CN113081882A - Washing-free skin-care bath lotion and preparation method thereof - Google Patents
Washing-free skin-care bath lotion and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a washing-free skin-care bath lotion and a preparation method thereof, belonging to the technical field of chemical daily necessities. The components of the bath lotion contain coco glucoside surfactant and dihydromyricetin antioxidant. The bath lotion disclosed by the invention has no irritation to skin, is green and nontoxic, ensures that the bath lotion has certain cleaning power, can avoid generating a large amount of foam, keeps the refreshing feeling during use, does not need to be cleaned after use, has strong antioxidant activity, has a good protection effect on the aged skin with damaged skin barrier and dry and water-deficient skin, and is particularly suitable for the aged.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a wash-free skin care bath lotion containing dihydromyricetin (ampelopsin) and a preparation method thereof.
Background
With the increasing aging process of the population, the number of the aged population is rapidly increasing, but the skin care needs of the aged are often neglected. The skin of the elderly is different from that of healthy young and middle-aged people, and is mainly manifested by sagging and loose skin, dryness and roughness. This is due to the impaired hydration of the stratum corneum, decreased water content, increased pH, impaired barrier function of the skin and reduced self-healing capacity of the elderly.
Wiping and bathing are one of the commonly used cleaning methods for old people with reduced mobility due to hypofunction, diseases, nutrition, etc. The common bath rubbing agent is mostly used by diluting with clear water or the existing common bath cream with water. The existing wiping bath only plays a basic cleaning role, is not suitable for the skin characteristics of the old, and cannot well meet the requirements of the old on body care. Common shower gel generally uses soap-based surfactants or sodium lauryl sulfate/sodium lauryl polyether sulfate (SLS/SLES) and the like as main cleaning components, has good cleaning power and strong effect of removing sebum, is easy to damage the fragile skin barrier of the old, causes dry and itching of the skin and aggravates the skin discomfort of the old. When the common shower gel is used for rubbing and bathing, the shower gel needs to be scrubbed for a plurality of times by clear water, which wastes time and labor.
Disclosure of Invention
In order to solve the problems that the skin is dry and needs to be washed by water in the traditional shower gel, the inventor provides a washing-free bath foam which is suitable for the skin characteristics of the old people, has low skin irritation and has dual functions of cleaning and protecting the skin, and the technical scheme is as follows:
a non-washing skin-care bath lotion contains coco glucoside as surfactant and dihydromyricetin as antioxidant, and has skin-care effect on cleaning.
The components of the bath lotion also comprise skin care functional components, preservatives, pH regulators, chelating agents and solvents.
The bath lotion comprises the following components in percentage by mass:
the preparation method of the bath lotion comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water, fully stirring while adding until completely dissolving, and swelling the obtained solution 1 at 2-8 ℃ for 20-28 h; mixing the enzyme-digested oligomeric sodium hyaluronate with 30-40 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2;
2) mixing coco glucoside with 3-15 times of deionized water, stirring, adding bisabolol, squalane, and phenoxyethanol, and stirring to obtain phase A;
3) mixing potassium sorbate and disodium ethylene diamine tetraacetate, and adding deionized water with the mass of 10-15 times of the mixture to obtain a solution 3; mixing betaine and deionized water of equal mass, stirring thoroughly to dissolve completely, adding allantoin, maintaining in 45-55 deg.C water bath for 10-15min, adding solution 1, solution 2 and solution 3, stirring in 45-55 deg.C water bath to dissolve completely to obtain phase B;
4) keeping the temperature of the phase B in a water bath at 45-55 ℃, adding the phase A into the phase B, fully stirring, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the temperature is cooled to room temperature;
5) mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in the last step, adding the rest amount of deionized water, and stirring thoroughly.
Different from the prior art, the technical scheme has the advantages that:
1. the washing-free skin care bath lotion provided by the invention adopts the mild degradable surfactant coco glucoside as a cleaning component, has no irritation to skin, and is green and nontoxic. The invention reduces the dosage of the surfactant in the bath lotion, ensures that the bath lotion has certain cleaning power, can avoid generating a large amount of foam, keeps the refreshing feeling during use and does not need to be cleaned after use.
