CN105434597A - Pharmaceutical preparation for treating arthritis and uses thereof - Google Patents

Pharmaceutical preparation for treating arthritis and uses thereof Download PDF

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CN105434597A
CN105434597A CN201610004595.7A CN201610004595A CN105434597A CN 105434597 A CN105434597 A CN 105434597A CN 201610004595 A CN201610004595 A CN 201610004595A CN 105434597 A CN105434597 A CN 105434597A
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parts
radix
herba
pharmaceutical preparation
radix angelicae
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段希福
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract

The invention relates to a pharmaceutical preparation for treating arthritis and uses thereof. A prescription of the pharmaceutical preparation comprises angelica sinensis, radix angelicae pubescentis, futokadsura stem, radix achyranthis bidentatae, Szechuan lovage rhizome, cassia bark, frankincense, clematis root, eucommia bark, largeleaf gentian root, fructus chaenomelis, India madder root, myrrh, pseudo-ginseng, Japanese honeysuckle stem, common cephalanoplos herb, earthworm, geranium wilfordii, common gendarussa herb, indigowoad root and common clubmoss herb. The pharmaceutical preparation disclosed by the invention is prepared from pure traditional Chinese medicine raw materials, is scientific and reasonable in prescription, has an exact curative effect on knee joints, and has certain social and economic value; all the medicines are matched, and discovered by a pharmacology experiment, the pharmaceutical preparation has obvious effects of activating blood, dispersing swelling and activating meridians to stop pain is used for treating arthritis; for convenient production, a preparation method provided by the invention is simple in operation; equipment related to a production process is easy to get, so the pharmaceutical preparation is worthy of being popularized and applied further.

Description

Pharmaceutical preparation of a kind for the treatment of of arthritis and uses thereof
Technical field
The invention belongs to treatment by Chinese herbs field, particularly relate to pharmaceutical preparation of a kind for the treatment of of arthritis and uses thereof
Background technology
Arthritis general reference occurs in the inflammatory diseases of human synovial and surrounding tissue thereof, can be divided into tens of kinds.The arthritic of China has more than 100,000,000, and number is in continuous increase.Clinical manifestation be joint red, swollen, hot, bitterly, dysfunction and joint deformity, severe patient cause joint disabled, affect patients ' life quality.Knee joint osseous arthritis in arthritis is one of a kind of more common disease, particularly the change of present social diet effects, causes the increase of body weight to cause the continuous increase of this disease.Specifically, knee joint osseous arthritis is, synovial membrane inflammation hypertrophy narrow with knee cartilage degeneration, joint space and joint margins hyperosteogeny is main pathological change, with the gonalgia, swelling, impact is squatted down and daily life is main manifestations common disease.
Doctor trained in Western medicine there is no effective especially Therapeutic Method to this disease, although application NSAI drugs can alleviating pain, but can not the cause of disease be dispelled, cannot delay or reverse the regression of articular cartilage, and easily recur after drug withdrawal and cause digestive system and hepatic and renal function injure, therefore, Chinese medicine increases gradually in the research in this field, and achieve good result, motherland's medical science thinks that it is fallen ill and caused by liver and kidney deficiency, and cold-damp is invaded, retardance meridians, caused by phlegm-turbidity and blood stasis blood stasis is stagnant, especially at the pathological factor that acute attack stage is very important.
For arthritic treatment, western medicine treatment can only cure the symptoms, not the disease, be difficult to patient disease is eradicated, and be all by injectable drug or take tablet treatment, this Therapeutic Method also may have side effects to human body, to human body generation secondary injury.And tcm therapy can treatment of arthritis can not have side effects, and can effect a permanent cure, therefore become the first-selection for the treatment of of arthritis.In general, the traditional Chinese medical science determines prescription and content according to the disease of patient and disease, and add according to different types or reduce some component, realizes treatment with this.About the treatment of the traditional Chinese medical science, domestic have many patents, such as: a kind of Chinese medicine for the treatment of knee osteoarthritis in CN201510545513 patent: wear rattan root 30-40 part, Ramulus Et Folium Adhatodae Ventricosea 20-30 part, Herba Ceropegiae Christensenianae 20-30 part, turn round GUFENG 15-25 part, Radix Angelicae Dahuricae 15-25 part, great Ye south Soviet Union 15-25 part, Radix seu Caulis Embeliae Parviflorae 15-25 part, Herba Taxilli 15-25 part, Eupolyphaga Seu Steleophaga 8-12 part, Cornu Elaphuri davidiani 5-10 part.CN104825561A patent discloses a kind of Chinese medicine for the treatment of of arthritis, composition is Radix Angelicae Pubescentis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Notoginseng 2 ~ 3 parts, Retinervus Luffae Fructus 15 ~ 30 parts, the Radix Paeoniae Alba 2 ~ 3 parts, Radix Angelicae Sinensis 20 ~ 50 parts, Ramulus Cinnamomi 15 ~ 25 parts, 3 ~ 8 parts, Flos Carthami, Rhizoma Chuanxiong 20 ~ 40 parts, Radix Scutellariae 10 ~ 20 parts, Herba Asari 2 ~ 5 parts.There is provided that a kind of therapeutic effect is good, effective percentage is high, Chinese medicine to the treatment knee osteoarthritis of human non-toxic's side effect.
