CN105079704A - Traditional Chinese medicine composition for treating brain glioma and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating brain glioma and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating brain glioma as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following ingredients by weight: 20 parts of ganoderma, 6 parts of mint, 10 parts of cenchrus echinatus, 10 parts of purslane, 10 parts of malus hupehensis leaf, 20 parts of astragalus membranaceus, 15 parts of ligusticum wallichii, 13 parts of hairyvein agrimonia herb and bud, 5 parts of turmeric, 5 parts of lily, 10 parts of radix paeoniae rubra, 12 parts of radix codonopsitis, 8 parts of panax notoginseng, 9 parts of coptis chinensis, 11 parts of centella, 4 parts of lucid asparagus, and 10 parts of poria cocos. The traditional Chinese medicine composition has an excellent curative effect on treating brain glioma, and has a remarkable clinical popularization value.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of Chinese medicine composition and preparation method thereof, be specifically related to a kind of Chinese medicine composition for the treatment of cerebral glioma and preparation method thereof and application.
Background technology
Glioma betides neuroectodermal tumor, therefore also known as neuroectodermal tumors or neurotic triad.Cerebral glioma is a kind of brain tumor disease of high recurrence, the feature of " three high and one low " such as have that the high and cure rate of sickness rate, relapse rate, mortality rate is low, and its pathogenesis etiology is still indefinite so far.Cerebral glioma (cerebral glioma) accounts for 46% of intracranial tumor, and sickness rate is 3 ~ 10 people/100,000 people, and age of onset peak is in 30-40 year, or 10-20 year.Cerebral glioma accounts for 1% ~ 3% of whole body malignant tumor, and the mean survival time (MST) that operation adds chemicotherapy is only 8 ~ 11 months.The growth characteristic of glioma is infiltrative growth, with normal cerebral tissue without obvious boundary, majority is not limited to a cerebral lobe, outside cerebral tissue, deeply destroy cerebral tissue, partially optimum person's poor growth in finger-like, the course of disease is longer, from there is symptom to consultation time average 2 years, pernicious person's tumor bulk-growth is fast, and the course of disease is short, from occurring that symptom is to most within 3 months time medical, 70-80% is many within half a year.
Cerebral glioma is a kind of infiltrative growth tumor, and tradition adopts operative treatment more, but be infiltrative growth due to it, and most and normal cerebral tissue is without obvious boundary, and perform the operation and be difficult to accomplish thorough excision, survival rate is lower.Adopt operative treatment to be main, the postoperative comprehensive therapeutic plan such as radiotherapy, chemotherapy that is aided with can improve curative effect.The chemotherapy work of cerebral glioma is as postoperative adjuvant therapy, and key is the medicine of development specially good effect.Temozolomide's (Temozolomide is called for short TMZ), being a kind of new drug for the treatment of cerebral glioma occurred in recent years, is oral second filial generation alkylating agent.Temozolomide does not directly play a role, under physiology PH condition, change reactive compound into through quick non-enzymatic catalysis, then plays cytotoxicity by the alkylation (methylating) of DNA guanine.Its advantage be have wider Antitumor test, can oral, be easy to through blood brain barrier, safety, do not superpose toxicity with other drug, for treatment malignant glioma brings breakthrough, thus cause extensive concern.But on clinical treatment, temozolomide has significant side effect to bone marrow, lymphsystem, testis and gastrointestinal tract, nausea and vomiting, weak and haematics toxicity can be caused.
