CN113143991A

CN113143991A - Traditional Chinese veterinary medicine composition for treating swine fever and preparation method thereof

Info

Publication number: CN113143991A
Application number: CN202110341294.4A
Authority: CN
Inventors: 张凤; 陈盟; 崔小七; 陈长青; 康玉霞; 路向阳; 王欣
Original assignee: Zhengzhou Bary Animal Pharmaceutical Co ltd
Current assignee: Zhengzhou Bary Animal Pharmaceutical Co ltd
Priority date: 2021-03-30
Filing date: 2021-03-30
Publication date: 2021-07-23
Anticipated expiration: 2041-03-30
Also published as: CN113143991B

Abstract

The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a traditional Chinese veterinary medicine composition for treating swine fever and a preparation method thereof, wherein the traditional Chinese veterinary medicine composition comprises the following components in parts by weight: 20-25 parts of isatis root, 15-20 parts of male fern rhizome, 10-15 parts of chrysanthemum, 10-15 parts of gypsum, 10-15 parts of honeysuckle, 5-10 parts of mint, 5-10 parts of poria cocos and 5-10 parts of honey-fried licorice root. In the traditional Chinese veterinary medicine composition for treating swine fever, the eight traditional Chinese medicine materials are reasonably combined, the isatis root, the male fern rhizome, the chrysanthemum and the gypsum are used for clearing away heat and toxic materials, the honeysuckle and the mint are used for dredging the exterior, the poria cocos is used for enhancing the immune function, the honey-fried licorice root is used for harmonizing the other medicines, and the eight traditional Chinese medicines are used together, so that the traditional Chinese veterinary medicine composition can clear away heat and toxic materials, promote blood circulation to remove blood stasis, nourish yin to cool blood, tonify qi and invigorate the spleen, and achieve the purpose of treating both symptoms and root causes.

Description

Traditional Chinese veterinary medicine composition for treating swine fever and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a traditional Chinese veterinary medicine composition for treating swine fever and a preparation method thereof.

Background

Hog cholera, commonly known as "gastrointestinal plague", is an acute, febrile, contagious infectious disease caused by hog cholera virus of the genus hog cholera virus of the family flaviviridae. Is highly contagious and lethal. The disease only infects pigs under natural conditions, and the pigs of different ages, sexes and breeds and wild pigs are susceptible and can occur all the year round. Known in europe as classical swine fever (csf), is a highly contagious disease caused by swine fever virus (HCV or CSFV), the only natural host for which pigs are responsible. It was first discovered in Ohio of the United states in 1833 and its popularity has spread throughout the world for centuries. The international animal epidemic department defines the infectious diseases as A class infectious diseases, and the infectious diseases are listed as a class infectious diseases by the animal epidemic prevention law in China, and are one of the main epidemic diseases which endanger the development of the pig industry in China at present.

Chinese hog cholera lapinized attenuated vaccine plays a decisive role in preventing and treating hog cholera, but in recent years, the immune effect is not ideal, and the immune failure also occurs by using tissue culture attenuated vaccine, so the reason is more. Because the economic loss caused by swine fever is huge and is a hot spot of research in various countries, the treatment of the diseases is still under discussion and research.

The toxic and side effects of chemical medicines are continuously appeared, the iatrogenic and pharmacogenic diseases are increasingly increased, and the development cost of biochemical medicines is huge. The traditional Chinese veterinary medicine has the characteristics of stable curative effect, relative safety and obvious curative effect on some stubborn diseases and chronic diseases. Therefore, the emergence of veterinary drug granules is becoming a necessity.

The traditional Chinese veterinary medicine can be used for preventing and treating swine fever, and has the following advantages: (1) through the traditional Chinese veterinary medicine, the energy for attacking and killing viruses in the body of the pig can be fully provided, and the defects of western medicine vaccines are overcome, so that the positive qi can suppress the pathogenic factors and can be prevented from being damaged. Hog cholera is a fever with infectious and acute exogenous febrile disease. The traditional Chinese veterinary medicine is used for dialectical treatment, if the medicine is used properly, the pathogenic factors can be removed, and the disease can be cured. (2) The traditional Chinese veterinary medicine has the advantages of no drug residue, difficulty in generating drug resistance, obvious curative effect on some chronic diseases and the like, and a plurality of medicinal materials belong to homology of medicine and food, have no toxic or side effect, and play an increasingly important role in livestock breeding. (3) Most of the traditional Chinese veterinary medicine products are derived from natural plants, animals, minerals and marine organisms, so that the traditional Chinese veterinary medicine products have no pollution to the ecological environment, are favorable for the safety of animal products, and better meet the requirement of environmental protection compared with chemical veterinary medicines. Currently, research, development and application of veterinary drug products have become a focus of attention in the industry.

