CN1048165C - Antitumor oral liquid and preparing process thereof - Google Patents

Abstract

The present invention relates to anti-tumor oral liquid which is composed of more than ten kinds of traditional Chinese medicines, such as ginseng, antler, psoralea, red sage root, agrimony, trichosanthes kirilowii maxim, rhizoma, asafetida, eaglewood, kaempferiae, cockroach, bletilla tuber, periplocae, etc. The anti-tumor oral liquid is used for curing various malignant tumors on clinic, and is particularly suitable for alleviating pain, prolonging life, eliminating metastatic lesions and primary lesions of patients with metaphase tumors and later-stage tumors, and curing various diseases with the deficiency of immune functions. Through the certification of tests, the effective rate of the anti-tumor oral liquid is over 96 %. The present invention also provides a preparation technology for the anti-tumor oral liquid.

Description

Antitumor oral liquid and preparation technology thereof

The present invention be a kind of can pain relieving and life-saving, the metastatic lesion of elimination middle and advanced stage tumour patient and antineoplastic oral liquid of primary focus and preparation method thereof.

According to the record of Chinese medicine pharmacopeia, the Chinese medicine Radix Pulsatillae, Radix Clematidis, Radix Notoginseng, Radix Angelicae Sinensis etc. have certain antitumor action.Therefore to prepare the example of antitumor drug a lot of for these compositions of domestic employing.As a kind of anticancer preparation as described in the CN1046460, it is 0～10 weight portion Radix Pulsatillae and 0～10 weight portion Radix Clematidis powder or extract to be added common auxiliary agent make tablet.The described a kind of compositions for the treatment of the immunologic function deficiency disease of CN1048497 can be used for antitumor, it by Radix Codonopsis, Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Lycii, Fructus Ligustri Lucidi, Semen Cuscutae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Draconis, Gypsum Fibrosum, Cornu Cervi Degelatinatum, Fructus Fici, Carapax Trionycis, Radix Asparagi, SEMEN COICIS, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Glycyrrhizae, Flos Lonicerae, Herba Violae, Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Fructus Jujubae totally 24 the flavor Chinese medicines form.Though these anti-tumor compositions all have certain curative effect, because compatibility is simple, use antitumor drug simply, unavoidable eliminating evil wound is just set upright and is helped heresy.

The objective of the invention is to identify and correct execute and control; take all factors into consideration; make that this oral liquid is eliminating evil is not just hindering; set upright and do not help heresy; thereby effective excitating organism immunologic function, protection human body hemopoietic system, reduce put, chemotherapy side effect and carcinous poisonous substance be to body damage; and effectively anticancer growth, thereby the diffusion that reaches control primary focus and neoplasm metastasis kitchen range is to reach the purpose of treatment tumor.

Motherland's medical science thinks that tumor belongs within " gathering " and " lump in the abdomen " scope of the traditional Chinese medical science, is that the stagnation of QI is tangible, and blood stasis has thing, fixing does not move, localized pain; Though in gas, be subjected to disease in blood, be to be disease of ZANG-organs.Point out that as " General Treatise on the Cause and Symptoms of Diseases lump in the abdomen sick duke or princess under an emperor " " the lump in the abdomen person, all uncomfortable by cold temperature, indigestion is with fight mutually knot and giving birth to also of visceral-qi." in through saying: " in healthy energy deposited, heresy can not be done, and the institute of heresy gathers, and its gas must be empty " proves absolutely the origin cause of formation of tumor, is empty earlier by healthy energy, and then pathogen is gathered it, and causes qi stagnation blood stasis, and poly-expectorant temperature poison is fought mutually to tie and formed.In a single day malignant tumor finds that major part has all belonged to middle and advanced stage, so healthy energy loses the evil Sheng of crossing of poison.Therefore, the present invention adopts:

