CN113164528A - 包含食窦魏斯氏菌wikim28作为有效成分的用于预防或治疗癌症的药学组合物 - Google Patents
包含食窦魏斯氏菌wikim28作为有效成分的用于预防或治疗癌症的药学组合物 Download PDFInfo
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- CN113164528A CN113164528A CN201980082213.4A CN201980082213A CN113164528A CN 113164528 A CN113164528 A CN 113164528A CN 201980082213 A CN201980082213 A CN 201980082213A CN 113164528 A CN113164528 A CN 113164528A
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Abstract
本发明涉及从泡菜中分离的新型食窦魏斯氏菌WIKIM28(Weissella cibaria WIKIM28,保藏编号:KCCM11879P)及包含其作为有效成分的组合物。本发明的窦魏斯氏菌WIKIM28在移植有癌症细胞的动模型中表现出优秀的抗癌活性,因此可以有用地用作用于人类或动物的癌症的治疗、预防或改善等用途的组合物。
Description
技术领域
本发明涉及包含从泡菜中分离的食窦魏斯氏菌WIKIM28(Weissella cibariaWIKIM28,保藏编号:KCCM11879P)作为有效成分的用于预防或治疗癌症的组合物。
背景技术
癌症在全世界都表现出很高的死亡率,在西欧社会中,是仅次于心血管疾病的非常普遍的死亡原因。尤其是饮食生活的西式化带来的普遍的高脂肪饮食的摄取、环境污染物质的急剧增加、饮酒量的增加等使大肠癌、乳腺癌、前列腺癌等呈持续增加的趋势,在人口老龄化的同时,因吸烟人数的增加及大气污染引起的肺癌也在增加。在这样的情况下,需要切实地创造出一种能够早期预防及治疗的,能够促进人类健康、提高健康的生活质量及促进保健的抗癌物质。
另一方面,乳酸菌广泛分布于人类和动物的口腔、肠、阴道、粪便,还有泡菜之类的发酵食品等,与人类和动物的健康有着密切的关联。乳酸菌表现出调理肠道、有害菌抑制、免疫调节、降低血液中胆固醇、抗癌等多种健康促进效果。
目前,韩国公开专利第10-2015-0068061号公开了植物乳杆菌(Lactobacillusplantarum)PNU(KCCM11352P)或肠模形乳杆菌(Lactobacillus mesenteroides)PNU(KCCM11353P)的抗癌活性,韩国授权专利第10-1287120号公开了包含植物乳杆菌DSR CK10(保藏编号:KFCC-11433P)或植物乳杆菌DSR M2(保藏编号:KFCC-11432P)作为有效成分的用于治疗癌症的药学组合物,但仍无有关窦魏斯氏菌的抗癌活性及优秀性的报告。
发明内容
技术问题
本发明的目的在于,提供包含食窦魏斯氏菌菌株作为有效成分的用于预防或改善癌症的药学组合物。
并且,本发明的再一目的在于,提供包含新型的泡菜乳酸菌食窦魏斯氏菌菌株作为有效成分的用于预防或改善癌症的食品组合物或食品添加剂组合物。
并且,本发明的另一目的在于,提供包含新型的泡菜乳酸菌食窦魏斯氏菌菌株作为有效成分的用于预防或改善癌症的饲料组合物或饲料添加剂组合物。
技术方案
于是,本发明人致力于在泡菜中寻找在作为益生菌而表现出优良效果的同时表现出癌症的预防及治疗效果的乳酸菌菌株,结果,分离、鉴定出作为具有抗癌活性的新型乳杆菌属乳酸菌菌株的食窦魏斯氏菌WIKIM28,从而完成本发明。
为了实现上述目的,本发明提供包含食窦魏斯氏菌WIKIM28作为有效成分的用于预防或治疗癌症的药学组合物。
并且,本发明提供包含食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)或其培养物作为有效成分的用于预防或改善癌症的食品组合物或食品添加剂组合物。
