CN1051011C - Instant granule preparation for strengthening the body resistance to brain tumor - Google Patents
Instant granule preparation for strengthening the body resistance to brain tumor Download PDFInfo
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- CN1051011C CN1051011C CN95115189A CN95115189A CN1051011C CN 1051011 C CN1051011 C CN 1051011C CN 95115189 A CN95115189 A CN 95115189A CN 95115189 A CN95115189 A CN 95115189A CN 1051011 C CN1051011 C CN 1051011C
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Abstract
The present invention relates to a traditional Chinese medicine, particularly to a soluble granule for supporting healthy energy and resisting cerebroma. The present invention mainly solves the problem of the bad effects of the existing medicines for treating cerebroma. The technical scheme adopts the following steps: firstly, oldenlandia, scutellariae barbatae, largehead atractylodes rhozome, milkvetch root, ginseng, glossy privet fruit, zedoray rhizome, tuckahoe, lightyellow sophora root, tangshen, manyprickle acanthopanax root, hemlock parsley and madder are selected; secondly, thirteen kinds of medicines are respectively decocted by adding water, the decoctions are combined, filtrated and concentrated, ethanol is added; then supernatant fluid is leached, evaporated and concentrated to obtain paste; sucrose powder and dextrin are added, and the mixtures are prepared into granules; finally, the sediment obtained after the supernatant fluid is leached, the sucrose powder and the dextrin are prepared into granules. The present invention has a good application prospect for treating cerebroma.
Description
The present invention relates to Chinese medicine, especially a kind ofly set upright anti-cerebroma electuary.
At present, the medicine of existing treatment cerebroma, the patient uses back focus minification, effective percentage all not high.
The object of the present invention is to provide a kind of focus minification, effective percentage height, treatment cerebroma effect is than the significant anti-cerebroma electuary of existing medicine.
Preparation raw material of the present invention is formed and the shared parts by weight of each composition are: Herba Hedyotidis Diffusae 105～113, Herba Scutellariae Barbatae 159～169, the Rhizoma Atractylodis Macrocephalae 79～85; the Radix Astragali 159～169; Radix Ginseng 159～169, Fructus Ligustri Lucidi 47～51, Rhizoma Curcumae 53～57; Poria 53～57; Radix Sophorae Flavescentis 15～17, Radix Codonopsis 53～57, Radix Et Caulis Acanthopanacis Senticosi 53～57; Rhizoma Chuanxiong 15～17; Radix Rubiae 15～17 decocts with water collecting decoction with above 13 flavor medicines; filter and concentrate; add an amount of ethanol, the evaporation of leaching supernatant; be concentrated into clear paste, add cane sugar powder; dextrin is prepared into granule; precipitate behind the aforementioned leaching supernatant is added cane sugar powder; dextrin is prepared into granule, and two kinds of granule mix homogeneously are got final product.
Main effect of the present invention:
Be applicable to cerebroma treatment, and can improve immunologic function and leukocyte increasing etc., use, be applicable to that metastatic encephaloma, cerebral glioma and prevention malignant tumor vertigo such as move at disease with radiotherapy, chemotherapy combined, and improve to put, the toleration of chemotherapy, reduce poison and pay effect.
Narrate preparation method of the present invention in conjunction with the embodiments.
During concrete enforcement, choose Hedyotidis Diffusae 109 grams, Herba Scutellariae Barbatae 164 grams, the Rhizoma Atractylodis Macrocephalae 82 grams, the Radix Astragali 164 grams, Radix Ginseng 164 grams, Fructus Ligustri Lucidi 49 grams, Rhizoma Curcumae 55 grams, Poria 55 grams, Radix Sophorae Flavescentis 16 grams, Radix Codonopsis 55 grams, Radix Et Caulis Acanthopanacis Senticosi 55 grams, Rhizoma Chuanxiong 16 grams, Radix Rubiae 16 grams, above 13 flavors are added decocting twice, three hours for the first time, one hour for the second time, collecting decoction, filter and concentrate, add an amount of ethanol and make and contain alcohol amount and reach 60%, standing over night, the leaching supernatant reclaims ethanol, be evaporated to no ethanol flavor, continue to be concentrated into the clear paste of relative density 1.30～1.35 (50 ℃～60 ℃), add cane sugar powder, dextrin is an amount of, mixed pelletization, drying, granulate are the yellowish-brown granule.Other gets, and precipitate behind the aforementioned leaching supernatant adds cane sugar powder, dextrin is an amount of, and mixing is granulated, drying, and granulate is the taupe granule.Two kinds of granule mix homogeneously get graininess electuary 1311.47 grams.