2. The pH value of the no-wash skin care bath lotion is close to that of normal skin, is weakly acidic, and is beneficial to maintaining the buffer function and the barrier function of the skin.
3. The washing-free skin-care bath lotion disclosed by the invention is added with functional components such as squalane, sodium hyaluronate, bisabolol, betaine, allantoin, dihydromyricetin and the like, can play roles in moisturizing, resisting oxidation, resisting inflammation, relieving skin, promoting cell repair and the like, and has a good protection effect on aged skin with damaged skin barrier and dry and water-deficient skin.
4. The washing-free skin-care bath lotion is particularly suitable for the old, is simple and convenient to operate and is easy to implement.
Detailed Description
In order to explain technical contents, structural features, and objects and effects of the technical means in detail, the following detailed description is given with reference to specific embodiments.
Example 1
1. The washing-free skin-care bath lotion is prepared from the following raw materials in percentage by mass:
2. preparation method
1) Adding low-molecular-weight sodium hyaluronate into 100 times of deionized water for 5-8 times, fully stirring while adding until completely dissolving to obtain a solution 1, and placing at 4 ℃ for fully swelling for 24 hours; and mixing the enzyme-digested oligomeric sodium hyaluronate with 30 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2.
2) Mixing different surfactants with 3-15 times of deionized water, stirring, adding bisabolol, plant squalane and phenoxyethanol, and stirring to obtain phase A.
3) Mixing potassium sorbate and EDTA-2Na, and adding deionized water 15 times the mass of the mixture to obtain a solution 3. Mixing betaine and deionized water of equal mass, stirring thoroughly until completely dissolved, adding allantoin, keeping temperature in 50 deg.C water bath for 10min, adding solution 1, solution 2, and solution 3, stirring in 50 deg.C water bath until completely dissolved to obtain phase B.
4) And (3) preserving the temperature of the phase B in a water bath at 50 ℃, adding the phase A into the phase B, stirring until the phase A is fully mixed, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the phase B is cooled to room temperature.
5) Mixing dihydromyricetin with different solvents, stirring, adding into the solution obtained in step 4, adding the rest deionized water in steps 1-4, and stirring.
3. Screening of surfactants
The ideal surfactant of the no-clean skin-care bath lotion has the characteristics of mildness, degradability, less foaming and good skin feel, so that an amino acid surfactant and an alkyl glycoside surfactant are initially selected as screening objects. The surfactant was mixed with water, observed for appearance, amount of lather, and applied to the skin to test the skin feel. The test results were as follows:
cococo glucoside was chosen as surfactant, with a combination of appearance, lathering level, skin feel.
4. Screening of Dihydromyricetin solvent
Dihydromyricetin has effects of scavenging free radicals and repairing oxidative stress related injury. However, the solubility of dihydromyricetin in normal temperature and cold water is low, and the key point is to fully exert the antioxidation of dihydromyricetin, select a proper solvent and improve the solubility of dihydromyricetin in the no-clean bath lotion. Isopropyl myristate is commonly used as a solvent, skin moisturizer, and penetrant in cosmetics. Ethanol is a common solvent for cosmetics, and has effects of solubilizing and promoting penetration of other components. Mixing dihydromyricetin with isopropyl myristate and ethanol, and observing its solubility. The test results were as follows:
the solubility of dihydromyricetin in ethanol is greater than that in isopropyl myristate, so ethanol is selected as the solvent for dihydromyricetin.
Example 2
1. The washing-free skin-care bath lotion is prepared from the following raw materials in percentage by mass:
2. the preparation method comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water for 5-8 times, fully stirring while adding until completely dissolving to obtain a solution 1, and placing at 4 ℃ for fully swelling for 24 hours; and mixing the enzyme-digested oligomeric sodium hyaluronate with 30 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2.
2) Mixing coco glucoside with 15 times of deionized water, stirring, adding bisabolol, plant squalane, and phenoxyethanol, and stirring to obtain phase A.
