CN113057929A - Hand-washing-free disinfection gel - Google Patents
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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Abstract
The invention discloses a hand-washing-free disinfection gel, and belongs to the technical field of disinfection products. The hand-washing-free disinfection gel provided by the invention comprises the following components: quaternized chitosan, polyhexamethylene biguanide, aloe gel freeze-dried powder, sodium hyaluronate, sodium tripolyphosphate and vitamin E. The quaternized chitosan and the polyhexamethylene biguanide are used together, the microbial killing effect is wide, the microbial killing effect is obviously enhanced compared with that of the quaternized chitosan and the polyhexamethylene biguanide which are used independently at the same concentration, drug-resistant bacteria can be effectively killed, the safety is high, no stimulation is caused to the skin, the aloe vera smell is fresh, the skin is smooth and not sticky after the use, and the added vitamin E has the effects of moistening and whitening, and also has the effects of protecting tiny wounds of hands and promoting wound healing by cooperating with the aloe vera freeze-dried powder.
Description
Technical Field
The invention relates to the technical field of disinfection products, in particular to a hand-washing-free disinfection gel.
Background
The hand-washing-free disinfectant can achieve the effects of sterilization and disinfection without water washing, and can effectively avoid cross infection. At present, the sterilization components contained in the hand-free disinfectant commonly used in the market have large irritation to skin, poor stability, unpleasant smell, sticky feeling after use and poor experience.
Therefore, the development of the hand-washing-free disinfection gel which has good stability, high sterilization rate, no irritation, fresh smell and fresh and non-sticky feeling after use has important significance.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the hand-washing-free disinfection gel which is good in stability, high in sterilization rate, fresh, cool, not sticky, nonirritating and fresh in smell.
The purpose of the invention is realized by the following technical scheme:
a hand-free disinfecting gel comprises the following components: quaternized chitosan, polyhexamethylene biguanide, aloe gel freeze-dried powder, sodium hyaluronate, sodium tripolyphosphate and vitamin E.
A hand-washing-free disinfection gel comprises the following components in parts by weight: 0.1-0.3 part of quaternized chitosan, 0.05-0.1 part of polyhexamethylene biguanide, 2-5 parts of aloe gel freeze-dried powder, 0.01-0.1 part of sodium hyaluronate, 0.01-0.03 part of sodium tripolyphosphate and 0.1-0.3 part of vitamin E.
Further, the preparation method of the quaternized chitosan comprises the following steps of: adding chitosan into acetic acid, and stirring for 1.5-2 hours at the temperature of 30-35 ℃ to obtain a chitosan acetic acid solution; secondly, cooling the chitosan acetic acid solution obtained in the step one to 0-3 ℃, adding cyanuric chloride and tetrahydrofuran, stirring, and reacting for 6-10 hours; after the reaction is finished, heating the system to 25-30 ℃, adding triethylamine, stirring, and reacting for 8-12 hours; fourthly, performing suction filtration on the product after the reaction in the third step, repeatedly washing the filter cake with deionized water, and then drying the filter cake in vacuum to obtain the quaternized chitosan.
Further, the mass ratio of the quaternized chitosan to the sodium tripolyphosphate is 10: 1.
Furthermore, the hand-washing-free disinfection gel also comprises other auxiliary agents, wherein the other auxiliary agents are one or more of sodium carboxymethylcellulose, glyceryl stearate, medical vaseline, liquid paraffin, octyl dodecanol, stearic acid, sodium dodecyl sulfate, glycerol and ethylparaben.
A method for preparing a hand-free disinfecting gel comprises the following steps:
(1) placing the aloe gel freeze-dried powder and sodium hyaluronate into a stirrer, adding a proper amount of deionized water, uniformly stirring, and standing to obtain a mixed material for later use;
(2) dispersing quaternized chitosan in water to form quaternized chitosan gel, adding polyhexamethylene biguanide and vitamin E into the quaternized chitosan gel, fully mixing, then adding sodium tripolyphosphate, uniformly stirring to form a reaction solution, quickly adding the material 1 obtained in the step (1) into the reaction solution in the step (2), quickly and uniformly stirring, carrying out room-temperature crosslinking reaction for 10-15 min to form gel, and subpackaging to obtain the hand-washing-free disinfection gel.
