CN113101330A - Menstruation regulating composition and application thereof - Google Patents
Menstruation regulating composition and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and discloses a menstruation regulating composition and application thereof, wherein the menstruation regulating composition comprises angelica sinensis, rhizoma cyperi with vinegar, white atractylodes rhizome fried with bran, white paeony root, noni fruit, rhizoma corydalis with vinegar, Chinese date, liquorice, ligusticum wallichii, red paeony root, prepared rehmannia root and moringa oleifera leaves; the application is the application of the menstruation regulating composition in preparing medicines for regulating menstruation and relieving pain. The menstruation regulating composition is prepared by selecting noni fruits and moringa leaves on the basis of the existing gynecological menstruation regulating granules, and by utilizing the synergistic effect of the noni fruits, the moringa leaves, angelica, bran-fried bighead atractylodes rhizome, ligusticum wallichii and red paeony roots, the effects of nourishing blood and regulating menstruation are achieved, and menstrual pain can be effectively relieved. Meanwhile, the added noni fruits and moringa leaves are new food raw materials, so that the safety of the existing components in use is improved, the noni fruits and moringa leaves are suitable for a wide range of people, and the popularization value is very high.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a menstruation regulating composition and application thereof in preparation of a medicine for regulating menstruation and relieving pain.
Background
The modern women suffer from irregular menstruation due to the increase of working pressure, the acceleration of working rhythm and irregular life, and in addition, many women deliberately eat food.
The irregular menstruation is a common gynecological disease, and the specific clinical symptoms are irregular metrorrhagia, functional metrorrhagia, amenorrhea, menopause, infertility caused by irregular menstruation, functional metrorrhagia, menopause, menoxenia and the like, and the pathogenesis of the irregular metrorrhagia basically comprises several aspects of emotional disorder, cold stimulation, diet, smoking and drinking, excessive pressure and the like.
At present, the western medicine basically adopts hormone medicines such as progesterone, ethylene estrogen and the like for treating the menstrual disorder, has good effect, but has higher recurrence rate in later period.
The traditional Chinese medicine considers that the menstrual disorder is a phenomenon, and the phenomenon of the menstrual disorder is summarized into four types of phenomena of advanced menstruation, later menstruation, hypermenorrhea and hypomenorrhea, and the four types of menstrual disorder summarize a plurality of reasons of yang exuberance and blood heat type, yin deficiency and blood heat type, qi deficiency and failure of control type, kidney deficiency and weakness type, blood cold type, qi depression type and the like, and have a plurality of etiological factors and complex pathology.
Along with the continuous and deep research on the traditional Chinese medicine and gynecologic theory and the combined research of Chinese and Western medicine, the content of regulating menstruation of traditional Chinese medicine is continuously enriched and developed in more than ten years.
CN103251769A discloses a gynecological menstruation regulating tablet, which is prepared by refining twenty-six traditional Chinese medicines, such as white atractylodes rhizome stir-fried with bran and rhizoma corydalis stir-fried with vinegar, angelica sinensis, ligusticum wallichii, rhizoma cyperi, white paeony root, red paeony root, prepared rehmannia root, Chinese date, costustoot, tuckahoe, cortex moutan, peach kernel, motherwort, cassia twig, codonopsis pilosula, salvia miltiorrhiza, radix bupleuri, combined spicebush root, fructus aurantii, safflower carthamus, fingered citron, szechwan chinaberry fruit, frankincense, myrrh, liquorice and the like, and has the functions of soothing the liver and tonifying the kidney, nourishing blood, regulating menstruation and relieving pain, can better regulate the endocrine.
CN106110190A discloses a traditional Chinese medicine composition for nourishing blood and regulating menstruation, which is prepared from the following raw materials: the Chinese medicinal composition for nourishing blood and regulating menstruation can nourish yin and tonify kidney, nourish blood and dredge collaterals, regulate endocrine, improve symptoms such as hypomenorrhea and the like.
Although the number of the traditional Chinese medicines for treating irregular menstruation and menstrual abdominal pain is not few, the clinical application effect of most prescriptions is not ideal, so that the provision of a menstruation regulating composition and a preparation thereof is urgently needed to meet the requirement of improving the quality of life of women in China.
Disclosure of Invention
In order to solve the technical problems, the invention provides a menstruation regulating composition and application thereof, the menstruation regulating composition is developed for the second time on the basis of the existing gynecological menstruation regulating granules, noni fruits and moringa leaves are selected, and by utilizing the synergistic effect of the noni fruits, the moringa leaves, angelica sinensis, bran-fried bighead atractylodes rhizome, ligusticum wallichii and red paeony roots, the menstrual period pain can be effectively relieved while the effects of nourishing blood and regulating menstruation are exerted, so that the menstruation regulating composition is more suitable for clinical requirements.