Motherland's medical science have accumulated a large amount of theories of Chinese medical science and Chinese medicine practice in treatment cerebral glioma.Chinese medicine is thought: " the essence of five ZANG-organs and six FU-organs gas; all rise in head ", " the brain being the reservoir of the marrow ", " all YANG-meridians meeting into the head ", " mansion of clear sun ", " the brain being the house of mentality " etc., point out that brain is by the poly-part of the clear sun of vital essence, and pivot god etc., and in do not allow heresy, if smart exogenous pathogen is violated, then, there are headache, dizzy, epilepsy, faintness etc. in repiece disease.Cerebral glioma, patient's condition is very grave, Chinese medicine many genus vital QI being weakened and pathogen being violent pathogenesis.People is an organic whole, " cancer is systemic disease ", though tumor is at brain, so caused by internal organs vital essence virtual loss and inside and outside pathogen infringement etc.As " heresy gather, its gas must be empty." " in healthy energy deposits, heresy can not be done." " the positive deficiency of vital energy is diagenesis (cancer) then." " marrow person based on brain, the inverse therefore order headache of brain." " old pathogen ... enter brain then vertigo.It is anxious that vertigo then draws order system, and order system is anxious then dizzy to turn." " the headache disorder of head, deficiency in the upper and excess in the lower." " blood vessels are not all right, and accumulation forms disease also." " expectorant be thing, fall with gas lift, nowhere less than " etc., set forth the Chinese medicine pathogenesis of this class disease from many aspects, and to treatment there is very important directive significance.The present invention aims to provide a kind of determined curative effect, glioma treatment pharmaceutical composition that toxicity is low and preparation method thereof.
Summary of the invention
Effective chemotherapeutics is lacked in existing glioma treatment, the defect that toxic and side is large, for providing one anti-cerebral glioma medicine safely and effectively, the clinical application increasing Patients with gliomas is selected, first object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cerebral glioma, and this Chinese medicine composition has good therapeutic effect in treatment cerebral glioma.Chinese medicine composition of the present invention, raw material primarily of following weight portion obtains: Ganoderma 20 parts, Herba Menthae 6 parts, sandbur 10 parts, Herba Portulacae 10 parts, 10 parts, Caulis et folium euphorbiae milii leaf, the Radix Astragali 20 parts, Rhizoma Chuanxiong 15 parts, Herba Agrimoniae 13 parts, 5 parts, Rhizoma Curcumae Longae, Bulbus Lilii 5 parts, Radix Paeoniae Rubra 10 parts, Radix Codonopsis 12 parts, Radix Notoginseng 8 parts, Rhizoma Coptidis 9 parts, Herba Centellae 11 parts, Radix Asparagi 4 parts, 10 parts, Poria.
Chinese medicinal components in Chinese medicine composition of the present invention is all got its conventional medicinal part and is used as medicine, and wherein the present composition has effect of significant dispersing swelling and dissipating binds, activating blood circulation to dissipate blood stasis, dispelling phlegm and eliminating dampness.Preferably, described Chinese medicine composition is obtained by the raw material of following weight portion: Ganoderma 20g, Herba Menthae 6g, sandbur 10g, Herba Portulacae 10g, Caulis et folium euphorbiae milii leaf 10g, Radix Astragali 20g, Rhizoma Chuanxiong 15g, Herba Agrimoniae 13g, Rhizoma Curcumae Longae 5g, Bulbus Lilii 5g, Radix Paeoniae Rubra 10g, Radix Codonopsis 12g, Radix Notoginseng 8g, Rhizoma Coptidis 9g, Herba Centellae 11g, Radix Asparagi 4g, Poria 10g.
The method preparing Chinese medicine composition of the present invention is as follows: each medical material getting above-mentioned components by weight percent, adds the 5-15 water doubly of medical material gross weight, soaks 10-60 minute, decoct 1-4 time, each 1-3 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, and this relative density is testing result at 60 c, and adding ethanol to alcohol content is 60-90% (v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, to obtain final product.The above-mentioned Chinese medicine composition of the present invention can be prepared into pharmaceutical preparation conventional clinically further, is preferably mixture, tablet, capsule.