The quaternized chitosan used in the hand-washing-free disinfection gel provided by the invention has high charge density and strong bactericidal performance, is cooperated with polyhexamethylene biguanide, has a bactericidal rate of more than 99%, and has good stability without precipitation and delamination through the crosslinking reaction of part of quaternized chitosan and sodium tripolyphosphate.
Compared with the prior art, the invention has the following beneficial effects:
(1) the hand-washing-free disinfection gel provided by the invention combines quaternized chitosan and polyhexamethylene biguanide, has a wide effect of killing microorganisms, has a significantly enhanced sterilization effect compared with the sterilization effect of the quaternized chitosan and the polyhexamethylene biguanide when used alone at the same concentration, and can effectively kill drug-resistant bacteria.
(2) The hand-washing-free disinfection gel provided by the invention is high in safety, free of stimulation to skin, and has fresh aloe smell, the skin is smooth and not sticky after use, and the added vitamin E has the effects of moistening and whitening, and also has the effects of protecting tiny wounds on hands and promoting wound healing in cooperation with the aloe gel freeze-dried powder.
Detailed Description
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments, and is not intended to limit the scope of the present invention; in the description and claims of the present application, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, and materials used in the examples, any methods, devices, and materials similar or equivalent to those described in the examples may be used in the practice of the invention in addition to the specific methods, devices, and materials used in the examples, in keeping with the knowledge of one skilled in the art and with the description of the invention.
Example 1
A hand-washing-free disinfection gel comprises the following components in parts by weight: 0.1 part of quaternized chitosan, 0.05 part of polyhexamethylene biguanide, 2 parts of aloe gel freeze-dried powder, 0.01 part of sodium hyaluronate, 0.01 part of sodium tripolyphosphate, 0.1 part of vitamin E, 2 parts of glycerol and 0.01 part of ethylparaben.
The preparation method comprises the following steps:
(1) placing the aloe gel freeze-dried powder, sodium hyaluronate, glycerol and ethylparaben in a stirrer, adding a proper amount of deionized water, stirring at 1000-2000 rpm for 15-20 min, and standing to obtain a mixed material for later use;
(2) dispersing quaternized chitosan in water to form quaternized chitosan gel, adding polyhexamethylene biguanide and vitamin E into the quaternized chitosan gel, fully mixing, then adding sodium tripolyphosphate, uniformly stirring to form a reaction solution, quickly adding the material 1 obtained in the step (1) into the reaction solution in the step (2), quickly and uniformly stirring, carrying out room-temperature crosslinking reaction for 10-15 min to form gel, and subpackaging to obtain the hand-washing-free disinfection gel.
Example 2
A hand-washing-free disinfection gel comprises the following components in parts by weight: 0.2 part of quaternized chitosan, 0.08 part of polyhexamethylene biguanide, 3 parts of aloe gel freeze-dried powder, 0.05 part of sodium hyaluronate, 0.02 part of sodium tripolyphosphate, 0.2 part of vitamin E, 0.01 part of sodium carboxymethylcellulose and 0.01 part of sodium dodecyl sulfate.
The preparation method comprises the following steps:
(1) placing the aloe gel freeze-dried powder, sodium hyaluronate, sodium carboxymethylcellulose and sodium dodecyl sulfate into a stirrer, adding a proper amount of deionized water, placing the aloe gel freeze-dried powder and the sodium hyaluronate into the stirrer, adding a proper amount of deionized water, stirring at 1000-2000 rpm for 15-20 min, and standing to obtain a mixed material for later use;
(2) dispersing quaternized chitosan in water to form quaternized chitosan gel, adding polyhexamethylene biguanide and vitamin E into the quaternized chitosan gel, fully mixing, then adding sodium tripolyphosphate, uniformly stirring to form a reaction solution, quickly adding the material 1 obtained in the step (1) into the reaction solution in the step (2), quickly and uniformly stirring, carrying out room-temperature crosslinking reaction for 10-15 min to form gel, and subpackaging to obtain the hand-washing-free disinfection gel.