并且,本发明提供包含食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)或其培养物作为有效成分的用于预防或改善家畜的癌症的饲料组合物或饲料添加剂组合物。
发明的效果
本发明的食窦魏斯氏菌WIKIM28在现有的动物模型及移植有人类癌细胞的动物模型中表现出优秀的抗癌活性,因此可以有用地用作用于人类或动物的癌症的治疗、预防或改善等用途的组合物。
附图说明
图1为示出向CT26细胞移植小鼠静脉注射本发明的组合物后,用来观察肿瘤细胞的大小随时间变化的小鼠的肿瘤局部照片的图。
图2为示出向CT26细胞移植小鼠静脉注射本发明的组合物后,测定肿瘤细胞的体积随时间变化的曲线图的图。
图3为示出向MC38细胞移植小鼠静脉注射本发明的组合后,用来观察肿瘤细胞的大小随时间变化的小鼠的肿瘤局部照片的图。
图4为示出向MC38细胞移植小鼠静脉注射本发明的组合物后,测定肿瘤细胞的体积随时间变化的曲线图的图。
图5为示出向MC38细胞移植小鼠静脉注射本发明的组合物后,测定肿瘤细胞的体积生长率随时间变化的曲线图的图。
具体实施方式
以下,通过实施例更为详细地说明本发明。对于本发明所属技术领域的普通技术人员来说显而易见的是,这些实施例仅用于更具体地说明本发明,根据本发明的要旨,本发明的范围不受这些实施例的限制。
包含本发明的食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)或其培养物作为有效成分的组合物具有癌症的预防或治疗效果,可以用作药剂学组合物。
食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)为源自泡菜的乳酸菌菌株。虽然在本发明中是从泡菜中分离、鉴定的食窦魏斯氏菌WIKIM28,但其获得途径不限于此。
进行用于鉴定及分类上述食窦魏斯氏菌WIKIM28的16S核糖体RNA(rRNA)碱基序列的分析结果,显出具有序列1(SEQ ID NO:1)的核酸序列。
因此,将具有序列1(SEQ ID NO:1)的16S rRNA碱基序列的本发明的微生物命名为食窦魏斯氏菌WIKIM28,于2015年10月08日保藏于韩国微生物保藏中心(保藏编号:KCCM11879P)。
本发明的食窦魏斯氏菌WIKIM28作为益生菌,具有乳酸菌的通常的调理肠道效果及免疫增强效果。乳杆菌属的乳酸菌具有调理肠道效果及免疫增强效果是广为人知的。
在本发明中,“益生菌(probiotics)”应理解为“在包括人类在内的动物的胃肠道内通过改善宿主肠内微生物环境来给宿主的健康带来有益的影响的活的微生物”。在以单独或复合菌株的形态将具有益生菌活性的活的微生物以干燥的细胞形态或发酵产物的形态提供时,益生菌可以给宿主的肠内菌群带来有益的影响。
上述癌症可以为选自由膀胱癌、乳腺癌、黑色素瘤、甲状腺癌、甲状旁腺癌、直肠癌、咽喉癌、喉癌、食管癌、胰腺癌、胃癌、舌癌、皮肤癌、脑肿瘤、子宫癌、胆囊癌、口腔癌、结肠癌、肛周癌、肝癌、肺癌以及大肠癌组成的组中的一种癌症,优选地,可以为大肠癌,但不限定于此。
包含于本发明组合物的食窦魏斯氏菌WIKIM28能够以活菌体或死菌体的方式存在,并且,还能够以干燥或冷冻干燥的形态存在。本发明所属技术领域的普通技术人员应该知道适合包含于多种组合物的乳酸菌的形态及制剂化方法。
上述组合物可以通过口服或胃肠外给药。胃肠外给药可以通过静脉内注入、皮下注入、肌肉注入、腹腔注入、经皮给药、局部给药、鼻内给药、肺内给药及直肠内给药等方式给药,优选地,可以通过静脉内注入的方法给药,但不限定于此。
上述组合物的适当给药量可以根据制剂化方法、给药方式、患者的年两、体重、性别、疾病状态、饮食、给药时间、给药途径、代谢速度及反应敏感性之类的因素给出多种处方。
在将本发明的组合物用作药剂学组合物的情况下,除上述有效成分外,本发明的药剂学组合物可以使用药剂学上适合的、生理学上可接受的辅助剂来制备,上述辅助剂可以使用赋形剂、崩解剂、甜味剂、结合剂、包衣剂、膨胀剂、润滑剂、滑泽剂或香味剂等。
为了给药,除上述有效成分以外,上述药剂学组合物还可以通过包含一种以上的药剂学上可接受的载体来优选地制剂化药剂学组合物。