In view of this, Western medicine is cured the symptoms, not the disease, and the theory of the traditional Chinese medical science is more, and drug use more complicated, therapeutic effect is not good enough.
Summary of the invention
For the defect of prior art, the present invention be directed to the present situation for the treatment of gonarthritis at present, the Chinese medicine composition that a kind of therapeutic effect is good is provided, and has no side effect.
Specifically, the present invention realizes like this.
Inventor provides a kind of prescriptions of Chinese medicine for the treatment of of arthritis according to drug matching experience, and the Chinese crude drug of prescription comprises: Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Pheretima, Herba Erodii, Herba Gendarussae, Radix Isatidis, Herba Lycopodii.
Subsequently, inventor provides a kind of prescriptions of Chinese medicine for the treatment of of arthritis according to drug matching experience, each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, described formula and weight portion are: Radix Angelicae Sinensis 8-15 part, Radix Angelicae Pubescentis 5-12 part, Caulis Piperis Kadsurae algae 5-15 part, Radix Achyranthis Bidentatae 5-12 part, Rhizoma Chuanxiong 3-10 part, Cortex Cinnamomi 1-6 part, Olibanum 6-12 part, Radix Clematidis 3-10 part, Cortex Eucommiae 7-15 part, Radix Gentianae Macrophyllae 5-15 part, Fructus Chaenomelis 10-20 part, Radix Rubiae 7-12 part, Myrrha 3-11 part, Radix Notoginseng 10-20 part, Caulis Lonicerae 1-5 part, Herba Cirsii 3-8 part, Pheretima 0.5-2 part, Herba Erodii 8-14 part, Herba Gendarussae 3-10 part, Radix Isatidis 10-25 part, Herba Lycopodii 5-15 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Radix Angelicae Sinensis 11.5 parts, Radix Angelicae Pubescentis 8 parts, 10 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 8 parts, Rhizoma Chuanxiong 6.5 parts, Cortex Cinnamomi 3.5 parts, Olibanum 9 parts, Radix Clematidis 7 parts, the Cortex Eucommiae 11 parts, Radix Gentianae Macrophyllae 10 parts, Fructus Chaenomelis 15 parts, 8 parts, Radix Rubiae, Myrrha 7 parts, Radix Notoginseng 15 parts, Caulis Lonicerae 3 parts, Herba Cirsii 5.5 parts, Pheretima 0.5 part, Herba Erodii 11 parts, Herba Gendarussae 6.5 parts, Radix Isatidis 13 parts, Herba Lycopodii 10 parts.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Radix Angelicae Sinensis 13 parts, Radix Angelicae Pubescentis 10 parts, 11 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 10 parts, Rhizoma Chuanxiong 7 parts, Cortex Cinnamomi 4.5 parts, Olibanum 10 parts, Radix Clematidis 9 parts, the Cortex Eucommiae 10 parts, Radix Gentianae Macrophyllae 11 parts, Fructus Chaenomelis 17 parts, 10 parts, Radix Rubiae, Myrrha 8 parts, Radix Notoginseng 17 parts, Caulis Lonicerae 4 parts, Herba Cirsii 6 parts, Pheretima 0.5 part, Herba Erodii 13 parts, Herba Gendarussae 8 parts, Radix Isatidis 17 parts, Herba Lycopodii 11 parts.
Chinese medicine composition of the present invention can treatment of arthritis, and be especially applicable to treatment gonarthritis, the function of each taste Chinese crude drug used in the Chinese medicine composition for the treatment of of arthritis of the present invention is as follows:
Caulis Piperis Kadsurae: acrid in the mouth, warm in nature.
Gui Jing: return Liver Channel.
Function cures mainly: wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, joint stuffiness.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.
Gui Jing: return liver, gallbladder, pericardium channel.
Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Cortex Cinnamomi: acrid in the mouth, hot in nature.
Gui Jing: return kidney, spleen, the heart, Liver Channel.
Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Olibanum: acrid in the mouth, warm in nature.
Function cures mainly: promoting blood circulation and stopping pain.For all pains of trusted subordinate, the contracture of muscle arteries and veins, traumatic injury, sore, carbuncle and painful swelling; Externally used detumescence granulation promoting.Radix Clematidis: bitter in the mouth, warm in nature.
