CN113134066A - 一种妇科凝胶的制作方法 - Google Patents

一种妇科凝胶的制作方法 Download PDF

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Publication number
CN113134066A
CN113134066A CN202110495003.7A CN202110495003A CN113134066A CN 113134066 A CN113134066 A CN 113134066A CN 202110495003 A CN202110495003 A CN 202110495003A CN 113134066 A CN113134066 A CN 113134066A
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root
angelica
radix
ylang
manufacture
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王小波
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Zhuji Bomei Biotechnology Co ltd
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Zhuji Bomei Biotechnology Co ltd
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Abstract

本发明公开了一种妇科凝胶的制作方法，通过将人参、黄柏、儿茶、丹参、蛇床子、白芍、泽兰、黄芩、地肤子、百部、芦荟、冰片、藏红花、依兰、天竺葵、苦参、艾叶、血竭、当归、乳香、蜂胶、白芷、淫羊藿等中药设置适当的配置比例，从而进一步采用上述中药的提取液作为主要有效成分，对人体无创伤、无刺激、无激素、无任何毒副作用，不存在微生物耐受现象。通过中药有效成分抑制病毒及细菌的活性，快速滋养及修复生殖细胞，提升自身分泌功能及局部免疫力，从而达到干预病毒与细菌的存活，最终实现对阴道炎、宫颈炎、宫颈糜烂的治疗。本发明的妇科凝胶对女性阴部的金黄色葡萄球菌、白色念珠菌、大肠杆菌有抑菌作用。

Description

一种妇科凝胶的制作方法
技术领域
本发明涉及一种医药技术领域，尤其是一种妇科凝胶的制作方法。
背景技术
女性生殖器官会根据生理需要，分泌一些必要的物质，这些分泌的物质结合人体的温度、润湿的环境及其他生理条件，恰好成为滋生微生物的“培养基”，容易感染有害细菌。正常情况下人体免疫力可以有效抑制大多数有害细菌，维持菌群保持一定的生态平衡。但是，当人体免疫力低下、内分泌激素发生变化，或外来因素如组织损伤、性交，超出了阴道的调节能力，破坏了平衡时，有害菌群可能引起阴道感染，而且来自于外界的病原微生物也可能趁虚而入。此外，伴随年龄增长、分娩等因素、外界环境周期因素，女性阴道会逐渐松弛，也会增加外源微生物侵入的风险。
当有害菌群超出正常的阀值时，会发生此类妇科疾病，就需要结合必要的药物治疗，可采用内服抗生素，外用抑菌药物等。采用外用药物疗效可能更加直接有效的作用于感染部位。而现有技术的阴道抑菌药物，通常为了快速达到治疗效果，常采用以抗生素为有效成分的抑菌药物，此类药物起效较快，但易发生耐受性，且对微生物的抑制不具有选择性，在治疗过程中，除了抑制或杀死有害菌群外，也会抑制或杀死有益菌群，会严重破坏女性生殖器官的生态平衡。在治疗后会产生不良后遗症，需要较长时间重新构建阴道菌群，在恢复过程中易发生再次感染。
发明内容
本发明为解决现有技术药物在治疗妇科疾病存在的问题，提供一种副作用小、不存在微生物耐受现象、减小对女性生殖器官生态平衡破坏的妇科凝胶的制作方法。
