CN113056457B - 用于治疗cns疾病的前药 - Google Patents

用于治疗cns疾病的前药 Download PDF

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Publication number
CN113056457B
CN113056457B CN201980075181.5A CN201980075181A CN113056457B CN 113056457 B CN113056457 B CN 113056457B CN 201980075181 A CN201980075181 A CN 201980075181A CN 113056457 B CN113056457 B CN 113056457B
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methyl
inden
dihydro
phenyl
chloro
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CN201980075181.5A
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Chinese (zh)
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CN113056457A (zh
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M·F·贾科布森
M·约尔根森
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H Lundbeck AS
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H Lundbeck AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/037—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980075181.5A 2018-12-03 2019-11-27 用于治疗cns疾病的前药 Active CN113056457B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201800947 2018-12-03
DKPA201800947 2018-12-03
PCT/EP2019/082715 WO2020114853A1 (en) 2018-12-03 2019-11-27 Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine

Publications (2)

Publication Number Publication Date
CN113056457A CN113056457A (zh) 2021-06-29
CN113056457B true CN113056457B (zh) 2025-06-20

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ID=69061245

Family Applications (1)

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CN201980075181.5A Active CN113056457B (zh) 2018-12-03 2019-11-27 用于治疗cns疾病的前药

Country Status (5)

Country Link
US (2) US11535600B2 (https=)
EP (1) EP3891134A1 (https=)
JP (1) JP7583719B2 (https=)
CN (1) CN113056457B (https=)
WO (1) WO2020114853A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020114853A1 (en) 2018-12-03 2020-06-11 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine

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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010192A1 (en) * 1990-12-04 1992-06-25 H. Lundbeck A/S Indan derivatives
WO2005016901A1 (en) * 2003-08-18 2005-02-24 H. Lundbeck A/S Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine

Also Published As

Publication number Publication date
US20220033367A1 (en) 2022-02-03
US11535600B2 (en) 2022-12-27
JP2022509965A (ja) 2022-01-25
EP3891134A1 (en) 2021-10-13
US12071416B2 (en) 2024-08-27
JP7583719B2 (ja) 2024-11-14
WO2020114853A1 (en) 2020-06-11
CN113056457A (zh) 2021-06-29
US20230159478A1 (en) 2023-05-25

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Denomination of invention: 4-((1R,3S)-6-Chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-(( 1R,3S)-6-Chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl- Prodrugs of 1-(methyl-d3)piperazine

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