One, sets upright with eliminating evil, support canonical and amass from disappearing.Abide by interior warp " damage person, benefit, treatment of deficiency-syndrome by reinforcement's " justice, YIN and YANG balance regulating, biochemical QI and blood promotes body's immunity, strengthens the resistance against diseases of self.Select strongly invigorating primordial QI such as Radix Ginseng, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae in the event side for use; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Caulis Spatholobi etc. to be enriching blood, YIN nourishing yin nourishing such as Radix Adenophorae (Radix Glehniae), Bie Jia, Fructus Lycii, and Cornu Cervi Pantotrichum, Fructus Psoraleae, Cortex Acanthopancis are with big complement sun;

The two heresies square peace of dispelling, eliminating evil purpose is eliminate indigestion, and eliminate indigestion must first circulation of qi promoting, and is interior through saying: " qi as the commander of blood, the capable then blood of gas is capable, airsetting is blood clotting then " so gas is capable, and knot looses, the stasis of bloodization, coldly loose, pain ends.As the justice of interior " hard masses should be resolved gradually " " diseases with invaded pathogens should be treated by expelling " " disease caused by accumulations of pathogen should be treated with therapy of dispersion " " disease with retention of pathogen in the body should be treated by elimination therapy " through pointing out, heresy is dispelled, is then pacified just certainly.Select circulation of qi promoting intestinal stasis relieving such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii Immaturus, Rhizoma Curcumae, Semen Arecae, wheat tooth for use, with blood circulation promoting and blood stasis dispelling such as Olibanum, Myrrha, Flos Carthami, Radix Et Rhizoma Rhei, Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Resina Ferulaes, loose and reach stasis of blood knot in the side, severe pain is ended.

Three, detoxicating and resolving stagnation of pathogens is the main purpose of treatment primary disease, in the side with Herba Hedyotidis Diffusae, Cortex Periplocae, Radix Clematidis, Drymotaenium miyoshianum (Mak.) Mak. Radix Sophorae Tonkinensis, Bie Jia, Eupolyphaga Seu Steleophaga, Rhizoma Kaempferiae, catechu with detoxifcation, hard masses softening and resolving.

Like this, antitumor oral liquid of the present invention comprises the extract of following Chinese medicine at least: Radix Ginseng, Cornu Cervi Pantotrichum, Fructus Psoraleae, Radix Salviae Miltiorrhizae, Herba Agrimoniae, Fructus Trichosanthis, Rhizoma Smilacis Glabrae, Resina Ferulae, Lignum Aquilariae Resinatum, Rhizoma Kaempferiae, Eupolyphaga Seu Steleophaga, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Periplocae.

Above-mentioned each components by weight is: Radix Ginseng 80～160, Cornu Cervi Pantotrichum 40～80g, Fructus Psoraleae 100～200, Radix Salviae Miltiorrhizae 250～300, Herba Agrimoniae 120～250, Fructus Trichosanthis 120～150, Rhizoma Smilacis Glabrae 80～100, Resina Ferulae 36～80, Lignum Aquilariae Resinatum 48～80, Rhizoma Kaempferiae 40～56, Eupolyphaga Seu Steleophaga 40～60, the Pseudobulbus Bletillae (Rhizoma Bletillae) 36～56, Cortex Periplocae 120～150.

Can also add some medicines in said components again and become following prescription: ginseng pilose antler Radix Astragali arillus longan Psoralea corylifolia bighead atractylodes rhizome Chinese angelica and red rooted salvia szechuan lovage rhizome and safflower curcuma zedoary triangular date Radix Glycyrrhizae hawthorn king does not stay the pseudo-ginseng radix glehniae RADIX SMILACIS SIEBOLDI reticulate millettia hairyvein agrimony turtle shell pangolin smilax melon fruit of Chinese wolfberry lily magnolia beans root Fructus Hordei Germinatus asafoetide fructus amomi oldenlandia diffusa umbellate pore furgus root of bidentate achyranthes dried immature fruit of citron orange gypsum agalloch eaglewood banksia rose santal Amomum cardamomum betel nut rhubarb kaempferia galamga catechu ground bettle kaladana cortex periplocae frankincense myrrh bletilla striata dark plum that withers

