CN113171431A - Capsule for treating rheumatoid and preparation method thereof - Google Patents

Capsule for treating rheumatoid and preparation method thereof Download PDF

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Publication number
CN113171431A
CN113171431A CN202110621460.6A CN202110621460A CN113171431A CN 113171431 A CN113171431 A CN 113171431A CN 202110621460 A CN202110621460 A CN 202110621460A CN 113171431 A CN113171431 A CN 113171431A
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parts
weight
radix
capsule
traditional chinese
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涂从刚
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Mianyang Dekang Pain Hospital
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Mianyang Dekang Pain Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention discloses a capsule for treating rheumatoid, which is prepared from the following Chinese medicinal herbs (by weight ratio): the traditional Chinese medicine composition comprises 2/27 parts by weight of processed nux vomica, 5/54 parts by weight of processed radix aconiti, 5/54 parts by weight of processed radix aconiti kusnezoffii, 1/27 parts by weight of processed frankincense, 1/27 parts by weight of processed myrrh, 2/9 parts by weight of rhizoma corydalis, 1/27 parts by weight of safflower, 1/27 parts by weight of mistletoe, 1/27 parts by weight of radix stephaniae tetrandrae, 2/27 parts by weight of rhizoma gastrodiae, 1/27 parts by weight of ginseng, 1/18 parts by weight of radix notoginseng, 1/27 parts by weight of whole worm, 1/27 parts by weight of centipede, 1/27 parts by weight of eucommia ulmoides and 1/18 parts by weight of radix angelicae; the invention has the advantages of pure Chinese medicine preparation, no toxic or side effect, 16 medicines of the Chinese medicine prescription, convenient material acquisition, low price, convenient taking and obvious treatment effect on rheumatoid arthritis.

Description

Capsule for treating rheumatoid and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine and medical treatment, in particular to a pill for treating rheumatoid arthritis.
Background
Rheumatoid Arthritis (RA), also known as rheumatoid arthritis, is an osteoid disease, is currently recognized to be an autoimmune disease which may be related to differences in endocrine, nutrition, geography, occupation, psychology and social environment, bacterial and viral infection, genetic cause and the like, becomes a main clinical manifestation with chronic, symmetrical, multiple synovial arthritis and extra-articular diseases, and belongs to autoimmune inflammatory diseases. The disease is well developed in the small joints of hands, wrists, feet and the like, and is recurrent and symmetrically distributed. Early stage joint red swelling and hot pain and dysfunction, and late stage joint can appear different degrees of rigidity deformity, and accompanied with atrophy of bones and skeletal muscles, and is easy to cause disability. From the pathological change point of view, rheumatoid arthritis is a widespread inflammatory disease that mainly involves the synovial membrane of joints (which may later spread to articular cartilage, bone tissue, articular ligaments and muscle bonds), and secondly, the connective tissues such as serosa, heart, lung and eyes. The systemic manifestations of rheumatoid arthritis include, besides arthropathy, fever, fatigue, weakness, subcutaneous nodules, pleuritis, arteritis, peripheral neuropathy, etc. The generalized rheumatoid arthritis includes a generalized disease of the whole body in addition to an inflammatory disease of a joint region.
The traditional Chinese medicine prescription has obvious effect on treating rheumatoid arthritis, and has long course of disease, the cause of disease is the deficiency of liver, spleen and kidney as the disease cause, wind-cold-damp-heat phlegm stasis as the index, and the obstruction of channels and collaterals and qi and blood stasis as the pathology, so the treatment mainly comprises nourishing liver and kidney, tonifying qi and blood, regulating and tonifying spleen and stomach, and is assisted by a great treatment method of clearing heat toxin, eliminating dampness and turbidity, eliminating blood stasis, eliminating phlegm and turbidity, removing wind and eliminating evil, and dispersing obstruction and relieving pain; rheumatoid arthritis is a chronic and recurrent painful disease mainly caused by systemic arthritis, and is a common disease and frequently encountered disease. The onset of disease can be days, weeks or months with varying degrees of mobility, often persisting, developing long-term pain, and localized pain only with joint movement due to swelling and expansion of joint tissue. The early stage of rheumatoid arthritis usually has general symptoms, such as fever, fatigue, poor diet, discomfort in the whole body, and severe cases may be accompanied by anemia. The main clinical manifestations are joint lesions, which are usually symmetrical and involve the facet joints, most common proximal interphalangeal joints of the hand, wrist joints and the toe joints of the foot, and severely affect the large joints and spine joints of the elbow, shoulder, ankle, knee, etc. The later-stage patients mainly have joint dislocation, subluxation, deformity change and serious movement disorder, and the patients can not take care of themselves in life.
