CN112933169A - Traditional Chinese medicine compatible component for treating chronic wound - Google Patents

Traditional Chinese medicine compatible component for treating chronic wound Download PDF

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Publication number
CN112933169A
CN112933169A CN202010164496.1A CN202010164496A CN112933169A CN 112933169 A CN112933169 A CN 112933169A CN 202010164496 A CN202010164496 A CN 202010164496A CN 112933169 A CN112933169 A CN 112933169A
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China
Prior art keywords
parts
powder
traditional chinese
chinese medicine
blood
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CN202010164496.1A
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Chinese (zh)
Inventor
张楠
马静华
高菲
张广仁
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Suzhou Kangsitan Health Technology Co ltd
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Suzhou Kangsitan Health Technology Co ltd
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Priority to CN202010164496.1A priority Critical patent/CN112933169A/en
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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Abstract

The invention provides a traditional Chinese medicine compatible component for treating chronic wound, which relates to the technical field of traditional Chinese medicine formulas and is prepared from the following components in parts by weight: 10-50 parts of lithospermum, 0.1-10 parts of bezoar, 30-90 parts of borneol, 0.1-1.0 part of pearl powder, 0.2-5 parts of amber powder, 30-80 parts of angelica, 50-120 parts of calcined calamine powder, 0.1-0.8 part of musk, 10-40 parts of dragon's blood, 5-20 parts of rheum officinale, 5-20 parts of garden burnet, 10-40 parts of Japanese ampelopsis root, 1-20 parts of ground beetle, 10-40 parts of honeysuckle, 1-5 parts of momordica cochinchinensis seed and 5-20 parts of borax; the invention applies the ideas of promoting blood circulation to remove blood stasis, promoting tissue regeneration and healing sore, clearing away heat and toxic materials, and relieving swelling and pain in traditional Chinese medicine, is used for healing wound surfaces, and has obvious curative effect on the wound surfaces which are not healed for a long time.

Description

Traditional Chinese medicine compatible component for treating chronic wound
Technical Field
The invention mainly relates to the technical field of traditional Chinese medicine formulas for treating chronic wounds, in particular to a traditional Chinese medicine compatible component for treating chronic wounds.
Background
The chronic wound surface is a kind of disease or complication which relates to various disciplines and a plurality of specialties, has complicated disease conditions and is difficult to handle, for example, the chronic wound surface such as diabetic foot, pressure sore, venous ulcer, limb arterial avascular necrosis and the like, and the chronic wound caused by various wounds, burns, scalds, non-healing wounds after operation, bedsore and the like are increased, the diseases are dispersed in the related specialties before, lack of unified diagnosis and treatment specifications, bring difficulties to diagnosis and treatment, delay treatment, cause huge social and family economic burden, seriously affect the life quality of patients, and finally cause amputation and even death. In recent years, along with the communication and fusion among multiple disciplines, the innovation and development of technology and materials, the cognition and diagnosis and treatment of diseases are continuously improved, and the disease which is not concerned about for many years, namely chronic wound, is more and more emphasized. At present, the main methods for treating chronic wounds are as follows:
debridement; in the most basic treatment, contaminated, lost blood supply and necrotic tissue can be removed. The curative effect is not exact, the time is longer, the financial resources are consumed, and larger scars can be left.
Negative pressure wound therapy; physical therapy methods to alleviate infection by inhibiting bacterial proliferation. But the use of the wound surface infected by anaerobic bacteria is not recommended, the treatment cost is high, and the popularization cannot be realized.
A growth factor; play an important role in cell division, migration, differentiation, protein expression and enzyme production. The wound healing is promoted by stimulating vascular proliferation, cell proliferation, chemotactic inflammatory cells and fibroblasts. The chronic wound surface is damaged due to the damage of the wound surface environment, the chronic wound surface is lack of growth factors or the growth factors cannot play a role, and particularly the expression levels of epidermal growth factors, fibroblast growth factors, vascular endothelial growth factors and the like are reduced.
Platelet rich plasma; taking autologous plasma of a patient, and centrifuging and processing the autologous plasma by an instrument to obtain the autologous plasma. Is not suitable for acute wound. Unstable curative effect, complex operation and high cost.