3) Mixing potassium sorbate and EDTA-2Na, and adding deionized water 15 times the mass of the mixture to obtain a solution 3. Mixing betaine and deionized water of equal mass, stirring thoroughly until completely dissolved, adding allantoin, keeping temperature in 50 deg.C water bath for 10min, adding solution 1, solution 2, and solution 3, stirring in 50 deg.C water bath until completely dissolved to obtain phase B.
4) And (3) preserving the temperature of the phase B in a water bath at 50 ℃, adding the phase A into the phase B, stirring until the phase A is fully mixed, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the phase B is cooled to room temperature.
5) Mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in step 4, adding the rest deionized water in steps 1-4, and stirring thoroughly.
3. Multiple complete skin irritation tests
The continuous skin irritation test was performed according to the relevant requirements in the technical Specification for cosmetic safety (2015 edition). 4 healthy New Zealand rabbits with half male and female body weight of 2.15-2.5kg are selected, and rabbit hair on two sides of the spine is shaved 24 hours before the test. 0.5mL of no-clean skin-care bath lotion is directly smeared on one side of the skin, and the smearing area is about 2.5cm multiplied by 2.5 cm. The other side was coated with deionized water as control and applied 1 time per day for 14 consecutive days. From the second day of the experiment, newly grown rabbit hairs were shaved off before each application, and the remaining test substance was removed with water. The results were observed after 1 hour after application.
The average integral per animal per day was calculated according to the following formula:
the stimulation intensity of the no-clean skin-care bath lotion to the skin is judged according to the following standards: the integral mean value is 0-less than 0.5, and no irritation exists; integral average value is 0.5-less than 2.0, and light irritation is caused; the integral mean value is 2.0-less than 6.0, and the stimulation is medium; the integral average value is 6.0-8.0, and the stimulation is strong.
The test result shows that the integral mean value of the irritation reaction of the no-clean skin-care bath lotion to the skin of the rabbit is 0, which indicates that the no-clean skin-care bath lotion has no irritation to the skin.
4. Measurement of hydroxyl radical scavenging ability
The hydroxyl radical scavenging ability is determined by using Fe2+And H2O2Mixing and reacting to generate hydroxyl free radical, adding antioxidant to inhibit the hydroxyl free radical, and developing with Griess reagent to obtain a direct proportion relationship between the amount of red substance and the amount of hydroxyl free radical. The hydroxyl radical scavenging capacity of the sample can be calculated by measuring the change of the absorbance value.
Using a hydroxyl radical measurement kit (purchased from Nanjing institute of bioengineering, lot number: 20201219), calculation was performed according to the instructions in the kit. The specific operation steps are as follows: taking 0.1mL of substrate application solution and 0.1mL of bath lotion, mixing uniformly in a water bath at 37 ℃, adding 0.2mL of reagent application solution, reacting for 1min accurately, immediately adding 1mL of color developing agent, mixing uniformly, and standing at room temperature for 20 min. The absorbance value was measured at a wavelength of 550nm using double distilled water as a control.
The hydroxyl radical inhibition rate is calculated by the formula:
since the OD value is small when the hydroxyl radical scavenging ability is measured using the stock solution, the stock solution is diluted and measured.
The stock solution was diluted 2.5 times and tested. The test result shows that the inhibition rate of the no-clean skin-care bath lotion to hydroxyl free radical is 88.74 percent. The no-clean skin care bath lotion has stronger capability of inhibiting hydroxyl free radical.
5. DPPH radical scavenging ability test
DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine) has a lone pair electron in the structure, the methanol or ethanol solution is dark purple, after a free radical scavenger is added, the lone pair electron is paired, DPPH free radicals are reduced into a yellow non-free radical form, and the DPPH free radical scavenging capacity of a sample can be calculated by measuring the change of absorbance values.
The DPPH free radical scavenging ability kit (purchased from Nanjing to institute for bioengineering, lot number: 20201223) is used, the operation is carried out according to the instruction in the kit, and the specific operation steps are as follows: 400 mul of bath lotion and 600 mul of DPPH working solution are added into the measuring tube, mixed evenly and placed in a dark place for 30min at room temperature, and centrifuged for 5min at 4000 rpm. 400 μ L of bath lotion was taken, 600 μ L of 80% methanol was added, and the same procedure as for the measurement tube was conducted, and this was used as a control tube. 400. mu.L of 80% methanol was taken and 600. mu.L of DPPH solution was added to the solution, and the mixture was used as a blank tube in the same manner as the measurement tube. And (3) putting 200 mu L of reaction liquid into a micro cuvette with the optical path of 1cm, adjusting the wavelength to be 517nm and absolute ethyl alcohol to be zero, and determining the absorbance value.