The traditional Chinese medicine considers that: the rheumatoid disease refers to the pathological changes characterized by aphasia, paralysis of the waist and knees, and numbness of the limbs caused by qi obstruction of the triple energizer due to the excessive addiction and the consumption of kidney qi; the main pathogenesis of the disease is that the appetite is not adjusted, the patient feels unconscious, and the inter-renal movement is injured, which is the 'source of qi generation', namely the root of the five zang-organs and six fu-organs, the root of the twelve main meridians, the respiratory gate and the origin of the triple energizer, and a series of symptoms occur because the inter-renal movement is injured and can not regularly push the functional activities of the triple energizer; the rheumatoid arthritis focuses on bones, and the police medical personnel seek the basis for the treatment of the disease, and the outline of the treatment is to supply kidney qi and dredge bone qi; bone, kidney qi governing; the tendons and kidneys governing kidney qi are homologous to the liver and kidney.
Modern medicine considers that: modern medicine considers rheumatoid arthritis as a disease closely related to environmental, cellular, viral, genetic, sex hormone and neuropsychiatric conditions.
(one) bacterial factors: experimental research shows that the group A streptococcus and the bacterial wall have peptidoglycan which can be a continuous stimulator of RA attack, and the group A streptococcus exists in vivo for a long time to become a continuous antigen, so that an organism is stimulated to generate antibodies, and immunopathology injury is caused to cause diseases. Mycoplasma-made animal models of arthritis resemble human RA, but do not produce Rheumatoid Factors (RF) that are characteristic of human RA. Bacterial or mycoplasmal antigenic material has never been found in synovial tissue and synovial fluid of RA patients, suggesting that bacteria may be involved in the onset of RA, but there is no direct evidence.
(II) viral factors: the relationship between RA and viruses, especially EB virus, is one of the problems noticed by scholars at home and abroad. Research shows that the arthritis caused by EB virus infection is different from RA, and RA patients have stronger response to EB virus than normal people. Persistent high levels of anti-EB virus-envelope antigen antibodies are present in the serum and synovial fluid of RA patients, but EB virus nuclear antigen or capsid antigen antibodies have not been found in the serum of RA patients to date.
(III) genetic factors: the disease is more frequent in some families.
(IV) sex hormones: research shows that the ratio of RA incidence rate between men and women is 1: 2-4, the pregnancy condition is relieved, and the incidence of diseases of women taking the contraceptive is reduced. Animal models show that LEW/n female mice have high sensitivity to arthritis and low male morbidity, and male mice have the same arthritis occurrence condition as female mice after being castrated or treated with beta-estradiol, so that the sex hormone plays a certain role in RA pathogenesis.
The first factor of the attack of the joint of the bone and the wind-solar energy is congenital weakness. The chapter of "Lingshu-shou Tian cong Rou" (Lingshu & shou Tian-Du-Rou): the nature of the human body is rigid, flexible, weak and strong. Pregnancy caused by deficiency of essence and blood due to weakness and sickliness of parents; or pregnancy in the aftermath; or pregnancy occurs after fifty years when the strength of vital essence is greatly reduced; or male and female with insufficient age and incomplete development, that is, pregnancy at early marriage, or excessive fertility and excessive loss of essence and blood; or during pregnancy, fetal qi is deficient, and is affected by five excesses and six qi, liver and kidney are deficient, and bone metabolism is inhibited, so that the joint paralysis and hip joint paralysis can be caused.
In the prior art, western medicine treatment is only symptomatic treatment, cannot comprehensively intervene symptoms of patients from the whole body, has large toxic and side effects, and treats the symptoms and the root causes in general.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a capsule for treating rheumatoid arthritis.
In order to achieve the purpose, the invention provides a capsule for treating rheumatoid arthritis, which comprises the following medicaments: semen Strychni preparata, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, rhizoma corydalis, Carthami flos, herba Taxilli, radix Stephaniae Tetrandrae, rhizoma Gastrodiae, Ginseng radix, Notoginseng radix, Scorpio, Scolopendra, Eucommiae cortex, and radix Angelicae Dahuricae.