例如,为了制剂化为片剂或胶囊剂,有效成分可以与乙醇、甘油、水等之类的口服、无毒性的药剂学上可接受的非活性载体结合。并且,可以根据需要包含适当的结合剂、润滑剂、崩解剂及发色剂以及混合物。适当的结合剂包括淀粉、明胶、葡萄糖或β-乳糖之类的天然糖、玉米甜味剂、阿拉伯胶、黄芪胶或油酸钠之类的天然或合成胶、硬脂酸钠、硬脂酸镁、苯甲酸钠、醋酸钠、氯化钠等,但不限定于此。崩解剂包括淀粉、甲基纤维素、琼脂、膨润土、黄原胶等,但不限定于此。在以液体溶液的形态制剂化的组合物中可接受的药剂学载体可以使用灭菌及适于活体的生理盐水、灭菌水、林格氏液、缓冲生理盐水、白蛋白注射溶液、葡萄糖溶液、麦芽糊精溶液、甘油、乙醇及混合一种以上这些成分来使用,可以根据需要添加抗氧化剂、缓冲液、抑菌剂等其他普通的添加剂。并且,还可以添加稀释剂、分散剂、表面活性剂、结合剂及润滑剂来制剂化为水溶液、悬浮液等之类的注射用剂型、丸药、胶囊、颗粒或片剂。
进而,可以将Remington's Pharmaceutical Science,Mack PublishingCompany,Easton PA中公开的方法用作本发明相关技术领域的适当的方法,根据各疾病或成分来优选地制剂化。
包含本发明的食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)或其培养物作为有效成分的组合物可以用作用于预防或改善癌症的食品组合物或食品添加剂组合物。
上述食品组合物可以为保健功能食品的形态。
上述“保健功能食品”是指根据有关保健功能食品的法律,使用具有对人体有用的功能性的原料或成分制备及加工的食品(第三条第一项),“功能性”是指通过调节营养素或生理学作用等之类的保健用途来在人体的结构及功能中获得有用的效果(同一条的第二项)。
上述食品组合物还可以包括食品添加物,若无特别说明,“食品添加物”是否适当则根据韩国食品药品监督管理局认可的韩国食品添加物法典的总则及通常的实验方法等并按照与相关品种有关的规格及标准来判定。
收录于上述“食品添加物法典”的品种有例如酮类、甘氨酸、柠檬酸钾、烟酸、肉桂酸等化学合成品、柿子色素、甘草提取物、结晶纤维素、瓜尔豆胶等天然添加物、L-谷氨酸钠制剂、面类添加碱剂、防腐剂、焦油色素制剂等混合制剂类。
包含本发明的有效成分的食品可以为面包、糕类、干果类、糖果类、巧克力类、口香糖、果酱类之类的饼干类、冰淇淋类、冰果类、冰淇淋粉末类之类的冰淇淋制品类、牛奶类、低脂牛奶类、乳糖分解牛奶、加工乳类、山羊奶、发酵乳类、黄油乳类、浓缩乳类、奶油类、黄油类、天然奶酪、加工奶酪、奶粉类、乳清类之类的乳加工品类、肉食加工品、蛋加工品、汉堡包之类的肉食制品类、鱼饼、火腿、香肠、培根等鱼肉制品之类的鱼肉制品类、拉面类、干面类、生面类、汤面类、豪华干面类、改良熟面类、冷冻面类、意大利面类之类的面类、水果饮料、蔬菜类饮料、碳酸饮料、豆乳类、酸奶等的乳酸菌饮料、混合饮料之类的饮料、酱油、黄豆酱、辣椒酱、干黄酱、清国酱、混合酱、食醋、酱类、番茄酱、咖喱、调味汁之类的调味食品、人造黄油、起酥油以及比萨,但不限定于此。
除上述以外,本发明的组合物还可以包含多种营养剂、维生素、电解质、风味剂、着色剂、果胶酸及其盐、海藻酸及其盐、有机酸、保护性胶体增稠剂、pH调节剂、稳定剂、防腐剂、甘油、乙醇、用于碳酸饮料的碳酸化剂等。此外,本发明的组合物还可以包含用来制备天然果汁、果汁饮料及蔬菜饮料的果肉。这些成分可单独或组合来使用。
包含本发明的有效成分的饮料组合物对其他成分没有特别限制,可以与普通饮料一样包含多种香味剂或天然碳水化合物等。上述天然碳水化合物的例有单糖(例如葡萄糖、果糖等)、二糖(例如麦芽糖、蔗糖等)以及多糖(例如糊精、环糊精等)之类的普通的糖以及木糖醇、山梨糖醇、赤藓糖醇等糖醇。除上述以外,还可以有利地将天然香味剂(索马甜、甜叶菊提取物(例如莱鲍迪甙A、甘草酸等))以及合成香味剂(糖精、阿巴斯甜等)用作香味剂。
并且,包含本发明的食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)或其培养物作为有效成分的组合物可以用作用于预防或改善家畜的癌症的饲料组合物或饲料添加剂组合物。