High pressure oxygen; promoting fibroblast proliferation, enhancing immunity, and stimulating angiogenesis. The clinical effect is not good, and a patient needs to be placed in a high-pressure oxygen-tight chamber, so that a plurality of adverse reactions exist.
But also grafts of skin grafting, nerves, blood vessels, tendons and the like, however, the prior treatment method is lack of universality and universality, high in treatment cost, long in time consumption and uncertain in curative effect.
Disclosure of Invention
The invention provides a traditional Chinese medicine compatibility component for treating chronic wounds in order to overcome the defects in the background technology, and the traditional Chinese medicine compatibility component is used for healing wounds by applying the concepts of promoting blood circulation to remove blood stasis, promoting granulation and healing sores, clearing away heat and toxic materials, and relieving swelling and pain, and has a remarkable curative effect on long-term unhealed wounds.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine compatible component for treating chronic wound surfaces is prepared from the following components in parts by weight: 10-50 parts of lithospermum, 0.1-10 parts of bezoar, 30-90 parts of borneol, 0.1-1.0 part of pearl powder, 0.2-5 parts of amber powder, 30-80 parts of angelica, 50-120 parts of calcined calamine powder, 0.1-0.8 part of musk, 10-40 parts of dragon's blood, 5-20 parts of rheum officinale, 5-20 parts of garden burnet root, 10-40 parts of Japanese ampelopsis root, 1-20 parts of ground beetle, 10-40 parts of honeysuckle, 1-5 parts of momordica cochinchinensis seed and 5-20 parts of borax.
The traditional Chinese medicine compatible component for treating chronic wound is prepared from the following components in parts by weight: 15-40 parts of lithospermum, 0.3-10 parts of bezoar, 40-80 parts of borneol, 0.3-0.7 part of pearl powder, 0.2-3 parts of amber powder, 40-60 parts of angelica, 70-100 parts of calcined calamine powder, 0.2-0.4 part of musk, 15-30 parts of dragon's blood, 8-18 parts of rheum officinale, 10-20 parts of garden burnet root, 15-30 parts of Japanese ampelopsis root, 5-15 parts of ground beetle, 15-30 parts of honeysuckle, 1-5 parts of momordica seed and 10 parts of borax.
The traditional Chinese medicine compatible component for treating chronic wound is prepared from the following components in parts by weight: 15-30 parts of lithospermum, 0.3-10 parts of bezoar, 30-50 parts of borneol, 0.3-0.7 part of pearl powder, 0.2-3 parts of amber powder, 40-60 parts of angelica, 90-110 parts of calcined calamine powder, 0.2-0.4 part of musk, 18-28 parts of dragon's blood, 10-15 parts of rheum officinale, 10-15 parts of garden burnet root, 20-30 parts of Japanese ampelopsis root, 8-15 parts of ground beetle, 20-30 parts of honeysuckle, 1-5 parts of momordica seed and 10 parts of borax.
The traditional Chinese medicine compatible component for treating chronic wound is prepared from the following components in parts by weight: 25 parts of lithospermum, 0.7 part of bezoar, 40 parts of borneol, 0.5 part of pearl powder, 0.5 part of amber powder, 50 parts of angelica, 108.6 parts of calcined calamine powder, 0.4 part of musk, 25 parts of dragon's blood, 13 parts of rhubarb, 13 parts of sanguisorba, 25 parts of ampelopsis japonica, 10 parts of ground beeltle, 25 parts of honeysuckle, 3 parts of momordica cochinchinensis and 10 parts of borax.