The invention further provides a capsule for treating rheumatoid arthritis, wherein the traditional Chinese medicines of semen strychni preparata, radix aconiti kusnezoffii preparata, frankincense, myrrh, rhizoma corydalis, safflower, parasitic loranthus, radix stephaniae tetrandrae, rhizoma gastrodiae, ginseng, pseudo-ginseng, scorpio, centipede, eucommia ulmoides and radix angelicae in parts by weight are respectively as follows: the traditional Chinese medicine composition comprises 2/27 parts of semen strychni preparata, 5/54 parts of radix aconiti preparata, 5/54 parts of radix aconiti kusnezoffii preparata, 1/27 parts of frankincense, 1/27 parts of myrrh, 2/9 parts of rhizoma corydalis, 1/27 parts of safflower, 1/27 parts of parasitic loranthus, 1/27 parts of radix stephaniae tetrandrae, 2/27 parts of rhizoma gastrodiae, 1/27 parts of ginseng, 1/18 parts of pseudo-ginseng, 1/27 parts of scorpion, 1/27 parts of centipede, 1/27 parts of eucommia ulmoides and 1/18 parts of radix angelicae.
The invention further provides a capsule for treating rheumatoid arthritis and a preparation method thereof, and the preparation method comprises the following preparation steps:
firstly, decocting traditional Chinese medicines, namely putting the traditional Chinese medicines into a stainless steel pot in sequence and decocting the traditional Chinese medicines for one hour with even fire;
step two, filtering, namely filtering the decocted traditional Chinese medicine to ensure that no medicine residue is left, and concentrating the traditional Chinese medicine into an ointment;
thirdly, mixing, namely adding starch and dextrin into the ointment, wherein the mixing ratio of the ointment to the starch to the dextrin is 1:1:1, and mixing the ointment, the starch and the dextrin into a solid medicinal mass;
fourthly, sieving and airing, sieving the solid drug mass with a sieve of 100 meshes to obtain fine particles, and drying the obtained particles in a constant-temperature drying oven at 35 ℃ for 36 hours;
fifthly, grinding, namely grinding the dried particles into fine powder by a machine;
sixthly, preparing the capsule, and filling the obtained fine powder into the capsule to obtain the required capsule.
The invention further provides a capsule for treating rheumatoid arthritis and a preparation method thereof, wherein a filtering tool in the second step is a 180-mesh traditional Chinese medicine separation sieve.
The capsule for treating rheumatoid disease provided by the invention can be prepared into tablets, pills, capsule granules or powder by modern biotechnology. The preparation is administered orally three times a day, 2-4 capsules each time, 2 capsules each time, and 3 days later. It should be noted that: it is forbidden for pregnant women, children, and patients with rheumatic fever.
The traditional Chinese medicine provided by the invention is mainly used for nourishing liver and kidney, tonifying qi and blood, and regulating and nourishing spleen and stomach, and is used for assisting in the treatment of clearing heat and toxic materials, eliminating dampness and turbidity, dispelling blood stasis, eliminating phlegm and turbidity, dispelling wind and eliminating evil, and relieving arthralgia and stopping pain, so as to achieve the purpose of treating rheumatoid; the Chinese medicine formula comprises the following medicinal materials in part by weight:
semen Strychni preparata for promoting blood circulation, removing obstruction in collaterals, diminishing inflammation, resisting bacteria, relieving pain, removing blood stasis and promoting granulation.
The prepared common monkshood mother root is pungent, bitter and hot in taste, and has the effects of dispelling wind and removing dampness, warming meridians and relieving pain.
The prepared kusnezoff monkshood root is pungent, bitter and hot in taste, and has the effects of dispelling wind and removing dampness, and warming channels and relieving pain.
The frankincense is prepared to activate blood, promote qi circulation, relieve pain, reduce swelling and promote granulation.
The prepared myrrh is pungent, bitter and neutral in flavor, can dissipate blood stasis and relieve pain, detumescence and promote granulation
Rhizoma corydalis: warm in nature, pungent and bitter in flavor, promoting blood circulation by removing blood stasis, activating qi-flowing and relieving pain.
Safflower: pungent and warm; promoting blood circulation, dredging channels, removing blood stasis and relieving pain.
Parasitic loranthus: bitter, sweet and mild in taste, dispel wind-damp, tonify liver and kidney, strengthen tendons and bones, and prevent abortion.
Stephania tetrandra: bitter and pungent taste, cold nature, expelling wind-damp, alleviating pain, inducing diuresis to alleviate edema.
