CN111714693A - Cellulose antibacterial film and preparation method thereof - Google Patents

Cellulose antibacterial film and preparation method thereof Download PDF

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Publication number
CN111714693A
CN111714693A CN202010646207.1A CN202010646207A CN111714693A CN 111714693 A CN111714693 A CN 111714693A CN 202010646207 A CN202010646207 A CN 202010646207A CN 111714693 A CN111714693 A CN 111714693A
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polyethyleneimine
polydopamine
solution
bacterial cellulose
film
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钟成
赵雪晴
赵翔军
秦晓彤
法兹利·瓦希德
贾士儒
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Tianjin University of Science and Technology
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Tianjin University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

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  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

The invention discloses a preparation method of a novel biocompatible antibacterial bacterial cellulose/polydopamine/polyethyleneimine antibacterial film, belonging to the technical field of biomedical gel and being characterized by comprising the following steps: (1) preparation of polydopamine solution and polyethyleneimine solution (2) impregnation and compounding of the bacterial cellulose/polydopamine/polyethyleneimine composite membrane. The method has the advantages of simple film formation, no toxicity, no harm, good antibacterial property and the like. Due to the existence of the bacterial cellulose, the prepared antibacterial film has high mechanical strength. Compared with the traditional micromolecule antibacterial material, the bacterial cellulose// polydopamine/polyethyleneimine antibacterial film prepared by the invention has broad-spectrum antibacterial effect and good biocompatibility.