在将上述组合物制备为饲料添加剂的情况下,上述组合物可以制备为20%至90%的高浓缩液或粉末或颗粒形态。上述饲料添加剂还可以包含柠檬酸、富马酸、己二酸、乳酸、苹果酸等有机酸或磷酸钠、磷酸钾、酸性焦磷酸盐、聚磷酸盐(聚合磷酸盐)等磷酸盐或多酚、儿茶素、α生育酚、迷迭香提取物、维生素C、绿茶提取物、甘草提取物、甲壳素、鞣酸、植酸等天然抗氧化剂中的一种或一种以上。在制备为饲料的情况下,上述组合物可以制剂化为普通的饲料形态,可以包含普通的饲料成分。
上述饲料及饲料添加剂还可以包含由粉碎或破碎的小麦、燕麦、大麦、玉米及大米;植物蛋白饲料,例如以芸苔、大豆以及葵花为主要成分的饲料;动物蛋白饲料,例如血粉、肉粉、骨粉及鱼粉;以及糖分及乳制品,例如各种奶粉及乳浆粉末组成的干燥成分等,此外还可以包含营养补充剂、消化及吸收促进剂、生长促进剂等。
上述饲料添加剂可以单独向动物给药,或者在食用载体中与其他饲料添加剂组合来给药。并且,上述饲料添加剂可以在追肥饲料中,或是将其与动物饲料直接混合,或者在饲料外以单独剂型的方式轻松地向动物给药。在上述饲料添加剂与饲料单独给药的情况下,可以与相关领域公知的药剂学上可接受的食用载体组合制备为即时释放或缓释剂型。上述载体可以为固体或液体载体,例如玉米淀粉、乳糖、蔗糖、玉米片、花生油、橄榄油、芝麻油及丙二醇。在使用固体载体的情况下,饲料添加剂可以为片剂、胶囊剂、散剂、含片或糖衣片剂或微分散性形态的追肥饲料。在使用液体载体的情况下,饲料添加剂可以为明胶软质胶囊剂,或者糖浆剂或悬浮液、溶液剂的剂型。
并且,上述饲料及饲料添加剂可以包含辅助剂,例如,保存剂、稳定剂、湿润剂或润滑剂、溶液促进剂等。上述饲料添加剂通过浸注、喷雾或混合的方式添加于动物的饲料来使用。
本发明的饲料或饲料添加剂可以适用于包括哺乳类、家禽及鱼类的大多数动物的饮食中。
上述哺乳类不仅可以为猪、牛、绵羊、山羊以及用于实验的啮齿动物,还可以为宠物(例如狗、猫),上述家禽类可以为鸡、火鸡、鸭、鹅、雉鸡以及鹌鹑等,上述鱼类可以为鲤鱼及鳟鱼等,但不限定于此。
并且,包含本发明的食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)或其培养物作为有效成分的组合物可以用作用于发酵的乳酸菌发酵剂。
实施例1.菌株的分离及培养
从世界泡菜研究所微生物基因银行获得食窦魏斯氏菌WIKIM28(保藏编号:KCCM11879P)进行实验。
将获得的食窦魏斯氏菌WIKIM28的单一菌落在MRS琼脂(agar)培养基中继代后,在30℃的温度下培养48小时后,将培养的单一菌落接种于10ml的MRS液体培养基中,在37℃的温度下,以200rpm的频率震动培养24小时。培养后,以8000rpm的转速进行离心分离5分钟来去除培养液后,使用磷酸盐缓冲溶液(PBS,Phosphate Buffered Saline)洗涤3次来去除剩余的培养基成分。
实施例2.实验动物(小鼠)的条件
实验中使用的实验动物为雄性5周龄的BALB/c小鼠(ORIENT BIO公司,韩国)、C57BL/6小鼠,在保持室内温度20±2℃、湿度55±15%的无特定病原体(SPF)环境的动物饲育室中经过1周的稳定化时间后,在实验期间进行饲育。饲料以未添加抗生素的普通托盘饲料的方式提供,水以随时可以摄取的方式提供。实验以世界泡菜研究所动物实验伦理委员会认可的规程来实施所有的动物饲育、实验及安乐死。肿瘤大小变化的观察使用3.14×(长度×高度×宽度)/6的方式来测定肿瘤的体积(mm3)。
实施例3.CT26及MC38小鼠大肠癌细胞移植动物模型的制备
3-1.细胞培养
购入CT26小鼠大肠癌细胞(韩国细胞株银行,韩国)来使用,而MC38小鼠大肠癌细胞(全南大学医学院)是获得提供的。使用包含10%的胎牛血清和1%的青霉素-链霉素(penicillin-streptomycin)的DMEM培养基(Hyclone公司,美国),在5%的CO2、37℃的条件下培养CT26、MC38小鼠大肠癌细胞。
3-2.细胞移植癌症动物模型的制备
为了制备CT26细胞移植动物模型,在实验中使用6周龄的BALB/c小鼠(18g~21g),为了制备MC38细胞移植动物模型,在实验中使用6周龄的C57BL/6小鼠(18g~21g)。分别获取(harvest)1×105细胞(cell)个培养的小鼠大肠癌细胞CT26和MC38后,在50μl的磷酸盐缓冲溶液中重悬后,注入小鼠的右侧大腿部(thigh)皮下。