The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, i.e. the purposes of above-mentioned Chinese medicine composition in preparation treatment cerebral glioma medicine.Chinese medicine composition of the present invention has significant antiphlogistic effects and strengthens the effect of patient's immunity when being used for cerebral glioma, cerebral glioma is had to the therapeutic effect for the treatment of both the principal and secondary aspects of a disease.By the antiinflammatory action investigating Chinese medicine composition xylol induced mice inflammatory model of the present invention, the embodiment of the present invention 4 confirms that Chinese medicine composition provided by the invention can have significant anti-inflammatory efficacy, its antiphlogistic effects is better than hydrocortisone, wherein high dose group and the antiphlogistic effects of middle dosage group have significant difference (P < 0.05) compared with hydrocortisone, this acts on comprehensively when showing traditional Chinese medicine composition for treating cerebral glioma of the present invention, has obvious synergism, achieves unforeseeable curative effect of medication.The embodiment of the present invention 5 has investigated the inhibitory action of Chinese medicine composition of the present invention to C6 cell in Wistar rat body, experimental result shows, Chinese medicine composition of the present invention can significantly suppress cerebral glioma to grow in vivo, reduce the tumor weight of cerebral glioma, and can life cycle of significant prolongation patient, it has synergistic function in Tumor suppression growth, is better than existing medicine.Compared with positive control drug temozolomide, Chinese medicine composition tumour inhibiting rate of the present invention significantly improves, and life cycle extends greatly, and this shows that Chinese medicine composition of the present invention is significantly better than existing medicine in treatment cerebral glioma.In a word, the present invention compared with prior art, have the activity for the treatment of cerebral glioma very well, and the present invention is pure Chinese medicinal preparation, to human body particularly to liver avirulence.When the present invention is as glioma treatment drug use, drug effect is comprehensive, and while dispersing the stagnated live-QI to relieve the stagnation of QI, spleen invigorating food stagnation removing, can also obtain effect of activating blood circulation to dissipate blood stasis, dispelling phlegm and eliminating dampness, sb.'s illness took a favorable turn can to make rapidly Patients with gliomas; And Chinese medicine composition preparation of the present invention is simple, and substantially nontoxic, raw material is easy to get, and is suitable for popular use, has good potential applicability in clinical practice.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Chinese medicine composition of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Part I, the preparation of Chinese medicine composition of the present invention
Embodiment 1 Chinese medicine composition mixture of the present invention
Prescription: Ganoderma 20g, Herba Menthae 6g, sandbur 10g, Herba Portulacae 10g, Caulis et folium euphorbiae milii leaf 10g, Radix Astragali 20g, Rhizoma Chuanxiong 15g, Herba Agrimoniae 13g, Rhizoma Curcumae Longae 5g, Bulbus Lilii 5g, Radix Paeoniae Rubra 10g, Radix Codonopsis 12g, Radix Notoginseng 8g, Rhizoma Coptidis 9g, Herba Centellae 11g, Radix Asparagi 4g, Poria 10g.
Preparation method: each medical material getting above-mentioned components by weight percent, adds the water of 5 times of medical material gross weight, soaks 30 minutes, decoct 2 times, each 2 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.1, and this relative density is testing result at 60 c, adding ethanol to alcohol content is 75% (v/v), leaves standstill 24 hours, gets supernatant, recovery ethanol concentrates, and adds water to 1000ml, stirs evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
Embodiment 2 Chinese medicine composition tablet of the present invention
Prescription: Ganoderma 200g, Herba Menthae 60g, sandbur 100g, Herba Portulacae 100g, Caulis et folium euphorbiae milii leaf 100g, Radix Astragali 200g, Rhizoma Chuanxiong 150g, Herba Agrimoniae 130g, Rhizoma Curcumae Longae 50g, Bulbus Lilii 50g, Radix Paeoniae Rubra 100g, Radix Codonopsis 120g, Radix Notoginseng 80g, Rhizoma Coptidis 90g, Herba Centellae 110g, Radix Asparagi 40g, Poria 100g.