：80～160g 40～80g 180～260g150～220g 100～180g 180～250g250～300g 120～160g 60～80g180～220g 120～180g 80～120g300～500g 280～350g 120～160g120～180g 42～52g 80～20g180～220g 120～160g120～160g 160～180g 60～80g80～100g 120～150g 120～150g80～100g 120～150g 45～80g18～220g 60～80g 250～320g120～180g 40～60g 80～96g36～48g 40～56g 42～60g40～60g 40～80g 48～70g120～220g 40～60g 42～56g120～150g 42～56g 40～65g42～56g 30～42g 36～48g

The preparation method of antitumor oral liquid of the present invention, contain following steps:

A, Radix Ginseng, Radix Salviae Miltiorrhizae, Resina Ferulae, Lignum Aquilariae Resinatum four flavor Chinese medicine powders are broken into 50 orders～100 order coarse powder, each more than 4 hours with 70～90% soak with ethanol twice,

B, above-mentioned soak is filtered, filtrate device is in addition preserved,

C, above-mentioned medicinal residues and Cornu Cervi Pantotrichum, Fructus Psoraleae, Herba Agrimoniae, Fructus Trichosanthis, Rhizoma Smilacis Glabrae, Rhizoma Kaempferiae, Eupolyphaga Seu Steleophaga, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Periplocae merged decoct with water three times, collecting decoction filters,

D, filtrate is concentrated into 1: 1.5～and 3,

E, cooling back add 95% ethanol, and make it always contain the alcohol amount and reach 60～80%,

F, leave standstill after merging, filter, steam to there not being the alcohol flavor with soak among the step b,

G, add an amount of distilled water alkene and release after-filtration,

Add conventional preservatives and correctives in h, the filtrate, and regulate pH value to prescribed limit.

After adding some other Chinese medicine ingredients, the preparation method of this antitumor oral liquid comprises following steps:

A, Radix Ginseng, Radix Salviae Miltiorrhizae, Resina Ferulae, Lignum Aquilariae Resinatum four flavor Chinese medicines are crushed to 50～100 orders, each more than 4 hours with 70～90% soak with ethanol twice,

B, above-mentioned soak is filtered, filtrate device is in addition preserved,

C, get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Curcumae, rhizoma sparganic, Radix Notoginseng Chinese medicine of the five flavours and extract volatile oil, device is collected in addition,

D, above-mentioned twice medicinal residues and all the other. pilose antler Radix Astragali arillus longan Psoralea corylifolia bighead atractylodes rhizome safflower date Radix Glycyrrhizae hawthorn king do not stay the fruit of Chinese wolfberry lily magnolia beans root Fructus Hordei Germinatus fructus amomi oldenlandia diffusa umbellate pore furgus root of bidentate achyranthes dried immature fruit of citron orange gypsum banksia rose santal Amomum cardamomum betel nut rhubarb kaempferia galamga catechu ± soft-shelled turtle worm kaladana cortex periplocae frankincense myrrh bletilla striata dark plum 41 flavor Chinese medicine boilings three times of withering of radix glehniae RADIX SMILACIS SIEBOLDI reticulate millettia hairyvein agrimony turtle shell pangolin smilax melon; Merge decoction liquor; Filter

E, filtrate is concentrated into 1: 1.5～and 3,

F, cooling back add 95% ethanol, and make it always contain the alcohol amount and reach 60～80%,

G, leave standstill filtration after merging, steam to there not being the alcohol flavor with soak among the step b,

H, with step c in volatile oil merge after, add an amount of distilled water, the dilution after-filtration.

Add conventional preservatives and correctives in i, the filtrate, and regulate pH value to prescribed limit.

Antitumor oral liquid according to set of dispense ratio according to the present invention and prepared is brown liquid, feeble QI, the sweet not little hardship of distinguishing the flavor of; Relative density is not less than 1.02, and pH value is 4.5～6.5.

