CN112955124A - 具有精确的活性物溶出谱的口腔膜组合物和剂型 - Google Patents

具有精确的活性物溶出谱的口腔膜组合物和剂型 Download PDF

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Publication number
CN112955124A
CN112955124A CN201980073077.2A CN201980073077A CN112955124A CN 112955124 A CN112955124 A CN 112955124A CN 201980073077 A CN201980073077 A CN 201980073077A CN 112955124 A CN112955124 A CN 112955124A
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film
hydrochloride
commercially available
available
active
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CN201980073077.2A
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Chinese (zh)
Inventor
亚历山大·马克·朔贝尔
斯蒂芬·瓦加基
文森特·J·博诺
苏珊·舒马德
克里斯托弗·詹姆斯·桑蒂
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Aquitif Therapy Co
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Aquitif Therapy Co
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Priority to CN202411090113.5A priority Critical patent/CN120789028A/zh
Publication of CN112955124A publication Critical patent/CN112955124A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980073077.2A 2018-09-07 2019-09-05 具有精确的活性物溶出谱的口腔膜组合物和剂型 Pending CN112955124A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411090113.5A CN120789028A (zh) 2018-09-07 2019-09-05 具有精确的活性物溶出谱的口腔膜组合物和剂型

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862728187P 2018-09-07 2018-09-07
US62/728,187 2018-09-07
US201862732720P 2018-09-18 2018-09-18
US62/732,720 2018-09-18
PCT/US2019/049725 WO2020051317A1 (en) 2018-09-07 2019-09-05 Oral film compositions and dosage forms having precise active dissolution profiles

Related Child Applications (1)

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CN202411090113.5A Division CN120789028A (zh) 2018-09-07 2019-09-05 具有精确的活性物溶出谱的口腔膜组合物和剂型

Publications (1)

Publication Number Publication Date
CN112955124A true CN112955124A (zh) 2021-06-11

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CN201980073077.2A Pending CN112955124A (zh) 2018-09-07 2019-09-05 具有精确的活性物溶出谱的口腔膜组合物和剂型
CN202411090113.5A Pending CN120789028A (zh) 2018-09-07 2019-09-05 具有精确的活性物溶出谱的口腔膜组合物和剂型

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Country Status (7)

Country Link
US (5) US11541002B2 (https=)
EP (1) EP3846778A1 (https=)
JP (2) JP7637616B2 (https=)
CN (2) CN112955124A (https=)
BR (1) BR112021004053A2 (https=)
CA (1) CA3110997A1 (https=)
WO (1) WO2020051317A1 (https=)

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CN114010575A (zh) * 2021-10-22 2022-02-08 江苏谛奇医药科技有限公司 新斯的明及其衍生物的新制剂
CN114983984A (zh) * 2022-07-26 2022-09-02 山东达因海洋生物制药股份有限公司 一种用于哮喘治疗复方口溶膜剂及其制备方法
CN115671078A (zh) * 2021-07-28 2023-02-03 上海博志研新药物技术有限公司 一种依匹斯汀口溶膜组合物、其制备方法及应用
CN116211833A (zh) * 2021-11-30 2023-06-06 南京海辰药业股份有限公司 一种咪唑立宾口腔速溶膜剂及其制备方法
CN117414352A (zh) * 2023-11-22 2024-01-19 湖北广济医药科技有限公司 一种瑞美吉泮口溶膜剂及其制备方法
CN117631135A (zh) * 2024-01-25 2024-03-01 四川大学 一种双功能柔性水凝胶光纤及其制备方法和应用
CN118903065A (zh) * 2024-10-12 2024-11-08 山东则正医药技术有限公司 一种卢美哌隆口溶膜掩味组合物、其制备方法及应用
CN119139272A (zh) * 2024-09-02 2024-12-17 华中药业股份有限公司 一种艾司唑仑口腔速溶膜剂及其制备方法
CN119970685A (zh) * 2025-02-18 2025-05-13 杭州成邦医药科技有限公司 一种卢美哌隆或其盐的膜剂与其制备方法
WO2025261492A1 (zh) * 2024-06-20 2025-12-26 广州玻思韬控释药业有限公司 一种秋水仙碱膜剂
WO2026002015A1 (zh) * 2024-06-26 2026-01-02 浙江同源康医药股份有限公司 依达拉奉口腔溶膜速释制剂组合物及其制剂和用途