The preparation method of the traditional Chinese medicine compatible components for treating the chronic wound comprises the following steps:
s1: placing borax in a calcining pot according to the formula amount, heating with strong fire, calcining to form white snow, crisp and loose blocks, taking out, cooling, grinding, sieving with a 200-mesh sieve to obtain powder I, or adding appropriate amount of vaseline to obtain paste I;
s2: grinding Moschus, calculus bovis, radix et rhizoma Rhei, Succinum, sanguis Draxonis, Borneolum Syntheticum, radix Ampelopsis, Eupolyphaga Seu Steleophaga, and semen Momordicae into fine powder P1; pulverizing the calcined calamine powder with the formula amount into fine powder, heating 800g of vaseline and 60g of wool fat, heating to about 150 ℃, slowly adding the calcined calamine powder, stirring, cooling to about 50 ℃, adding the fine powder P1 with the formula amount, and stirring uniformly to form paste II;
s3: soaking radix Arnebiae, radix Angelicae sinensis, and flos Lonicerae in small amount of oleum Sesami for 15-30 days, boiling, cooling to 50 deg.C, keeping for about 20 min, and filtering to obtain extract III;
s4: parching radix Sangusorbae to brown, and grinding into powder IV;
s5: mixing paste I obtained from S1 or paste II obtained from powder I, S2, extract III obtained from S3 and powder IV obtained from S4 to obtain paste.
The traditional Chinese medicine compatible component preparation for treating the chronic wound is an ointment, and an equal amount of Jingwanhong ointment is added for mixing.
The application of the traditional Chinese medicine compatible components for treating chronic wound surfaces can be added with sulfadiazine ointment with the same amount to improve the antiviral effect of the ointment.
The traditional Chinese medicine compatible component for treating the chronic wound is prepared into paste and patches.
The traditional Chinese medicine compatible components are applied to treating chronic wounds.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine for treating chronic wounds comprises 16 medicinal materials, is simple in compatibility, easy to control in medicine property and effect, and does not generate toxic or side effect due to complicated compatibility. The 16 medicinal materials comprise lithospermum, bezoar, borneol, pearl powder, amber powder, angelica, calcined calamine powder, musk, dragon's blood, rhubarb, garden burnet root, Japanese ampelopsis root, ground beetle, honeysuckle, cochinchina momordica seed and borax, wherein the medicinal materials comprise functional components for cooling blood and stopping bleeding, clearing heat and detoxifying, functional components for promoting blood circulation and removing blood stasis, functional components for promoting granulation and healing sore and functional components for diminishing inflammation and relieving pain, the scientific compatibility is realized, the effects of clearing heat and sterilizing, promoting granulation and healing sore are taken into consideration, and the curative effects of cooling blood, diminishing inflammation and the like are also realized;
wherein the effective components for cooling blood, stopping bleeding, clearing heat and detoxicating comprise radix Arnebiae, calculus bovis, Borneolum Syntheticum, Margarita powder, and radix Sangusorbae; the effective components for promoting blood circulation and removing blood stasis comprise Succinum powder and Eupolyphaga Seu Steleophaga; the effective components for promoting granulation and healing wound comprise radix Angelicae sinensis, calcined calamine powder, radix Ampelopsis, and sanguis Draxonis; the anti-inflammatory and analgesic effective components include Moschus, flos Lonicerae, semen Momordicae, radix et rhizoma Rhei, and Borax.
Compared with the existing products on the market, the ointment has the remarkable effects of removing the necrotic tissue and promoting tissue regeneration and diminishing inflammation; meanwhile, the peculiar smell of the wound can be removed, and a comfortable environment is created for patients and medical staff; compared with other methods in the prior art, the product has low price, universality and no special requirements on the pathogenesis and the diseased part of the wound. The compatibility of the medicinal materials can accelerate the healing of the wound surface, and has obvious curative effect on the wound surface which is not healed for a long time.
The traditional Chinese medicine compatible components can be prepared into paste and patch, the total effective rate of the wound paste and the wound patch is 100%, and the cure rate is more than 95%.