Chinese medicine of the present invention is formed, and mostly is Xin Wen (heat) and hard masses softening and resolving blood circulation promoting and blood stasis dispelling greatly, the product of strengthening the body resistance; The fragrance that has is walked to scurry, hard masses softening and resolving, all warps of each internal organs of owner, the suffering gas that can loose, but warm dispersing cold for relieving pain; This disease belongs to the stasis of blood disease sympotoms caused by cold factors of the traditional Chinese medical science, so with this blood stasis dispelling, cold expelling is helped based on strengthening the body resistance.Therefore oral liquid of the present invention has strengthening the body resistance, and blood circulation promoting and blood stasis dispelling, eliminating stagnation, pain relieving, detoxifcation are not just being hindered thereby reach eliminating evil with anticancer effect, set upright the advantage that does not help heresy.

This medicine is through trying out in clinical for many years, it is evident in efficacy, use through several families hospital clinicals such as province tumour hospital, total effective rate reaches 96%, the then more apparent special effect of the case that has, can make the middle and advanced stage tumor patient change cachexia, appetite stimulator, the detoxifcation pain relieving, the metastatic lesion of the internal energy elimination tumour patient of short-term and dwindle primary lesion can obviously prolong middle and advanced stage patient's life-span simultaneously, having the heresy of attacking is not just hindering, pick out the characteristic that does not just help heresy, thereby improved patient's existence quality greatly, so that the purpose (seeing Appendix 1) of treatment.

This product is made long term toxicity test through Pharmaceutic Inst., No. 4 Millitary Medical Univ. P. L. A., shows that this reagent is nontoxic to human body, is applicable to oral (seeing Appendix 2).

By this product antitumor action is studied, proving has obvious inhibitory action to sarcoma, hepatocarcinoma, breast carcinoma, gastric cancer, and to kinds of tumors effective (seeing Appendix 3).

By to this product stability test, prove that this product is stable, meets Ministry of Public Health provisions for new drugs approval pertinent regulations (seeing Appendix 4) in processes such as storage, transportation, use.

Therefore, this oral liquid can be used for esophageal carcinoma, gastric cancer, intestinal cancer, bone marrow cancer and metastatic tumor of bone, cancer of pancreas, cervical cancer, malignant lymphoma and various cancer recurrence transferrer.The growth of energy anticancer, obviously relief of symptoms eases pain and detoxifies, and various immunologic function deficiency diseases are produced effect.

The following examples are narrated each component in conjunction with preparation method and are formed.

Example 1: with Radix Ginseng 120g, Radix Salviae Miltiorrhizae 250g, Resina Ferulae 36g, Lignum Aquilariae Resinatum 48g mixing is crushed to 50 orders, with 80% alcohol-pickled twice, each 4 hours, and filter, filtrate is numbered NO.1, with medicinal residues and Cornu Cervi Pantotrichum 42g, Fructus Psoraleae 200g, Herba Agrimoniae 250g, Fructus Trichosanthis 120g, Rhizoma Smilacis Glabrae 80g, Rhizoma Kaempferiae 42g, Eupolyphaga Seu Steleophaga 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 36g, Cortex Periplocae 150g merging adds water to and buries medical material, decoct three times, collecting decoction is concentrated into 1: 2, the cooling back adds 95% ethanol, makes it always contain the alcohol amount and reaches 80%, and this solution is numbered NO.2, with No. 1, leave standstill filtration after No. 2 solution merges, being evaporated to does not have the alcohol flavor, adding distil water dilution after-filtration, and add antiseptic, correctives, and regulate pH value to 4.5.