Patent CN1114441C provides a specific medicine for treating swine fever, which is a mixed injection prepared from Chinese herbal medicines, namely compound peony injection, and can be used for subcutaneous or intramuscular injection. The medicine has the effects of removing toxic substances, clearing away yin fire, removing subcutaneous congestion, nourishing liver, and removing blood spot, and can be used for treating four to five days after healing. However, the injection prepared from traditional Chinese veterinary medicinal materials has long process and complicated operation, and the components with curative effect, such as polysaccharide, peptide, protein and the like, in the medicament are lost to different degrees, and the cost is high. Patent CN104491509B provides a traditional Chinese veterinary medicine preparation for treating swine fever. Is prepared from cornu Bubali, radix rehmanniae, rhizoma anemarrhenae, radix Paeoniae Rubra, fructus Aurantii, fructus Gardeniae, Bombyx Batryticatus, cimicifugae rhizoma, Achyranthis radix, radix Ophiopogonis, folium Bambusae, rhizoma Phragmitis, and exocarpium Benincase at a certain ratio. However, the white muscardine silkworm has high price, and is prepared into powder or decoction, so the white muscardine silkworm has poor palatability and is inconvenient to transport, carry and use.

Disclosure of Invention

The invention aims to provide a traditional Chinese veterinary medicine granule for treating swine fever and a preparation method thereof, and solves the problems that the drug effect of the traditional medicament for treating swine fever needs to be improved, the cost needs to be reduced, and the dosage form needs to be optimized.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a traditional Chinese veterinary medicine composition for treating swine fever, which comprises the following components in parts by weight: 20-25 parts of isatis root, 15-20 parts of male fern rhizome, 10-15 parts of chrysanthemum, 10-15 parts of gypsum, 10-15 parts of honeysuckle, 5-10 parts of mint, 5-10 parts of poria cocos and 5-10 parts of honey-fried licorice root.

Preferably, the composition comprises the following components in parts by weight: 24 parts of isatis root, 20 parts of rhizoma dryopteris crassirhizomae, 15 parts of chrysanthemum, 12 parts of gypsum, 12 parts of honeysuckle, 7 parts of mint, 5 parts of poria cocos and 5 parts of honey-fried licorice root.

The invention also provides a preparation method of the traditional Chinese veterinary medicine composition for treating swine fever, which comprises the following steps: weighing the above components according to a ratio, decocting for three times, mixing the filtrates of the three decoctions, concentrating into an extract, adding adjuvants, and making into veterinary Chinese medicinal granule for treating swine fever.

Preferably, the method specifically comprises the following steps:

1) weighing radix Isatidis, rhizoma Dryopteris Crassirhizomatis, flos Chrysanthemi, Gypsum Fibrosum, flos Lonicerae, herba Menthae, Poria, and radix Glycyrrhizae Preparata at above ratio;

2) first decoction: adding 5-10 times of purified water, heating to boil, decocting for 2-4 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate; and (3) second decoction: adding 3-8 times of purified water, heating to boil, decocting for 1-3 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate; and (3) decocting for the third time: adding 3-8 times of purified water, heating to boil, decocting for 0.5-1.5 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate;

3) mixing the filtrates of the three times of decoction, and concentrating at the temperature of 65-85 ℃ and the vacuum degree of-0.02 to-0.06 Mpa to obtain an extract;

4) weighing 0.8-1.2 times of the total mass of the medicinal materials, adding purified water, stirring to dissolve until no granules exist, adding the extract, stirring to dissolve uniformly, filtering with 50-mesh filter cloth into a material barrel of a boiling drying granulator, stirring uniformly, premixing for 10 minutes, spraying for granulation, drying for cooling, and sieving out of a pot to obtain the veterinary Chinese medicinal granule for treating swine fever.

Preferably, the auxiliary material is selected from one or more of sucrose, glucose, dextrin, sodium cyclamate or water-soluble starch.

Preferably, the concentration is finished until the relative density of the extract reaches 1.15-1.35.

In the medicine of the invention:

radix isatidis:

the functional indications are as follows: clear heat, remove toxicity, cool blood. Treating influenza, epidemic cerebrospinal meningitis, encephalitis B, pneumonia, erysipelas, heat toxin and macula, coma, epistaxis, pharyngeal swelling, mumps, eyes, sore and eruption, crimson and dark tongue, pharyngitis, erysipelas, fever with swollen head, carbuncle and swelling; can be used for preventing and treating epidemic encephalitis B, acute and chronic hepatitis, mumps, and osteomyelitis. Nature and taste: bitter and cold. Meridian tropism: the liver meridian.

(1) Rihuazi Bencao: for heat-toxicity in the daytime.

(2) The text of materia Medica: for heat-toxicity on large head in Tian xing.

(3) The book materia Medica is just written: clearing away heat and toxic material, removing epidemic disease and killing parasite.

(4) Classification of herb Properties: relieving various noxious materials and malignant sores, dispelling toxic materials and removing fire, and pounding into juice or taking or coating.

(5) Modern practical traditional Chinese medicine: radix Isatidis is used for clearing away heat, relieving toxic materials, and treating erysipelas and puerperal fever.

(6) The book of Traditional Chinese Medicine (TCM) (J: clear fire and remove toxicity, cool blood and stop bleeding. It is indicated for macula due to heat disease, erysipelas, sore throat, fever with swollen head, hematemesis, epistaxis, etc.