Wherein each medicinal material has the following functions:
the active ingredients of the lithospermum are mainly naphthalene pigments with strong fat solubility: comprises shikonin, acetylshikonin, beta-dimethylacrylshikonin, deoxyshikonin, isovalerylshikonin and isobutylidene, and the shikonin can cure malignant sore according to the record of the medical treatise; the compendium of materia medica records that the alkanna tinctoria has the functions of cooling blood and activating blood and benefiting large and small intestines, so that people with pockmark rash without eruption and blood heat toxin sore eruption can use the alkanna tinctoria with the action of making the medicine to erupt, blood heat toxin is excessive and stool is blocked, and people with eruption and purple black constipation can use the alkanna tinctoria; the lithospermum has good antiviral, broad-spectrum and high-efficiency antibacterial effects, and has obvious inhibiting effects on staphylococcus aureus, staphylococcus albus, streptococcus A and the like. Persistent inflammatory reaction and infection are the main reasons for chronic wound surface, so that effective inhibition of inflammatory reaction and bacteriostasis of the wound are the prerequisite for wound healing;
calculus bovis mainly comprises bile pigment (bilirubin and biliverdin), bile acid, cholesterol, fatty acid, lecithin, mucin, smooth muscle contraction substance, amino acids, carotenoid, oily cardiotonic component, inorganic component and vitamin D. The compendium of materia medica records that pimples are purple, and can be used for patients suffering from mania and delirium; bezoar antidotal pill from Baoyingdu (infant care for health): calculus bovis, radix Glycyrrhizae, flos Lonicerae, radix Glycyrrhizae, and placenta hominis by pulverizing into powder, and making honeyed pill for oral administration; the research finds that the bezoar can inhibit the inflammatory reaction. The anti-inflammatory matrix can affect charged groups of tissue proteins through the surface activity of bile acid, inhibit mutual recognition and interaction among proteins to play an anti-inflammatory role, and can also inhibit the generation of inflammation mediators leukotriene B4 and PGE to reduce the synthesis and release of Nitric Oxide (NO) and histamine; also has effects of promoting hematopoiesis, clearing away heat and toxic materials;
the borneol is mainly borneol, contains various terpenoids, has the effect of promoting transdermal penetration, and also has the effects of resisting inflammation and relieving pain; for sores and ulcers which are not healed for a long time after they are ulcerated, it is combined with niu Huang, Zhen Zhu and Galamina, such as Babaodan; bing pian (Chinese character of 'Yi Lin Shu Yao)' records that Bing pian can dispel stagnated fire, and can be used for treating epilepsy, phlegm stagnation, pharyngitis, tongue distention, toothache, deafness, nasal obstruction, conjunctival congestion, nebula, acne, insect killing, hemorrhoid, promoting growth, promoting sexual intercourse, promoting granulation, and relieving pain. Naturally dispersing and being exhausted, it is finally returned to cold; modern pharmacological studies show that borneol can promote drug absorption and relieve pain, peripheral neurons expressing TRPM8 are activated by borneol to trigger nerve discharge, cell membrane protein molecules of a type called metabotropic glutamate receptor located in spinal cord are activated, pain nerve signal transmission is inhibited finally, pain is relieved on subjective feeling, and the analgesic effect is achieved.
The pearl powder contains trace elements such as manganese, copper, zinc and the like, and the pearl powder is recorded in the book Ben Cai Hui Yan and is used for treating all the symptoms of carbuncle and sore, tendon penetration, vein ulceration, muscle damage, bone fracture, joint opening, bloody pus dripping and failure of ulceration for a long time: zhenzhu Yiqian (ground into superfine powder), and Duan Ying (dried and ground into superfine powder); melting white wax and lard oil on fire, mixing with exocarpium powder and pearl powder, and mixing. Washing the sore with pig trotter soup, applying wax oil medicine, and sticking with lead powder, sesame oil plaster; the pearl powder has the effects of calming heart, tranquilizing mind, relieving inflammation, removing toxic substances, removing malignant boil, and ulcerating internal organs; the "orthodox surgery" records pearl powder: the pearl powder treats skin and meat rot of chancroid, extremely intolerable pain, skin sore with full new meat, skin and meat rot, soup splashed with fire, and pain caused by: five cents in green jar, one money in pearl (finely ground), and two in true calomel. The three herbs are ground into thousands of turns and are as thin as flying noodles. It is applied when the skin is damaged at the beginning of malnutrition; for those with rot pain, cleaning Glycyrrhrizae radix decoction, and applying on pig spinal cord; such as those who do not suffer from skin sores, are dry blended. It can also be used for treating gynecological erosion of yin. When the soup splashes fire and burns with pain, the yuhong ointment is used for mixing and applying; modern pharmacological studies show that the pearl powder mainly has the effects of resisting inflammation, detoxifying, promoting granulation, promoting the activity of cell superoxide dismutase and resisting inflammation;
