CN112969784A - 工程化调节性t细胞 - Google Patents

工程化调节性t细胞 Download PDF

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Publication number
CN112969784A
CN112969784A CN201980067986.5A CN201980067986A CN112969784A CN 112969784 A CN112969784 A CN 112969784A CN 201980067986 A CN201980067986 A CN 201980067986A CN 112969784 A CN112969784 A CN 112969784A
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seq
car
motif
treg
engineered
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M·马丁内斯-洛德拉
A·桑切斯-富尤
G·隆巴尔迪
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King's College London
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/00—Fusion polypeptide
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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CN201980067986.5A 2018-08-31 2019-08-30 工程化调节性t细胞 Pending CN112969784A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1814203.4 2018-08-31
GBGB1814203.4A GB201814203D0 (en) 2018-08-31 2018-08-31 Engineered regulatory t cell
PCT/GB2019/052422 WO2020044055A1 (en) 2018-08-31 2019-08-30 Engineered regulatory t cell

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CN112969784A true CN112969784A (zh) 2021-06-15

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US (1) US20210338726A1 (enExample)
EP (1) EP3844264A1 (enExample)
JP (2) JP2021536237A (enExample)
KR (1) KR20210054543A (enExample)
CN (1) CN112969784A (enExample)
AU (1) AU2019333012A1 (enExample)
CA (1) CA3110012A1 (enExample)
GB (2) GB201814203D0 (enExample)
IL (1) IL280942A (enExample)
SG (1) SG11202101668TA (enExample)
WO (1) WO2020044055A1 (enExample)

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CN113811363A (zh) * 2019-03-29 2021-12-17 汉诺威医学院 用于HvG病的治疗的CAR
CN114369621A (zh) * 2021-12-07 2022-04-19 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用
CN115427440A (zh) * 2020-02-25 2022-12-02 圭尔医疗有限公司 用于工程化细胞的嵌合受体
CN117947070A (zh) * 2024-02-01 2024-04-30 中山大学附属第三医院 一种嵌合抗原受体基因及其应用

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US20230149465A1 (en) * 2020-04-06 2023-05-18 Celledit Llc Genetically modified immune cells expressing a chimeric antigen receptor and having reduced proinflammatory cytokine signaling
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TW202321286A (zh) 2021-09-21 2023-06-01 英商圭爾醫療有限公司 抗p75ntr嵌合抗原受體
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EP4453022A1 (en) 2021-12-22 2024-10-30 Quell Therapeutics Limited Constitutive cytokine receptors
WO2023156587A1 (en) * 2022-02-18 2023-08-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
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EP4577222A2 (en) * 2022-08-26 2025-07-02 Sonoma Biotherapeutics, Inc. Tethered interleukin-2 recombinant receptors and methods of use
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EP4403580A1 (en) 2023-01-23 2024-07-24 Medizinische Hochschule Hannover Anti-entpd3 chimeric antigen receptor
JP2026507781A (ja) 2023-01-23 2026-03-06 メディツィニシェ ホゥーシュル ハノーファー キメラ抗原受容体
CN120787258A (zh) 2023-02-07 2025-10-14 圭尔医疗有限公司 Treg细胞培养方法
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113811363A (zh) * 2019-03-29 2021-12-17 汉诺威医学院 用于HvG病的治疗的CAR
CN113811363B (zh) * 2019-03-29 2025-01-10 汉诺威医学院 用于HvG病的治疗的CAR
US12486327B2 (en) 2019-03-29 2025-12-02 Medizinische Hochschule Hannover CAR for use in the treatment of HvG disease
CN115427440A (zh) * 2020-02-25 2022-12-02 圭尔医疗有限公司 用于工程化细胞的嵌合受体
CN114369621A (zh) * 2021-12-07 2022-04-19 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用
CN114369621B (zh) * 2021-12-07 2023-10-31 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用
CN117947070A (zh) * 2024-02-01 2024-04-30 中山大学附属第三医院 一种嵌合抗原受体基因及其应用

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