The removal rate of DPPH free radicals by the bath lotion is calculated according to the following formula:
the test result shows that the clearance rate of DPPH free radical of the no-clean skin care bath lotion is 27.80 percent. The washing-free skin care bath lotion has stronger capability of inhibiting DPPH free radicals.
Example 3
1. The washing-free skin-care bath lotion is prepared from the following raw materials in percentage by mass:
2. the preparation method comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water for 5-8 times, fully stirring while adding until the low-molecular-weight sodium hyaluronate is completely dissolved, and placing the obtained solution 1 at 4 ℃ for fully swelling for 24 hours; and mixing the enzyme-digested oligomeric sodium hyaluronate with 30 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2.
2) Mixing coco glucoside with 10 times of deionized water, stirring, adding bisabolol, plant squalane, and phenoxyethanol, and stirring to obtain phase A.
3) Mixing potassium sorbate and EDTA-2Na, and adding deionized water 15 times the mass of the mixture to obtain a solution 3. Mixing betaine and deionized water of equal mass, stirring thoroughly until completely dissolved, adding allantoin, keeping temperature in 50 deg.C water bath for 10min, adding solution 1, solution 2, and solution 3, stirring in 50 deg.C water bath until completely dissolved to obtain phase B.
4) And (3) preserving the temperature of the phase B in a water bath at 50 ℃, adding the phase A into the phase B, stirring until the phase A is fully mixed, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the phase B is cooled to room temperature.
5) Mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in step 4, adding the rest deionized water in steps 1-4, and stirring thoroughly.
3. Multiple complete skin irritation tests
The test method is referred to example 1.
The test result shows that the integral mean value of the irritation reaction of the washing-free skin-care bath lotion to the skin of the rabbit is 0.036, which indicates that the washing-free skin-care bath lotion has no irritation to the skin of the rabbit.
4. Measurement of hydroxyl radical scavenging ability
The test method is referred to example 1.
The stock solution was diluted 5-fold and tested. The test result shows that the inhibition rate of the no-clean skin care bath lotion to hydroxyl free radical is 89.83 percent. The no-clean skin care bath lotion has stronger capability of inhibiting hydroxyl free radical.
5. DPPH radical scavenging ability test
The test method is referred to example 1.
The test result shows that the clearance rate of DPPH free radical of the no-clean skin care bath lotion is 57.52 percent. The washing-free skin care bath lotion has stronger capability of inhibiting DPPH free radicals.
Example 4
1. The washing-free skin-care bath lotion is prepared from the following raw materials in percentage by mass:
2. the preparation method comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water for 5-8 times, fully stirring while adding until the low-molecular-weight sodium hyaluronate is completely dissolved, and placing the obtained solution 1 at 4 ℃ for fully swelling for 24 hours; and mixing the enzyme-digested oligomeric sodium hyaluronate with 30 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2.
2) Mixing coco glucoside with 8 times of deionized water, stirring, adding bisabolol, plant squalane, and phenoxyethanol, and stirring to obtain phase A.
3) Mixing potassium sorbate and EDTA-2Na, and adding deionized water with the mass of 12 times of the mixture to obtain a solution 3. Mixing betaine and deionized water of equal mass, stirring thoroughly until completely dissolved, adding allantoin, keeping temperature in 50 deg.C water bath for 10min, adding solution 1, solution 2, and solution 3, stirring in 50 deg.C water bath until completely dissolved to obtain phase B.
4) And (3) preserving the temperature of the phase B in a water bath at 50 ℃, adding the phase A into the phase B, stirring until the phase A is fully mixed, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the phase B is cooled to room temperature.
5) Mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in step 4, adding the rest deionized water in steps 1-4, and stirring thoroughly.
