CN105381500A - Functional wound surface repairing material and preparation method thereof - Google Patents
Functional wound surface repairing material and preparation method thereof Download PDFInfo
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- CN105381500A CN105381500A CN201510815832.3A CN201510815832A CN105381500A CN 105381500 A CN105381500 A CN 105381500A CN 201510815832 A CN201510815832 A CN 201510815832A CN 105381500 A CN105381500 A CN 105381500A
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- bioactivity glass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0095—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention belongs to the field of medical materials and particularly relates to a functional wound surface repairing material and a preparation method thereof. The wound surface repairing material is prepared by compounding 7-14 parts of bioactive glass, 0.5-0.7 part of silver nitrate, 0.2-0.6 part of antibiotics, 15-25 parts of degradable polymer and 80-160 parts of deionized water. The functional wound surface repairing material is loaded with silver ions and antibiotics, wherein the silver ions and the antibiotics respectively have bactericidal performance, and the silver ions can enable the antibiotics to more easily enter bacteria to exert synergistic action by increasing the generation of oxygen free radicals and increasing the permeability of bacterial membranes, so that the functional wound surface repairing material has relatively strong antibacterial performance and can solve the problem that bacteria are easy to adhere to the existing wound surface repairing material to cause infection and then the curative effect is not ideal.
Description
Technical field
The invention belongs to field of medical materials, relate to Wound surface active repair material, be specifically related to a kind of functional wound repair material and preparation method thereof.
Background technology
The repair materials of prior art treatment wound surface has a lot, but in wound surface osmotic absorption, promote angiogenic growth, and wound healing minimizing spot formation aspect haves much room for improvement, particularly to the difficulty healing wound surface that hemorrhoid, burn, diabetic ulcer and unknown cause cause, treatment effect is poorer, brings the misery on serious mind & body to patient, adds the financial burden of patient.
Research through decades finds, bioactivity glass has certain cell and gene activation effect, the proliferation and differentiation of osteocyte can not only be promoted, chemical bonding is formed with osseous tissue, can also be combined with soft tissue, promote skin regeneration---just according to this characteristic, people develop again the bioactivity glass repair materials that can promote union of wounded skin.Multiplely used for main active external medical accessory such as skin life, De Molin etc. with it, preliminary study shows, and this series products has higher effectiveness and safety.
Repair materials based on bioactivity glass has very excellent biological activity, in application clinicalization increasingly of tissue repair and alternative aspect, but a lot of researchs in recent years show, when bioactivity glass contacts with tissue, one deck albuminous coat is formed at material surface, be easy to Adherent bacteria, then growth and breeding generation severe infections, thus cause wound surface to be difficult to healing.Therefore, research and development have the bioactivity glass of anti-microbial property, treatment reparation and prevention infection are integrated and have very important medical value.
Summary of the invention
One object of the present invention is to provide a kind of functional wound repair material and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of functional wound repair material, it is characterized in that, be prepared from by bioactivity glass, silver nitrate, antibiotic and the degradable polymer compound that adds water, each raw material components is counted by weight: bioactivity glass 7 ~ 14 parts, silver nitrate 0.5 ~ 0.7 part, 0.2 ~ 0.6 part, antibiotic, degradable polymer 15 ~ 25 parts, deionized water 80 ~ 160 parts.
In such scheme, each raw material components of described bioactivity glass is counted by weight: 50 ~ 55 parts of calcium silicates, 5 ~ 15 parts of calcium hydrogen phosphate, 5 ~ 15 parts of sodium hydrogen phosphates and 35 ~ 40 parts of sodium silicate.
In such scheme, the particle diameter of described bioactivity glass is 20 ~ 100um.
In such scheme, described antibiotic is the one in chloromycetin, chlortetracycline, oxytetracycline and tetracycline.
In such scheme, described degradable polymer is one or both in matter acid, chitosan, sodium alginate and polyvinyl alcohol, during two kinds of mixing be any than.
The preparation method of above-mentioned functions wound repair material, comprises the steps:
(1) preparation of bioactivity glass: take 50 ~ 55 parts of calcium silicates, 5 ~ 15 parts of calcium hydrogen phosphate, 5 ~ 15 parts of sodium hydrogen phosphates and 35 ~ 40 parts of sodium silicate, make uniform melt at the temperature of 1250 ~ 1300 DEG C, namely obtains bioactivity glass after cooling, pulverizing;
(2) preparation of silver-colored support type bioactivity glass: take bioactivity glass 7 ~ 14 parts, silver nitrate 0.5 ~ 0.7 part, adds a small amount of deionized water, stirring reaction 4h at 40 ~ 60 DEG C, and filtration washing drying obtains silver-colored support type bioactivity glass;
(3) preparation of functional wound repair material: take 80 ~ 160 parts of deionized waters, add the silver-colored support type bioactivity glass that step (2) prepares, 0.2 ~ 0.6 part of antibiotic, 15 ~ 25 parts of degradable polymers wherein, stir, obtain functional wound repair material after deaeration.