Preparation method: each medical material getting above-mentioned components by weight percent, adds the water of 10 times of medical material gross weight, soaks 60 minutes, decoct 1 time, each 1 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.25, and this relative density is testing result at 60 c, adding ethanol to alcohol content is 80% (v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulation, tabletting and get final product.
Embodiment 3 Chinese medicinal composition capsules of the present invention
Prescription: Ganoderma 2000g, Herba Menthae 600g, sandbur 1000g, Herba Portulacae 1000g, Caulis et folium euphorbiae milii leaf 1000g, Radix Astragali 2000g, Rhizoma Chuanxiong 1500g, Herba Agrimoniae 1300g, Rhizoma Curcumae Longae 500g, Bulbus Lilii 500g, Radix Paeoniae Rubra 1000g, Radix Codonopsis 1200g, Radix Notoginseng 800g, Rhizoma Coptidis 900g, Herba Centellae 1100g, Radix Asparagi 400g, Poria 1000g.
Preparation method: each medical material getting above-mentioned components by weight percent, adds the water of 8 times of medical material gross weight, soaks 45 minutes, decoct 4 times, each 1.5 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.2, and this relative density is testing result at 60 c, adding ethanol to alcohol content is 90% (v/v), leaves standstill 24 hours, gets supernatant, reclaim ethanol to concentrated, vacuum drying, granulates, encapsulated and get final product.
Part II, the pharmacodynamics of Chinese medicine composition of the present invention is investigated
The antiinflammatory action of embodiment 4 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Hydrocortisone is synthetic is also naturally occurring glucocorticoid, after hydrocortisone enters cell, activates cytoplasmic receptor, nucleus is entered after allosteric, be combined with DNA response element, cause suppression or the induction of genetic transcription, the expression of inflammation related proteins is changed.Hydrocortisone has stronger anti-inflammatory activity, is usually used in the treatment of arthritis, chronic bronchitis conjunction clinically.
1, experimental technique:
50 KM mices, male and female half and half, body weight 25-30 gram, 5 groups are divided at random, i.e. dosage group in model control group, combination group high dose group, compositions, compositions low dose group, positive controls by body weight, often organize 10, each administration group mice gives following medicine respectively:
Model control group: gavage gives the normal saline of same volume;
Positive controls: gavage gives the hydrocortisone drug solution of 5mg/kg;
Compositions high dose group: gavage gives 5g/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Dosage group in compositions: gavage gives 2g/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Compositions low dose group: gavage gives 1g/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Each administration group is administered once every day, successive administration 7d.Get dimethylbenzene 20 μ l after last administration, be applied to each mouse right ear.Get after 30 minutes and be respectively evenly applied to mouse right ear respectively by reagent 0.03ml, auris dextra is put to death after 3.5 hours to dimethylbenzene, measures each group of mice left and right ear method of double differences.Ear method of double differences assay method: place cuts two ears along auricle baseline, lays auricle with 8mm card punch at the same position of left and right ear, weighs, the ear method of double differences=auris dextra sheet weight-left auricle weight.The ear method of double differences can be used as evaluates antiinflammatory index.
Experimental result: measure the antiphlogistic effects that each experimental mice ear method of double differences evaluates each medication group medicine.Measurement result is in table 1.
Table 1 each experimental mice ear method of double differences compares
| Group | n | The ear method of double differences (mg) |
| Model control group | 10 | 8.21±1.15 |
| Positive controls | 10 | 6.15±1.24 * |
| Compositions high dose group | 10 | 2.66±1.75 **## |
| Dosage group in compositions | 10 | 4.53±1.28 **# |
| Compositions low dose group | 10 | 5.93±1.36 * |
Compare with model control group,
*p < 0.05; Compare with model control group,
*p < 0.01;
Compare with positive controls,
#p < 0.05; Compare with positive controls,
##p < 0.01.
Result display gives positive drug and Chinese medicine composition of the present invention all can obtain significant antiphlogistic effects, wherein the antiphlogistic effects of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, and this shows that the antiphlogistic effects of the high dose group of Chinese medicine composition of the present invention, middle dosage group and low dose group significantly will be better than positive controls.