(7) Handbook of Chinese herbal medicine for Liaoning: it can be used for treating hepatitis and parotitis.

(8) Shanghai commonly used Chinese herbal medicine: it is used to treat common cold with fever.

(9) Guangxi Chinese herbal medicine: it can be used for treating epidemic encephalitis B, influenza, epidemic encephalitis, pharyngolaryngitis, stomatitis, and tonsillitis.

Rhizoma Dryopteris Crassirhizomatis:

the functional indications are as follows: clear heat and remove toxicity, expel parasites and stop bleeding. Can be used for treating epidemic common cold, headache due to wind-heat, epidemic heat, speckle, pyocutaneous disease, toxic swelling, metrorrhagia, metrostaxis, hematochezia, and abdominal pain due to parasitic infestation. Nature and taste: slightly cold in nature and bitter in taste; has little toxicity. Meridian tropism: it enters liver and stomach meridians.

(1) Compendium (compendium): guan Zhong is indicated for blood and qi of women. Wanghai zang is used for treating summer pox with fast pox emergence and quick speckle, Yun guan is toxic and can relieve the toxin of pathogenic heat in the abdomen. The internal pathogenic factors are usually caused by external factors, and the meridians are not the ancient ones.

(2) Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): guan Zhong is bitter and cold in nature and is mainly used for the pathogenic heat and toxic qi in the abdomen. It is accompanied by the meaning of dispersing and purging, so it breaks the abdominal mass. Bitter and cold can remove wind-heat, so it can stop headache. After bleeding, the sores will be healed, and the heat will be released to dissipate nodulation.

(3) The book Ben Cao Hui Yan (treatise on materia Medica): cyrtomium fortunei, also insecticidally and chemolithospermic. Since ancient times mainly refer to pathogenic heat in the abdomen, it is indicated for the symptoms of insect disinfestation and transformation, and also refers to pathogenic heat in the abdomen and damp stagnation. Su Shi Fang is also indicated for metrorrhagia and stranguria due to bleeding, and it is also used for treating bitter and cold flavor and removing heat from ears. But due to the cold nature and dry qi, it is toxic, and it is not suitable for patients with yin deficiency and cough, for example, the patients with liver and kidney fire due to deficiency of nutrient and blood are lusterless.

(4) The book of materia Medica: cyrtomium fortunei is bitter, cold and sinking in nature, so it is mainly indicated for heat in blood, and it is very effective in treating bloody dysentery with bloody stool, and it is also bitter in action of drying dampness and cold in dispelling heat. Since the natural qi is also strong, it can remove the heat-binding toxicity of the pathogenic factors. In the book of allopathy, the term "do not refer to wind-heat, and it is used to treat epidemic swollen head with ear-eye disease but to disperse pathogen without abrupt effect, but guan Zhong is added to treat epidemic swollen head with pathogenic pathogen, so that it can clear away heat, and it is not bitter and cold to disperse pathogen and descend, and qi is enough to disperse pathogen. Therefore, epidemic disease is prevalent and should invade into water vat, and if it is drunk frequently, it will not infect, while if it sinks one in well, it will not attack the toxin, so it will have the effect of removing toxin, especially alone, it will not be easy to use and neglect.

(5) The book Jing: mainly treats pathogenic heat in the abdomen, and kills three worms.

(6) The bibliography: remove the white, open the abdomen, remove wind in the head and stop incised wound.

(7) A handbook of Chinese herbal medicines commonly used in northeast China: expel parasites, stop bleeding, clear heat and remove toxicity. For ascarid, tapeworm, abdominal pain due to parasitic infestation; functional bleeding of the uterus, leucorrhea. Rhizoma Osmundae is placed in water jar, and drinking water can prevent influenza, common cold, epidemic cerebrospinal meningitis, and measles.

(8) The Yunnan herbal medicine: dispel toxicity, stop bleeding and remove water toxicity.

(9) Compendium (compendium): it is used for treating metrorrhagia, leukorrhagia, puerperal blood-qi distending pain, macula exanthesis, lacquer toxin, choking on bone.

(10) Shanxi Chinese herbal medicine: clear heat and remove toxicity, stop bleeding and kill parasites. Preventing infectious diseases such as epidemic encephalitis B and mumps. It is indicated for hemafecia, hematuria, epistaxis, menorrhagia, ascariasis, and pinworm.

Chrysanthemum:

the functional indications are as follows: dispelling wind, clearing heat, improving eyesight, and removing toxic substance. It can be used for treating headache, vertigo, conjunctival congestion, dysphoria with smothery sensation in chest, furuncle, and toxic swelling. Meridian tropism: it enters lung and liver meridians.

(1) The book Jing: wind-syndrome manifested as dizziness, swelling and pain, eye exhaustion, tear, dead skin, aversion to wind-damp arthralgia, and blood and qi promotion.

(2) The bibliography: treat lumbago, remove Laotai pottery, remove dysphoria with smothery sensation in chest, relieve gastrointestinal disturbance, benefit five channels, and regulate limbs.

(3) Ceramic carry scene: white chrysanthemum: mainly wind dazzling.