Gastrodia elata: sweet taste, mild nature, extinguishing wind and relieving convulsion, calming down liver yang, dispelling wind and dredging collaterals.
Ginseng: sweet and slightly bitter, slightly warm in nature, and can tonify primordial qi, tonify spleen and lung, promote fluid production, soothe nerves and benefit intelligence.
Pseudo-ginseng: sweet, slightly bitter, warm, removing blood stasis to stop bleeding, promoting blood circulation to relieve pain.
Whole worm: salty, pungent, mild, poisonous, wind-extinguishing, spasm-relieving, collateral obstruction-dredging, toxicity-removing.
Centipede: pungent and warm; toxic, extinguishing wind, relieving spasm, counteracting toxic pathogen, dissipating nodulation, unblocking collaterals and alleviating pain.
Eucommia ulmoides: sweet taste, warm nature, liver and kidney nourishing, bone and muscle strengthening, miscarriage prevention.
Radix angelicae: pungent and warm in property, relieving exterior syndrome and dispelling cold, dispelling pathogenic wind and relieving pain, dredging nasal orifice, eliminating dampness and stopping leukorrhagia, relieving swelling and pus discharge, dispelling pathogenic wind and relieving itching.
Compared with the prior art, the invention has the following characteristics:
the oral traditional Chinese medicine prescription for treating rheumatoid disease provided by the invention is a pure traditional Chinese medicine preparation, has no toxic or side effect, and 16 medicines of the traditional Chinese medicine prescription have the advantages of convenient material acquisition, low price and convenient taking.
Detailed Description
The preferred embodiments of the present invention will now be described in conjunction with the detailed description, it being understood that they are set forth herein only to illustrate and explain the present invention and are not intended to limit the present invention.
Example 1
The capsule for treating rheumatoid disease provided by the embodiment comprises the following medicines: semen Strychni preparata, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, rhizoma corydalis, Carthami flos, herba Taxilli, radix Stephaniae Tetrandrae, rhizoma Gastrodiae, Ginseng radix, Notoginseng radix, Scorpio, Scolopendra, Eucommiae cortex, and radix Angelicae Dahuricae.
Preferably, the capsule for treating rheumatoid disease provided by the invention comprises the following traditional Chinese medicines in parts by weight: 40 g of semen strychni preparata, 50 g of radix aconiti kusnezoffii preparata, 20 g of frankincense, 20 g of myrrh, 120 g of rhizoma corydalis, 20 g of safflower, 20 g of parasitic loranthus, 20 g of radix stephaniae tetrandrae, 40 g of rhizoma gastrodiae, 20 g of ginseng, 30 g of pseudo-ginseng, 20 g of scorpion, 20 g of centipede, 20 g of eucommia bark and 30 g of angelica dahurica.
The invention provides a capsule for treating rheumatoid and a preparation method thereof, and the preparation method comprises the following preparation steps:
firstly, decocting traditional Chinese medicines, namely putting the traditional Chinese medicines into a stainless steel pot in sequence and decocting the traditional Chinese medicines for one hour with even fire;
step two, filtering, namely filtering the decocted traditional Chinese medicine to ensure that no medicine residue is left, and concentrating the traditional Chinese medicine into an ointment;
thirdly, mixing, namely adding starch and dextrin into the ointment, wherein the mixing ratio of the ointment to the starch to the dextrin is 1:1:1, and mixing the ointment, the starch and the dextrin into a solid medicinal mass;
fourthly, sieving and airing, sieving the solid drug mass with a sieve of 100 meshes to obtain fine particles, and drying the obtained particles in a constant-temperature drying oven at 35 ℃ for 36 hours;
fifthly, grinding, namely grinding the dried particles into fine powder by a machine;
sixthly, preparing the capsule, and filling the obtained fine powder into the capsule to obtain the required capsule.
Preferably, the filtering tool in the second step of the step is a 180-mesh Chinese medicine separating sieve.
The capsule for treating rheumatoid disease provided by the invention can be prepared into tablets, pills, capsule granules or powder by modern biotechnology. The preparation is orally administered three times a day, 2-4 capsules each time, 2 capsules each time, and 3 capsules each time after 3 days without discomfort. It should be noted that: it is forbidden for pregnant women, children, and patients with rheumatic fever.