Take the present invention, one time 8 gram, boiled water is taken after mixing it with water, and three times on the one, taking medicine before meal usefulness was obeyed three months continuously.Set upright anti-cerebroma capsule as taking before taking the present invention, can make therapeutic effect better.Setting upright the capsular compound method of anti-cerebroma is: choose 500 milligrams of CH3-CCNU, and 25 milligrams of metoclopramides, an amount of excipient incapsulates above each medicine mix homogeneously, but is total to 10 in glue capsule.Before taking the present invention at every turn, take earlier and set upright 4 of anti-cerebroma capsules.
In conjunction with zoopery, clinical experiment pharmacological effect of the present invention is described.
One, chmice acute toxicity test
Get 10 of mices, body weight 10～22 grams, male and female all have, press 30 times of oral administrations of people's oral dose, administration is forward and backward weighs respectively, observes mice diet, activity and fur situation in the administration process, successive administration seven days, the result is no abnormal, and body weight all has increase.
Two, the rabbit immune function experiment is observed
Get four of large ear rabbits, body weight is divided into two groups about 2.5 kilograms, one group is matched group, and one group is the administration group, the 5 times of continuous oral administrations of dosing 15 days per capita of administration group, matched group is taken normal saline simultaneously, puts to death animal, and gets internal organs section statining microscopy in the 16th day, two groups compare, the obvious hypertrophy of white pulp in the spleen as a result, phagocyte increases in the red pulp, and function is active, acidocyte increases, and shows that the present invention has the raising immunity function.
Three, clinical experiment
31 routine cerebroma patients are carried out the clinical research of random packet, and treatment is organized 17 routine radiotherapies and is added and set upright anti-cerebroma electuary, and matched group 14 routine radiation alone are more remarkable than matched group effect through observation on Clinical Application treatment group.
Select the patient of no obvious cachexia and no radiotherapy contraindication, two groups of physical data are similar substantially, have comparability.Among the 31 routine patients, metastatic encephaloma 12 examples, primary brain tumor 19 examples all confirm that through pathology and CT 31 routine patients are divided into two groups at random, do detailed clinical examination before and after the treatment, do brain CT, blood, routine urinalysis, platelet and liver power checking.
The radiotherapy of treatment group adds with setting upright anti-cerebroma electuary, 1 time 8 gram, 3 times on the 1st, ante cibum mixing in water for oral taking, the matched group radiation alone.Two groups of patients all use the external exposure of linear accelerator 8mv-x line, DT1.8～2Gy/ time, and 1 week 5 times, whole brain irradiation DT36～40Gy, DT18～20Gy is shone again at focus in the open country of contracting then, and radiation period is all used for two groups and is fallen cranium pressing thing and leucocyte increasing agent.
Brain CT curative effect determinate standard: cerebroma is dwindled more than 70% for obviously dwindling, and cerebroma is dwindled more than 20% for dwindling, and cerebroma is dwindled and is basic no change below 20%.