(4) Treatise on herb Property: it can be used for treating wind-cold head turning over the ground, brain and bone pain, and wind-damp dispersing.

(5) Rihuazi Bencao: promoting blood circulation, and treating limb migratory wind, vexation, choking and stuffiness of chest and diaphragm, carbuncle and headache; used as a pillow for improving eyesight.

(6) Pearl sacs: nourishing the eyes and blood.

(7) The method of medication administration: remove nebula membrane and improve eyesight.

(8) Wang Hao Gu: mainly for liver qi deficiency.

(9) Compendium supplement: enter yang fen. For wind syndrome, dizziness, wind-syndrome of wind-dampness, wind-heat-evil, wind-heat evil, wind-heat-evil, wind-heat-evil, wind-heat-evil, wind-heat-evil, wind-heat-evil, wind-evil and furuncle, wind-evil and other wind-evil, wind.

Gypsum:

the functional indications are as follows: relieving muscles and clearing heat; relieve restlessness and quench thirst. The strong fever of the main febrile disease does not recede; vexation and coma; delirium mania; thirst and dry throat; lung heat dyspnea; spontaneous sweating in heatstroke; headache due to stomach fire; stomach fire toothache; excessive heat-toxicity; speckle and rash are caused; sores in the mouth and tongue; carbuncle, cellulitis, sore and ulcer; the ulcer can not be closed; scald due to hot water or fire. Meridian tropism: it enters lung and stomach meridians.

(1) Supplement to the Yanyi of Ben Cao (supplement to the Yan Yi of materia Medica): gypsum, a yangming meridian herb, is a major muscle herb, and is sweet in flavor, and can relieve the spleen and replenish qi, quench thirst and remove fire, while pungent in flavor can release muscles and expel sweat, and go upward to the head, enter taiyin and shaoyang in the hand, and can be the main of three meridians. Grinding into powder, and grinding into pills with vinegar as big as mung bean to purge stomach fire, phlegm fire and food retention.

(2) The book Jing: it is indicated for wind stroke with chills and fever, adverse qi in the heart, convulsion and asthma, dry mouth and tongue with symptoms of indigestion, abdominal mass and pain, milk production and incised wound.

(3) The bibliography: it can be used for relieving headache, fever, triple warmer, skin heat, diaphragm heat in intestine and stomach, relieving muscles and perspiration, quenching thirst, dysphoria, abdominal distention, flatulence, asthma, and pharyngalgia. It can also be used as bath soup.

(4) Treatise on herb Property: for typhoid fever, headache, splitting, high fever, dry skin, polydipsia, relieving muscles, expelling toxin and sweating, mainly clearing away the stomach-heat, restlessness, dysphoria, heart-fire, irritability and dry and scorched lips. And herba Alii Fistulosi decocting to remove headache.

(5) Rihuazi Bencao: for mania due to heat in the upper reaches, lactation, wind-cold in the head, restlessness, and tooth-brushing and tooth-nourishing.

(6) Pearl sacs: to relieve thirst, sunstroke and hectic fever.

(7) The method of medication administration: the stomach meridian herbs that are cold in nature can moisten lung and remove heat, disperse yin pathogen, slow spleen and replenish qi.

(8) Changsha Yao Jie (Changsha Yao Jie solution): clearing heart and lung, treating dysphoria, clearing stagnated heat, relieving dryness and thirst, treating mania, cough, astringing hot sweat, eliminating phlegm, stopping epistaxis, regulating aphtha, relieving pharyngalgia, promoting lactation, relieving mammary abscess, clearing pathogenic fire, and treating incised wound.

(9) The "Renzai of materia Medica": for headache, fever, blurred vision, nebula, toothache, insecticiding and diuresis.

Honeysuckle flower:

the functional indications are as follows: clear heat and remove toxicity, cool and disperse wind-heat. Can be used for treating carbuncle, furuncle, sore throat, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever. Meridian tropism: it enters lung, heart and stomach meridians.

(1) The Yunnan herbal medicine: clear heat, relieve sores, abscess, deep-rooted carbuncle, hairy dorsum, erysipelas and scrofula.

(2) Preparation of raw herb Property: can eliminate carbuncle, deep-rooted carbuncle, furunculosis, dysentery, eczema and skin heat.

(3) The materia Medica is in the future: nourish blood and quench thirst. It is indicated for scabies.

(4) Chongqingtang (Chongqingtang along with pen): wind-fire damp-heat in collaterals is cleared, epidemic febrile disease is relieved, evil is aversion to evil, liver and gallbladder are attacked by wind-yang, and symptoms of convulsion, syncope and epilepsy are treated.

(5) Guangzhou army 'handbook of Chinese herbal medicines for general use': clearing away heat and toxic material. It can be used for treating fever, cough, enteritis, bacillary dysentery, measles, parotitis, septicemia, skin ulcer, furuncle, toxic swelling, appendicitis, traumatic infection, and infantile miliaria. The herbal tea can be used for preventing heatstroke, common cold and intestinal infectious disease.