In order to achieve the purpose, the invention adopts the following technical scheme:
a menstruation regulating composition comprises radix Angelicae sinensis, rhizoma Cyperi processed with vinegar, Atractylodis rhizoma processed with bran, radix Paeoniae alba, Morinda citrifolia, rhizoma corydalis processed with vinegar, fructus Jujubae and Glycyrrhrizae radix.
Preferably, the menstruation regulating composition comprises the following components in parts by weight: 30-45 parts of angelica, 120 parts of vinegar rhizoma cyperi, 5-8 parts of bran-fried bighead atractylodes rhizome, 2-4 parts of white paeony root, 50-80 parts of noni fruit, 8-10 parts of vinegar rhizoma corydalis, 18-25 parts of Chinese date and 2.5-4 parts of liquorice.
Preferably, the mass ratio of the angelica sinensis, the bran-fried bighead atractylodes rhizome and the noni fruit is 35-40: 6: 60-70.
Preferably, the menstruation regulating composition further comprises ligusticum wallichii, red peony root, prepared rehmannia root and moringa oleifera leaf.
Preferably, the menstruation regulating composition further comprises the following components in parts by weight: 3-6 parts of ligusticum wallichii, 2-4 parts of red paeony root, 10-15 parts of prepared rehmannia root and 20-40 parts of moringa leaves.
Preferably, the mass ratio of the ligusticum wallichii, the red paeony root and the moringa oleifera leaves is 4-5: 2.5-3.6: 24-36.
The invention also provides application of the menstruation regulating composition in preparing a medicine for regulating menstruation and relieving pain.
Preferably, the dosage form of the medicine is granules, tablets, capsules, pills and oral liquid.
The invention also provides menstruation regulating granules comprising the menstruation regulating composition.
Preferably, the menstruation regulating granule further comprises pharmaceutically acceptable auxiliary materials.
The invention also provides a preparation method of the menstruation regulating granule, which comprises the following steps:
s1, decocting radix Angelicae sinensis, rhizoma Cyperi preparata, rhizoma Atractylodis Macrocephalae preparata, radix Paeoniae alba, rhizoma corydalis preparata, fructus Jujubae, radix Glycyrrhizae, rhizoma Chuanxiong, radix Paeoniae Rubra, and radix rehmanniae Preparata with water twice, filtering, and mixing filtrates;
s2, adding noni and moringa leaves into the filtrate obtained in the step S1, and concentrating under reduced pressure to obtain an extract with the relative density of 1.18-1.20(80 ℃);
s3, adding auxiliary materials into the extract obtained in the step S2, granulating and drying to obtain the Chinese medicinal composition.
The invention has the beneficial effects that:
the menstruation regulating composition is prepared by selecting noni fruits and moringa leaves on the basis of the existing gynecological menstruation regulating granules, and by utilizing the synergistic effect of the noni fruits, the moringa leaves, angelica, bran-fried bighead atractylodes rhizome, ligusticum wallichii and red paeony roots, the effects of nourishing blood and regulating menstruation are achieved, and menstrual pain can be effectively relieved.
Meanwhile, the added noni fruits and moringa leaves are new food raw materials, so that the safety of the existing components in use is improved, the noni fruits and moringa leaves are suitable for a wide range of people, and the popularization value is very high.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The sources of the raw materials used in the present invention are not limited, and the raw materials used in the present invention are all those commonly available in the art unless otherwise specified. The noni fruit used in this example was noni pulp, and the soluble solids (refractometry at 20 ℃) were 7.0-9.0%; the particle size of the moringa leaves is 80-150 microns.
Basic embodiment
A menstruation regulating composition comprises the following components in parts by weight: 30-45 parts of angelica, 120 parts of vinegar rhizoma cyperi, 5-8 parts of bran-fried bighead atractylodes rhizome, 2-4 parts of white paeony root, 50-80 parts of noni fruit, 8-10 parts of vinegar rhizoma corydalis, 18-25 parts of Chinese date, 2.5-4 parts of liquorice, 3-6 parts of ligusticum wallichii, 2-4 parts of red paeony root, 10-15 parts of prepared rehmannia root and 20-40 parts of moringa leaves.
Preferably, the mass ratio of the angelica sinensis, the bran-fried bighead atractylodes rhizome and the noni fruit is 35-40: 6: 60-70.
Preferably, the mass ratio of the ligusticum wallichii, the red paeony root and the moringa oleifera leaves is 4-5: 2.5-3.6: 24-36.
The invention also provides application of the menstruation regulating composition in preparing a medicine for regulating menstruation and relieving pain.
Preferably, the dosage form of the medicine is granules, tablets, capsules, pills and oral liquid.
The invention also provides menstruation regulating granules comprising the menstruation regulating composition.