Description

Cellulose antibacterial film and preparation method thereof
Technical Field
The invention relates to the technical field of biomedical gel, in particular to a preparation method of an antibacterial bacterial cellulose/polydopamine/polyethyleneimine antibacterial film with good biocompatibility.
Background
At present, skin wounds caused by medical operations or accidents such as fire and traffic accidents are inevitable, and infectious diseases caused by bacteria, fungi and viruses also become more and more serious health threats. The most common complication in the care of skin burn wounds is wound infection, a process accompanied by massive exudate, resulting in breakdown of various growth factors and extracellular matrix, and impaired wound growth and wound healing. The dressing can prevent the wound surface from secondary damage in the process of nursing the wound, and the novel medical dressing also becomes a hotspot of social research more and more. At present, the auxiliary materials on the market are various in types, but the quality is different, for example, the performance of absorbing wound exudate is poor, the cost is high, the wound is easy to be infected, and the like, the auxiliary materials can generate greater threat to the wound rehabilitation of patients, so that the research on novel antibacterial materials is still the key research direction in the field of medical dressing materials.
The traditional antibacterial materials are prepared by introducing some antibacterial agents (such as antibiotics, quaternary ammonium salts, bactericides and the like) on the surface or the body of the materials by a chemical or physical method to endow the biomedical materials with certain antibacterial capability. The Bacterial Cellulose (BC) has the advantages of hyperfine three-dimensional network structure, no toxicity, no harm, high crystallinity, good moisture absorption and retention performance, good biocompatibility, extremely high tensile strength and the like, thereby having great prospect in the field of biomedical dressings. The bacterial cellulose-based hydrogel can effectively relieve pain, has good adhesiveness, effectively prevents bacterial invasion and infection, is beneficial to skin tissue growth, and quickly promotes wound healing.
The bacterial cellulose has no inhibition or sterilization capability on bacteria, so that the bacterial cellulose has the bacteriostatic capability and can be widely applied to the field of medical dressings. The poly-dopamine (PDA) can be generated at normal temperature, has the characteristics of good stability, strong water dispersibility, good biocompatibility and the like, can be used for carrying out secondary functional modification on a nano material, and can have a better adsorption effect on sewage by compounding the nano material with an environmental material. PDA has a large number of active sites for combining heavy metal ions and organic matters through multiple interactions such as electrostatic interaction, coordination or chelation, hydrogen bonding or pi-pi stacking, and the like, so that the adhesion capability can be obviously improved. Polyethyleneimine (PEI) has excellent antibacterial properties due to polycationic properties, and has good biocompatibility for L929 fibroblasts. Therefore, the polydopamine and the polyethyleneimine are compounded on the bacterial cellulose, so that the cellulose-based material can have good antibacterial performance, and technical support is provided for developing a novel cellulose antibacterial film medical dressing material.
Disclosure of Invention
The invention aims to provide a novel antibacterial bacterial cellulose/polydopamine/polyethyleneimine composite membrane with excellent biocompatibility and a preparation method thereof. The composite membrane has good antibacterial activity and lasting antibacterial activity.
The technical principle of the invention is as follows:
the bacterial cellulose/polydopamine/polyethyleneimine antibacterial film is prepared by taking bacterial cellulose natural hydrogel with good biocompatibility as a main material and adopting a dipping and compounding method.
In order to achieve the above object and solve the above technical problems, the present invention adopts the following technical solutions:
(1) preparing a polydopamine solution:
756mL of deionized water, 6mL of ammonia water and 336mL of ethanol were mixed in a beaker and stirred for 30 min. 4.2g dopamine was dissolved in 84mL deionized water and added to a medium beaker and mixed well. The polydopamine solution was equally divided into 10 500mL volumetric flasks.
(2) Preparing a polyethyleneimine solution:
2g,4g,6g and 10g of polyethyleneimine are respectively weighed and dissolved in 200mL of deionized water to prepare polyethyleneimine solutions with concentrations of 1%, 2%, 3% and 5%. The polyethyleneimine solution was equally distributed in 10 500mL volumetric flasks.
(3) Dipping and compounding the bacterial cellulose/polydopamine/polyethyleneimine composite membrane:
placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours. Taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, placing into polyethyleneimine solution, shaking and soaking at 100rpm and 30 deg.C in a shaking table for compounding for 24 h.
Moreover, the concentration of the polydopamine solution is 3.55 g/L.
The concentrations of the polyethyleneimine solutions were 1%, 2%, 3%, and 5%, respectively.
The invention has the beneficial effects that:
(1) the bacterial cellulose/polydopamine/polyethyleneimine antibacterial film prepared by the invention has good antibacterial effects on staphylococcus aureus, escherichia coli, bacillus subtilis and pseudomonas aeruginosa.
(2) Compared with the traditional micromolecule antibacterial material, the invention provides a preparation method of a broader-spectrum antibacterial composite material.
(3) The antibacterial composite membrane prepared by the invention has good biocompatibility, biodegradability, no toxicity and high mechanical strength.
Drawings
FIG. 1 is a diagram showing the effect of the bacterial cellulose/polydopamine/polyethyleneimine antibacterial film prepared by the invention.
FIG. 2 is a diagram showing the experimental effect of the bacterial cellulose/polydopamine/polyethyleneimine antibacterial film on the inhibition zones of staphylococcus aureus, escherichia coli, bacillus subtilis and pseudomonas aeruginosa. (BP, BPP-1, BPP-2, BPP-3, BPP-5, for BC/PDA, respectively, and 1%, 2%, 3%, 5% PEI concentration in BC/PDA/PEI, respectively.)
FIG. 3 is a scanning electron micrograph (5.00. mu.m on the scale) of a 5% PEI concentration of 3% respectively in PDA, BC/PDA/PEI of the present invention.
Detailed Description
In order to better understand the present invention, the following examples are further provided to illustrate the present invention, but the present invention is not limited to the following examples. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A cellulose antibacterial film and a preparation method thereof are characterized by comprising the following steps:
(1) preparing a polydopamine solution: 756mL of deionized water, 6mL of ammonia water and 336mL of ethanol were mixed in a beaker and stirred for 30 min. 4.2g dopamine was dissolved in 84mL deionized water and added to a medium beaker and mixed well. The polydopamine solution was equally divided into 10 500mL volumetric flasks.
(2) Preparation of polyethyleneimine solution: 2g,4g,6g and 10g of polyethyleneimine are respectively weighed and dissolved in 200mL of deionized water to prepare polyethyleneimine solutions with concentrations of 1%, 2%, 3% and 5%. The polyethyleneimine solution was equally distributed in 10 500mL volumetric flasks.
(3) Dipping and compounding the bacterial cellulose/polydopamine/polyethyleneimine composite membrane: placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours. Taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, placing into polyethyleneimine solution, shaking and soaking at 100rpm and 30 deg.C in a shaking table for compounding for 24 h.
(4) Preparing a bacterial cellulose/polydopamine/polyethyleneimine composite membrane: and taking out the wet film after the dipping and compounding, and naturally airing in the air to obtain the bacterial cellulose/polydopamine/polyethyleneimine film.
Example 2
Placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours. Taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, placing into 1% polyethyleneimine solution, shaking and soaking at 100rpm and 30 deg.C in a shaking table for compounding for 24 h.
And taking out the wet film after the dipping and compounding, and naturally airing in the air to obtain the bacterial cellulose/polydopamine/polyethyleneimine film.
Example 3
Placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours. Taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, placing into 2% polyethyleneimine solution, shaking and soaking at 100rpm and 30 deg.C in a shaking table for compounding for 24 h.
And taking out the wet film after the dipping and compounding, and naturally airing in the air to obtain the bacterial cellulose/polydopamine/polyethyleneimine film.
Example 4
Placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours. Taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, placing into 3% polyethyleneimine solution, shaking and soaking at 100rpm and 30 deg.C in a shaking table for compounding for 24 h.
And taking out the wet film after the dipping and compounding, and naturally airing in the air to obtain the bacterial cellulose/polydopamine/polyethyleneimine film.
Example 5
Placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours. Taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, placing into 5% polyethyleneimine solution, shaking and soaking at 100rpm and 30 deg.C in a shaking table for compounding for 24 h.
And taking out the wet film after the dipping and compounding, and naturally airing in the air to obtain the bacterial cellulose/polydopamine/polyethyleneimine film.

