CN113180244A - 一种叶酸干燥工艺 - Google Patents
一种叶酸干燥工艺 Download PDFInfo
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title claims abstract description 98
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 229960000304 folic acid Drugs 0.000 title claims abstract description 49
- 235000019152 folic acid Nutrition 0.000 title claims abstract description 49
- 239000011724 folic acid Substances 0.000 title claims abstract description 49
- 238000001035 drying Methods 0.000 title claims abstract description 18
- 238000001694 spray drying Methods 0.000 claims abstract description 16
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 12
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 12
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 12
- 239000000047 product Substances 0.000 claims abstract description 12
- 239000011265 semifinished product Substances 0.000 claims abstract description 8
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 6
- 238000005406 washing Methods 0.000 claims abstract description 4
- 238000003825 pressing Methods 0.000 claims abstract description 3
- 239000006185 dispersion Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004945 emulsification Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 239000002245 particle Substances 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 3
- 239000003995 emulsifying agent Substances 0.000 description 4
- 239000011859 microparticle Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010002065 Anaemia megaloblastic Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000000682 Megaloblastic Anemia Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100001016 megaloblastic anemia Toxicity 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
- A23P10/47—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added using additives, e.g. emulsifiers, wetting agents or dust-binding agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明涉及叶酸干燥领域，具体涉及一种叶酸干燥工艺。具体为叶酸半成品经洗涤压滤后，添加麦芽糊精，经乳化分散、喷雾干燥后制得叶酸。叶酸成品呈微粒状，具有流动性、分散性和溶解性特性，较之粗烘干的叶酸成品更易与其他产品混合，不至因膨松性影响混合效果，具有显著的推广意义。
Description
技术领域
本发明涉及叶酸干燥领域，具体涉及一种叶酸干燥工艺。
背景技术
叶酸是一种水溶性维生素，在蛋白质合成及细胞分裂与生长过程中具有重要作用，对正常红细胞的形成有促进作用。缺乏时可致红细胞中血红蛋白生成减少、细胞成熟受阻，导致巨幼红细胞性贫血。现有的叶酸工艺中，多采用直接粉碎的加工工艺，由于叶酸成分微溶于水，粉碎的叶酸成为多边形形状，特别膨松，在与其他物质混合时，膨松、质轻，造成混料不均匀，影响物质的整体效果。
因此，有必要解决上述技术问题。
发明内容
为了解决背景技术中的问题，本发明提供了一种新的叶酸干燥工艺，解决了烘干工艺干燥叶酸流动性差，溶解性差，分散性差的缺陷，使微颗粒叶酸以更好形态添加于其他产品。本发明采用的技术方案如下：
一种叶酸干燥工艺，具体为叶酸半成品经洗涤压滤后，添加麦芽糊精，经乳化分散、喷雾干燥后制得叶酸。
进一步地，所述麦芽糊精的加入量为半成品叶酸重量的0.5％。
进一步地，所述叶酸半成品与麦芽糊精的混料，与水按1:12的料液比配制成稀糊状。
进一步地，所述乳化分散在乳化机中进行，乳化机分散的时间为10分钟，转速为2900转。
进一步地，所述喷雾干燥在喷雾干燥塔中进行，喷雾干燥塔的进风温度为180度，出风温度为100度。
进一步地，叶酸成品呈微粒状，具有流动性。
与现有技术相比，本发明所具有的有益效果为：
本发明所提供的一种叶酸干燥工艺制得的成品呈微粒状，具有流动性、分散性和溶解性特性，较之粗烘干的叶酸成品更易与其他产品混合，不至因膨松性影响混合效果，添加的麦芽糊精，可以增加稠度，使叶酸产品更易凝聚成型，麦芽糊精中的维生素D和E比较丰富，可以增加骨骼对钙离子吸收，降低骨质疏松发生的概率，还可以美白皮肤，促进体内废物的排出，同时具有润肠通便及减肥的功效。
具体实施方式
下面对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明提供了一种一种叶酸干燥工艺，具体工艺为叶酸半成品经洗涤压滤后，添加麦芽糊精，经乳化分散、喷雾干燥后制得叶酸，其中叶酸经合成-酸精制-碱精制后形成半成品。
进一步地，所述麦芽糊精的加入量为半成品叶酸重量的0.5％。
进一步地，所述叶酸半成品与麦芽糊精的混料，与水按1:12的料液比配制成稀糊状。