Preferably, the menstruation regulating granule further comprises pharmaceutically acceptable auxiliary materials.
The invention also provides a preparation method of the menstruation regulating granule, which comprises the following steps:
s1, decocting radix Angelicae sinensis, rhizoma Cyperi preparata, rhizoma Atractylodis Macrocephalae preparata, radix Paeoniae alba, rhizoma corydalis preparata, fructus Jujubae, radix Glycyrrhizae, rhizoma Chuanxiong, radix Paeoniae Rubra, and radix rehmanniae Preparata with water twice, filtering, and mixing filtrates;
s2, adding noni and moringa leaves into the filtrate obtained in the step S1, and concentrating under reduced pressure to obtain an extract with the relative density of 1.18-1.20(80 ℃);
s3, adding auxiliary materials into the extract obtained in the step S2, granulating and drying to obtain the Chinese medicinal composition.
EXAMPLES 1-7A menstruation regulating composition
The raw materials and the amounts (parts by weight) of the menstruation regulating compositions of examples 1 to 7 are shown in Table 1.
TABLE 1
Comparative example 1
This comparative example differs from example 7 in that: the menstruation regulating composition comprises 20 parts by weight of angelica sinensis, 9 parts by weight of bran-fried bighead atractylodes rhizome and 90 parts by weight of noni fruit, and the menstruation regulating composition comprises 7 parts by weight of ligusticum wallichii, 1 part by weight of red paeony root and 15 parts by weight of moringa leaves.
Comparative example 2
This comparative example differs from example 7 in that: in the menstruation regulating composition, 60 parts by weight of angelica sinensis, 4 parts by weight of bran-fried bighead atractylodes rhizome, 40 parts by weight of noni fruit, 2 parts by weight of ligusticum wallichii, 5 parts by weight of red paeony root and 50 parts by weight of moringa leaves are used.
The menstruation regulating granules of the above examples 1 to 7 and comparative examples 1 to 2 were prepared into menstruation regulating granules, respectively, wherein the weight ratio of the menstruation regulating composition to the auxiliary materials in the menstruation regulating granules was 1: 10.
The preparation method of the menstruation regulating granule comprises the following steps:
s1, decocting radix Angelicae sinensis, rhizoma Cyperi preparata, rhizoma Atractylodis Macrocephalae preparata, radix Paeoniae alba, rhizoma corydalis preparata, fructus Jujubae, radix Glycyrrhizae, rhizoma Chuanxiong, radix Paeoniae Rubra, and radix rehmanniae Preparata with water twice, filtering, and mixing filtrates;
s2, adding noni and moringa leaves into the filtrate obtained in the step S1, and concentrating under reduced pressure to obtain an extract with the relative density of 1.18-1.20(80 ℃);
s3, adding auxiliary materials into the extract obtained in the step S2, granulating, drying and preparing 1000 g.
Evaluation of efficacy of treating dysmenorrhea
1. Experimental animals: healthy adult female SPF-grade SD rats, 2-3 months of age, weighing 200-.
2. The experimental method comprises the following steps: SD rats were randomly divided into 12 groups by body weight, namely a model group, experimental groups 1-7, comparative groups 1-2, a positive control group and a normal control group, and 8 rats were each group. In addition to the normal control group, SD rats were injected with estradiol benzoate injection (E2) 2mg/kg subcutaneously every day for 12 days continuously, and the intragastric administration of each group was started for 14 days from the 7 th day of injection; wherein, the experimental groups 1-7 and the comparative groups 1-2 were administered with 5.4g/kg of menstruation regulating granules prepared in examples 1-7 and comparative examples 1-2, respectively, the positive control group was administered with commercial gynecological menstruation regulating granules at an administration amount of 7.56g/kg, the model group and the normal control group were administered with an equal volume of physiological saline, and were administered with intragastric administration for 1h on day 12, and then oxytocin 20IM/kg was injected into the abdominal cavity, and the time (torsion latency) and the number of torsion times within 30min of the SD rats after oxytocin injection were recorded, and the results are shown in table 2.
TABLE 2 influence of menstruation regulating granule of the present invention on pain in model of dysmenorrhea caused by oxytocin in mice (chi + -s)
| Group of | Incubation period min | Number of wriggling within 30min |
| Normal control group | 0 | 0 |
| Model set | 3.13±0.91# | 35.62±1.72# |
| Experimental group 1 | 6.07±0.94* | 17.99±1.37* |
| Experimental group 2 | 6.24±0.98* | 16.42±1.26* |
| Experimental group 3 | 6.68±0.88** | 12.41±1.13** |
| Experimental group 4 | 7.18±0.90** | 11.66±1.20** |
| Experimental group 5 | 7.69±0.91** | 10.12±0.95** |
| Experimental group 6 | 7.26±0.85** | 11.15±0.85** |
| Experimental group 7 | 9.32±0.82** | 6.21±0.57** |
| Comparative example group 1 | 5.16±0.79 | 24.67±1.15 |
| Comparative example group 2 | 5.43±0.81 | 22.38±1.03 |
| Positive control group | 5.72±0.53* | 19.74±0.89* |
Note: compared with a normal control group, the # P is less than 0.01 and has a very significant difference; p <0.05, significantly different compared to model group; p <0.01, with very significant differences.