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US20210346385A1 (en) * 2018-09-21 2021-11-11 MSB Holdings, Inc Taste-masked dosage forms
US11331309B2 (en) 2019-06-05 2022-05-17 Cure Pharmaceutical Holding Corp. Methods and compositions for improving sleep
EP3895692A1 (en) * 2020-04-15 2021-10-20 LTS Lohmann Therapie-Systeme AG Oral thin film with smooth fused film
CN112697937A (zh) * 2020-12-18 2021-04-23 卓和药业集团有限公司 泊沙康唑肠溶片溶出度的分析方法
CA3210706A1 (en) * 2021-03-09 2022-09-15 Alexander Mark Schobel Dosage forms having equivalent biocomparable profiles
CN113311124B (zh) * 2021-06-08 2023-11-14 湖南慧泽生物医药科技有限公司 模拟药剂在体释放及吸收过程的二室模型实验装置
KR20240093850A (ko) * 2021-10-22 2024-06-24 어퀘스티브 테라퓨틱스, 아이엔씨. 개선된 안정성 프로파일을 갖는 약제학적 조성물
CN119909044A (zh) * 2023-10-31 2025-05-02 浙江紫藤药业科技有限公司 一种口腔膜剂及其制备方法
JP7659339B1 (ja) 2023-11-21 2025-04-09 東海カプセル株式会社 ピモベンダンを含有する経口フィルム製剤
CN118576571B (zh) * 2024-05-31 2025-02-14 浙江大学 一种药物释放曲线可定制的口服膜剂及其制备方法
WO2026024790A1 (en) * 2024-07-23 2026-01-29 Aquestive Therapeutics, Inc. Methods of administering enhanced delivery epinephrine and prodrug compositions

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CN115671078A (zh) * 2021-07-28 2023-02-03 上海博志研新药物技术有限公司 一种依匹斯汀口溶膜组合物、其制备方法及应用
CN114010575A (zh) * 2021-10-22 2022-02-08 江苏谛奇医药科技有限公司 新斯的明及其衍生物的新制剂
CN116211833A (zh) * 2021-11-30 2023-06-06 南京海辰药业股份有限公司 一种咪唑立宾口腔速溶膜剂及其制备方法
CN114983984A (zh) * 2022-07-26 2022-09-02 山东达因海洋生物制药股份有限公司 一种用于哮喘治疗复方口溶膜剂及其制备方法
CN114983984B (zh) * 2022-07-26 2023-09-01 山东达因海洋生物制药股份有限公司 一种用于哮喘治疗复方口溶膜剂及其制备方法
CN117414352A (zh) * 2023-11-22 2024-01-19 湖北广济医药科技有限公司 一种瑞美吉泮口溶膜剂及其制备方法
CN117631135A (zh) * 2024-01-25 2024-03-01 四川大学 一种双功能柔性水凝胶光纤及其制备方法和应用
CN117631135B (zh) * 2024-01-25 2024-04-09 四川大学 一种双功能柔性水凝胶光纤及其制备方法和应用
US12099165B1 (en) 2024-01-25 2024-09-24 Sichuan University Bifunctional and flexible hydrogel optical fiber, preparation method and application thereof
WO2025261492A1 (zh) * 2024-06-20 2025-12-26 广州玻思韬控释药业有限公司 一种秋水仙碱膜剂
WO2026002015A1 (zh) * 2024-06-26 2026-01-02 浙江同源康医药股份有限公司 依达拉奉口腔溶膜速释制剂组合物及其制剂和用途
CN119139272A (zh) * 2024-09-02 2024-12-17 华中药业股份有限公司 一种艾司唑仑口腔速溶膜剂及其制备方法
CN118903065A (zh) * 2024-10-12 2024-11-08 山东则正医药技术有限公司 一种卢美哌隆口溶膜掩味组合物、其制备方法及应用
CN118903065B (zh) * 2024-10-12 2025-02-07 山东则正医药技术有限公司 一种卢美哌隆口溶膜掩味组合物、其制备方法及应用
CN119970685A (zh) * 2025-02-18 2025-05-13 杭州成邦医药科技有限公司 一种卢美哌隆或其盐的膜剂与其制备方法

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JP7637616B2 (ja) 2025-02-28
BR112021004053A2 (pt) 2021-05-25
US20250339367A1 (en) 2025-11-06
US20230149304A1 (en) 2023-05-18
US20200101009A1 (en) 2020-04-02
CN120789028A (zh) 2025-10-17
US20230145752A1 (en) 2023-05-11
US12290597B2 (en) 2025-05-06
JP2021536466A (ja) 2021-12-27
JP2025093925A (ja) 2025-06-24
US12403090B2 (en) 2025-09-02
US20260034059A1 (en) 2026-02-05
CA3110997A1 (en) 2020-03-12
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