JP7456668B2 - ワイセラ・シバリアwikim28を有効成分として含む癌の予防又は治療用薬学組成物 - Google Patents
ワイセラ・シバリアwikim28を有効成分として含む癌の予防又は治療用薬学組成物 Download PDFInfo
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- JP7456668B2 JP7456668B2 JP2022546683A JP2022546683A JP7456668B2 JP 7456668 B2 JP7456668 B2 JP 7456668B2 JP 2022546683 A JP2022546683 A JP 2022546683A JP 2022546683 A JP2022546683 A JP 2022546683A JP 7456668 B2 JP7456668 B2 JP 7456668B2
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Description
分譲を受けたワイセラ・シバリアWIKIM28をMRS液体培地30mlに1%接種し、37℃で6時間静置培養した。培養後、3500rpmで10分間遠心分離し、培養液は除去し、菌体をPBS(リン酸緩衝生理食塩水:phosphate buffered saline)溶液で2回洗浄し、残っている培地成分を除去した。洗浄した菌体中の半分を細胞培養培地に入れ、37℃、5%CO2培養器で4時間静置培養した後、培養液を0.22μmフィルターで濾過し、細胞に処理した。洗浄した菌体中の半分を細胞培養培地で希釈して生菌で処理した。
分譲を受けたワイセラ・シバリアWIKIM28をMRS液体培地30mlに1%接種し、37℃で24時間静置培養した。培養後、3500rpmで10分間遠心分離し、培養液を除去し、菌体をPBS(phosphate buffered saline)溶液で2回洗浄し、残っている培地成分を除去した。菌体をPBS溶液に懸濁し、90℃で30分間熱処理した。熱処理後、菌体と菌体から溶出した細菌内物質を含有した上澄み液を遠心分離により分離した。上澄み液を0.22μmフィルターで濾過した後、細胞に処理した。
ワイセラ・シバリアWIKIM28の抗癌活性効果を観察するために、Cell counting Kit-8を用いて細胞生存アッセイ(cell viability assay)を測定した。抗癌活性効能実験に用いられた細胞は、非小細胞肺癌H1650、A549細胞株、膵臓癌AsPC-1細胞株、膀胱癌T24細胞株、メラノーマB16-F10、A375P、A375SM細胞株、および正常細胞株であるNIH/3T3である。
本発明は、肺癌(2種)、膵臓癌(1種)、膀胱癌(1種)、メラノーマ(3種)細胞および正常細胞(1種)を培養した後、前記実施例1にて調製したワイセラ・シバリアWIKIM28菌体、生菌培養液又は死菌上澄み液を処理し、細胞生存(cell viability)を測定した。
Claims (14)
- ワイセラ・シバリア(Weissella cibaria)WIKIM28(寄託番号KCCM11879P)又はその培養物を有効成分として含む癌の予防又は治療用医薬組成物であって、
前記癌は、肺癌、膵臓癌、膀胱癌、皮膚癌、又は、メラノーマである、癌の予防又は治療用医薬組成物。 - 前記ワイセラ・シバリアWIKIM28のDNAの配列は、配列番号1の核酸配列を有することを特徴とする、請求項1に記載の組成物。
- 前記組成物は、経口投与又は非経口投与の方法で投与可能であることを特徴とする、請求項1に記載の組成物。
- 前記非経口投与の方法は、静脈内注入、皮下注入、筋肉注入、腹腔注入、皮内投与、局所投与、鼻内投与、肺内投与および直腸内投与である、請求項3に記載の癌の予防又は治療用医薬組成物。
- 前記ワイセラ・シバリアWIKIM28は、生菌又は死菌の形態であることを特徴とする、請求項1に記載の癌の予防又は治療用医薬組成物。
- 前記培養物は、生菌培養物又は死菌上澄み液であることを特徴とする、請求項1に記載の癌の予防又は治療用医薬組成物。
- 前記死菌は、前記ワイセラ・シバリアWIKIM28を25~37℃で4時間~48時間静置培養したことを特徴とする、請求項5に記載の癌の予防又は治療用医薬組成物。
- ワイセラ・シバリア(Weissella cibaria)WIKIM28(寄託番号KCCM11879P)又はその培養物を有効成分として含む、癌の予防又は改善用食品組成物であって、
前記癌は、肺癌、膵臓癌、膀胱癌、皮膚癌、又は、メラノーマである、癌の予防又は改善用食品組成物。 - 前記食品は、健康機能食品である、請求項8に記載の癌の予防又は改善用食品組成物。
- 前記食品は、パン、餅、キャンディ、チョコレート、ガム、アイスクリーム、ミルク、チーズ、食肉加工品、魚肉加工品、キムチ、醤油、味噌、コチュジャン、チュンジャン、清麹醤、酢、ケチャップ、カレー、ドレッシング、飲料および発酵乳からなる群から選択されるいずれかの食品であることを特徴とする、請求項8に記載の癌の予防又は改善用食品組成物。
- ワイセラ・シバリア(Weissella cibaria)WIKIM28(寄託番号KCCM11879P)又はその培養物を有効成分として含む、癌の予防又は改善用食品添加剤組成物であって、
前記癌は、肺癌、膵臓癌、膀胱癌、皮膚癌、又は、メラノーマである、癌の予防又は改善用食品添加剤組成物。 - ワイセラ・シバリア(Weissella cibaria)WIKIM28(寄託番号KCCM11879P)又はその培養物を有効成分として含む、家畜における癌の予防又は改善用飼料組成物であって、
前記癌は、肺癌、膵臓癌、膀胱癌、皮膚癌、又は、メラノーマである、家畜における癌の予防又は改善用飼料組成物。 - 前記家畜は、豚、牛、馬、羊、ウサギ、ヤギ、ラット、ハムスター、モルモット、犬、猫、鶏、七面鳥、アヒル、ガチョウ、キジ、ウズラ、コイ、フナ、マスからなる群から選択されるいずれかである、請求項12に記載の家畜における癌の予防又は改善用飼料組成物。
- ワイセラ・シバリア(Weissella cibaria)WIKIM28(寄託番号KCCM11879P)又はその培養物を有効成分として含む、家畜における癌の予防又は改善用飼料添加剤組成物であって、
前記癌は、肺癌、膵臓癌、膀胱癌、皮膚癌、又は、メラノーマである、家畜における癌の予防又は改善用飼料添加剤組成物。
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KR10-2020-0012144 | 2020-01-31 | ||
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KR10-2020-0056138 | 2020-05-11 | ||
KR1020200056138A KR102339314B1 (ko) | 2020-01-31 | 2020-05-11 | 와이셀라 시바리아 wikim28을 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물 |
PCT/KR2021/001059 WO2021153980A1 (ko) | 2020-01-31 | 2021-01-27 | 와이셀라 시바리아 wikim28을 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물 |
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KR101667496B1 (ko) | 2015-10-15 | 2016-10-18 | 한국식품연구원 | 김치 유산균 와이셀라 시바리아(Weissella cibaria) WIKIM28을 유효성분으로 포함하는 아토피 피부염 치료용 약학 조성물 |
KR101834383B1 (ko) | 2016-11-14 | 2018-03-05 | 한국식품연구원 | 항비만 활성을 갖는 와이셀라 시바리아 WIKIM28(Weissella cibaria WIKIM28) 및 이를 포함하는 조성물 |
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