternary ammonium salt bactericide.
The biguanide belongs to one of cationic bactericides, has good antibacterial and bactericidal effects, no toxicity, strong bactericidal effect, small local irritation and low anaphylactic reaction rate, and is particularly suitable for gynecological sterilization.
The quaternary ammonium salt bactericide has enhanced bactericidal effect, less influence by water hardness, no corrosion to metal, no irritation to skin and low toxicity.
Preferably, the biguanide bactericide includes one of amixidine acetate, chlorhexidine gluconate, and polyhexamethylene biguanide.
Preferably, the bactericide is a biguanide bactericide and a silver ion solution with the concentration of 0.5 mg/L-50 mg/L.
The invention adopts the combined action of the cationic bactericide and the silver ion bactericide, preferably adopts 0.8-2 parts of chlorhexidine gluconate and 0.5-1.5 parts of 10 mg/L-25 mg/L silver ion solution, has the highest combined antibacterial efficiency of more than 92 percent and stable performance.
Preferably, the bactericide comprises 0.8-2 parts of chlorhexidine gluconate and 0.5-1.5 parts of silver ion solution with the concentration of 10-25 mg/L.
The invention also provides a preparation method of the antibacterial gynecological gel, which comprises the following steps:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
The gel has good antibacterial effect by adopting the synergistic antibacterial effect of a plurality of bactericides, has the effect of killing staphylococcus aureus, candida albicans, escherichia coli and the like, has the highest antibacterial efficiency of 96 percent, has stable performance, simultaneously gives consideration to good viscosity, humidity and comfort level, and has good effect of keeping the health of the vagina.
Detailed Description
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments disclosed below.
An antibacterial gynecological gel comprises the following components in parts by weight:
1-3 parts of solubilizer, 2-3 parts of bactericide, 80-92 parts of purified water, 0.8-1.5 parts of ginger root extract, 0.8-1.5 parts of clausena lansium extract, 0.8-1.5 parts of hypericum perforatum extract, 0.8-1.5 parts of artemisia capillaris extract, 0.8-1.5 parts of radix stemonae erecta extract, 0.8-1.5 parts of sophora flavescens root extract, 0.8-1.5 parts of fructus cnidii extract and 0.8-1.5 parts of scutellaria baicalensis root extract;
the bactericide is one or a composition of more than two of cationic bactericide, silver ion bactericide or ozone bactericide.
The solubilizer in this example is glycerol.
In another preferred embodiment, the composition comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
The biguanide bactericide includes one of chlorhexidine acetate, chlorhexidine gluconate, and polyhexamethylene biguanide. Chlorhexidine gluconate is further preferably used.
In another embodiment, the bactericide comprises chlorhexidine gluconate 0.8-1.6 parts and silver ion aqueous solution with concentration of 10 mg/L-25 mg/L0.5-1.5 parts.
The embodiment also provides a preparation method of the antibacterial gynecological gel, which comprises the following steps:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
Example 1
The antibacterial gynecological gel in the embodiment comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
Wherein the solubilizer is glycerol, and the bactericide is a cationic bactericide, specifically chlorhexidine gluconate.
The preparation steps are as follows:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
Example 2
The antibacterial gynecological gel in the embodiment comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
Wherein the solubilizer is glycerol, and the bactericide is 10mg/L silver ion aqueous solution.
The preparation steps are as follows:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
Example 3
The antibacterial gynecological gel in the embodiment comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
Wherein the solubilizer is glycerol, and the bactericide is silver ion aqueous solution with the concentration of 25 mg/L.
The preparation steps are as follows:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
Example 4
The antibacterial gynecological gel in the embodiment comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
Wherein, the solubilizer is glycerol, and the bactericide comprises 1 part of chlorhexidine gluconate and 1.5 parts of silver ion aqueous solution with the concentration of 20 mg/L.
The preparation steps are as follows:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
Example 5
The antibacterial gynecological gel in the embodiment comprises the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
Wherein the solubilizer is glycerol, and the bactericide comprises 1.5 parts of chlorhexidine gluconate and 1 part of silver ion aqueous solution with the concentration of 20 mg/L.
The preparation steps are as follows:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
The antibacterial gynecological gels of examples 1 to 5 were tested for antibacterial activity (GB15979-2002 appendix C) with the following results:
the gynecological gel provided by the embodiment has the highest antibacterial rate of 96% for staphylococcus aureus, candida albicans and escherichia coli, and has a good antibacterial effect.
The above description is only exemplary of the preferred embodiments of the present invention, and is not intended to limit the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. The antibacterial gynecological gel is characterized by comprising the following components in parts by weight:
1-3 parts of solubilizer, 2-3 parts of bactericide, 80-90 parts of purified water, 0.8-1.5 parts of ginger root extract, 0.8-1.5 parts of clausena lansium extract, 0.8-1.5 parts of hypericum perforatum extract, 0.8-1.5 parts of artemisia capillaris extract, 0.8-1.5 parts of radix stemonae erecta extract, 0.8-1.5 parts of sophora flavescens root extract, 0.8-1.5 parts of fructus cnidii extract and 0.8-1.5 parts of scutellaria baicalensis root extract;
the bactericide is one or a composition of more than two of cationic bactericide, silver ion bactericide or ozone bactericide.
2. The antibacterial gynecological gel according to claim 1, wherein the solubilizer comprises any one or a combination of at least two of glycerin, propylene glycol, pentanediol or hydrogenated castor oil.
3. The antibacterial gynecological gel according to claim 2, characterized in that the solubilizer is glycerol.
4. The antibacterial gynecological gel according to claim 1, which is characterized by comprising the following components in parts by weight: 1 part of solubilizer, 2.5 parts of bactericide, 88.5 parts of purified water, 1 part of ginger root extract, 1 part of clausena lansium extract, 1 part of hypericum perforatum extract, 1 part of artemisia capillaris extract, 1 part of stemona sessilifolia extract, 1 part of sophora flavescens root extract, 1 part of fructus cnidii extract and 1 part of scutellaria baicalensis root extract.
5. The antibacterial gynecological gel according to claim 1, wherein the bactericide is a cationic bactericide, in particular one of biguanide bactericides and quaternary ammonium salt bactericides.
6. The antibacterial gynecological gel according to claim 1, wherein the biguanide bactericide comprises one of amixidine acetate, chlorhexidine gluconate and polyhexamethylene biguanide.
7. The antibacterial gynecological gel according to claim 6, wherein the bactericide is a biguanide bactericide and a silver ion solution with a concentration of 0.5mg/L to 50 mg/L.
8. The antibacterial gynecological gel according to claim 7, wherein the bactericide comprises chlorhexidine gluconate 0.8-2 parts and silver ion solution 0.5-1.5 parts at a concentration of 10-25 mg/L.
9. Method for the preparation of an antibacterial gynaecological gel according to any of the claims 1-8, characterized in that it comprises the following steps:
(1) adding water to a solubilizer for dissolving;
(2) mixing bactericide, rhizoma Zingiberis recens extract, cortex Phellodendri extract, herba Hyperici perforati extract, herba Artemisiae Scopariae extract, radix Stemonae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract and radix Scutellariae extract, and dissolving in water;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2) to obtain the antibacterial gynecological gel.
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Application publication date: 20210806 |