(6) The herbal medicine Tongxian: honeysuckle flower, flos Lonicerae, mainly used for treating dysentery, abscess and toxin, deficiency-tonifying and wind-curing, is known to have its disinfection function, and is used for treating wind deficiency, and is often effective in various diseases.

(7) The book materia Medica is as follows: honeysuckle flower, being good at resolving toxin, is the key herb for treating toxicity of abscess, swollen toxin, sore and tinea, waxberry and rheumatism. The herbs with slow property can be added in weight or decocted in wine, or smashed and mixed with wine for drinking, or ground and mixed with wine for thick application. For scrofula, all the toxins in the upper qi system are decocted for one or two times with great efficacy.

(8) The original menstrual period was: honeysuckle flower, flos Lonicerae, a holy drug for removing toxicity and pus, tonifying in diarrhea, abscess, deep-rooted carbuncle and ulceration.

Mint:

the functional indications are as follows: wind heat is dissipated; clearing head and eyes; relieving sore throat; promoting eruption; relieving depression. Wind-heat exterior syndrome; headache with reddish eyes; swollen and sore throat; measles without adequate eruption; itching due to rash and sinking; liver depression and hypochondriac pain. Meridian tropism: entering the lung; liver meridian

(1) Compendium (compendium): mint, pungent in flavor and cool in flavor can dispel heat, so it is specially used for dispelling wind and dissipating heat. So it is the key herb for headache, wind syndrome of head, eye, throat and mouth, infantile convulsions, scrofula, sores and scabies.

(2) Treatise on herb Property: remove anger qi, induce toxicity and sweat, break blood and check dysentery, and relieve joint movement.

(3) Qianjin dietetic therapy: to cool kidney qi and make human body fragrant and clean. Mainly remove pathogenic factors and pathogenic toxicity and remove consumptive diseases.

(4) The "Renzai of materia Medica": eliminating nebula.

(5) Tang Ben Cao (materia Medica of Tang Dynasty): mainly attack harmful wind and induce sweating. For (curing) aversion to qi and abdominal distension. Cholera. Indigestion and qi retention.

(6) Dietary therapy Ben Cao: take juice with pestle to remove heart wind-heat.

(7) Dietary materia Medica: can introduce various medicines into the nutrient and the defense. Treating yin and yang toxicity, typhoid fever and pain.

(8) Rihuazi Bencao: it is indicated for wind stroke with aphonia and expectoration. And (4) removing harmful wind. Treat abdominal distention, descending qi, indigestion, head wind, etc.

(9) The "the herbal atlas" (the book's Manual of medical science): it is used to treat common cold. Wind in the head, passing through guan Ge. The wind and saliva of the children.

(10) The Yunnan herbal medicine: it is used to treat typhoid fever, headache, cholera, vomiting, diarrhea, carbuncle, cellulitis, scabies, and scabies. And the following steps: herba Menthae can clear wind, relieve headache, vertigo and fever. Dispel wind-phlegm, treat cough due to wind injury, and nasal discharge due to brain and nose. Can be used for treating fever due to consumptive disease.

(11) The text of materia Medica: it is indicated for apoplexy, epilepsy, dryness due to injury and heat stagnation.

(12) The essentials of medical analysis: the toothache is healed, the cough is already hot, the depression and the summer heat are relieved, the polydipsia is relieved, the bleeding and the dysentery are stopped, and the urination is promoted.

Tuckahoe, poria cocos:

the functional indications are as follows: eliminating dampness and promoting diuresis; strengthening the spleen and stomach; to calm heart and induce tranquilization. Difficulty in urination; edema and fullness; cough with phlegm and fluid retention; vomiting; poor appetite due to spleen deficiency; diarrhea; palpitation and uneasiness; insomnia and amnesia; seminal emission is white and turbid. Meridian tropism: it enters heart, lung, spleen and kidney meridians.

(1) The book of materia Medica Yan: fu Ling and Fu Shen have the actions of moving water, so it is also good at tonifying heart and spleen.

(2) The method of medication administration: poria, a holy drug that is bland in flavor and good at inducing resuscitation, sweet in flavor and good at supporting yang and removing dampness, is also used. Sweet and neutral in flavor, tonifying yang, invigorating spleen, expelling water, promoting the production of body fluid and guiding qi.

(3) The herbal decoction (Ben Cao Tang Ye): poria cocos, semen plantaginis, Poria cocos, semen plantaginis, Poria cocos, semen plantaginis, Poria cocos, Poria cocos, semen plantaginis, Poria cocos, Poria, semen, Poria. When soaked in wine, it is combined with Guangming Zhu Sha, which can secret and true.

(4) The book materia Medica is as follows: poria cocos is capable of inducing resuscitation to remove dampness, inducing resuscitation to induce heart and intelligence, and promoting production of body fluid; removing dampness can expel water and dry spleen, strengthen middle-jiao and invigorate stomach; to dispel fright epilepsy, thick intestine storing, treat phlegm root and promote the descending of herbs.