The result:
Symptom and sign change 7,/17 1,/14 4.644＜0.05 6,/17 4,/14 0.159＜0.05 improvement, 4,/17 5,/14 0.553＞0.05 unchanged 0,/17 3,/14 4.033＜0.05 deterioration 0,/17 1,/14 1.255＞0.05 that is clearly better that substantially disappears of symptom and sign treatment group control group X P value behind the table 1 liang group Case treatment
Table 2 a liang group patient hindbrain CT change cerebroma variation treatment group matched group X P value is obviously dwindled 13,/17 5,/14 5.237＜0.05 and is dwindled 3,/17 5,/14 1.309＞0.05 basic no change 1,/17 4,/14 2.922＞0.05
Claims (1)
1; a kind ofly set upright anti-cerebroma electuary; the preparation raw material of electuary is formed and the shared parts by weight of each composition are: Herba Hedyotidis Diffusae 105～113; Herba Scutellariae Barbatae 159～169; the Rhizoma Atractylodis Macrocephalae 79～85, the Radix Astragali 159～169, Radix Ginseng 159～169; Fructus Ligustri Lucidi 47～51; Rhizoma Curcumae 53～57, Poria 53～57, Radix Sophorae Flavescentis 15～17; Radix Codonopsis 53～57; Radix Et Caulis Acanthopanacis Senticosi 53～57, Rhizoma Chuanxiong 15～17, Radix Rubiae 15～17; above 13 flavor medicines are decocted with water; collecting decoction, filtration concentrates, and adds an amount of ethanol; the evaporation of leaching supernatant; be concentrated into clear paste; add cane sugar powder; dextrin is prepared into granule, and the precipitate behind the aforementioned leaching supernatant is added cane sugar powder; dextrin is prepared into granule, and two kinds of granule mix homogeneously get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95115189A CN1051011C (en) | 1995-09-29 | 1995-09-29 | Instant granule preparation for strengthening the body resistance to brain tumor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95115189A CN1051011C (en) | 1995-09-29 | 1995-09-29 | Instant granule preparation for strengthening the body resistance to brain tumor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1134294A CN1134294A (en) | 1996-10-30 |
| CN1051011C true CN1051011C (en) | 2000-04-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95115189A Expired - Fee Related CN1051011C (en) | 1995-09-29 | 1995-09-29 | Instant granule preparation for strengthening the body resistance to brain tumor |
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| CN (1) | CN1051011C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793877A (en) * | 2019-04-03 | 2019-05-24 | 赤峰市肿瘤医院(赤峰学院第二附属医院) | A kind of Chinese medicine composition for treating tumour |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061892C (en) * | 1998-07-25 | 2001-02-14 | 朱社奇 | Oral liquid for treating tumor |
| CN101073611B (en) * | 2006-05-15 | 2010-11-10 | 山东轩竹医药科技有限公司 | Medicinal composition for preventing tumor |
| CN104127798B (en) * | 2013-05-02 | 2019-04-23 | 河北以岭医药研究院有限公司 | A kind of application of Chinese medicine composition in the drug that preparation inhibits cancer cell to shift to peritonaeum |
| CN104189804A (en) * | 2014-08-11 | 2014-12-10 | 孔令刚 | Traditional Chinese medicine composition for removing toxicity and resisting cancer |
| CN104547362B (en) * | 2015-01-27 | 2016-08-24 | 解锋 | A kind of Chinese medicine composition treating cerebral glioma and preparation method thereof |
| CN105079704A (en) * | 2015-09-07 | 2015-11-25 | 邹士东 | Traditional Chinese medicine composition for treating brain glioma and preparation method of traditional Chinese medicine composition |
| CN111358914A (en) * | 2020-04-07 | 2020-07-03 | 袁能忍 | A composition for treating leukemia, tumor, AIDS and aging, and its application |
-
1995
- 1995-09-29 CN CN95115189A patent/CN1051011C/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 《中华肿瘤杂志》1990年第12卷第2期 1990. 2.28 王冠庭等,扶正抗癌方结合化疗对158例晚期胃癌的术后治疗及动物实验研究 * |
| 《中华肿瘤杂志》1990年第12卷第2期 1990. 2.28 王冠庭等,扶正抗癌方结合化疗对158例晚期胃癌的术后治疗及动物实验研究;《中西医结合杂志》1990年第19卷第12期 1990.12.31 赵冠英等,参草扶正抗癌治疗恶性肿瘤64例临床观察;《中西医结合杂志》1992年第12卷第5期 1992. 5.31 赵冠英等,参草扶正抗癌冲剂的抗癌作用研究 * |
| 《中西医结合杂志》1990年第19卷第12期 1990.12.31 赵冠英等,参草扶正抗癌治疗恶性肿瘤64例临床观察 * |
| 《中西医结合杂志》1992年第12卷第5期 1992. 5.31 赵冠英等,参草扶正抗癌冲剂的抗癌作用研究 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793877A (en) * | 2019-04-03 | 2019-05-24 | 赤峰市肿瘤医院(赤峰学院第二附属医院) | A kind of Chinese medicine composition for treating tumour |
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| Publication number | Publication date |
|---|---|
| CN1134294A (en) | 1996-10-30 |
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