Embodiment 5 Chinese medicine composition of the present invention is tested the inhibitory action of C6 cell in Wistar rat body
1, the foundation of Wistar glioma model:
Select healthy male Wistar rat 80, body weight 250 ~ 280g.Tumor cell adopts C6 brain glioblastoma cell (cell concentration is 1.0 × 106/ul, and cell survival rate is more than 95%).After 2% pentobarbital sodium (40mg/kg) lumbar injection general anesthesia, rat head is fixed on stereotactic apparatus, inoculation target spot coordinate selectes RCN (coordinate: 1.0cm before anterior fontanelle mid point, sagittal suture right other 3.0cm, Subdural space 6.0cm).By cell suspension 3ul for subsequent use with 1ul/3 minute speed injection target spot, after injection, let the acupuncture needle remain at a certain point 5 minutes, and cell is fully deposited.Bone hole is closed with bone wax, postoperative injection penicillin 40,000 U/ day for three days on end after pulling out pin.Sub-cage rearing, observes existing state and the operative incision situation of rat every day.The rat of 12 days after implantation tumor is used for experiment.
2, experiment grouping is as follows with administration final concentration:
Model control group: gavage gives the normal saline of same volume;
Positive controls: gavage gives temozolomide's drug solution of 5mg/kg;
Compositions high dose group: gavage gives 5g/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Dosage group in compositions: gavage gives 2g/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Compositions low dose group: gavage gives 1g/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
3, experimental result statistics is as follows:
The front DMSO of administration dissolves each effective ingredient, every day gastric infusion 1 time.The state of close observation rat after chemotherapy, Discovery Status is not good puts to death at once, records life cycle, before execution animal, injects 0.5% serge blue alcoholic solution, make tumor tissue and cerebral tissue demarcate clearer to the chambers of the heart.Take out Mus brain, isolate tumor body, after weighing ,-70 DEG C of Refrigerator stores are for subsequent use.Often group is got 3 Mus brain 10% formalins and is fixed, for pathological examination.
Calculate tumor control rate:
The average tumor of tumor tumour inhibiting rate=(matched group average tumor weight-administration group average tumor weight)/matched group heavy × 100%
Table 2 compositions is on the impact of Wistar rat brain glioma size
| Group | Tumor weight (g) | Tumour inhibiting rate (%) |
| Model control group | 2.62±0.53 | — |
| Positive controls | 1.46±0.30 ## | 45.2 |
| Compositions low dose group | 0.94±0.25 ##* | 64.4 |
| Dosage group in compositions | 0.87±0.21 ##* | 67.4 |
| Compositions high dose group | 0.72±0.10 ##** | 72.8 |
Compared with model control group,
##p < 0.01; Compared with positive controls group,
*p < 0.05,
*p < 0.01;
Can be found out by the result of above-mentioned table 2, all there were significant differences compared with model control group for each treatment group (P < 0.05), wherein Chinese medicine composition group of the present invention has pole significant difference compared with model control group, also this shows to have significant difference (P < 0.05) compared with positive controls, Chinese medicine composition of the present invention significantly can suppress cerebral glioma to grow in vivo, reduce tumor weight, it has synergistic function in Tumor suppression growth, is better than existing medicine.
Table 3 compositions is on the impact of Wistar survival of rats time
| Group | Time-to-live (my god) |
| Model control group | 18.2±2.32 |
| Positive controls | 32.3±4.45 ## |
| Compositions low dose group | 40.5±5.01 ##* |
| Dosage group in compositions | 43.5±5.12 ##** |
| Compositions high dose group | 45.2±5.23 ##** |
Compared with model control group,
##p < 0.01; Compared with positive controls group,
*p < 0.05,
*p < 0.01;
Can be found out by the result of above-mentioned table 3, all there were significant differences compared with model control group for each treatment group (P < 0.05), Chinese medicine composition group of the present invention has significant difference (P < 0.05) compared with positive controls, and wherein Chinese medicine composition high dose group has the difference of pole significance compared with positive controls.This shows, Chinese medicine composition of the present invention can life cycle of significant prolongation patient, its in vivo Tumor suppression growth there is synergistic function, this tool in clinical practice is of great significance.