Example 3
A hand-washing-free disinfection gel comprises the following components in parts by weight: 0.3 part of quaternized chitosan, 0.1 part of polyhexamethylene biguanide, 5 parts of aloe gel freeze-dried powder, 0.1 part of sodium hyaluronate, 0.03 part of sodium tripolyphosphate, 0.3 part of vitamin E and 1 part of medical vaseline.
The preparation method comprises the following steps:
(1) placing the aloe gel freeze-dried powder, sodium hyaluronate and medical vaseline in a stirrer, adding a proper amount of deionized water, 1000(1) placing the aloe gel freeze-dried powder and the sodium hyaluronate in the stirrer, adding a proper amount of deionized water, stirring at 1000-2000 rpm for 15-20 min, and standing to obtain a mixed material for later use;
(2) dispersing quaternized chitosan in water to form quaternized chitosan gel, adding polyhexamethylene biguanide and vitamin E into the quaternized chitosan gel, fully mixing, then adding sodium tripolyphosphate, uniformly stirring to form a reaction solution, quickly adding the material 1 obtained in the step (1) into the reaction solution in the step (2), quickly and uniformly stirring, carrying out room-temperature crosslinking reaction for 10-15 min to form gel, and subpackaging to obtain the hand-washing-free disinfection gel.
Comparative example 1
The procedure is as in example 2 except that polyhexamethylene biguanide is not included.
Comparative example 2
The procedure is as in example 2 except that sodium tripolyphosphate is not present, i.e., no crosslinking reaction occurs.
Comparative example 3
The same procedure as in example 2 was repeated, except that the mass ratio of the quaternized chitosan to the sodium tripolyphosphate was 5: 1.
And (3) stability test:
the content of the effective sterilization components in the hand-free disinfection gel before and after being placed is respectively measured by adopting an accelerated test method, the hand-free disinfection gel prepared in 3 embodiments and 3 comparative examples of the invention is placed in a glass container, the glass container is sealed and placed in a constant temperature oven at 37 ℃ for 3 months.
The determination results show that the content of the quaternary ammonium chitosan and the polyhexamethylene biguanide as effective components in the hand-washing-free disinfection gel prepared in the embodiments 1-3 and the comparative examples 1-2 is reduced by less than 1%; the hand-washing-free disinfection gel prepared in the examples 1-3 and the comparative example 1 has no phenomena of precipitation, delamination and the like, while the comparative example 2 has a delamination phenomenon and the comparative example 3 has a precipitation phenomenon.
Skin irritation test:
the hand-free disinfection gel provided by 3 embodiments and 3 comparative examples of the invention is smeared on the damaged skin of New Zealand white rabbits for 4 hours, the average value of the total integral is 0, the skin irritation index is less than 0.5, and the irritation strength is nonirritant.
And (3) bacteriostatic test:
the hand-free disinfection gel prepared in the examples 1-3 and the comparative examples 1-2 was tested for bacteriostasis rate according to the method in appendix C of 15979 plus 2002 hygienic Standard for Disposable sanitary articles, and the test results are shown in Table 1:
TABLE 1
As can be seen from Table 1, the hand-washing-free disinfection gel prepared in the embodiments 1 to 3 of the invention has a good effect of killing escherichia coli, staphylococcus aureus, candida albicans and aspergillus niger, and the bacteriostasis rate is greater than 95%. The comparative example 1 contains no polyhexamethylene biguanide, and the bacteriostasis rate is lower than that of examples 1-3, which shows that the quaternized chitosan and the polyhexamethylene biguanide can be synergistically enhanced when being used together; comparative example 2 does not contain sodium tripolyphosphate, the bacteriostasis rate is reduced, and the crosslinking structure in the disinfection gel is supposed to play a certain promoting role in the bacteriostasis process; comparative example 3 the mass ratio of the quaternized chitosan to the sodium tripolyphosphate is 5:1, the bacteriostasis rate is lower than that of example 2, even lower than that of comparative example 2, and it is speculated that the gel curing is serious and the contact of the bactericidal component and bacteria is not facilitated due to the excessively high crosslinking degree, which shows that the mass ratio of the quaternized chitosan to the sodium tripolyphosphate has an important influence on the bacteriostasis effect of the disinfection gel.