the amber powder contains resin, volatile oil, succinic acid, succinic abietic acid, succinic pinosylvic acid, succinic fatty alcohol, succinic abietic alcohol, succinic acid and the like, and also contains trace elements, and can promote blood circulation by removing blood stasis and promoting blood circulation of wound surfaces, and amber is described in the original meridian: the herb should not be administered by mistake for those who do not have blood clotting and do not have the property of removing abrasion and draining dampness. In powder with rhubarb and turtle shell, cun an ancient type of spoon below the wine is indicated for lochia in abdomen of women, which stops the blood exhaustion. For blood stasis and swelling, the abdomen is bulging and difficult to urinate, it is combined with qi-breaking herbs of Chen Xiang Dynasty. It is also ground and applied on jin Jiang to remove blood stasis without scar. "
The angelica contains ligustilide, n-butenyl lactone, angelone and other trace elements as well as vitamin B12, iron, zinc and other trace elements. In addition, ferulic acid, acetophenone, caladiene, carvacrol, guaiacol, anisic acid, angelica lactone, ligustilide dimer and the like are contained, the composition has the functions of resisting inflammation, inhibiting bacteria and the like, and the medical application is wide and the composition is compatible with the lithospermum to enhance the effect; the book of entry records: warming middle energizer to relieve pain, removing obstruction of blood, relieving spasm and sweating, treating arthralgia due to dampness, treating nausea, qi deficiency, and restoring muscle; the compendium of materia medica records that the headache, the pain of heart and abdomen, the intestine moistening, the stomach moistening, the muscles and the bones and the skin are treated. For superficial infection, pus discharge and pain relief, blood circulation and blood tonifying; the miraculous effect of Liang Fang records that Dang Gui san is used for treating bone abscess and all malignant sores: half two angelica, one two liquorice, twelve gardenia jasminoides and one momordica seed (peeled). Grinding into fine powder, taking three coins each time, and mixing with cold wine; modern pharmacological studies show that angelica has the effects of resisting anoxia, resisting inflammation, inhibiting bacteria and the like, enriching blood and activating blood.
Calcined calamine powder, described in compendium of materia Medica, has the effects of stopping bleeding, removing toxic swelling, promoting granulation, improving eyesight, removing nebula and red skin, removing dampness and removing rotten. Has antibacterial, astringent, antiseptic, and wound surface protecting effects. Is recorded in modern practical traditional Chinese medicines and used for treating chronic ulcer and lower leg ulcer with difficult healing, and has the efficacy of preventing corrosion and promoting tissue regeneration. The prescription of Imperial medicine has recorded Pingyi powder: 45 g of calamine (baked) and 15 g of keel. Grinding into fine powder, mixing with the affected part in dry form, and applying plaster; modern pharmacological studies show that the calcined calamine powder has the effects of healing sore, promoting granulation, inhibiting bacteria, astringing, preventing corrosion and protecting wound surfaces.
Musk contains muscone, musk pyridine, 11 androstane derivatives, cholesterol, fat, protein, wax and inorganic salt, and the musk recorded in Ben Cao Zheng can be used for treating skin sore, anal fistula, swelling and pain, pus, saprophy, and macula. It is suitable for patients with qi stagnation. Sealing with Moschus if skin sore is caused by mouse bite or insect bite; the musk is used for treating sore and ulcer pyogenic infections, sore throat and musk pungent and fragrant powder, has good effects of promoting blood circulation, removing stasis, relieving swelling and pain, and has good effects for oral administration and external application. For sores and ulcers, she Xiang is often combined with Xiong Huang, Ru Xiang and Mo Yao, i.e. xing Xiao Wan, or niu Huang, Ru Xiang and Mo Yao; for swollen and sore throat, she Xiang can be combined with niu Huang, Chan Su and Zhen Zhu, such as Liu Shen Wan; record musk cream in Qianjin Fang: musk is used for treating carbuncle, deep-rooted carbuncle, back and various malignant sores and removing malignant flesh: 50 g of musk, realgar, aluminite and jianzhu (a herb is Zhenzhu'). The four herbs are treated with the above herbs and sieved, and the raw meat paste is applied after the meat is cured by the pig paste.