本发明解决现有问题的技术方案是，一种妇科凝胶的制作方法，步骤如下：
步骤一，将人参6-15g、黄柏3-8g、儿茶2.9-8.4g、丹参7-15g、蛇床子1.8-4.2g、白芍3-7g、泽兰6.5-14.5g、黄芩3.5-7.8g、地肤子6.8-13.5g、百部3.5-7.5g、芦荟6.8-14.5g、冰片3.8-7g、藏红花3.5-6.8g、依兰3.6-7.2g、天竺葵7.6-14.5g、苦参3.6-6.9g、艾叶7.8-14.6g、血竭3-7.5g、当归3.5-6.8g、乳香2-4g、蜂胶4.1-6.8g、白芷3.9-6.9g、淫羊藿2.1-4.2g浸入300-3000g的水中充分浸泡后混煮0.6-1.5小时得到原液。步骤二，将步骤一得到的原液过滤挤压提取汁液、继续熬制成200-300g浓缩液。步骤三，将步骤二的全部浓缩液及、替硝唑120-180g、吐温-80 120-180ml、凝胶基质4.1-6.2kg加入4-6kg的纯化水中内搅拌混合均匀成混合液。步骤四，将步骤三的混合液乳化、凝胶。
作为进一步的优选，所述的步骤一中将人参8-13g、黄柏4-6g、儿茶3.2-8g、丹参8-13g、蛇床子2-4g、白芍4-6.5g、泽兰7.5-13.5g、黄芩4.5-6.8g、地肤子7.5-12.8g、百部3.8-6.5g、芦荟7.5-13.8g、冰片4.2-6.8g、藏红花4.1-6.5g、依兰3.8-6.9g、天竺葵8.4-13.5g、苦参4.3-6.5g、艾叶8.4-13.8g、血竭4.5-6.5g、当归3.9-6.1g、乳香2.5-3.6g、蜂胶4.5-6.5g、白芷4.3-6.4g、淫羊藿2.4-3.8g浸入400-2800g的水中充分浸泡后混煮0.8-1.3小时得到原液。
作为进一步的优选，所述的步骤一中将人参8.8-12.6g、黄柏4.5-5.8g、儿茶3.8-6.9g、丹参8.6-12.8g、蛇床子2.2-3.8g、白芍4.5-6.2g、泽兰8.2-12.8g、黄芩4.8-5.9g、地肤子8.2-11.9g、百部4.1-6.1g、芦荟8.9-12.8g、冰片4.6-6.2g、藏红花4.5-6.1g、依兰4.2-6.1g、天竺葵8.9-12.5g、苦参4.6-5.9g、艾叶8.9-12.8g、血竭4.8-5.8g、当归4.3-5.9g、乳香2.6-3.4g、蜂胶4.8-6.1g、白芷4.6-6.1g、淫羊藿2.7-3.4g浸入400-2200g的水中充分浸泡后混煮0.9-1.2小时得到原液。
作为进一步的优选，所述的步骤一中将人参9g、黄柏4.8g、儿茶5.2g、丹参9.2g、蛇床子2.8g、白芍5.1g、泽兰9.8g、黄芩4.9g、地肤子10.4g、百部5.2g、芦荟9.1g、冰片4.9g、藏红花4.95g、依兰5.2g、天竺葵11.3g、苦参5.4g、艾叶10.8g、血竭5.6g、当归5.8g、乳香3.2g、蜂胶5.6g、白芷5.2g、淫羊藿3.1g浸入1900-2000g的水中充分浸泡后混煮0.9-1.2小时得到原液。
作为进一步的优选，所述的步骤一中将人参10g、黄柏5g、儿茶5g、丹参10g、蛇床子3g、白芍5g、泽兰10g、黄芩5g、地肤子10g、百部5g、芦荟10g、冰片5g、藏红花5g、依兰5g、天竺葵10g、苦参5g、艾叶10g、血竭5g、当归5g、乳香3g、蜂胶5g、白芷5g、淫羊藿3g浸入500g的水中充分浸泡后混煮1小时得到原液。
作为进一步的优选，所述的步骤二中将步骤一得到的原液过滤挤压提取汁液、继续熬制成240-280g浓缩液。
作为进一步的优选，所述的步骤二中将步骤一得到的原液过滤挤压提取汁液、继续熬制成250g浓缩液
作为进一步的优选，所述的步骤三，将步骤二的全部浓缩液及、替硝唑130-160g、吐温-80 125-170ml、凝胶基质4.8-5.9 kg加入4.8-5.8kg的纯化水中内搅拌混合均匀成混合液。