(5) The book of medical science: bai Fu Ling is sweet and light in flavor, sweet can tonify when it is sweet, and light can permeate when it is sweet, sweet and light pertains to earth, and can tonify spleen yin, earth flourishing to produce gold, and also can tonify lung qi. The traditional Chinese medicine composition is mainly used for treating incoordination between spleen and stomach, diarrhea and abdominal distension, adverse qi of chest and hypochondrium, worry and irritability, fetal qi lack, soul and convulsion, and phlegm qi inquiry by diaphragm. The spleen is benefited by the sweet lid, while the middle-jiao energy is neutralized, the body fluid is white, the mouth is scorched, and the tongue is dry and polydipsia is relieved. It also cures lower damp-heat, stranguria, edema, constipation, yellow-red urine, difficulty in loins and umbilicus, and stops storing pathogenic water. The pale and oozing of the cap can nourish the bladder, the kidney qi is vigorous, the blood between the waist and the umbilicus is self-benefited, the body fluid is popular, the lung is benefited from the upper source, the spleen is supplemented in the middle part, the qi of the spleen and the lung flows down from the upper part, and the water channel is regulated to transport the bladder, so the urine is abundant and can be stopped, and the urine is astringent and can be benefited.

(6) The herbal Zhenzhen: poria enters four monarchs, and Shen shu is used to drain dampness of spleen, while Liu Wei, Alisma orientale is used as the key herb for promoting diuresis and removing dampness. The book is called strengthening the spleen, namely the spleen is self-healthy when water is removed. When water is removed, the urine is self-opened, and urine retention is serious, and when water is removed, internal dampness is eliminated, so that urine is abundant. Therefore, water consumption will cause the chest and diaphragm to widen and cause pain and restlessness, and water consumption will cause body fluid to grow and cause bitter taste and dry tongue.

(7) The book Jing: for example, it is indicated for adverse qi in chest and hypochondrium, fear anger, fear and palpitation, pain in the lower part of the heart, chills and fever, restlessness, cough, dry mouth and tongue, and diuresis.

(8) The bibliography: stop diabetes, sleep well, abdomen, dripping, phlegm in diaphragm, edema and stranguria accumulation. Open the chest, regulate the qi of the zang-organs, suppress the pathogenic kidney, nourish yin, benefit strength, and keep the mind in mind.

(9) Treatise on herb Property: promote appetite, stop vomiting and improve mind. Governing lung atrophy and phlegm accumulation. It is indicated for infantile convulsion, fullness and distention of heart and abdomen, and heat stranguria of women.

(10) Rihuazi Bencao: tonify internal organs, prevent miscarriage, warm waist and knees, relieve mental uneasiness and prevent amnesia.

(11) The medical inspiration is: to remove dampness, induce diuresis, harmonize the middle energizer and replenish qi. It is indicated for yellow or red urine. In Yun from the formula of the main indications, it can stop diarrhea, remove deficiency heat, open striae and promote the production of body fluid.

The veterinary drug composition disclosed by the invention has the following symptoms for swine fever: the pigskin has macula, fever, dry stool or alternate appearance of constipation and diarrhea, dry mouth and nose, red and swollen eyes and conjunctiva. For treatment, it should clear away heat and toxic material, relieve exterior syndrome with pungent and cool natured drugs, and enhance immunity and antiviral ability.

The invention has the beneficial effects that:

(1) the traditional Chinese veterinary medicine composition for treating swine fever comprises eight medicinal materials including isatis root, male fern rhizome, chrysanthemum, gypsum, honeysuckle, mint, tuckahoe and honey-fried licorice root. The medicines are shown in the dictionary of herbs, and are safe and effective.

(2) In the traditional Chinese veterinary medicine composition prescription for treating swine fever, the eight traditional Chinese medicine materials are reasonably compatible, the isatis root, the male fern rhizome, the chrysanthemum and the gypsum clear away heat and toxic materials, the honeysuckle and the mint dredge the exterior, the poria cocos enhances the immune function, and the honey-fried licorice root is used for harmonizing the other drugs. The eight medicines are combined to achieve the purposes of clearing heat, expelling toxin, promoting blood circulation, removing blood stasis, nourishing yin, cooling blood, tonifying qi and invigorating spleen, and treating both symptoms and root causes, so that the body indexes such as the skin macula and rash shedding and the body temperature of the pigs are recovered to be normal, the appetite is increased, and the income of farmers is increased.

(3) The veterinary drug composition for treating swine fever is prepared into granules in a compatibility manner, so that the requirements of appetite reduction and drinking preference of animals after the animals suffer from diseases are met, and the granules have the advantages of quick absorption, good palatability, convenience in transportation and convenience in taking.

Detailed Description

The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art. The test methods in the following examples are conventional methods unless otherwise specified.