Function cures mainly: can wind-damp dispelling, diuresis, stimulate the menstrual flow, ease pain, control that wind and cold is damp and hot, migraine, jaundice edema, the hard larynx of fishbone, waist knee joint legs and feet cold type of pain.Fresh strain energy treating acute tonsillitis, pharyngolaryngitis; Radical cure filaricide, toothache is controlled in external.Herb can used as pesticides, control bridging worm, Pieris rapae, cutworm, wriggler etc. of going out.
Radix Isatidis: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving, detumescence.For hyperactivity of toxic heat, laryngopharynx swelling and pain; Tonsillitis, parotitis are shown in above-mentioned patient.
The Cortex Eucommiae: sweet in the mouth, warm in nature.
Gui Jing: return liver, kidney channel.
Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix Gentianae Macrophyllae: acrid in the mouth, property is put down.
Gui Jing: return stomach, liver, gallbladder meridian.
Function cures mainly: wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.
Fructus Chaenomelis: sour in the mouth, warm in nature.
Function cures mainly: main arthralgia chiefly caused by damp pathogen tinea pedis, and cholera is told down greatly, and convulsion is more than, Fructus Chaenomelis temperature, report the sky spring and wood gas, sour in the mouth is nontoxic, obtain the woody flavour in east, ground, temperature liter reaches, and sour in the mouth is restrained, one is bent always, and right and wrong is wood, enters liver channel of foot-Jueyin, abnormal smells from the patient falls more than liter, the moon also, liver governing tendons, wet muscle and tendon injury. clonic spasm of the muscle is numbness then. Fructus Chaenomelis temperature can wet dissipation. acid can relaxing muscles and tendons. therefore main arthralgia chiefly caused by damp pathogen. tinea pedis person is wet invades liver network also. acid can liver nourishing. temperature can wet dissipation. therefore also lead it
Herba Erodii: dispel the wind, invigorates blood circulation, heat-clearing and toxic substances removing.Dispelling the wind and dampness pathogens pain, contracture is numb, carbuncle, traumatic injury, enteritis, dysentery.
Caulis Lonicerae: sweet in the mouth, warm in nature, nontoxic.
Gui Jing: enter lung meridian.
Function cures mainly: heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.
Herba Cirsii: sweet in the mouth, cool in nature.
Gui Jing: GUIXIN, Liver Channel.
Function cures mainly: herb: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Pheretima: salty in the mouth, cold in nature.
Gui Jing: return liver, spleen, urinary bladder channel.
Function cures mainly: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Myrrha: bitter in the mouth is pungent, warm in nature.
Gui Jing: enter spleen, kidney two warp.
Herba Gendarussae: taste acrid in the mouth; Bitter; Property is put down.
Gui Jing: return liver; Kidney; Lung meridian.
Function cures mainly: wind-damp dispelling; Dissipating blood stasis blood; Reuniting the fractured tendons and bones.Main air pain of dampness syndrome; Menoxenia; Puerperal abdonimal pain; Treating swelling and pain by traumatic injury; Fracture.
Radix Notoginseng: puckery, property is put down.
Function cures mainly: hemostasis, analgesia, strong muscle, long bone.Control traumatic injury, fracture.
Radix Angelicae Sinensis: sweet in the mouth, warm in nature.
Gui Jing: return liver, the heart, spleen channel.
Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Angelicae Pubescentis: acrid in the mouth, warm in nature.
Gui Jing: return kidney, urinary bladder channel.
Function cures mainly: expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.
Radix Achyranthis Bidentatae: bitter in the mouth, property is put down.
Gui Jing: return liver, kidney channel.
Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Herba Lycopodii: bitter in the mouth, warm in nature.
Gui Jing: return liver,spleen,kidney warp.
Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Radix Rubiae: bitter in the mouth, cold in nature.
Gui Jing: return Liver Channel.
Function cures mainly: removing heat from blood, and hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.
In order to express pharmaceutical preparation of the present invention better, pharmaceutical preparation of the present invention can be prepared into dosage form conventional clinically.Such as, the preparation such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule.Preferably, pharmaceutical preparation of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
Present invention also offers a kind of preparation method of pharmaceutical preparation described above, it mainly comprises following step:
1) Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Herba Erodii, Radix Isatidis and Herba Lycopodii raw material add 12 times of water soakings, then decoct 2 times, 1 hour first time, second time 2 hours, merge decoction liquor, being evaporated to relative density is 1.15, obtains concentrated solution, for subsequent use;
2) Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Pheretima and Herba Gendarussae pulverize add 2-4 doubly 75% ethanol, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, reservation precipitate;
3) step 1) concentrated solution but add afterwards 4-6 doubly 70% ethanol, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, reservation precipitate;
3) by step 2) and step 3) precipitate with a small amount of 50%-60% ethanol clean, washing liquid and supernatant merge, and after decompression recycling ethanol, being evaporated to relative density is 1.20, leave standstill 24h, precipitate, filtration;
4) filtrate low-temperature evaporation is the extractum of 1.03 ~ 1.09 to density, claims its weight, can its weight 10-30% pharmaceutic adjuvant, conventionally make the dosage form that tablet, capsule, granule, pill etc. are different.