作为进一步的优选，所述的步骤三，将步骤二的全部浓缩液及、替硝唑140-155g、吐温-80 138-165ml、凝胶基质5-5.5kg加入4.9-5.6kg的纯化水中内搅拌混合均匀成混合液。
作为进一步的优选，所述的步骤三，将步骤二的全部浓缩液及、替硝唑150g、吐温-80 150ml、凝胶基质5kg加入5kg的纯化水中内搅拌混合均匀成混合液。
本发明与现有技术相比较，通过将人参、黄柏、儿茶、丹参、蛇床子、白芍、泽兰、黄芩、地肤子、百部、芦荟、冰片、藏红花、依兰、天竺葵、苦参、艾叶、血竭、当归、乳香、蜂胶、白芷、淫羊藿等中药设置适当的配置比例，从而进一步采用上述中药的提取液作为主要有效成分，对人体无创伤、无刺激、 无激素、 无任何毒副作用，不存在微生物耐受现象。通过中药有效成分抑制病毒及细菌的活性，快速滋养及修复生殖细胞， 提升自身分泌功能及局部免疫力， 从而达到干预病毒与细菌的存活， 最终实现对阴道炎、 宫颈炎、 宫颈糜烂的治疗。
本发明方法所制作的妇科凝胶对女性阴部的金黄色葡萄球菌、白色念珠菌、大肠杆菌有抑菌作用。
本发明方法所制作的妇科凝胶适用于各种原因引起的女性阴部瘙痒、异味及各种炎症的抑菌。排除体内垃圾，活血止痛，止血生肌，湿热泻痢，黄疸尿赤，带下阴痒，热淋涩痛，骨蒸劳热，疮疡肿毒，湿疹湿疮。让女性生殖回复年轻态。
具体实施方式
实施案例1，一种妇科凝胶的制作方法，步骤如下：
步骤一，将人参6-15g、黄柏3-8g、儿茶2.9-8.4g、丹参7-15g、蛇床子1.8-4.2g、白芍3-7g、泽兰6.5-14.5g、黄芩3.5-7.8g、地肤子6.8-13.5g、百部3.5-7.5g、芦荟6.8-14.5g、冰片3.8-7g、藏红花3.5-6.8g、依兰3.6-7.2g、天竺葵7.6-14.5g、苦参3.6-6.9g、艾叶7.8-14.6g、血竭3-7.5g、当归3.5-6.8g、乳香2-4g、蜂胶4.1-6.8g、白芷3.9-6.9g、淫羊藿2.1-4.2g浸入300-3000g的水中充分浸泡后混煮0.6-1.5小时得到原液。步骤二，将步骤一得到的原液过滤挤压提取汁液、继续熬制成200-300g浓缩液。步骤三，将步骤二的全部浓缩液及、替硝唑120-180g、吐温-80 120-180ml、凝胶基质4.1-6.2kg加入4-6kg的纯化水中内搅拌混合均匀成混合液。步骤四，将步骤三的混合液乳化、凝胶。
本发明方法所制作的妇科凝胶作用于微生物及抑菌检验结果如下表，
Figure 537701DEST_PATH_IMAGE002
本发明方法所制作的妇科凝胶抑菌试验。
一、器材 1、试验菌株：大肠杆菌（8099），培养9代、金黄色葡萄球菌（ATCC6538），培养9代、白色念珠菌（ATCC10231），培养9代。
2、普通营养琼脂培养基，沙氏琼脂培养基。
3、0.03mol/L磷酸盐缓冲液（PBS）。
4、载体：滤纸片（2.0cm×3.0cm）、无菌刻度吸管、无菌平皿、无菌试管、恒温培养箱等。
二、样品 1、样品：依据本发明方法获得的妇科凝胶。 2、样品处理：称取5g样品，放无菌研钵中研磨、混匀，放入无菌平皿中直接进行抑菌试验。
三、方法
1、依据GB15979-2002《一次性使用卫生品标准》附录C4及《消毒技术规范》2002版进行。
2、抑菌试验为载体试验。试验温度20℃±1℃。
下表是本发明方法所制作的妇科凝胶在试验温度20℃±2℃的条件下分别对大肠杆菌（8099）、白色念珠菌（ATCC10231）、金黄色葡萄球菌（ATCC6538）的平均抑菌率。
Figure 986000DEST_PATH_IMAGE004
实施案例2，在实施案例1的基础上，所述的步骤一中将人参8-13g、黄柏4-6g、儿茶3.2-8g、丹参8-13g、蛇床子2-4g、白芍4-6.5g、泽兰7.5-13.5g、黄芩4.5-6.8g、地肤子7.5-12.8g、百部3.8-6.5g、芦荟7.5-13.8g、冰片4.2-6.8g、藏红花4.1-6.5g、依兰3.8-6.9g、天竺葵8.4-13.5g、苦参4.3-6.5g、艾叶8.4-13.8g、血竭4.5-6.5g、当归3.9-6.1g、乳香2.5-3.6g、蜂胶4.5-6.5g、白芷4.3-6.4g、淫羊藿2.4-3.8g浸入400-2800g的水中充分浸泡后混煮0.8-1.3小时得到原液。