3. Multiple complete skin irritation tests
The test method is referred to example 1.
The test result shows that the integral mean value of the irritation reaction of the washing-free skin-care bath lotion to the rabbit skin is 0.054, which indicates that the washing-free skin-care bath lotion has no irritation to the rabbit skin.
4. Measurement of hydroxyl radical scavenging ability
The test method is referred to example 1.
The stock solution was diluted 25-fold and tested. The test result shows that the inhibition rate of the no-clean skin-care bath lotion to hydroxyl radical is 85.99%. The no-clean skin care bath lotion has stronger capability of inhibiting hydroxyl free radical.
5. DPPH radical scavenging ability test
The test method is referred to example 1.
The test result shows that the clearance rate of DPPH free radical of the no-clean skin care bath lotion is 68.62 percent. The washing-free skin care bath lotion has stronger capability of inhibiting DPPH free radicals.
Example 5
1. The washing-free skin-care bath lotion is prepared from the following raw materials in percentage by mass:
2. the preparation method comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water for 5-8 times, fully stirring while adding until the low-molecular-weight sodium hyaluronate is completely dissolved, and placing the obtained solution 1 at 4 ℃ for fully swelling for 24 hours; and mixing the enzyme-digested oligomeric sodium hyaluronate with 30 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2.
2) Mixing coco glucoside with 5 times of deionized water, stirring, adding bisabolol, plant squalane, and phenoxyethanol, and stirring to obtain phase A.
3) Mixing potassium sorbate and EDTA-2Na, and adding deionized water with the mass of 12 times of the mixture to obtain a solution 3. Mixing betaine and deionized water of equal mass, stirring thoroughly until completely dissolved, adding allantoin, keeping temperature in 50 deg.C water bath for 15min, adding solution 1, solution 2, and solution 3, stirring in 50 deg.C water bath until completely dissolved to obtain phase B.
4) And (3) preserving the temperature of the phase B in a water bath at 50 ℃, adding the phase A into the phase B, stirring until the phase A is fully mixed, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the phase B is cooled to room temperature.
5) Mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in step 4, adding the rest deionized water in steps 1-4, and stirring thoroughly.
3. Multiple complete skin irritation tests
The test method is referred to example 1.
The test result shows that the integral mean value of the irritation reaction of the washing-free skin-care bath lotion to the skin of the rabbit is 0.16, which indicates that the washing-free skin-care bath lotion has no irritation to the skin of the rabbit.
4. Measurement of hydroxyl radical scavenging ability
The test method is referred to example 1.
The stock solution was diluted 50-fold and tested. Test results show that the inhibition rate of the no-clean skin-care bath lotion to hydroxyl free radicals is 85.05 percent. The no-clean skin care bath lotion has stronger capability of inhibiting hydroxyl free radical.
5. DPPH radical scavenging ability test
The test method is referred to example 1.
The stock solution was diluted 4-fold and tested. The test result shows that the clearance rate of DPPH free radical of the no-clean skin care bath lotion is 66.45 percent. The washing-free skin care bath lotion has stronger capability of inhibiting DPPH free radicals.
Example 6
1. The washing-free skin-care bath lotion is prepared from the following raw materials in percentage by mass:
2. the preparation method comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water for 5-8 times, fully stirring while adding until the low-molecular-weight sodium hyaluronate is completely dissolved, and placing the obtained solution 1 at 4 ℃ for fully swelling for 24 hours; and mixing the enzyme-digested oligomeric sodium hyaluronate with 30 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2.
2) Mixing coco glucoside with 3 times of deionized water, stirring, adding bisabolol, plant squalane, and phenoxyethanol, and stirring to obtain phase A.
3) Mixing potassium sorbate and EDTA-2Na, and adding deionized water with the amount of 10 times of the mixture to obtain a solution 3. Mixing betaine and deionized water of equal mass, stirring thoroughly until completely dissolved, adding allantoin, keeping temperature in 50 deg.C water bath for 15min, adding solution 1, solution 2, and solution 3, stirring in 50 deg.C water bath until completely dissolved to obtain phase B.