The present invention also asks to protect the purposes of said medicine preparation in preparation treatment gonarthritis medicine.
Medicine of the present invention can make tablet, capsule, granule or pill.The moulding process preparing different dosage form only used is different with adjuvant, effective ingredient or the same, and therapeutic effect is also identical or approximate.The adjuvant of tablet can be selected from starch, microcrystalline Cellulose, pregelatinized Starch, lactose, Icing Sugar, carboxymethylstach sodium etc.; The adjuvant of granule is select in cane sugar powder, dextrin and correctives etc., and the adjuvant of capsule can be selected from starch, microcrystalline Cellulose, pregelatinized Starch, lactose, Icing Sugar, carboxymethylstach sodium, carmethose, hypromellose etc.; The adjuvant of pill can be selected from starch, microcrystalline Cellulose, pregelatinized Starch etc.
Compared with prior art, the invention has the advantages that: the present invention is that pure raw material of Chinese medicine medicine is made, scientific formula is reasonable, and treatment knee joint determined curative effect, has certain society and economic worth.All medicines fit through the pharmaceutical preparation that pharmacological evaluation finds to have obvious promoting blood circulation and detumescence, removing obstruction in the collateral to relieve pain effect, be used for the treatment of arthritis, for the ease of producing, preparation method provided by the invention is simple to operate, and the equipment that production technology relates to is easy to get and is worthy of further application.
Specific embodiment
Although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Embodiment 1: a kind of granule for the treatment of gonarthritis, the Chinese crude drug containing, for example lower weight portion:
Radix Angelicae Sinensis 8 parts, Radix Angelicae Pubescentis 5 parts, 5 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 5 parts, Rhizoma Chuanxiong 3 parts, Cortex Cinnamomi 1 part, Olibanum 6 parts, Radix Clematidis 3 parts, the Cortex Eucommiae 7 parts, Radix Gentianae Macrophyllae 5 parts, Fructus Chaenomelis 10 parts, 7 parts, Radix Rubiae, Myrrha 3 parts, Radix Notoginseng 10 parts, Caulis Lonicerae 1 part, Herba Cirsii 3 parts, Pheretima 0.5 part, Herba Erodii 8 parts, Herba Gendarussae 3 parts, Radix Isatidis 10 parts, Herba Lycopodii 5 parts.
Concrete preparation method is as follows:
1) Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Herba Erodii, Radix Isatidis and Herba Lycopodii raw material add 12 times of water soakings, then decoct 2 times, 1 hour first time, second time 2 hours, merge decoction liquor, being evaporated to relative density is 1.15, obtains concentrated solution, for subsequent use;
2) Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Pheretima and Herba Gendarussae pulverize the ethanol adding 2 times 75%, fully mix, place 24 hours, make it precipitate, get its supernatant after 24h, retain precipitate;
3) step 1) concentrated solution but add the ethanol of 4 times 70% afterwards, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, retain precipitate;
3) by step 2) and step 3) precipitate with a small amount of 50% ethanol clean, washing liquid and supernatant merge, and after decompression recycling ethanol, being evaporated to relative density is 1.20, leave standstill 24h, precipitate, filtration;
4) filtrate low-temperature evaporation is the extractum of 1.03 to density, claims its weight, can the lactose of its weight 10% and dextrin (weight ratio is 1:1), stir and be heated to 80 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 2: a kind of granule for the treatment of gonarthritis, the Chinese crude drug containing, for example lower weight portion:
Radix Angelicae Sinensis 15 parts, Radix Angelicae Pubescentis 12 parts, 15 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 12 parts, Rhizoma Chuanxiong 10 parts, Cortex Cinnamomi 6 parts, Olibanum 12 parts, Radix Clematidis 10 parts, the Cortex Eucommiae 15 parts, Radix Gentianae Macrophyllae 15 parts, Fructus Chaenomelis 20 parts, 12 parts, Radix Rubiae, Myrrha 11 parts, Radix Notoginseng 20 parts, Caulis Lonicerae 5 parts, Herba Cirsii 8 parts, Pheretima 2 parts, Herba Erodii 14 parts, Herba Gendarussae 10 parts, Radix Isatidis 25 parts, Herba Lycopodii 15 parts.
Concrete preparation method is with embodiment 1.