The water-soluble polypeptide protein in musk has the effects of resisting inflammation, promoting blood circulation, dredging channels, relieving swelling and alleviating pain by reducing the generation of active lipid of neutrophils, weakening the release effect of neutrophils, reducing the release content of granules by the neutrophils and reducing the level of free calcitonin; musk has the functions of sore and ulcer pyogenic infection, anti-inflammation, detumescence and acesodyne, and has good effect for oral administration and external application.
Borax mainly contains sodium tetraborate; and also contains a small amount of impurities such as lead, copper, calcium, aluminum, iron, magnesium, silicon and the like, and the regeneration of tissue is promoted when the raw materials are calcined to wither. The compendium of materia medica records that the medicine treats the diseases of upper jiao phlegm-heat, body fluid generation, mouth qi removal, nebula elimination, hiccup regurgitation, accumulated blocks, stasis, ulceration, bone sticking, malignant boil and oral teeth; has antibacterial, toxic materials clearing away, and repercussive effects.
Sanguis Draxonis contains dracorhodin, demethyl dracorhodin, pinoresinoic acid, isopinic acid, abietic acid, sanguis Draxonis flavan A, dehydroabietic acid, isopimaric acid, pimaric acid, and sanguis Draxonis dioxepin; record the sudden cardiac and abdominal pain, the bleeding of incised wound, the blood stasis, the pain and the flesh generation in the New revised materia Medica; the record of the book Guangli Fang from the book Ben Cao Hui Yan (materia Medica of materia Medica) is to treat all incised sores and pyogenic infections and ulcerations without muscle generation: sanguis Draxonis, hair ash, Olibanum, Myrrha, Calomelas, and dens Elephatis powder. A little borneol is mixed into powder; the book Shengjie general book records Xue Xie san: all the diseases are not detected, malignant sores are treated, and the sore is not cured in the deep year: 30 g of dragon's blood and 15 g of red lead (fried purple), smashing the two medicines into powder, washing sores with salt soup and then sticking the sores; modern pharmacological research shows that the dragon's blood can shorten the calcification time of blood plasma; remarkably inhibiting platelet aggregation and preventing thrombosis; improving microcirculation, and inhibiting various pathogenic fungi to different degrees; promoting tissue regeneration and healing wound; relieving pain.
The radix et rhizoma Rhei contains rhein, emodin, aloe-emodin, alpha-catechin, and gallic acid as main ingredients; the "Rihuazi materia Medica" records: dredge all qi, regulate blood vessels, benefit joints, purge plastic stagnation, water-qi, abnormal cold and heat of limbs, warm miasma, heat phlegm, relieve constipation and apply topically to sore, furuncle and carbuncle. 'gang mu Shi Yi' records the new use of removing blood stasis. For traumatic injury, abscess and swelling, bleeding stopping; the record of rhubarb in the Ministry of health and precious medicine records that the chilblain skin is broken and rotten and has intolerable pain: the Chuan Da Huang is smashed and mixed with fresh water, and applied on the cold sores, such as Shen san; modern pharmacological research shows that the action mechanism of the rhubarb is to promote the adhesion and aggregation of blood platelets; increasing platelet count and fibrinogen content; reducing antithrombin III activity; causing vasoconstriction of the injured local area; the bacteriostasis mechanism mainly inhibits the oxidation and dehydrogenation of thalli sugar metabolism intermediate products, inhibits the synthesis of protein and nucleic acid, and inhibits a bacterial biological oxidase system; inducing interferon; the anti-inflammatory action mechanism of rhubarb is mainly related to the inhibition of blood cell aggregation reaction related to arachidonic acid metabolism and the inhibition of oxidase reaction path in cells.