实施例4.食窦魏斯氏菌WIKIM28的抗肿瘤效果分析
4-1.在CT26细胞移植动物模型中的抗肿瘤效果分析
向所形成的肿瘤的体积为约80mm3~100mm3的CT26细胞移植小鼠的尾部静脉内注射食窦魏斯氏菌WIKIM28。利用磷酸盐缓冲溶液将食窦魏斯氏菌WIKIM28定量为1×1010CFU/ml的细菌数来准备,分别向实验动物静脉注射0.1ml(1×109CFU),向阴性对照组给药磷酸盐缓冲溶液。通过肉眼确认CT26细胞移植小鼠的大肠癌肿瘤大小随时间变化的结果如图1所示。
如图1所示,比起阴性对照组(PBS),静脉注入食窦魏斯氏菌WIKIM28的情况下,经过12天后,观察到肿瘤细胞缩小到肉眼能够确认的程度。
并且,在CT26细胞移植小鼠中测定肿瘤大小的体积随时间变化的结果如图2所示。
如图2所示,在注射食窦魏斯氏菌WIKIM28的情况下,16天后,CT26细胞移植小鼠大肠癌肿瘤与阴性对照组相比,确认具有约2.4倍的抗肿瘤效果。
实施例5.食窦魏斯氏菌WIKIM28注射后的生物学分布分布(biodistribution
study)
向所形成的肿瘤的体积为约80mm3~100mm3的MC38细胞移植小鼠的尾部静脉内注射食窦魏斯氏菌WIKIM28。利用磷酸盐缓冲溶液将食窦魏斯氏菌WIKIM28定量为1×1010CFU/ml的细菌数来准备,向实验动物的尾部静脉注射0.1ml(1×109CFU),向阴性对照组给药磷酸盐缓冲溶液。通过肉眼确认MC38细胞移植小鼠的大肠癌肿瘤大小随时间变化的结果如图3所示。
如图3所示,比起阴性对照组(PBS),静脉注入食窦魏斯氏菌WIKIM28的情况下,可以观察到肿瘤细胞缩小到肉眼能够确认的程度。经过15天后,确认肿瘤缩小到肉眼观察不到的程度。
并且,在MC38细胞移植小鼠中测定肿瘤大小的体积随时间变化的结果及体积生长率如图4及图5所示。
如图4及图5所示,可以确认在注射食窦魏斯氏菌WIKIM28的情况下,MC38细胞移植小鼠的大肠癌肿瘤大小的体积及生长率与阴性对照组相比有大幅度的缩小,12天后,确认具有约16.3倍的抗肿瘤效果。
本发明人通过上述实验结果确认食窦魏斯氏菌WIKIM28的抗肿瘤效果优秀,作为用于预防、改善及治疗癌症的组合物的利用价值高。
双侧检验t-test验证了阴性对照组与食窦魏斯氏菌WIKIM28处理组之间的肿瘤生长在统计学上具有显著性差异。P<0.05可以在所有肿瘤生长曲线图分析中考虑为具有显著性。
PCT
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序列表
<110> 韩国食品研究所
<120> 包含食窦魏斯氏菌WIKIM28作为有效成分的用于预防或治疗癌症的药学组合物
<130> WIKIM28
<160> 1
<170> SIPOSequenceListing 1.0
<210> 1
<211> 1508
<212> DNA
<213> 食窦魏斯氏菌WIKIM28()
<400> 1
ggatgacgct ggcggcgtgc ctaatacatg caagtcgaac gctttgtggt tcaactgatt 60
tgaagagctt gctcagatat gacgatggac attgcaaaga gtggcgaacg ggtgagtaac 120
acgtgggaaa cctacctctt agcaggggat aacatttgga aacagatgct aataccgtat 180
aacaatagca accgcatggt tgctacttaa aagatggttc tgctatcact aagagatggt 240
cccgcggtgc attagttagt tggtgaggta atggctcacc aagacgatga tgcatagccg 300
agttgagaga ctgatcggcc acaatgggac tgagacacgg cccatactcc tacgggaggc 360
agcagtaggg aatcttccac aatgggcgaa agcctgatgg agcaacgccg cgtgtgtgat 420