Embodiment 3: a kind of granule for the treatment of gonarthritis, the Chinese crude drug containing, for example lower weight portion:
Radix Angelicae Sinensis 11.5 parts, Radix Angelicae Pubescentis 8 parts, 10 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 8 parts, Rhizoma Chuanxiong 6.5 parts, Cortex Cinnamomi 3.5 parts, Olibanum 9 parts, Radix Clematidis 7 parts, the Cortex Eucommiae 11 parts, Radix Gentianae Macrophyllae 10 parts, Fructus Chaenomelis 15 parts, 8 parts, Radix Rubiae, Myrrha 7 parts, Radix Notoginseng 15 parts, Caulis Lonicerae 3 parts, Herba Cirsii 5.5 parts, Pheretima 0.5 part, Herba Erodii 11 parts, Herba Gendarussae 6.5 parts, Radix Isatidis 13 parts, Herba Lycopodii 10 parts.
Concrete preparation method is with embodiment 1.
Embodiment 4: a kind of granule for the treatment of gonarthritis, the Chinese crude drug containing, for example lower weight portion:
Radix Angelicae Sinensis 13 parts, Radix Angelicae Pubescentis 10 parts, 11 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 10 parts, Rhizoma Chuanxiong 7 parts, Cortex Cinnamomi 4.5 parts, Olibanum 10 parts, Radix Clematidis 9 parts, the Cortex Eucommiae 10 parts, Radix Gentianae Macrophyllae 11 parts, Fructus Chaenomelis 17 parts, 10 parts, Radix Rubiae, Myrrha 8 parts, Radix Notoginseng 17 parts, Caulis Lonicerae 4 parts, Herba Cirsii 6 parts, Pheretima 0.5 part, Herba Erodii 13 parts, Herba Gendarussae 8 parts, Radix Isatidis 17 parts, Herba Lycopodii 11 parts.
Concrete preparation method is with embodiment 1.
Embodiment 5: a kind of capsule for the treatment of gonarthritis, the Chinese crude drug containing, for example lower weight portion:
Radix Angelicae Sinensis 11.5 parts, Radix Angelicae Pubescentis 8 parts, 10 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 8 parts, Rhizoma Chuanxiong 6.5 parts, Cortex Cinnamomi 3.5 parts, Olibanum 9 parts, Radix Clematidis 7 parts, the Cortex Eucommiae 11 parts, Radix Gentianae Macrophyllae 10 parts, Fructus Chaenomelis 15 parts, 8 parts, Radix Rubiae, Myrrha 7 parts, Radix Notoginseng 15 parts, Caulis Lonicerae 3 parts, Herba Cirsii 5.5 parts, Pheretima 0.5 part, Herba Erodii 11 parts, Herba Gendarussae 6.5 parts, Radix Isatidis 13 parts, Herba Lycopodii 10 parts.
Concrete preparation method is as follows:
1) Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Herba Erodii, Radix Isatidis and Herba Lycopodii raw material add 12 times of water soakings, then decoct 2 times, 1 hour first time, second time 2 hours, merge decoction liquor, being evaporated to relative density is 1.15, obtains concentrated solution, for subsequent use;
2) Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Pheretima and Herba Gendarussae pulverize the ethanol adding 3 times 75%, fully mix, place 24 hours, make it precipitate, get its supernatant after 24h, retain precipitate;
3) step 1) concentrated solution but add the ethanol of 3 times 70% afterwards, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, retain precipitate;
3) by step 2) and step 3) precipitate with a small amount of 55% ethanol clean, washing liquid and supernatant merge, and after decompression recycling ethanol, being evaporated to relative density is 1.20, leave standstill 24h, precipitate, filtration;
4) filtrate low-temperature evaporation is the extractum of 1.06 to density, claims its weight, can the lactose of its weight 10% and dextrin (weight ratio is 1:1), stir and be heated to 85 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, incapsulate and obtain capsule.
Embodiment 6: a kind of tablet for the treatment of gonarthritis, the Chinese crude drug containing, for example lower weight portion:
Radix Angelicae Sinensis 13 parts, Radix Angelicae Pubescentis 10 parts, 11 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 10 parts, Rhizoma Chuanxiong 7 parts, Cortex Cinnamomi 4.5 parts, Olibanum 10 parts, Radix Clematidis 9 parts, the Cortex Eucommiae 10 parts, Radix Gentianae Macrophyllae 11 parts, Fructus Chaenomelis 17 parts, 10 parts, Radix Rubiae, Myrrha 8 parts, Radix Notoginseng 17 parts, Caulis Lonicerae 4 parts, Herba Cirsii 6 parts, Pheretima 0.5 part, Herba Erodii 13 parts, Herba Gendarussae 8 parts, Radix Isatidis 17 parts, Herba Lycopodii 11 parts.