Claims (5)
1. treat the Chinese medicine composition of cerebral glioma for one kind, it is characterized in that it obtains primarily of the raw material of following weight portion: Ganoderma 20 parts, Herba Menthae 6 parts, sandbur 10 parts, Herba Portulacae 10 parts, 10 parts, Caulis et folium euphorbiae milii leaf, the Radix Astragali 20 parts, Rhizoma Chuanxiong 15 parts, Herba Agrimoniae 13 parts, 5 parts, Rhizoma Curcumae Longae, Bulbus Lilii 5 parts, Radix Paeoniae Rubra 10 parts, Radix Codonopsis 12 parts, Radix Notoginseng 8 parts, Rhizoma Coptidis 9 parts, Herba Centellae 11 parts, Radix Asparagi 4 parts, 10 parts, Poria.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, it obtains primarily of the raw material of following weight portion: Ganoderma 20g, Herba Menthae 6g, sandbur 10g, Herba Portulacae 10g, Caulis et folium euphorbiae milii leaf 10g, Radix Astragali 20g, Rhizoma Chuanxiong 15g, Herba Agrimoniae 13g, Rhizoma Curcumae Longae 5g, Bulbus Lilii 5g, Radix Paeoniae Rubra 10g, Radix Codonopsis 12g, Radix Notoginseng 8g, Rhizoma Coptidis 9g, Herba Centellae 11g, Radix Asparagi 4g, Poria 10g.
3. pharmaceutical composition as claimed in claim 1, is characterized in that described pharmaceutical composition is mixture, tablet or capsule.
4. prepare the method for Chinese medicine composition as claimed in claim 1 or 2 for one kind, it is characterized in that it comprises the following steps: get each medical material, add the 5-15 water doubly of medical material gross weight, soak 10-60 minute, decoct 1-4 time, each 1-3 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, this relative density is testing result at 60 c, adding ethanol to alcohol content is 60-90% (v/v), leaves standstill 24 hours, gets supernatant, reclaim ethanol to concentrated, to obtain final product.
5. the purposes of the Chinese medicine composition described in claim 1 or 2 in preparation treatment cerebral glioma medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748955A (en) * | 2016-03-16 | 2016-07-13 | 王德亮 | Medicine composition for treating brain glioma and preparation method thereof |
| CN113663052A (en) * | 2021-07-30 | 2021-11-19 | 海南康盾生物制药有限公司 | Pharmaceutical composition for treating brain glioma and preparation method thereof |
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| CN1134294A (en) * | 1995-09-29 | 1996-10-30 | 李修植 | Instant granule preparation for strengthening the body resistance to brain tumor |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
| CN104547362A (en) * | 2015-01-27 | 2015-04-29 | 邹士东 | Traditional Chinese medicine composition for treating glioma and preparation method of traditional Chinese medicine composition |
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- 2015-09-07 CN CN201510563211.0A patent/CN105079704A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134294A (en) * | 1995-09-29 | 1996-10-30 | 李修植 | Instant granule preparation for strengthening the body resistance to brain tumor |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
| CN104547362A (en) * | 2015-01-27 | 2015-04-29 | 邹士东 | Traditional Chinese medicine composition for treating glioma and preparation method of traditional Chinese medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105748955A (en) * | 2016-03-16 | 2016-07-13 | 王德亮 | Medicine composition for treating brain glioma and preparation method thereof |
| CN113663052A (en) * | 2021-07-30 | 2021-11-19 | 海南康盾生物制药有限公司 | Pharmaceutical composition for treating brain glioma and preparation method thereof |
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