gaagggtttc ggctcgtaaa acactgttgt aagagaagaa tgacattgag agtaactgtt 480
caatgtgtga cggtatctta ccagaaagga acggctaaat acgtgccagc agccgcggta 540
atacgtatgt tccaagcgtt atccggattt attgggcgta aagcgagcgc agacggttat 600
ttaagtctga agtgaaagcc ctcagctcaa ctgaggaatt gctttggaaa ctggatgact 660
tgagtgcagt agaggaaagt ggaactccat gtgtagcggt gaaatgcgta gatatatgga 720
agaacaccag tggcgaaggc ggctttctgg actgtaactg acgttgaggc tcgaaagtgt 780
gggtagcaaa caggattaga taccctggta gtccacaccg taaacgatga gtgctaggtg 840
tttgagggtt tccgccctta agtgccgcag ctaacgcatt aagcactccg cctggggagt 900
acgaccgcaa ggttgaaact caaaggaatt gacggggacc cgcacaagcg gtggagcatg 960
tggtttaatt cgaagcaacg cgaagaacct taccaggtct tgacatccct tgacaactcc 1020
agagatggag cgttcccttc ggggacaagg tgacaggtgg tgcatggttg tcgtcagctc 1080
gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccttattac tagttgccag 1140
catttagttg ggcactctag tgagactgcc ggtgacaaac cggaggaagg tggggatgac 1200
gtcaaatcat catgcccctt atgacctggg ctacacacgt gctacaatgg cgtatacaac 1260
gagttgccaa cccgcgaggg tgagctaatc tcttaaagta cgtctcagtt cggattgtag 1320
gctgcaactc gcctacatga agtcggaatc gctagtaatc gcggatcagc acgccgcggt 1380
gaatacgttc ccgggtcttg tacacaccgc ccgtcacacc atgagagttt gtaacaccca 1440
aagccggtgg ggtaaccttc gggagccagc cgtctaaggt gggacagatg attagggtga 1500
agtctaca 1508
Claims (13)
1.一种用于预防或治疗癌症的药学组合物,其特征在于,包含保藏编号为KCCM11879P的食窦魏斯氏菌WIKIM28或其培养物作为有效成分。
2.根据权利要求1所述的用于预防或治疗癌症的药学组合物,其特征在于,上述食窦魏斯氏菌WIKIM28具有序列1的核酸序列。
3.根据权利要求1所述的用于预防或治疗癌症的药学组合物,其特征在于,上述癌症为选自由膀胱癌、乳腺癌、黑色素瘤、甲状腺癌、甲状旁腺癌、直肠癌、咽喉癌、喉癌、食管癌、胰腺癌、胃癌、舌癌、皮肤癌、脑肿瘤、子宫癌、胆囊癌、口腔癌、结肠癌、肛周癌、肝癌、肺癌以及大肠癌组成的组中的一种癌症。
4.根据权利要求1所述的用于预防或治疗癌症的药学组合物,其特征在于,上述组合物能够通过口服给药或胃肠外给药的方法给药。
5.根据权利要求4所述的用于预防或治疗癌症的药学组合物,其特征在于,上述胃肠外给药的方法为静脉注射给药。
6.根据权利要求1所述的用于预防或治疗癌症的药学组合物,其特征在于,上述组合物为活菌形态。