Functional wound repair material of the present invention adopts bioactivity glass, silver nitrate, antibiotic, degradable polymer to add water and be prepared from.Wherein, silver ion, antibiotic have bactericidal property separately, and silver ion by increasing the generation of oxygen-derived free radicals and increasing the permeability of bacterial cell membrane, can make antibiotic more easily enter antibacterial and play synergism in addition; At skin wound, bioactivity glass can promote that wound surface grows, and can be used as film forming crosslinking agent, realizes skin healing; Bioactivity glass, degradable polymer have good biocompatibility simultaneously, under both synergism, can promote the increase of wound tissue Concentrations of Epidermal Growth Factor content, suppress collagenous tissue contracture.In addition, the functional wound repair material that preparation method of the present invention obtains exists with the form of composite aquogel, and bioactivity glass, silver ion, antibiotic are in the product dispersed, is not easy to reunite or sedimentation; Meanwhile, antibiotic is wrapped up by degradable polymer, can realize the object of product controlled slow releasing over the course for the treatment of.
Beneficial effect of the present invention is as follows:
(1) functional wound repair material load silver ion of the present invention and antibiotic, wherein, silver ion, antibiotic have bactericidal property separately, in addition silver ion can by increasing the generation of oxygen-derived free radicals and increasing the permeability of bacterial cell membrane, make antibiotic more easily enter antibacterial and play synergism, therefore, functional wound repair material of the present invention has stronger anti-microbial property, can solve the problem that the easy Adherent bacteria of existing wound repair material causes infecting and then therapeutic effect is undesirable.
(2) functional wound repair material of the present invention exists with the form of composite aquogel, solves bioactivity glass powder and not easily fixes, and is difficult in the uniform problem of wound surface smearing; In wound repair material, load has degradable polymer simultaneously, degradable polymer has good biocompatibility, is attached directly on wound surface, has certain film property and repairs wound effect, can grow by wound healing, reduce dressing change frequency and cicatrix generation;
(3) the invention solves existing wound repair material, to there is permeability too high, wound surface is easily caused to dewater, and the problem such as mechanical injuries, in functional wound repair material of the present invention, bioactivity glass, silver ion, antibiotic are in the product dispersed, are not easy to reunite or sedimentation; Meanwhile, antibiotic is wrapped up by degradable polymer, can realize the object of product controlled slow releasing over the course for the treatment of.
Detailed description of the invention
In order to understand the present invention better, illustrate content of the present invention further below in conjunction with embodiment, but content of the present invention is not only confined to the following examples.
Embodiment 1
A kind of functional wound repair material, prepares by the following method:
(1) preparation of bioactivity glass: take 5g calcium silicates, 0.5g calcium hydrogen phosphate, 0.5g sodium hydrogen phosphate and 3.5g sodium silicate, make uniform melt, cool, be crushed to 20-100um and namely obtain bioactivity glass at the temperature of 1250 DEG C;
(2) preparation of silver-colored support type bioactivity glass powder: take bioactivity glass 7g, add in the 50g aqueous solution containing 0.5g silver nitrate, stirring reaction 4h at 40 DEG C, filtration washing drying obtains silver-colored support type bioactivity glass;
(3) preparation of functional wound repair material: take 160g deionized water, add silver-colored support type bioactivity glass that step (2) prepares, 0.2g chloromycetin, the acid of 15g matter wherein, stir, obtain functional wound repair material after deaeration.
Embodiment 2
A kind of functional wound repair material, prepares by the following method:
(1) preparation of bioactivity glass: take 5.2g calcium silicates, 1g calcium hydrogen phosphate, 1.5g sodium hydrogen phosphate and 3.7g sodium silicate, make uniform melt, cool, be crushed to 20-100um and namely obtain bioactivity glass at the temperature of 1250 DEG C;
(2) preparation of silver-colored support type bioactivity glass: take bioactivity glass 7g, add in the 50g aqueous solution containing 0.6g silver nitrate, stirring reaction 4h at 50 DEG C, filtration washing drying obtains silver-colored support type bioactivity glass;
(3) preparation of functional wound repair material: take 120g deionized water, add silver-colored support type bioactivity glass, 0.4g chlortetracycline, 20g chitosan that step (2) prepares wherein, stir, obtain functional wound repair material after deaeration.