进一步地，所述乳化分散在乳化机中进行，乳化机分散的时间为10分钟，转速为2900转。
进一步地，所述喷雾干燥在喷雾干燥塔中进行，喷雾干燥塔的进风温度为180度，出风温度为100度。
进一步地，叶酸成品呈微粒状，具有流动性。
本发明所涉及的原理为：
由于叶酸成分微溶于水，粉碎的叶酸成为多边形形状，特别膨松，在与其他物质混合时，膨松、质轻，造成混料不均匀，影响物质的整体效果，本发明中使微溶于水的叶酸经过乳化分散、喷雾干燥后，形成可完全溶于水的微颗粒状态，解决了烘干工艺干燥叶酸流动性差，溶解性差，分散性差的缺陷，使微颗粒叶酸以更好形态添加于其他产品。
本发明中添加有麦芽糊精，可以增加稠度，使叶酸产品更易凝聚成型，麦芽糊精中的维生素D和E比较丰富，可以增加骨骼对钙离子吸收，降低骨质疏松发生概率，还可以美白皮肤，促进体内废物的排出，同时具有润肠通便及减肥的功效。
上面仅对本发明的较佳实施例作了详细说明，但是本发明并不限于上述实施例，在本领域普通技术人员所具备的知识范围内，还可以在不脱离本发明宗旨的前提下作出各种变化，各种变化均应包含在本发明的保护范围之内。
Claims (6)
1.一种叶酸干燥工艺，其特征在于：叶酸半成品经洗涤压滤后，添加麦芽糊精，经乳化分散、喷雾干燥后制得叶酸。
2.根据权利要求1所述的一种叶酸干燥工艺，其特征在于：所述麦芽糊精的加入量为半成品叶酸重量的0.5％。
3.根据权利要求1所述的一种叶酸干燥工艺，其特征在于：所述叶酸半成品与麦芽糊精的混料，与水按1:12的料液比配制成稀糊状。
4.根据权利要求1所述的一种叶酸干燥工艺，其特征在于：所述乳化分散在乳化机中进行，乳化机分散的时间为10分钟，转速为2900转。
5.根据权利要求1所述的一种叶酸干燥工艺，其特征在于：所述喷雾干燥在喷雾干燥塔中进行，喷雾干燥塔的进风温度为180度，出风温度为100度。
6.根据权利要求1所述的一种叶酸干燥工艺，其特征在于：叶酸成品呈微粒状，具有流动性。
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397576A (en) * | 1992-09-23 | 1995-03-14 | Hoffmann-La Roche Inc. | Spray triturated micronutrient compositions |
| JPH0977669A (ja) * | 1995-09-19 | 1997-03-25 | Takeda Chem Ind Ltd | ビタミンｂ群顆粒品の組成物およびその製造方法 |
| US5714168A (en) * | 1996-12-11 | 1998-02-03 | Basf Corporation | Method for increasing flowability of spray dried vitamin powders having low vitamin concentrations |
| CN1633991A (zh) * | 2004-11-08 | 2005-07-06 | 常州市牛塘化工厂 | 颗粒状叶酸的生产方法和产品 |
| EP2258218A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
| US20110038940A1 (en) * | 2008-02-06 | 2011-02-17 | Innov'ia | Pulverulent composition and a process for preparing the same |
| CN102000345A (zh) * | 2010-11-16 | 2011-04-06 | 广西大学 | 包合态的叶酸/β-环糊精组合物及其制备方法 |
| CN103070831A (zh) * | 2013-02-02 | 2013-05-01 | 常州市新鸿医药化工技术有限公司 | 10～90%叶酸颗粒制备方法 |
| CN107969704A (zh) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | 一种适宜软胶囊制剂的维生素预混料及其制备方法 |
-
2021
- 2021-05-31 CN CN202110604691.6A patent/CN113180244A/zh active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397576A (en) * | 1992-09-23 | 1995-03-14 | Hoffmann-La Roche Inc. | Spray triturated micronutrient compositions |
| JPH0977669A (ja) * | 1995-09-19 | 1997-03-25 | Takeda Chem Ind Ltd | ビタミンｂ群顆粒品の組成物およびその製造方法 |
| US5714168A (en) * | 1996-12-11 | 1998-02-03 | Basf Corporation | Method for increasing flowability of spray dried vitamin powders having low vitamin concentrations |
| CN1633991A (zh) * | 2004-11-08 | 2005-07-06 | 常州市牛塘化工厂 | 颗粒状叶酸的生产方法和产品 |
| US20110038940A1 (en) * | 2008-02-06 | 2011-02-17 | Innov'ia | Pulverulent composition and a process for preparing the same |
| EP2258218A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
| CN102000345A (zh) * | 2010-11-16 | 2011-04-06 | 广西大学 | 包合态的叶酸/β-环糊精组合物及其制备方法 |
| CN103070831A (zh) * | 2013-02-02 | 2013-05-01 | 常州市新鸿医药化工技术有限公司 | 10～90%叶酸颗粒制备方法 |
| CN107969704A (zh) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | 一种适宜软胶囊制剂的维生素预混料及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 井乐刚等: "喷雾干燥法制备复合维生素微胶囊的研究", 《中国药学杂志》 * |
| 吴克刚等: "《食品微胶囊技术》", 31 July 2006, 中国轻工业出版社 * |
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