7.一种用于预防或改善癌症的食品组合物,其特征在于,包含保藏编号为KCCM11879P的食窦魏斯氏菌WIKIM28或其培养物作为有效成分。
8.根据权利要求7所述的用于预防或改善癌症的食品组合物,其特征在于,上述食品为保健功能食品。
9.根据权利要求7所述的用于预防或改善癌症的食品组合物,其特征在于,上述食品为选自由泡菜、酱油、黄豆酱、辣椒酱、饮料及发酵乳组成的组中的一种食品。
10.一种用于预防或改善癌症的食品添加剂组合物,其特征在于,包含保藏编号为KCCM11879P的食窦魏斯氏菌WIKIM28或其培养物作为有效成分。
11.一种用于预防或改善家畜的癌症的饲料组合物,其特征在于,包含保藏编号为KCCM11879P的食窦魏斯氏菌WIKIM28或其培养物作为有效成分。
12.根据权利要求11所述的用于预防或改善家畜的癌症的饲料组合物,其特征在于,上述家畜为选自由猪、牛、马、绵羊、兔、山羊、鼠、仓鼠、豚鼠、狗、猫、鸡、火鸡、鸭、鹅、雉鸡、鹌鹑、鲤鱼、鲫鱼以及鳟鱼组成的组中的一种。
13.一种用于预防或改善家畜癌症的饲料添加剂组合物,其特征在于,包含保藏编号为KCCM11879P的食窦魏斯氏菌WIKIM28或其培养物作为有效成分。
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KR102339314B1 (ko) | 2020-01-31 | 2021-12-14 | 주식회사 리스큐어바이오사이언시스 | 와이셀라 시바리아 wikim28을 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물 |
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PL443929A1 (pl) * | 2023-02-28 | 2024-09-02 | Instytut Biochemii I Biofizyki Polskiej Akademii Nauk | Nowy szczep bakterii Weissella cibaria, kompozycja go zawierająca, kompozycja farmaceutyczna do zastosowania, suplement diety, preparat probiotyczny, bakteryjna kultura starterowa do wyrobu pieczywa, zakwas, pieczywo, sposób wytwarzania pieczywa, sposób mikrobiologicznego wytwarzania dekstranu, preparat bakteryjny oraz zastosowania wykorzystujące ten szczep |
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WO2020122484A1 (ko) | 2020-06-18 |
US20220031774A1 (en) | 2022-02-03 |
JP2022511893A (ja) | 2022-02-01 |
EP3895717A4 (en) | 2022-11-23 |
AU2019396103B2 (en) | 2023-04-13 |
CN113164528B (zh) | 2024-09-03 |
EP3895717B1 (en) | 2024-08-07 |
CA3122291A1 (en) | 2020-06-18 |
SG11202106160WA (en) | 2021-07-29 |
KR102009742B1 (ko) | 2019-08-12 |
AU2019396103A1 (en) | 2021-07-22 |
EP3895717A1 (en) | 2021-10-20 |
BR112021011289A2 (pt) | 2022-04-26 |
JP7282891B2 (ja) | 2023-05-29 |
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