Embodiment 3
A kind of functional wound repair material, prepares by the following method:
(1) preparation of bioactivity glass: take 5.5g calcium silicates, 1.5g calcium hydrogen phosphate, 1g sodium hydrogen phosphate and 4g sodium silicate, make uniform melt, cool, be crushed to 20-100um and namely obtain bioactivity glass at the temperature of 1250 DEG C;
(2) preparation of silver-colored support type bioactivity glass: take bioactivity glass 7g, add in the 50g aqueous solution containing 0.7g silver nitrate, stirring reaction 4h at 60 DEG C, filtration washing drying obtains silver-colored support type bioactivity glass;
(3) preparation of functional wound repair material: take 80g deionized water, add silver-colored support type bioactivity glass, 0.6g oxytetracycline, 10g chitosan, 15g sodium alginate that step (2) prepares wherein, stir, obtain functional wound repair material after deaeration.
Embodiment 4
A kind of functional wound repair material, prepares by the following method:
(1) preparation of bioactivity glass: take 5g calcium silicates, 1.5g calcium hydrogen phosphate, 1.5g sodium hydrogen phosphate and 3.5g sodium silicate, make uniform melt, cool, be crushed to 20-100um and namely obtain bioactivity glass (BAG4) at the temperature of 1250 DEG C;
(2) preparation of silver-colored support type bioactivity glass powder: take bioactivity glass 7g, add in the 50g aqueous solution containing 0.6g silver nitrate, stirring reaction 4h at 60 DEG C, filtration washing drying obtains silver-colored support type bioactivity glass (BAG-Ag4);
(3) preparation of functional wound repair material: take 100g deionized water, add silver-colored support type bioactivity glass, 0.5g tetracycline, 20g polyvinyl alcohol that step (2) prepares wherein, stir, obtain functional wound repair material after deaeration.
Carry out silver carrying amount and bacteriostasis property detection thereof to the functional wound repair material that the embodiment of the present invention 1 ~ 4 prepares, result is as follows:
(1) silver-colored load capacity measures: adopt Volhard method to measure the concentration (C of the silver ion after silver nitrate and load in filtrate
initially, C
filtrate), silver-colored load capacity=108xV
agNO3x (C
initially-C
filtrate)/7, load factor=(C
initially-C
filtrate)/C
initially.
The silver carrying amount testing result of the functional wound repair material of table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| C Initiallymg/ml | 6.3 | 7.6 | 8.8 | 7.6 |
| Silver load capacity mg/g | 21.0 | 23.7 | 25.6 | 25.9 |
| Load factor % | 46.4 | 43.6 | 40.3 | 47.7 |
As can be seen from Table 1, embodiment of the present invention gained bioactivity glass for the load factor of silver ion all more than 40%.From upper table analysis also, when equal in quality bioactivity glass, although the initial concentration of silver ion is low in embodiment 1, but its load factor is higher, this is because embodiment 2,3 mesosilicic acid salt (calcium silicates, sodium silicate) content is higher, the porosity of gained bioactivity glass is on the low side, thus affects adsorption effect.On the whole, the silver-colored load capacity of embodiment 4 and load factor the highest.
(2) antibacterial circle diameter measures: adopt culture medium inoculated method, in the culture dish filling agar culture medium, cultivate staphylococcus aureus.Then the embodiment 1 ~ 4 dripping 0.2g sterilizing in the culture medium of microbiological contamination prepares the wound repair material of gained, culture medium is put into 37 DEG C of calorstats and cultivates 24h, with the diameter of vernier caliper measurement record inhibition zone, measures an inhibition zone every 3 days later.Replaced medium repeats said process.With the bioactivity glass BAG-Ag4 of the bioactivity glass BAG4 of embodiment four gained and silver-colored load for contrast.
Table 2 bacteriostasis property testing result (diameter of inhibition zone)
* the large I of antibacterial circle diameter that surrounding materials produces directly illustrates the power of its anti-microbial property.
As can be seen from the above table, the fungistatic effect of the first day of the wound repair material that the embodiment of the present invention prepares is best, along with the prolongation fungistatic effect of time weakens gradually, but by the tenth day, all also there is good bacteriostasis property, the requirement that wound repair is antibacterial can be met.From matched group result, original bioactivity glass does not have bacteriostasis property, has certain bacteriostasis property after load silver ion, but the wound repair material prepared not as the present embodiment.This is because silver ion is by increasing the generation of oxygen-derived free radicals, can not only bacteria growing inhibiting, the permeability of bacterial cell membrane can also be increased, make antibiotic more easily enter antibacterial and play synergism.
Obviously, above-described embodiment is only for the example done clearly is described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And therefore amplified apparent change or variation are still within the protection domain of the invention.
Claims (6)
1. a functional wound repair material, it is characterized in that, be prepared from by bioactivity glass, silver nitrate, antibiotic and the degradable polymer compound that adds water, each raw material components is counted by weight: bioactivity glass 7 ~ 14 parts, silver nitrate 0.5 ~ 0.7 part, 0.2 ~ 0.6 part, antibiotic, degradable polymer 15 ~ 25 parts, deionized water 80 ~ 160 parts.