实施案例3，在实施案例1的基础上，所述的步骤一中将人参8.8-12.6g、黄柏4.5-5.8g、儿茶3.8-6.9g、丹参8.6-12.8g、蛇床子2.2-3.8g、白芍4.5-6.2g、泽兰8.2-12.8g、黄芩4.8-5.9g、地肤子8.2-11.9g、百部4.1-6.1g、芦荟8.9-12.8g、冰片4.6-6.2g、藏红花4.5-6.1g、依兰4.2-6.1g、天竺葵8.9-12.5g、苦参4.6-5.9g、艾叶8.9-12.8g、血竭4.8-5.8g、当归4.3-5.9g、乳香2.6-3.4g、蜂胶4.8-6.1g、白芷4.6-6.1g、淫羊藿2.7-3.4g浸入400-2200g的水中充分浸泡后混煮0.9-1.2小时得到原液。
实施案例4，在实施案例1的基础上，所述的步骤一中将人参9g、黄柏4.8g、儿茶5.2g、丹参9.2g、蛇床子2.8g、白芍5.1g、泽兰9.8g、黄芩4.9g、地肤子10.4g、百部5.2g、芦荟9.1g、冰片4.9g、藏红花4.95g、依兰5.2g、天竺葵11.3g、苦参5.4g、艾叶10.8g、血竭5.6g、当归5.8g、乳香3.2g、蜂胶5.6g、白芷5.2g、淫羊藿3.1g浸入1900-2000g的水中充分浸泡后混煮0.9-1.2小时得到原液。
实施案例5，在实施案例1的基础上，所述的步骤一中将人参6g、黄柏3g、儿茶2.9g、丹参7g、蛇床子1.8g、白芍3g、泽兰6.5g、黄芩3.5g、地肤子6.8g、百部3.5g、芦荟6.8g、冰片3.8g、藏红花3.5g、依兰3.6g、天竺葵7.6g、苦参3.6g、艾叶7.8g、血竭3g、当归3.5g、乳香2g、蜂胶4.1g、白芷3.9g、淫羊藿2.1g浸入300-3000g的水中充分浸泡后混煮0.6-1.5小时得到原液。
实施案例6，在实施案例1的基础上，所述的步骤一中将人参15g、黄柏8g、儿茶8.4g、丹参15g、蛇床子4.2g、白芍7g、泽兰14.5g、黄芩7.8g、地肤子13.5g、百部7.5g、芦荟14.5g、冰片7g、藏红花6.8g、依兰7.2g、天竺葵14.5g、苦参6.9g、艾叶14.6g、血竭7.5g、当归6.8g、乳香4g、蜂胶6.8g、白芷6.9g、淫羊藿4.2g浸入300-3000g的水中充分浸泡后混煮0.6-1.5小时得到原液。
实施案例7，在实施案例1的基础上，所述的步骤一中将人参8g、黄柏4g、儿茶3.2g、丹参8g、蛇床子2g、白芍4g、泽兰7.5g、黄芩4.5g、地肤子7.5g、百部3.8g、芦荟7.5g、冰片4.2g、藏红花4.1g、依兰3.8g、天竺葵8.4g、苦参4.3g、艾叶8.4g、血竭4.5g、当归3.9g、乳香2.5g、蜂胶4.5g、白芷4.3、淫羊藿2.4g浸入400-2800g的水中充分浸泡后混煮0.8-1.3小时得到原液。
实施案例8，在实施案例1的基础上，所述的步骤一中将人参13g、黄柏6g、儿茶8g、丹参13g、蛇床子4g、白芍6.5g、泽兰13.5g、黄芩6.8g、地肤子12.8g、百部6.5g、芦荟13.8g、冰片6.8g、藏红花6.5g、依兰6.9g、天竺葵13.5g、苦参6.5g、艾叶13.8g、血竭6.5g、当归6.1g、乳香3.6g、蜂胶6.5g、白芷6.4g、淫羊藿3.8g浸入2200g的水中充分浸泡后混煮0.8-1.3小时得到原液。