Concrete preparation method is as follows:
1) Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Herba Erodii, Radix Isatidis and Herba Lycopodii raw material add 12 times of water soakings, then decoct 2 times, 1 hour first time, second time 2 hours, merge decoction liquor, being evaporated to relative density is 1.15, obtains concentrated solution, for subsequent use;
2) Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Pheretima and Herba Gendarussae pulverize the ethanol adding 4 times 75%, fully mix, place 24 hours, make it precipitate, get its supernatant after 24h, retain precipitate;
3) step 1) concentrated solution but add the ethanol of 6 times 70% afterwards, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, retain precipitate;
3) by step 2) and step 3) precipitate with a small amount of 60% ethanol clean, washing liquid and supernatant merge, and after decompression recycling ethanol, being evaporated to relative density is 1.20, leave standstill 24h, precipitate, filtration;
4) filtrate low-temperature evaporation is the extractum of 1.09 to density, claims its weight, can the starch of its weight 10% and microcrystalline Cellulose (weight ratio is 1:1), and granulation drying adds magnesium stearate, tabletting.
Embodiment 7: zoology model experiment
7.1, model preparation
5-6 week age Kunming rat animal adaptability raise one week after, being divided into 2 groups: first group 30 to be only left intact at random, is Normal group; Second group 50 is model group, every day sooner or later with 4 DEG C of cold water freezing stimulation mice right lower limb knee joint each 25min in place, continuous 30 days.
7.2, grouping and administration
Model group: dosage group (6g/kg), Chinese medicine composition low dose group (3g/kg) in Chinese medicine composition high dose group (12g/kg), Chinese medicine composition, often organize 10, described Chinese medicine composition prepares according to the embodiment of the present invention 4.Model group often organize every day 8:00 respectively gastric infusion feed Chinese medicine composition solution 1 time, successive administration is observed result after 7 days.
Positive controls: sinew-soothing Network-Quickening Pill is tested as positive control, dose is 80mg/kg, 10, and every day, 8:00 gastric infusion fed solution 1 time, successive administration 7 days observed results.
Matched group is group 1.: every day, 8:00 gastric infusion fed normal saline (6g/kg) 1 time, and successive administration is observed result after 7 days.
Matched group is group 2.: modeling mice 10, every day 8:00 respectively gastric infusion feed normal saline 1 time, successive administration is observed result after 7 days.
7.3, diagnostic criteria
Arthritis index evaluation adopts arthritis score method:
0 point: without arthritis;
1 point: there are punctation or mild swelling in joint;
2 points: joint moderate is red and swollen;
3 points: joint severe is red and swollen;
4 points: joint is serious red and swollen and can not bear a heavy burden.
Specific experiment the results are shown in Table 1.
Table 1, the arthritis observed result of each group after 7 days
From the results shown in Table 1, the result of the arthritis score that 2. matched group is organized proves gonarthritis mice modeling success, positive controls and each dosage group of Chinese medicine composition all clearly can treat the effect of gonarthritis, but Chinese medicine composition each dosage group therapeutic effect is better than positive controls, especially the therapeutic effect of Chinese medicine composition high dose group is more outstanding, and the therapeutic effect of Chinese medicine composition to gonarthritis is dose-dependence.
7.4, Serum Level of Tumor Necrosis Factor and hyaluronic mensuration
Normal group, model group, positive control group are taken out 10 eyeball of mouse immediately and are got blood, leave standstill the centrifugal 10min of 30min, 2500r/min with separation of serum ,-20 DEG C of preservations.Enzyme linked immunosorbent assay (ELISA) method detects TNF-α (pg/mL), hyaluronic acid (HA) content (ng/mL) in serum.Detailed results is in table 2
TNF-α and HA assay result in table 2 mice serum
Note:
★with matched group 2. group compare, there is significant difference (P<0.05);
★ ★with matched group 2. group compare, there is extremely significant difference (P<0.01);
As can be seen from table 1,2, model group and positive controls and matched group 2. compared with all there is significant difference, wherein in Chinese medicine composition of the present invention, dosage group is suitable with positive controls therapeutic effect, and Chinese medicine composition high dose group is better than positive controls.The all non-phenomena of mortality of all mices, alternatively the safety of bright prescription of the present invention is higher thus, is applicable to applying.
Embodiment 8: clinical trial
8.1, physical data
My institute have collected 225 routine gonarthritis patients altogether, and filtering out qualified is 212 people, wherein, and man 107 example, female 105 example, 50 years old ~ 70 years old age, the state of an illness 6 months ~ 10 years.Be divided at random: treatment group 106 example, matched group 106 example.The data there was no significant differences such as two groups of ages, have comparability.
8.2, diagnostic criteria
Draft with reference to " arthritis diagnosis and treatment draft guidelines gonarthritis in 2002 diagnostic criteria of rheumatism branch of Chinese Medical Association ": 1. nearly one month frequent gonalgia repeatedly; 2. X-ray film (erect position or Weight carrying position) joint space narrows; 3. limpid, the thickness of joint fluid (at least 2 times), WBC≤200/ml; 4. person in middle and old age person (>=40 years old); 5. knee joint deadlock in morning≤30 minutes; 6. friction sound is had during activity.Meet and 1. 2. or 3. 5. 6. or 1. 4. 5. 6. namely form diagnosis.According to sign: the 1. gonalgia, walking function obstacle, exacerbation of symptoms when fatigue and stair activity, involves periarticular muscles pain.2. health check-up knee joint is unrestrained swollen, patella and inside and outside Xiyan place tenderness+, patella grinding pain, floating patella test+, it is limited that knee joint stretches flex, atrophy of quadriceps femoris.