Example 2
The capsule for treating rheumatoid disease provided by the embodiment comprises the following medicines: semen Strychni preparata, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, rhizoma corydalis, Carthami flos, herba Taxilli, radix Stephaniae Tetrandrae, rhizoma Gastrodiae, Ginseng radix, Notoginseng radix, Scorpio, Scolopendra, Eucommiae cortex, and radix Angelicae Dahuricae.
Preferably, the capsule for treating rheumatoid disease provided by the invention comprises the following traditional Chinese medicines in parts by weight: 50 g of semen strychni preparata, 62.5 g of radix aconiti kusnezoffii preparata, 25 g of frankincense, 25 g of myrrh, 150 g of rhizoma corydalis, 25 g of safflower, 25 g of Chinese taxillus twig, 25 g of radix stephaniae tetrandrae, 50 g of rhizoma gastrodiae, 25 g of ginseng, 37.5 g of pseudo-ginseng, 25 g of scorpion, 25 g of centipede, 25 g of eucommia bark and 37.5 g of angelica dahurica.
The invention provides a capsule for treating rheumatoid and a preparation method thereof, and the preparation method comprises the following preparation steps:
firstly, decocting traditional Chinese medicines, namely putting the traditional Chinese medicines into a marmite in sequence and decocting the traditional Chinese medicines for one hour with even fire;
step two, filtering, namely filtering the decocted traditional Chinese medicine to ensure that no medicine residue is left, and concentrating the traditional Chinese medicine into an ointment;
thirdly, mixing, namely adding starch and dextrin into the ointment, wherein the mixing ratio of the ointment to the starch to the dextrin is 1:1:1, and mixing the ointment, the starch and the dextrin into a solid medicinal mass;
fourthly, sieving and airing, sieving the solid drug mass with a sieve of 100 meshes to obtain fine particles, and drying the obtained particles for 35 hours at the temperature of 36 ℃ in a constant-temperature drying box;
fifthly, grinding, namely grinding the dried particles into fine powder by a machine;
sixthly, preparing the capsule, and filling the obtained fine powder into the capsule to obtain the required capsule.
Preferably, the filtering tool in the second step of the step is a 180-mesh Chinese medicine separating sieve.
The capsule for treating rheumatoid disease provided by the invention can be prepared into tablets, pills, capsule granules or powder by modern biotechnology. The preparation is orally administered three times a day, 2-4 capsules each time, 2 capsules each time, and 4 capsules each time after 3 days without discomfort. It should be noted that: it is forbidden for pregnant women, children, and patients with rheumatic fever.
Example 3
The capsule for treating rheumatoid disease provided by the embodiment comprises the following medicines: semen Strychni preparata, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, rhizoma corydalis, Carthami flos, herba Taxilli, radix Stephaniae Tetrandrae, rhizoma Gastrodiae, Ginseng radix, Notoginseng radix, Scorpio, Scolopendra, Eucommiae cortex, and radix Angelicae Dahuricae.
Preferably, the capsule for treating rheumatoid disease provided by the invention comprises the following traditional Chinese medicines in parts by weight: 30 g of semen strychni preparata, 37.5 g of radix aconiti kusnezoffii preparata, 15 g of frankincense, 15 g of myrrh, 90 g of rhizoma corydalis, 15 g of safflower, 15 g of loranthus parasiticus, 15 g of radix stephaniae tetrandrae, 30 g of rhizoma gastrodiae, 15 g of ginseng, 22.5 g of pseudo-ginseng, 15 g of scorpion, 15 g of centipede, 15 g of eucommia ulmoides and 22.5 g of angelica dahurica.
The invention provides a capsule for treating rheumatoid and a preparation method thereof, and the preparation method comprises the following preparation steps:
firstly, decocting traditional Chinese medicines, namely sequentially putting the traditional Chinese medicines into an electric cooker to be decocted for one hour;
step two, filtering, namely filtering the decocted traditional Chinese medicine to ensure that no medicine residue is left, and concentrating the traditional Chinese medicine into an ointment;
thirdly, mixing, namely adding starch and dextrin into the ointment, wherein the mixing ratio of the ointment to the starch to the dextrin is 1:1:1, and mixing the ointment, the starch and the dextrin into a solid medicinal mass;
fourthly, sieving and airing, sieving the solid drug mass with a sieve of 100 meshes to obtain fine particles, and drying the obtained particles in a constant-temperature drying oven at 35 ℃ for 36 hours;
fifthly, grinding, namely grinding the dried particles into fine powder by a machine;
sixthly, preparing the capsule, and filling the obtained fine powder into the capsule to obtain the required capsule.
