CN113015540A - 使用mrna治疗剂治疗癌症的方法和组合物 - Google Patents

使用mrna治疗剂治疗癌症的方法和组合物 Download PDF

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Publication number
CN113015540A
CN113015540A CN201980074987.2A CN201980074987A CN113015540A CN 113015540 A CN113015540 A CN 113015540A CN 201980074987 A CN201980074987 A CN 201980074987A CN 113015540 A CN113015540 A CN 113015540A
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polypeptide
mrna
seq
human
lipid
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J·弗雷德里克
S·古鲁穆尔蒂
A·米什拉
A·巴依
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ModernaTx Inc
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ModernaTx Inc
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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CN201980074987.2A 2018-09-14 2019-09-13 使用mrna治疗剂治疗癌症的方法和组合物 Pending CN113015540A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862731335P 2018-09-14 2018-09-14
US62/731,335 2018-09-14
US201862770024P 2018-11-20 2018-11-20
US62/770,024 2018-11-20
US201962881322P 2019-07-31 2019-07-31
US62/881,322 2019-07-31
PCT/US2019/051072 WO2020056304A1 (en) 2018-09-14 2019-09-13 Methods and compositions for treating cancer using mrna therapeutics

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CN113015540A true CN113015540A (zh) 2021-06-22

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US (1) US20230081530A1 (https=)
EP (1) EP3849589A1 (https=)
JP (1) JP7556848B2 (https=)
CN (1) CN113015540A (https=)
AU (1) AU2019338535A1 (https=)
CA (1) CA3112781A1 (https=)
WO (1) WO2020056304A1 (https=)

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CN114457054A (zh) * 2022-02-24 2022-05-10 中国科学技术大学 一种cGAS mRNA的制备及作为免疫激活剂的应用
CN115869332A (zh) * 2022-10-27 2023-03-31 北京新合睿恩生物医疗科技有限公司 递送至体内后在肝脏少表达的mRNA药物及其制备方法
WO2024032613A1 (zh) * 2022-08-09 2024-02-15 斯微(上海)生物科技股份有限公司 一种脂质组合物
CN119662655A (zh) * 2023-12-04 2025-03-21 武汉厚先生物医药有限公司 Rna分子及其组合物在肿瘤免疫治疗中的应用

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US20240200106A1 (en) * 2021-04-17 2024-06-20 Intellia Thrapeutics, Inc. Lipid nanoparticles compositions
CN116406426A (zh) * 2021-04-29 2023-07-07 苏州沙砾生物科技有限公司 一种修饰的肿瘤浸润淋巴细胞及其用途
US20220364078A1 (en) 2021-05-14 2022-11-17 Crispr Therapeutics Ag Mrna large scale synthesis and purification
US12251471B2 (en) * 2021-07-26 2025-03-18 Oregon State University Inhalable therapeutics
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CN119486749A (zh) * 2022-06-22 2025-02-18 武汉厚先生物医药有限公司 Il-12和ox40l组合物在肿瘤免疫治疗中的应用
WO2024015955A2 (en) * 2022-07-15 2024-01-18 President And Fellows Of Harvard College Mucispirillum compositions and cancer treatment methods thereof
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114457054A (zh) * 2022-02-24 2022-05-10 中国科学技术大学 一种cGAS mRNA的制备及作为免疫激活剂的应用
WO2024032613A1 (zh) * 2022-08-09 2024-02-15 斯微(上海)生物科技股份有限公司 一种脂质组合物
CN115869332A (zh) * 2022-10-27 2023-03-31 北京新合睿恩生物医疗科技有限公司 递送至体内后在肝脏少表达的mRNA药物及其制备方法
WO2024087423A1 (zh) * 2022-10-27 2024-05-02 北京新合睿恩生物医疗科技有限公司 递送至体内后在肝脏少表达的mRNA药物及其制备方法
CN120112297A (zh) * 2022-10-27 2025-06-06 北京新合睿恩生物医疗科技有限公司 递送至体内后在肝脏少表达的mRNA药物及其制备方法
CN119662655A (zh) * 2023-12-04 2025-03-21 武汉厚先生物医药有限公司 Rna分子及其组合物在肿瘤免疫治疗中的应用

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JP2022501336A (ja) 2022-01-06
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AU2019338535A1 (en) 2021-04-15
WO2020056304A1 (en) 2020-03-19
EP3849589A1 (en) 2021-07-21

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