2. functional wound repair material according to claim 1, is characterized in that, each raw material components of described bioactivity glass is counted by weight: 50 ~ 55 parts of calcium silicates, 5 ~ 15 parts of calcium hydrogen phosphate, 5 ~ 15 parts of sodium hydrogen phosphates and 35 ~ 40 parts of sodium silicate.
3. functional wound repair material according to claim 1, is characterized in that, the particle diameter of described bioactivity glass is 20 ~ 100um.
4. functional wound repair material according to claim 1, is characterized in that, described antibiotic is the one in chloromycetin, chlortetracycline, oxytetracycline and tetracycline.
5. functional wound repair material according to claim 1, is characterized in that, described degradable polymer is one or both in matter acid, chitosan, sodium alginate and polyvinyl alcohol.
6. the preparation method of the arbitrary described functional wound repair material of claim 1 ~ 5, is characterized in that, comprise the steps:
(1) preparation of bioactivity glass: take 50 ~ 55 parts of calcium silicates, 5 ~ 15 parts of calcium hydrogen phosphate, 5 ~ 15 parts of sodium hydrogen phosphates and 35 ~ 40 parts of sodium silicate, make uniform melt at the temperature of 1250 ~ 1300 DEG C, namely obtains bioactivity glass after cooling, pulverizing;
(2) preparation of silver-colored support type bioactivity glass: take bioactivity glass 7 ~ 14 parts, silver nitrate 0.5 ~ 0.7 part, adds a small amount of deionized water, stirring reaction 4h at 40 ~ 60 DEG C, and filtration washing drying obtains silver-colored support type bioactivity glass;
(3) preparation of functional wound repair material: take 80 ~ 160 parts of deionized waters, add the silver-colored support type bioactivity glass that step (2) prepares, 0.2 ~ 0.6 part of antibiotic, 15 ~ 25 parts of degradable polymers wherein, stir, obtain functional wound repair material after deaeration.
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| CN201510815832.3A CN105381500A (en) | 2015-11-23 | 2015-11-23 | Functional wound surface repairing material and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215232A (en) * | 2016-08-29 | 2016-12-14 | 重庆理工大学 | A kind of wound antibacterial promoting healing dressing and preparation method thereof |
| CN106924867A (en) * | 2017-03-29 | 2017-07-07 | 连光 | A kind of bio-vitric dressing and doser for uterine neck surface of a wound promoting healing |
| CN107281541A (en) * | 2016-04-11 | 2017-10-24 | 李永生 | A kind of preparation method of medical temperature-sensitive hydrogel |
| CN108210982A (en) * | 2016-12-22 | 2018-06-29 | 南通蓝智新材料科技有限公司 | Wound repair dressing and its preparation method and application |
| CN108498855A (en) * | 2018-05-09 | 2018-09-07 | 福州大学 | A kind of antibacterial anti hemorrhagic colloidal sol and preparation method thereof |
| CN110478608A (en) * | 2019-09-19 | 2019-11-22 | 连光 | A kind of bio-vitric dressing and drug delivery device for uterine neck surface of a wound promoting healing |
| CN112300980A (en) * | 2020-10-23 | 2021-02-02 | 紫水晶(海南)再生医学科技有限公司 | Skin culture medium for skin grafting operation of bioactive glass material and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281541A (en) * | 2016-04-11 | 2017-10-24 | 李永生 | A kind of preparation method of medical temperature-sensitive hydrogel |
| CN106215232A (en) * | 2016-08-29 | 2016-12-14 | 重庆理工大学 | A kind of wound antibacterial promoting healing dressing and preparation method thereof |
| CN108210982A (en) * | 2016-12-22 | 2018-06-29 | 南通蓝智新材料科技有限公司 | Wound repair dressing and its preparation method and application |
| CN106924867A (en) * | 2017-03-29 | 2017-07-07 | 连光 | A kind of bio-vitric dressing and doser for uterine neck surface of a wound promoting healing |
| CN108498855A (en) * | 2018-05-09 | 2018-09-07 | 福州大学 | A kind of antibacterial anti hemorrhagic colloidal sol and preparation method thereof |
| CN110478608A (en) * | 2019-09-19 | 2019-11-22 | 连光 | A kind of bio-vitric dressing and drug delivery device for uterine neck surface of a wound promoting healing |
| CN112300980A (en) * | 2020-10-23 | 2021-02-02 | 紫水晶(海南)再生医学科技有限公司 | Skin culture medium for skin grafting operation of bioactive glass material and preparation method thereof |
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Application publication date: 20160309 |