8.3, test method:
(1) matched group takes Rhizoma Gastrodiae Pilulae, takes to specifications, oral.1 ball, 2 ~ 3 times on the one, hurt like hell person takes appropriate ibuprofen granule to be alleviated, 30 days courses for the treatment of.
(2) the oral the present invention for the treatment of group is according to the obtained granule of specific embodiment 3, early, middle and late each once.Each 10g, 30 days courses for the treatment of.
8.4, criterion of therapeutical effect and therapeutic outcome:
Criterion of therapeutical effect:
Cure: knee joint swelling, pain disappear, flexion-extension motion scope recovers normal, and walking freely;
Effective: knee joint swelling substantially disappears or obviously goes down, and pain obviously alleviates, flexion-extension motion scope is normal;
Take a turn for the better: knee joint swelling and pain all have and alleviates in various degree and alleviate, and flexion-extension motion scope is also improved;
Invalid: knee joint swelling and pain are all without alleviation;
Effective percentage: (cure+effective+take a turn for the better)/ill sum
The therapeutic outcome of table 3 treatment group and matched group
As can be seen from Table 3, the successful for the treatment of group is better than matched group, and the effective percentage for the treatment of group is 100%, and the average effectiveness level of matched group is 86.5%.
8.5, model case
Case 1: shut out certain, man, 58 years old, the right gonalgia of patient is had a surplus for nearly 1 year, over nearly 1 month, left side knee joint is swollen starts pain and the right gonalgia increases the weight of, seat dysstasia, hurt like hell, my institute checked afterwards, and check result is as follows: inner side tenderness under kneecap: left knee joint (+), right knee joint (++); Left Range of motion of knee joint: be less than 45 °; Be diagnosed as gonarthritis.Take the Granules in Treating of Medications Example 3 of the present invention, treat 30 days, two swelling and pain in knee obviously alleviate, and the improvement gradually of left knee joint continues to take 60 days, and patient fully recovers, and within 3 months, follow up a case by regular visits to without recurrence.
Case 2, Hu, female, 66 years old, existing 10 years of patient two knee joint soreness, uses unblocking collaterals to treat arthritis to paste and folk prescription (close scholar is along plaster) treatment, does not almost have effect, my institute checked afterwards: right medial meniscus of knee joint anterior angle shifts forward, visible bars lamellar height signal in it, obscure boundary, edge arrives at articular surface.Visible bar shaped height signal in medial meniscus relief angle and the forward and backward angle of lateral meniscus, sharpness of border, edge does not arrive at articular surface.Front and back ligamentaum cruciatum and interior lateral collateral ligament no abnormality seen.Knee-joint anatomy relation no abnormality seen.Joint space narrows.Articular cavity and suprapatellar bursa visible fluidity signal stove.The visible hyperosteogeny in joint set skeletonization edge.Take Medications Example 5 of the present invention capsule treatment, every day 3 times, the morning, noon and afternoon respectively once, each 2, after 30 days, two knee joints are ached and are alleviated, and walk lamely not obvious, swelling disappears substantially, continue to take 60 days, every day 2 times, sooner or later each once each 2 return to one's perfect health, and within 3 months, follow up a case by regular visits to without recurrence.
Case 3: Zhao, man, 54 years old, existing 3 years of patient two knee joint soreness, recently, patient pain comes my institute unbearably and checks, imaging diagnosis: 1. right medial meniscus of knee joint anterior angle damage (II degree) 2. right medial meniscus of knee joint relief angle and lateral meniscus forward and backward angle damage (III degree) 3. right knee joint degeneration, arthroedema.Take the tablet in treatment of Medications Example 6 of the present invention, every day 3 times, the morning, noon and afternoon respectively once, each 4, after 30 days, two knee joints are ached and are alleviated, and walk lamely not obvious, swelling disappears substantially, continue to take 60 days, every day 3 times, morning, noon and afternoon respectively once, each 2, return to one's perfect health, and within 3 months, follow up a case by regular visits to without recurrence.
Scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.

Claims (7)

1. the pharmaceutical preparation of a treatment of arthritis, it is characterized in that, be made up of following bulk drugs: Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Pheretima, Herba Erodii, Herba Gendarussae, Radix Isatidis, Herba Lycopodii.