Example 1

(1) Weighing 100g of radix isatidis 20 parts, male fern 18 parts, chrysanthemum 12 parts, gypsum 12 parts, honeysuckle 12 parts, mint 8 parts, poria cocos 8 parts and honey-fried licorice root 10 parts;

(2) first decoction: weighing the medicinal materials according to the ratio of the formula, adding 5 times of purified water, and heating until boiling and decocting. Boiling and decocting for 2 hr. The decoction is screened by a 80-mesh screen and the filtrate is collected. And (3) second decoction: adding 3 times of purified water, and boiling and decocting. Boiling, decocting for 1 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate. And (3) decocting for the third time: 5 times of purified water is added in a metering way, and the mixture is heated to boiling and decocted. Boiling, decocting for 0.5 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate;

(3) combining the three decocted filtrates, and concentrating at 70-75 ℃ and under the vacuum degree of-0.02 to-0.06 Mpa until the relative density of the extract reaches 1.15-1.35 (measured at 70-80 ℃).

The yield of the concentrated solution is (amount of concentrated liquid medicine/total mass of medicinal materials) multiplied by 100%. The index range of the yield of the concentrated solution is as follows: 40 to 50 percent.

(4) Weighing 0.8 time of the total mass of the medicinal materials as auxiliary materials, wherein the auxiliary materials comprise sucrose and anhydrous glucose in a mass ratio of 1: 1. Adding purified water, stirring to dissolve until no particulate matter exists, adding the extract, stirring to dissolve uniformly, filtering with 50 mesh filter cloth to a material barrel of a boiling drying granulator, and stirring uniformly. Premixing for 10 minutes, and starting spraying granulation. After the extract is sprayed, boiling, drying, cooling for about 10 minutes, sieving and taking out of the pot to obtain the traditional Chinese veterinary medicine granules.

Example 2

(1) Weighing 100g of radix isatidis 23 parts, male fern 18 parts, chrysanthemum 12 parts, gypsum 12 parts, honeysuckle 11 parts, mint 8 parts, poria cocos 8 parts and honey-fried licorice root 8 parts;

(2) first decoction: weighing the medicinal materials according to the ratio of the formula, adding 8 times of purified water, and heating until boiling and decocting. Boiling and decocting for 3 hr. The decoction is screened by a 80-mesh screen and the filtrate is collected. And (3) second decoction: adding 5 times of purified water, and boiling and decocting. Keeping boiling, after decocting for 2 hours, passing the decoction through a 80-mesh screen, and collecting the filtrate. And (3) decocting for the third time: adding 6 times of purified water, and boiling and decocting. Boiling, decocting for 1 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate;

(3) combining the three decocted filtrates, and concentrating at 75-80 deg.C under-0.02 to-0.06 Mpa until the relative density of the extract reaches 1.15-1.35 (70-80 deg.C).

(4) Weighing 1 time of auxiliary materials of the total mass of the medicinal materials, wherein the auxiliary materials are sucrose and anhydrous glucose with the mass ratio of 4: 1. Adding purified water, stirring to dissolve until no particulate matter exists, adding the extract, stirring to dissolve uniformly, filtering with 50 mesh filter cloth to a material barrel of a boiling drying granulator, and stirring uniformly. Premixing for 10 minutes, and starting spraying granulation. After the extract is sprayed, boiling, drying, cooling for about 10 minutes, sieving and taking out of the pot to obtain the traditional Chinese veterinary medicine granules.

Example 3

(1) Weighing 100g of radix isatidis 24 parts, rhizoma dryopteris crassirhizomae 20 parts, chrysanthemum 15 parts, gypsum 12 parts, honeysuckle 12 parts, mint 7 parts, poria cocos 5 parts and honey-fried licorice root 5 parts;

(2) first decoction: weighing the medicinal materials according to the ratio of the formula, adding 9 times of purified water, and heating until boiling and decocting. Boiling and decocting for 4 hr. The decoction is screened by a 80-mesh screen and the filtrate is collected. And (3) second decoction: adding 7 times of purified water, and boiling and decocting. Keeping boiling, after decocting for 3 hours, passing the decoction through a 80-mesh screen, and collecting the filtrate. And (3) decocting for the third time: 4 times of purified water is added in a metered manner, and the mixture is heated to boiling and decocted. Boiling, decocting for 1.5 hr, sieving the decoction with 80 mesh sieve, and collecting filtrate;

(3) combining the three decocted filtrates, and concentrating at 80-85 deg.C under-0.02 to-0.06 Mpa until the relative density of the extract reaches 1.15-1.35 (70-80 deg.C).

(4) Weighing 1.1 times of the total mass of the medicinal materials as auxiliary materials, wherein the auxiliary materials are anhydrous glucose and soluble starch in a mass ratio of 3: 1. Adding purified water, stirring to dissolve until no particulate matter exists, adding the extract, stirring to dissolve uniformly, filtering with 50 mesh filter cloth to a material barrel of a boiling drying granulator, and stirring uniformly. Premixing for 10 minutes, and starting spraying granulation. After the extract is sprayed, boiling, drying, cooling for about 10 minutes, sieving and taking out of the pot to obtain the traditional Chinese veterinary medicine granules.

The traditional Chinese medicinal materials used in the embodiments 1 to 3 are all commercial products, the use amounts of the components are increased or decreased according to the same proportion, and the obtained weight part relationship of the components all belongs to the protection scope of the invention.