Example 2: Radix Ginseng 130g, Radix Salviae Miltiorrhizae 300g, Resina Ferulae 70g, Lignum Aquilariae Resinatum 70g mixed being crushed to 80 orders, with 85% alcohol-pickled twice.Each 4 hours, filter, filtrate is defined as NO.1, use Radix Angelicae Sinensis 200g, Rhizoma Curcumae 150g, rhizoma sparganic 100g, Radix Notoginseng 50g, Rhizoma Chuanxiong 150g extracts volatile oil with the way of distillation, device is collected in addition, be numbered NO.2, do not stay 120g Radix Glehniae 80g Radix Clematidis 180g Caulis Spatholobi 120g Herba Agrimoniae 120g Carapax Trionycis 160g Squama Manis 60g Rhizoma Smilacis Glabrae 80g Fructus Trichosanthis 120g Fructus Lycii 120g Drymotaenium miyoshianum (Mak.) Mak. Radix Sophorae Tonkinensis 80g Fructus Hordei Germinatus 120g Gypsum Fibrosum 180g Herba Hedyotidis Diffusae 250g Polyporus 120g Radix Achyranthis Bidentatae 40g Fructus Aurantii Immaturus 80g Rhizoma Kaempferiae 36g catechu 40g Radix Aucklandiae 42g Lignum Santali Albi 40g Fructus Amomi Rotundus 40g Semen Arecae 48g Radix Et Rhizoma Rhei 120g Eupolyphaga Seu Steleophaga 40g Semen Pharbitidis 42g Cortex Periplocae 120g Olibanum 42g Myrrha 40g Pseudobulbus Bletillae (Rhizoma Bletillae) 42g Fructus Mume 30g Fructus Amomi 36g41 flavor Chinese medicine to decoct with water three times above-mentioned twice medicinal residues and Cornu Cervi Pantotrichum 40～80g Radix Astragali 260g Arillus Longan 150g Fructus Psoraleae 100g Rhizoma Atractylodis Macrocephalae 180g Flos Carthami 80g Fructus Jujubae 300g Radix Glycyrrhizae 280g mountain wingceltis 120g king, collecting decoction filters, be concentrated into 1: 1.5, the cooling back adds 95% ethanol, make and always contain alcohol and measure 70%, this solution is numbered NO.3, with No. 1 liquid with leave standstill filtration after No. 3 liquid mix, be evaporated to and do not have the alcohol flavor, and merge with No. 2 liquid and to add an amount of distilled water diluting after-filtration, add antiseptic in the filtrate, correctives, and regulate pH value be 6 this product.

Embodiment 3: preparation process is as described in the example 2, but each component ratio is: ginseng 160g pilose antler 40～80g Radix Astragali 260g arillus longan 220g Psoralea corylifolia 180g bighead atractylodes rhizome 250g red sage root 300g Ligusticum wallichii 160g safflower 80g Radix Angelicae Sinensis 220g curcuma zedoary 180g triangular 120g date 500g Radix Glycyrrhizae 350g hawthorn 160g king does not stay the 180g pseudo-ginseng 52g radix glehniae 120g RADIX SMILACIS SIEBOLDI 220g reticulate millettia 160g hairyvein agrimony 160g turtle shell 180g pangolin 80g smilax 100g melon 150g fruit of Chinese wolfberry 150g lily magnolia beans root 100g Fructus Hordei Germinatus 150g asafoetide 80g gypsum 220g agalloch eaglewood 80g oldenlandia diffusa 320g umbellate pore furgus 180g root of bidentate achyranthes 60g dried immature fruit of citron orange 96g kaempferia galamga 48g catechu 56g banksia rose 60g santal 60g Amomum cardamomum 80g betel nut 70g rheum officinale 220g ground bettle 60g kaladana 56g cortex periplocae 150g frankincense 56g myrrh 65g bletilla striata 56g dark plum 42g fructus amomi 48g that withers

Embodiment 4: the preparation method is with 2,3, but each composition weight is: ginseng 100g pilose antler 60g Radix Astragali 200g arillus longan 200g Psoralea corylifolia 150g bighead atractylodes rhizome 200g red sage root 280g Ligusticum wallichii 150g safflower 70g Radix Angelicae Sinensis 200g curcuma zedoary 160g triangular 100g date 400g Radix Glycyrrhizae 320g hawthorn 140g king does not stay the 150g pseudo-ginseng 50g radix glehniae 100g RADIX SMILACIS SIEBOLDI 200g reticulate millettia 140g hairyvein agrimony 140g turtle shell 170g pangolin 70g smilax 90g melon 140g fruit of Chinese wolfberry 130g lily magnolia beans root 90g Fructus Hordei Germinatus 140g asafoetide 65g gypsum 200g agalloch eaglewood 70g oldenlandia diffusa 300g umbellate pore furgus 150g root of bidentate achyranthes 50g dried immature fruit of citron orange 90g kaempferia galamga 42g catechu 50g banksia rose 50g santal 50g Amomum cardamomum 60g betel nut 62g rheum officinale 180g ground bettle 50g kaladana 50g cortex periplocae 130g frankincense 50g myrrh 55g bletilla striata 50g dark plum 35g fructus amomi 40g that withers

