CN113056472A - 抗凝血的五糖类化合物、组合物及其制备方法和医药用途 - Google Patents
抗凝血的五糖类化合物、组合物及其制备方法和医药用途 Download PDFInfo
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- CN113056472A CN113056472A CN201980075677.2A CN201980075677A CN113056472A CN 113056472 A CN113056472 A CN 113056472A CN 201980075677 A CN201980075677 A CN 201980075677A CN 113056472 A CN113056472 A CN 113056472A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
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Abstract
本发明涉及其阴离子形式如式(A)所示的抗凝血化合物、其制备方法以及其在制备预防和/或治疗与血液凝固障碍相关的疾病的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (28)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811478647 | 2018-12-05 | ||
| CN201811478647X | 2018-12-05 | ||
| PCT/CN2019/122954 WO2020114418A1 (zh) | 2018-12-05 | 2019-12-04 | 抗凝血的五糖类化合物、组合物及其制备方法和医药用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113056472A true CN113056472A (zh) | 2021-06-29 |
| CN113056472B CN113056472B (zh) | 2022-09-06 |
Family
ID=70974511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980075677.2A Active CN113056472B (zh) | 2018-12-05 | 2019-12-04 | 抗凝血的五糖类化合物、组合物及其制备方法和医药用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113056472B (zh) |
| WO (1) | WO2020114418A1 (zh) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5543403A (en) * | 1990-04-23 | 1996-08-06 | Akzo Nobel Nv | Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109134555B (zh) * | 2017-06-15 | 2021-09-28 | 南京正大天晴制药有限公司 | 抗凝血的五糖类化合物及其制备方法和医药用途 |
| CN109134553B (zh) * | 2017-06-15 | 2021-09-28 | 南京正大天晴制药有限公司 | 抗凝血的五糖类化合物及其制备方法和医药用途 |
| CN109134554B (zh) * | 2017-06-15 | 2021-09-28 | 南京正大天晴制药有限公司 | 抗凝血的五糖类化合物及其制备方法和医药用途 |
-
2019
- 2019-12-04 CN CN201980075677.2A patent/CN113056472B/zh active Active
- 2019-12-04 WO PCT/CN2019/122954 patent/WO2020114418A1/zh active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5543403A (en) * | 1990-04-23 | 1996-08-06 | Akzo Nobel Nv | Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type |
Non-Patent Citations (1)
| Title |
|---|
| P. WESTERDUIN等: "Feasible Synthesis and Biological Properties of Six ‘Non-Glycosamino’ Glycan Analogues of the Antithrombin III", 《BIOORGANIC & MEDICINAL CHEMIMY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020114418A1 (zh) | 2020-06-11 |
| CN113056472B (zh) | 2022-09-06 |
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