As can be seen from the table above, compared with the model group, the mouse writhing reaction latency and the writhing reaction times of the experimental group 1-7 mice have significant differences (P <0.05), which indicates that the menstruation regulating granule prepared by the invention can effectively relieve menstrual pain. Compared with the model group, the mouse writhing reaction latency and the writhing reaction times of the experimental group 3-7 groups of mice have very significant differences (P is less than 0.01), which shows that when the mass ratio of the ligusticum wallichii to the red paeony root to the moringa oleifera leaves in the menstruation regulating granules is 4-5: 2.5-3.6: 24-36 and/or the mass ratio of angelica, bran-fried atractylodes and noni fruit is 35-40: 6: the prepared menstruation regulating granule has good effect of relieving menstrual pain when the menstruation is 60-70 days.
The menstruation regulating composition is prepared by selecting noni fruits and moringa leaves on the basis of the existing gynecological menstruation regulating granules, and by utilizing the synergistic effect of the noni fruits, the moringa leaves, angelica, bran-fried bighead atractylodes rhizome, ligusticum wallichii and red paeony roots, the effects of nourishing blood and regulating menstruation are achieved, and menstrual pain can be effectively relieved.
Meanwhile, the added noni fruits and moringa leaves are new food raw materials, so that the safety of the existing components in use is improved, the noni fruits and moringa leaves are suitable for a wide range of people, and the popularization value is very high.
The present invention has been further described with reference to specific embodiments, which are only exemplary and do not limit the scope of the present invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (10)
1. A menstruation regulating composition is characterized by comprising angelica sinensis, rhizoma cyperi with vinegar, bighead atractylodes rhizome fried with bran, radix paeoniae alba, noni fruits, rhizoma corydalis with vinegar, Chinese dates and liquorice.
2. The composition for regulating menstruation according to claim 1, comprising the following components in parts by weight: 30-45 parts of angelica, 120 parts of vinegar rhizoma cyperi, 5-8 parts of bran-fried bighead atractylodes rhizome, 2-4 parts of white paeony root, 50-80 parts of noni fruit, 8-10 parts of vinegar rhizoma corydalis, 18-25 parts of Chinese date and 2.5-4 parts of liquorice.
3. The composition for regulating menstruation according to claim 2, wherein the weight ratio of angelica sinensis, bran-fried atractylodes macrocephala koidz and morinda citrifolia is 35-40: 6: 60-70.
4. The composition for regulating menstruation according to claim 1, further comprising cnidium officinale, paeonia lactiflora, rehmanniae praeparata and moringa oleifera leaves.
5. The composition for regulating menstruation according to claim 4, further comprising the following components in parts by weight: 3-6 parts of ligusticum wallichii, 2-4 parts of red paeony root, 10-15 parts of prepared rehmannia root and 20-40 parts of moringa leaves.
6. The composition for regulating menstruation according to claim 5, wherein the mass ratio of ligusticum wallichii, red peony root and moringa oleifera leaves is 4-5: 2.5-3.6: 24-36.
7. Use of a menstruation regulating composition according to any one of claims 1 to 6 in the manufacture of a medicament for the treatment of menstruation regulating pain relief.
8. The use of claim 7, wherein the medicament is in the form of granules, tablets, capsules, pills and oral liquid.
9. Menstruation regulating granules comprising the menstruation regulating composition according to any one of claims 1 to 6 and a pharmaceutically acceptable excipient.
10. The method for preparing menstruation regulating granule according to claim 9, comprising the steps of:
s1, decocting radix Angelicae sinensis, rhizoma Cyperi preparata, rhizoma Atractylodis Macrocephalae preparata, radix Paeoniae alba, rhizoma corydalis preparata, fructus Jujubae, radix Glycyrrhizae, rhizoma Chuanxiong, radix Paeoniae Rubra, and radix rehmanniae Preparata with water twice, filtering, and mixing filtrates;
s2, adding noni and moringa leaves into the filtrate obtained in the step S1, and concentrating under reduced pressure to obtain an extract with the relative density of 1.18-1.20(80 ℃);
s3, adding auxiliary materials into the extract obtained in the step S2, granulating and drying to obtain the Chinese medicinal composition.
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