Claims (4)

1. A cellulose antibacterial film and a preparation method thereof are characterized by comprising the following steps:
(1) preparing a polydopamine solution: uniformly mixing 756mL of deionized water, 6mL of ammonia water and 336mL of ethanol in a beaker, stirring for 30min, dissolving 4.2g of dopamine in 84mL of deionized water, adding the deionized water into the beaker, uniformly mixing, and averagely distributing polydopamine solution into 10 500mL volumetric flasks;
(2) preparing a polyethyleneimine solution: respectively weighing 2g,4g,6g and 10g of polyethyleneimine, dissolving in 200mL of deionized water to prepare 1%, 2%, 3% and 5% polyethyleneimine solution, and averagely distributing the polyethyleneimine solution into 10 500mL volumetric flasks;
(3) dipping and compounding the bacterial cellulose/polydopamine/polyethyleneimine composite membrane: placing the bacterial cellulose film cultured for 7d in a 500mL volumetric flask filled with polydopamine solution, placing the volumetric flask in a shaking table at 100rpm and 30 ℃, and carrying out shaking, dipping and compounding for 24 hours; taking out the bacterial cellulose film in Polydopamine (PDA) solution, washing with deionized water for 2-3 times, putting into polyethyleneimine solution, shaking and soaking at 100rpm and 30 ℃ in a shaking table for compounding for 24 h;
(4) preparing a bacterial cellulose/polydopamine/polyethyleneimine composite membrane: and taking out the wet film after the dipping and compounding, and naturally airing in the air to obtain the bacterial cellulose/polydopamine/polyethyleneimine film.
2. The method of preparing a polydopamine solution according to claim 1, wherein: the concentration of the polydopamine solution is 3.55 g/L.
3. The method for preparing a polyethyleneimine solution according to claim 1, wherein: the concentrations of the polyethyleneimine solutions were 1%, 2%, 3%, and 5%, respectively.
4. The preparation method of the bacterial cellulose/polydopamine/polyethyleneimine composite membrane according to claim 1, wherein the preparation method comprises the following steps: the dipping and compounding conditions are 100rpm and 30 ℃, and the mixture is placed in a shaking table to be shaken, dipped and compounded for 24 hours.
CN202010646207.1A 2020-07-07 2020-07-07 Cellulose antibacterial film and preparation method thereof Pending CN111714693A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113121872A (en) * 2019-12-30 2021-07-16 华东交通大学 Polydopamine/polyethyleneimine codeposition coating modified bacterial cellulose and preparation method thereof
CN114246181A (en) * 2021-12-27 2022-03-29 华南师范大学 Antibacterial material and preparation method and application thereof

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113121872A (en) * 2019-12-30 2021-07-16 华东交通大学 Polydopamine/polyethyleneimine codeposition coating modified bacterial cellulose and preparation method thereof
CN114246181A (en) * 2021-12-27 2022-03-29 华南师范大学 Antibacterial material and preparation method and application thereof
CN114246181B (en) * 2021-12-27 2023-06-13 华南师范大学 Antibacterial material and preparation method and application thereof

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Application publication date: 20200929