实施案例9，在实施案例1的基础上，所述的步骤一中将人参8.8-12.6g、黄柏4.5-5.8g、儿茶3.8-6.9g、丹参8.6-12.8g、蛇床子2.2-3.8g、白芍4.5-6.2g、泽兰8.2-12.8g、黄芩4.8-5.9g、地肤子8.2-11.9g、百部4.1-6.1g、芦荟8.9-12.8g、冰片4.6-6.2g、藏红花4.5-6.1g、依兰4.2-6.1g、天竺葵8.9-12.5g、苦参4.6-5.9g、艾叶8.9-12.8g、血竭4.8-5.8g、当归4.3-5.9g、乳香2.6-3.4g、蜂胶4.8-6.1g、白芷4.6-6.1g、淫羊藿2.7-3.4g浸入400-2200g的水中充分浸泡后混煮0.9-1.2小时得到原液。
实施案例10，在实施案例1的基础上，所述的步骤一中将人参8.8g、黄柏4.5g、儿茶3.8g、丹参8.6g、蛇床子2.2g、白芍4.5g、泽兰8.2g、黄芩4.8g、地肤子8.2g、百部4.1g、芦荟8.9g、冰片4.6g、藏红花4.5g、依兰4.2g、天竺葵8.9g、苦参4.6g、艾叶8.9g、血竭4.8g、当归4.3g、乳香2.6g、蜂胶4.8g、白芷4.6g、淫羊藿2.7g浸入2000g的水中充分浸泡后混煮0.9小时得到原液。
实施案例11，在实施案例1的基础上，所述的步骤一中将人参12.6g、黄柏5.8g、儿茶6.9g、丹参12.8g、蛇床子3.8g、白芍6.2g、泽兰12.8g、黄芩5.9g、地肤子11.9g、百部6.1g、芦荟12.8g、冰片6.2g、藏红花6.1g、依兰6.1g、天竺葵12.5g、苦参5.9g、艾叶12.8g、血竭5.8g、当归5.9g、乳香3.4g、蜂胶6.1g、白芷6.1g、淫羊藿3.4g浸入1900g的水中充分浸泡后混煮1.2小时得到原液。
实施案例12，在实施案例1的基础上，所述的步骤一中将人参10g、黄柏5g、儿茶5g、丹参10g、蛇床子3g、白芍5g、泽兰10g、黄芩5g、地肤子10g、百部5g、芦荟10g、冰片5g、藏红花5g、依兰5g、天竺葵10g、苦参5g、艾叶10g、血竭5g、当归5g、乳香3g、蜂胶5g、白芷5g、淫羊藿3g浸入2000g的水中充分浸泡后混煮1小时得到原液。
实施案例13，实施案例1-12中任一一案例中，所述的步骤二中将步骤一得到的原液过滤挤压提取汁液、继续熬制成240-280g浓缩液。
实施案例14，实施案例1-12中任一一案例中，所述的步骤二中将步骤一得到的原液过滤挤压提取汁液、继续熬制成250g浓缩液。
实施案例15，实施案例1-14中任一一案例中，所述的步骤三，将步骤二的全部浓缩液及、替硝唑130-160g、吐温-80 125-170ml、凝胶基质4.8-5.9 kg加入4.8-5.8kg的纯化水中内搅拌混合均匀成混合液。
实施案例16，实施案例1-14中任一一案例中，所述的步骤三，将步骤二的全部浓缩液及、替硝唑140-155g、吐温-80 138-165ml、凝胶基质5-5.5kg加入4.9-5.6kg的纯化水中内搅拌混合均匀成混合液。
实施案例17，实施案例1-14中任一一案例中，所述的步骤三，将步骤二的全部浓缩液及、替硝唑150g、吐温-80 150ml、凝胶基质5kg加入5kg的纯化水中内搅拌混合均匀成混合液。

Claims (10)

1.一种妇科凝胶的制作方法，其特征在于：步骤如下， 步骤一，将人参6-15g、黄柏3-8g、儿茶2.9-8.4g、丹参7-15g、蛇床子1.8-4.2g、白芍3-7g、泽兰6.5-14.5g、黄芩3.5-7.8g、地肤子6.8-13.5g、百部3.5-7.5g、芦荟6.8-14.5g、冰片3.8-7g、藏红花3.5-6.8g、依兰3.6-7.2g、天竺葵7.6-14.5g、苦参3.6-6.9g、艾叶7.8-14.6g、血竭3-7.5g、当归3.5-6.8g、乳香2-4g、蜂胶4.1-6.8g、白芷3.9-6.9g、淫羊藿2.1-4.2g浸入300-3000g的水中充分浸泡后混煮0.6-1.5小时得到原液； 步骤二，将步骤一得到的原液过滤挤压提取汁液、继续熬制成200-300g浓缩液； 步骤三，将步骤二的全部浓缩液及、替硝唑120-180g、吐温-80 120-180ml、凝胶基质4.1-6.2kg加入4-6kg的纯化水中内搅拌混合均匀成混合液； 步骤四，将步骤三的混合液乳化、凝胶。