The traditional Chinese medicinal materials in the embodiments 1 to 3 all meet the second standard of the 2015 edition of Chinese veterinary pharmacopoeia. Each 1g of the traditional Chinese veterinary medicine granules prepared by the invention is equivalent to 0.5-1.0g of the original medicine.

Comparative example 1

Compared with the example 3, the isatis root and the rhizoma dryopteris crassirhizomae are not contained, and the rest is the same as the example 3.

Comparative example 2

Compared with the example 3, the honeysuckle and the mint are not contained, and the rest is the same as the example 3.

Comparative example 3

Compared with example 3, the method does not contain tuckahoe and honey-fried licorice root, and the rest is the same as example 3.

Test example 1: the veterinary drug granules are applied to treating swine fever.

350 sick pigs with uniform age and weight and confirmed swine fever are selected in a certain pig farm and are randomly divided into 7 groups, each group comprises 50 pigs, a control group is fed with basic daily ration, other groups add the veterinary drug granules into the daily ration, the amount of the veterinary drug granules is 0.15g per 1kg of pigs, the veterinary drug granules is used 2 times a day, and the mortality and the treatment effective rate of each group are counted after the veterinary drug granules are used for 10 days. The standard of treatment effectiveness: normal body temperature, macula shedding, conjunctival redness and swelling disappearing, good spirit, appetite increase, and normal defecation.

TABLE 1 statistics of different veterinary drug granules for treating classical swine fever

The results show that the traditional Chinese veterinary medicine granules prepared from the isatis root, the male fern rhizome, the chrysanthemum, the gypsum, the honeysuckle, the mint, the tuckahoe and the honey-fried licorice root have obvious treatment effect on the swine fever, can reduce the death rate of sick pigs, and has the treatment effective rate of over 90 percent.

Test example 2: toxicology test

Acute oral toxicity test: experimental groups: 30 Kunming white mice are randomly divided into 3 groups, each group comprises 10 mice, each half of the mice is male and female, and the weight of the mice ranges from 18 g to 21 g. The veterinary drug granules prepared in example 3 were taken from fasting 16h mice and administered orally at a dose of 3000mg/kg · bw, 4000mg/kg · bw and 5000mg/kg · bw once, and the poisoning manifestations and death conditions were recorded after continuously observing 14 d. Negative control group: 10 test animals, each half of male and female, weighing 17-22 g, were given equal amounts of sterileDistilled water, and the control observation is carried out simultaneously with the test group. As a result: mouse acute oral LD₅₀More than 5000mg/kg bw. According to the grading standard of acute oral toxicity, the traditional Chinese veterinary medicine particles prepared by the invention belong to actual non-toxic grade on the acute oral toxicity of mice.

The preparation method of the veterinary traditional Chinese medicine granules for treating swine fever provided by the embodiment of the invention reserves the active ingredients of the traditional Chinese medicine, has good drug effect, and the granules are sweet in taste and good in palatability of pigs, and are more acceptable.

The above-mentioned embodiments are merely preferred embodiments of the present invention, which are merely illustrative and not restrictive, and it should be understood that other embodiments may be easily made by those skilled in the art by replacing or changing the technical contents disclosed in the specification, and therefore, all changes and modifications that are made on the principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A traditional Chinese veterinary medicine composition for treating swine fever is characterized by comprising the following components in parts by weight: 20-25 parts of isatis root, 15-20 parts of male fern rhizome, 10-15 parts of chrysanthemum, 10-15 parts of gypsum, 10-15 parts of honeysuckle, 5-10 parts of mint, 5-10 parts of poria cocos and 5-10 parts of honey-fried licorice root.

2. The veterinary drug composition for treating swine fever according to claim 1, which is characterized by comprising the following components in parts by weight: 24 parts of isatis root, 20 parts of rhizoma dryopteris crassirhizomae, 15 parts of chrysanthemum, 12 parts of gypsum, 12 parts of honeysuckle, 7 parts of mint, 5 parts of poria cocos and 5 parts of honey-fried licorice root.

3. The preparation method of the veterinary drug composition for treating swine fever according to any one of claims 1 to 2, which comprises the following steps: the components of claim 1 or 2 are weighed according to the proportion, decocted for three times, the filtrates obtained after the three times of decoction are combined, concentrated into extract, added with auxiliary materials and prepared into the veterinary traditional Chinese medicine granules for treating swine fever.

4. The preparation method of the veterinary herbal medicine composition for treating swine fever according to claim 3, is characterized by comprising the following steps:

1) weighing radix Isatidis, rhizoma Dryopteris Crassirhizomatis, flos Chrysanthemi, Gypsum Fibrosum, flos Lonicerae, herba Menthae, Poria, and radix Glycyrrhizae Preparata according to the proportion of claim 1 or 2;

5. The preparation method of the veterinary drug composition for treating swine fever according to claim 3 or 4, wherein the auxiliary materials are selected from one or more of sucrose, glucose, dextrin, sodium cyclamate or water-soluble starch.

6. The preparation method of the veterinary drug composition for treating swine fever according to claim 3 or 4, wherein the concentration is finished until the relative density of the extract reaches 1.15-1.35.