4) And (3) preserving the temperature of the phase B in a water bath at 50 ℃, adding the phase A into the phase B, stirring until the phase A is fully mixed, stopping heating, and adding citric acid to adjust the pH value of the system to 5-6 when the phase B is cooled to room temperature.
5) Mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in step 4, adding the rest deionized water in steps 1-4, and stirring thoroughly.
3. Multiple complete skin irritation tests
The test method is referred to example 1.
The test result shows that the integral mean value of the irritation reaction of the washing-free skin-care bath lotion to the skin of the rabbit is 0.11, which indicates that the washing-free skin-care bath lotion has no irritation to the skin of the rabbit.
4. Measurement of hydroxyl radical scavenging ability
The test method is referred to example 1.
The stock solution was diluted 125 times and tested. The test result shows that the inhibition rate of the no-clean skin care bath lotion to hydroxyl free radical is 83.91 percent. The no-clean skin care bath lotion has stronger capability of inhibiting hydroxyl free radical.
5. DPPH radical scavenging ability test
The test method is referred to example 1.
The stock solution was diluted 10-fold and tested. The test result shows that the clearance rate of DPPH free radical of the no-clean skin care bath lotion is 60.42 percent. The washing-free skin care bath lotion has stronger capability of inhibiting DPPH free radicals.
It should be noted that, although the above embodiments have been described herein, the invention is not limited thereto. Therefore, based on the innovative concepts of the present invention, the technical solutions of the present invention can be directly or indirectly applied to other related technical fields by making changes and modifications to the embodiments described herein or by using equivalent structures or equivalent processes performed in the present specification, and are included in the scope of the present invention.
Claims (3)
1. A no-clean skin-care bath lotion is characterized in that: the components of the bath lotion contain coco glucoside surfactant and dihydromyricetin antioxidant.
2. The leave-in skin wipe bath of claim 1, wherein: the bath lotion comprises 2.0-6.0% of coco glucoside, 0.1-0.5% of bisabolol, 0.1-0.3% of allantoin, 1.0-6.0% of plant squalane, 1.0-5.0% of betaine, 0.1-0.5% of enzyme-cutting oligomeric sodium hyaluronate, 0.05-0.25% of low-molecular sodium hyaluronate, 0.002-0.1% of dihydromyricetin, 0.3-0.8% of phenoxyethanol, 0.1-0.6% of potassium sorbate, 0.05-0.2% of disodium ethylenediamine tetraacetic acid, 0.02-0.045% of citric acid, 0.032-1.6% of anhydrous ethanol and the balance of deionized water in percentage by mass.
3. The leave-in skin wipe bath of claim 1 or 2, wherein: the preparation method of the bath lotion comprises the following steps:
1) adding low-molecular-weight sodium hyaluronate into 100 times of deionized water, fully stirring while adding until completely dissolving, and swelling the obtained solution 1 at 2-8 ℃ for 20-28 h; mixing the enzyme-digested oligomeric sodium hyaluronate with 30-40 times of deionized water, and fully stirring until the enzyme-digested oligomeric sodium hyaluronate is completely dissolved to obtain a solution 2;
2) mixing coco glucoside with 3-15 times of deionized water, stirring, adding bisabolol, squalane, and phenoxyethanol, and stirring to obtain phase A;
3) mixing potassium sorbate and disodium ethylene diamine tetraacetate, and adding deionized water with the mass of 10-15 times of the mixture to obtain a solution 3; mixing betaine and deionized water of equal mass, stirring thoroughly to dissolve completely, adding allantoin, maintaining in 45-55 deg.C water bath for 10-15min, adding solution 1, solution 2 and solution 3, stirring in 45-55 deg.C water bath to dissolve completely to obtain phase B;
4) keeping the temperature of the phase B in a water bath at 45-55 ℃, adding the phase A into the phase B, fully stirring, stopping heating, and adding citric acid to adjust the pH of the system to 5-6 when the temperature is cooled to room temperature;
5) mixing dihydromyricetin and anhydrous ethanol, stirring thoroughly until completely dissolved, adding into the solution obtained in the last step, adding the rest amount of deionized water, and stirring thoroughly.
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