2.如权利要求1所述的妇科凝胶制造方法，其特征在于：所述的步骤一中将人参8-13g、黄柏4-6g、儿茶3.2-8g、丹参8-13g、蛇床子2-4g、白芍4-6.5g、泽兰7.5-13.5g、黄芩4.5-6.8g、地肤子7.5-12.8g、百部3.8-6.5g、芦荟7.5-13.8g、冰片4.2-6.8g、藏红花4.1-6.5g、依兰3.8-6.9g、天竺葵8.4-13.5g、苦参4.3-6.5g、艾叶8.4-13.8g、血竭4.5-6.5g、当归3.9-6.1g、乳香2.5-3.6g、蜂胶4.5-6.5g、白芷4.3-6.4g、淫羊藿2.4-3.8g浸入400-2800g的水中充分浸泡后混煮0.8-1.3小时得到原液。
3.如权利要求1或2所述的妇科凝胶制造方法，其特征在于：所述的步骤一中将人参8.8-12.6g、黄柏4.5-5.8g、儿茶3.8-6.9g、丹参8.6-12.8g、蛇床子2.2-3.8g、白芍4.5-6.2g、泽兰8.2-12.8g、黄芩4.8-5.9g、地肤子8.2-11.9g、百部4.1-6.1g、芦荟8.9-12.8g、冰片4.6-6.2g、藏红花4.5-6.1g、依兰4.2-6.1g、天竺葵8.9-12.5g、苦参4.6-5.9g、艾叶8.9-12.8g、血竭4.8-5.8g、当归4.3-5.9g、乳香2.6-3.4g、蜂胶4.8-6.1g、白芷4.6-6.1g、淫羊藿2.7-3.4g浸入400-2200g的水中充分浸泡后混煮0.9-1.2小时得到原液。
4.如权利要求3所述的妇科凝胶制造方法，其特征在于：所述的步骤一中将人参9g、黄柏4.8g、儿茶5.2g、丹参9.2g、蛇床子2.8g、白芍5.1g、泽兰9.8g、黄芩4.9g、地肤子10.4g、百部5.2g、芦荟9.1g、冰片4.9g、藏红花4.95g、依兰5.2g、天竺葵11.3g、苦参5.4g、艾叶10.8g、血竭5.6g、当归5.8g、乳香3.2g、蜂胶5.6g、白芷5.2g、淫羊藿3.1g浸入1900-2000g的水中充分浸泡后混煮0.9-1.2小时得到原液。
5.如权利要求4所述的妇科凝胶制造方法，其特征在于：所述的步骤一中将人参10g、黄柏5g、儿茶5g、丹参10g、蛇床子3g、白芍5g、泽兰10g、黄芩5g、地肤子10g、百部5g、芦荟10g、冰片5g、藏红花5g、依兰5g、天竺葵10g、苦参5g、艾叶10g、血竭5g、当归5g、乳香3g、蜂胶5g、白芷5g、淫羊藿3g浸入500g的水中充分浸泡后混煮1小时得到原液。
6.如权利要求1所述的妇科凝胶制造方法，其特征在于：所述的步骤二中将步骤一得到的原液过滤挤压提取汁液、继续熬制成240-280g浓缩液。
7.如权利要求1或6所述的妇科凝胶制造方法，其特征在于：所述的步骤二中将步骤一得到的原液过滤挤压提取汁液、继续熬制成250g浓缩液。
8.如权利要求1所述的妇科凝胶制造方法，其特征在于：所述的步骤三，将步骤二的全部浓缩液及、替硝唑130-160g、吐温-80 125-170ml、凝胶基质4.8-5.9 kg加入4.8-5.8kg的纯化水中内搅拌混合均匀成混合液。
9.如权利要求1或8所述的妇科凝胶制造方法，其特征在于：所述的步骤三，将步骤二的全部浓缩液及、替硝唑140-155g、吐温-80 138-165ml、凝胶基质5-5.5kg加入4.9-5.6kg的纯化水中内搅拌混合均匀成混合液。
10.如权利要求9所述的妇科凝胶制造方法，其特征在于：所述的步骤三，将步骤二的全部浓缩液及、替硝唑150g、吐温-80 150ml、凝胶基质5kg加入5kg的纯化水中内搅拌混合均匀成混合液。
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