Claims (2)

1, a kind of can pain relieving and life-saving, the metastatic lesion of elimination middle and advanced stage tumour patient and the antitumor oral liquid of primary lesion, it is characterized in that it is to be made by the raw material of following consumption:

Radix Ginseng 80～160g Cornu Cervi Pantotrichum 40～80g Radix Astragali 180～260g Arillus Longan 150～220g Fructus Psoraleae 100～180g Rhizoma Atractylodis Macrocephalae 180～250g

The red sage root 250～300g Ligusticum wallichii 120～160g safflower 60～80g Radix Angelicae Sinensis 180～220g curcuma zedoary 120～180g triangular 80～120g date 300～500g Radix Glycyrrhizae 280～350g hawthorn 120～160g king does not stay 120～180g pseudo-ginseng, 42～52g radix glehniae, 80～120g RADIX SMILACIS SIEBOLDI, 180～220g chicken blood to rise 120～160g hairyvein agrimony, 120～160g turtle shell, 160～180g pangolin, 60～80g smilax, 80～100g melon, 120～150g fruit of Chinese wolfberry, 120～150g lily magnolia beans root, 80～100g Fructus Hordei Germinatus, 120～150g asafoetide, 45～80g fructus amomi, 36～48g oldenlandia diffusa, 250～320g umbellate pore furgus, 120～180g root of bidentate achyranthes, 40～60g dried immature fruit of citron orange, 80～96g gypsum, 180～220g agalloch eaglewood, 60～80g santal, the 40～60g that withers

Fructus Amomi Rotundus 40～80g Semen Arecae 48～70g Radix Et Rhizoma Rhei 120～220g Rhizoma Kaempferiae 36～48g catechu 40～56g Eupolyphaga Seu Steleophaga 40～60g Semen Pharbitidis 42～56g Cortex Periplocae 120～150g Olibanum 42～56g Myrrha 40～65g Pseudobulbus Bletillae (Rhizoma Bletillae) 42～56g Fructus Mume 30～42g Radix Aucklandiae 42～60g.

2, the preparation method of the described antitumor oral liquid of a kind of claim 1 is characterized in that comprising following steps:

A, Radix Ginseng 80～160g Radix Salviae Miltiorrhizae 250～300g Resina Ferulae 45～80g Lignum Aquilariae Resinatum 60～80g four flavor Chinese medicines are crushed to 50～100 orders, soak twice with 70～90% ethanol, each more than 4 hours;

B, above-mentioned soak is filtered, filtrate device is in addition preserved;

C, get Radix Angelicae Sinensis 180～220g Rhizoma Chuanxiong 120～160g Rhizoma Curcumae 120～180g rhizoma sparganic 80～120g Radix Notoginseng 42～52g Chinese medicine of the five flavours and extract volatile oil, device is collected in addition;

D, above-mentioned twice medicinal residues and all the other:

40～80g 180～260g 150～220g100～180g 180～250g 60～80g 300～500g 280～350g 120～160g 120～180g 80～120g 180～220g120～160g 120～160g 120～180g60～80g 80～100g 120～150g120～150g 80～100g 120～150g36～48g 250～300g 120～180g40～60g 80～96g 180～220g 42～60g 40～60g 40～80g 48～70g 120～220g 36～48g40～56g 40～60g 42～56g 120～150g 42～56g 40～65g 42～56g 30～42g； 41 flavor Chinese medicine boilings three times; Merge decoction liquor, filter;

E, filtrate is concentrated into 1: 1.5～and 3;

F, cooling back add 95% ethanol, make it always contain the alcohol amount and reach 60～80%;

G, leave standstill filtration after merging, steam to there not being the alcohol flavor with soak among the step b;

H, with step c in volatile oil merge after, add an amount of distilled water, the dilution after-filtration;

Add conventional preservatives and correctives in i, the filtrate, and regulate pH value to prescribed limit.