2. pharmaceutical preparation according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Angelicae Sinensis 8-15 part, Radix Angelicae Pubescentis 5-12 part, Caulis Piperis Kadsurae algae 5-15 part, Radix Achyranthis Bidentatae 5-12 part, Rhizoma Chuanxiong 3-10 part, Cortex Cinnamomi 1-6 part, Olibanum 6-12 part, Radix Clematidis 3-10 part, Cortex Eucommiae 7-15 part, Radix Gentianae Macrophyllae 5-15 part, Fructus Chaenomelis 10-20 part, Radix Rubiae 7-12 part, Myrrha 3-11 part, Radix Notoginseng 10-20 part, Caulis Lonicerae 1-5 part, Herba Cirsii 3-8 part, Pheretima 0.5-2 part, Herba Erodii 8-14 part, Herba Gendarussae 3-10 part, Radix Isatidis 10-25 part, Herba Lycopodii 5-15 part.
3. pharmaceutical preparation according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Angelicae Sinensis 11.5 parts, Radix Angelicae Pubescentis 8 parts, 10 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 8 parts, Rhizoma Chuanxiong 6.5 parts, Cortex Cinnamomi 3.5 parts, Olibanum 9 parts, Radix Clematidis 7 parts, the Cortex Eucommiae 11 parts, Radix Gentianae Macrophyllae 10 parts, Fructus Chaenomelis 15 parts, 8 parts, Radix Rubiae, Myrrha 7 parts, Radix Notoginseng 15 parts, Caulis Lonicerae 3 parts, Herba Cirsii 5.5 parts, Pheretima 0.5 part, Herba Erodii 11 parts, Herba Gendarussae 6.5 parts, Radix Isatidis 13 parts, Herba Lycopodii 10 parts.
4. pharmaceutical preparation according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Angelicae Sinensis 13 parts, Radix Angelicae Pubescentis 10 parts, 11 parts, Caulis Piperis Kadsurae algae, Radix Achyranthis Bidentatae 10 parts, Rhizoma Chuanxiong 7 parts, Cortex Cinnamomi 4.5 parts, Olibanum 10 parts, Radix Clematidis 9 parts, the Cortex Eucommiae 10 parts, Radix Gentianae Macrophyllae 11 parts, Fructus Chaenomelis 17 parts, 10 parts, Radix Rubiae, Myrrha 8 parts, Radix Notoginseng 17 parts, Caulis Lonicerae 4 parts, Herba Cirsii 6 parts, Pheretima 0.5 part, Herba Erodii 13 parts, Herba Gendarussae 8 parts, Radix Isatidis 17 parts, Herba Lycopodii 11 parts.
5. pharmaceutical preparation according to claim 1, is characterized in that, described pharmaceutical preparation can be prepared into the pharmaceutically acceptable dosage forms such as tablet, capsule, pill, granule.
6. prepare a preparation method for the pharmaceutical preparation described in any one of claim 1-3, it is characterized in that, concrete step is:
1) Radix Angelicae Pubescentis, Caulis Piperis Kadsurae algae, Rhizoma Chuanxiong, Cortex Cinnamomi, Olibanum, Radix Clematidis, the Cortex Eucommiae, Radix Gentianae Macrophyllae, Fructus Chaenomelis, Radix Rubiae, Myrrha, Radix Notoginseng, Caulis Lonicerae, Herba Cirsii, Herba Erodii, Radix Isatidis and Herba Lycopodii raw material add 12 times of water soakings, then decoct 2 times, 1 hour first time, second time 2 hours, merge decoction liquor, being evaporated to relative density is 1.15, obtains concentrated solution, for subsequent use;
2) Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Pheretima and Herba Gendarussae pulverize add 2-4 doubly 75% ethanol, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, reservation precipitate;
3) step 1) concentrated solution but add afterwards 4-6 doubly 70% ethanol, fully mix, place 24 hours, make it precipitate, after 24h, get its supernatant, reservation precipitate;
3) by step 2) and step 3) precipitate with a small amount of 50%-60% ethanol clean, washing liquid and supernatant merge, and after decompression recycling ethanol, being evaporated to relative density is 1.20, leave standstill 24h, precipitate, filtration;
4) filtrate low-temperature evaporation is the extractum of 1.03 ~ 1.09 to density, claims its weight, can its weight 10-30% pharmaceutic adjuvant, be conventionally prepared into pharmaceutically acceptable dosage form.
7. pharmaceutical preparation according to claim 1, is characterized in that: the application of described pharmaceutical preparation in preparation treatment gonarthritis medicine.
CN201610004595.7A 2016-01-04 2016-01-04 Pharmaceutical preparation for treating arthritis and uses thereof Withdrawn CN105434597A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108721686A (en) * 2018-04-20 2018-11-02 朱清 A kind of preparation method of low toxicity compound hemostatic powder

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108721686A (en) * 2018-04-20 2018-11-02 朱清 A kind of preparation method of low toxicity compound hemostatic powder

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