The above description is only for the specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and other modifications or equivalent substitutions made by the technical solution of the present invention by the ordinary skilled in the art should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (6)
1. A hand-washing-free disinfecting gel is characterized by comprising the following components: quaternized chitosan, polyhexamethylene biguanide, aloe gel freeze-dried powder, sodium hyaluronate, sodium tripolyphosphate and vitamin E.
2. The hand-washing-free disinfecting gel as claimed in claim 1, which is characterized by comprising the following components in parts by weight: 0.1-0.3 part of quaternized chitosan, 0.05-0.1 part of polyhexamethylene biguanide, 2-5 parts of aloe gel freeze-dried powder, 0.01-0.1 part of sodium hyaluronate, 0.01-0.03 part of sodium tripolyphosphate and 0.1-0.3 part of vitamin E.
3. A hand sanitizer gel according to claim 1 or 2, wherein said quaternized chitosan is prepared by a process comprising the steps of: adding chitosan into acetic acid, and stirring for 1.5-2 hours at the temperature of 30-35 ℃ to obtain a chitosan acetic acid solution; secondly, cooling the chitosan acetic acid solution obtained in the step one to 0-3 ℃, adding cyanuric chloride and tetrahydrofuran, stirring, and reacting for 6-10 hours; after the reaction is finished, heating the system to 25-30 ℃, adding triethylamine, stirring, and reacting for 8-12 hours; fourthly, performing suction filtration on the product after the reaction in the third step, repeatedly washing the filter cake with deionized water, and then drying the filter cake in vacuum to obtain the quaternized chitosan.
4. A hand-free disinfecting gel according to claim 1 or 2, characterized in that the mass ratio of the quaternized chitosan to sodium tripolyphosphate is 10: 1.
5. A hand sanitizer gel in accordance with claim 1 or 2, further comprising other adjuvants, wherein said other adjuvants are one or more selected from the group consisting of sodium carboxymethylcellulose, glyceryl stearate, medical petrolatum, liquid paraffin, octyldodecanol, stearic acid, sodium lauryl sulfate, glycerin, and ethylparaben.
6. A method of preparing a hands-free disinfecting gel as claimed in any one of claims 1 to 5, comprising the steps of:
(1) placing the aloe gel freeze-dried powder and sodium hyaluronate into a stirrer, adding a proper amount of deionized water, uniformly stirring, and standing to obtain a mixed material for later use;
(2) dispersing quaternized chitosan in water to form quaternized chitosan gel, adding polyhexamethylene biguanide and vitamin E into the quaternized chitosan gel, fully mixing, then adding sodium tripolyphosphate, uniformly stirring to form a reaction solution, quickly adding the material 1 obtained in the step (1) into the reaction solution in the step (2), quickly and uniformly stirring, carrying out room-temperature crosslinking reaction for 10-15 min to form gel, and subpackaging to obtain the hand-washing-free disinfection gel.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645455A (en) * | 2022-11-01 | 2023-01-31 | 宁波泉水生物科技有限公司 | High-concentration ethanol/chitosan derivative wash-free disinfection gel composition and application thereof |
| CN115645455B (en) * | 2022-11-01 | 2023-08-25 | 中山自然说生物科技有限公司 | High-concentration ethanol/chitosan derivative washing-free disinfection gel composition and application thereof |
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| CN113057929B (en) | 2023-03-17 |
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