The capsule for treating rheumatoid disease provided by the invention can be prepared into tablets, pills, capsule granules or powder by modern biotechnology. The preparation is administered orally three times a day, 2-4 capsules each time, 2 capsules each time, and 3 days later. It should be noted that: it is forbidden for pregnant women, children, and patients with rheumatic fever.
Preferably, the filtering tool in the second step of the step is a 180-mesh Chinese medicine separating sieve.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (4)

1. A capsule for treating rheumatoid arthritis is characterized by comprising the following medicines: semen Strychni preparata, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, rhizoma corydalis, Carthami flos, herba Taxilli, radix Stephaniae Tetrandrae, rhizoma Gastrodiae, Ginseng radix, Notoginseng radix, Scorpio, Scolopendra, Eucommiae cortex, and radix Angelicae Dahuricae.
2. The capsule for treating rheumatoid as claimed in claim 1, wherein the weight ratio of the traditional Chinese medicines of semen Strychni preparata, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, rhizoma corydalis, Carthami flos, herba Taxilli, radix Stephaniae Tetrandrae, rhizoma Gastrodiae, Ginseng radix, Notoginseng radix, Scorpio, Scolopendra, Eucommiae cortex and radix Angelicae Dahuricae is respectively: the traditional Chinese medicine composition comprises 2/27 parts of semen strychni preparata, 5/54 parts of radix aconiti preparata, 5/54 parts of radix aconiti kusnezoffii preparata, 1/27 parts of frankincense, 1/27 parts of myrrh, 2/9 parts of rhizoma corydalis, 1/27 parts of safflower, 1/27 parts of parasitic loranthus, 1/27 parts of radix stephaniae tetrandrae, 2/27 parts of rhizoma gastrodiae, 1/27 parts of ginseng, 1/18 parts of pseudo-ginseng, 1/27 parts of scorpion, 1/27 parts of centipede, 1/27 parts of eucommia ulmoides and 1/18 parts of radix angelicae.
3. A preparation method of a capsule for treating rheumatoid arthritis is characterized by comprising the following preparation steps:
firstly, decocting traditional Chinese medicines, namely putting the traditional Chinese medicines into a stainless steel pot in sequence and decocting the traditional Chinese medicines for one hour with even fire;
step two, filtering, namely filtering the decocted traditional Chinese medicine to ensure that no medicine residue is left, and concentrating the traditional Chinese medicine into an ointment;
thirdly, mixing, namely adding starch and dextrin into the ointment, wherein the mixing ratio of the ointment to the starch to the dextrin is 1:1:1, and mixing the ointment, the starch and the dextrin into a solid medicinal mass;
fourthly, sieving and airing, sieving the solid drug mass with a sieve of 100 meshes to obtain fine particles, and drying the obtained particles in a constant-temperature drying oven at 35 ℃ for 36 hours;
fifthly, grinding, namely grinding the dried particles into fine powder by a machine;
sixthly, preparing the capsule, and filling the obtained fine powder into the capsule to obtain the required capsule.
4. The method for preparing a capsule for treating rheumatoid disease according to claim 3, wherein the filtering means used in the second step is a 180-mesh Chinese medicinal sieve.
CN202110621460.6A 2021-06-03 2021-06-03 Capsule for treating rheumatoid and preparation method thereof Pending CN113171431A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1569085A (en) * 2003-07-18 2005-01-26 刘吉领 Pharmaceutical composition for treating rheumatic arthritis and rheumatoid arthritis
CN1250247C (en) * 2003-12-05 2006-04-12 吉林省辽源亚东药业股份有限公司 Luyang kidney yang strengthening Chinese traditional medicinal formula and its preparation
CN108939018A (en) * 2018-10-12 2018-12-07 杨会明 The traditional Chinese medicine for outer use for treating cervical spondylosis, lumbar vertebra disease and rheumathritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1569085A (en) * 2003-07-18 2005-01-26 刘吉领 Pharmaceutical composition for treating rheumatic arthritis and rheumatoid arthritis
CN1250247C (en) * 2003-12-05 2006-04-12 吉林省辽源亚东药业股份有限公司 Luyang kidney yang strengthening Chinese traditional medicinal formula and its preparation
CN108939018A (en) * 2018-10-12 2018-12-07 杨会明 The traditional Chinese medicine for outer use for treating cervical spondylosis, lumbar vertebra disease and rheumathritis

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