Sanguisorba officinalis contains catechins, 3', 4-tri-0-methyl gallic acid, and is described in the journal of Ou Lu: stopping purulent blood, fistula, malignant boil, eliminating wine, removing thirst, tonifying wound, and puerperal internal obstruction, and can be used as incised wound ointment. The main leakage is not stopped, and the blood is insufficient. Recorded in Ben Cao gang mu, sang Yu can remove heat from lower energizer and treat hemafecia and stool. Stopping bleeding, the cut pieces are taken and stir-baked, and the tip of the cut pieces can move blood. Yang Shiyin cloud: radix Sangusorbae for sore patients, and Scutellariae radix for itching patients; modern pharmacological research shows that sanguisorba has hemostatic effect, anti-inflammatory effect and wound healing promotion. The sanguisorbin I and the isomorphous acid have the effect of promoting thrombopoiesis.
Radix Ampelopsis contains tartaric acid, fumaric acid, gallic acid, etc.; still contains mucoid, starch, tannin, flavonoid glycoside, glucose, etc.; the prescription of Jifeng Puji records 15 g of radix ampelopsis, rhizoma bletillae and Chinese starjasmine stem respectively, and the dry ingredients are taken out. Grinding into fine powder, and scattering on the sore; the "Rihuazi materia Medica" records: stopping convulsion, back attack, scrofula, intestinal wind, anal fistula, knife and arrow sores, acute eczema, warm malaria, bloody dysentery, scald, fire sores, granulation promoting and pain relieving; modern pharmacological research shows that the ampelopsis japonica has a strong inhibition effect on tyrosinase; has effects in resisting pathogenic microorganism, promoting T lymphocyte proliferation and macrophage phagocytosis.
Relevant functional components of the ground beetle: active ingredients such as a plurality of active proteases, 17 amino acids, 12 unsaturated fatty acids, trace elements, alkaloids, fat-soluble vitamins and the like; recorded in Sheng Ji Zong Lu (holy economic book) that the ground dried Eupolyphaga Seu Steleophaga and Moschus are ground into small amount respectively. The two herbs are ground uniformly. Dry blending or sticking, and treating with dry and wet; modern pharmacological research shows that the ground beetles promote blood circulation, cure injuries and regulate inflammatory reaction; the extract can inhibit platelet aggregation and adhesion rate, and reduce aggregation number; the water extract of total alkaloids of Eupolyphaga Seu Steleophaga has antihypoxic effect.
The honeysuckle flower contains luteolin, inositol 1%, volatile oil, terpenes, phenolic acid and other chemical components. Wherein the composition comprises chlorogenic acid, isochlorogenic acid, ginkgol, beta-sitosterol, stigmasterol-D-glucoside, etc.; huichang honeysuckle powder is recorded in Huofan mechanical essences: for sores and ulcers with severe pain and purple-black color: 60g of honeysuckle flower twig and leaf (file), 120 g of astragalus root and 30 g of liquorice. Cutting, adding wine one liter, sealing, decocting for three or two hours, removing residues, and taking immediately; the Chinese angelica flower soup is recorded in Dongtian AoZhi: treating early onset of carbuncle, cellulitis and hair on the back: 240 g of honeysuckle and ten bowls of water are decocted to two bowls, 60g of angelica is added, and the mixture is decocted to one bowl and taken in one dose; the record of Yunnan herbal medicine: clear heat, relieve sores, abscess, deep-rooted carbuncle, hairy dorsum, erysipelas and scrofula. Modern pharmacological research shows that honeysuckle has the functions of antibiosis and inflammatory reaction regulation.
The related functional components of the momordica cochinchinensis seeds are as follows: fatty oils, saponins, sterols, and polysaccharides (trehalose), etc.; the record of the "Yi Zong jin Jian" (medical Zong golden seal): sores and ulcers, swelling and toxin, scrofula, acute mastitis, hemorrhoids, swelling and pain, tinea, and tinea pedis. It can resolve stagnation, resolve swelling, counteract toxic pathogen and cure sore, and promote tissue regeneration and alleviate pain, so it is indicated for the above mentioned diseases. If it is used alone, it is ground into juice with vinegar and applied externally or ground into powder with vinegar and applied to the affected part. For abscess and swelling due to toxin, it is stir-baked into coke and ground into fine powder, and mixed with water for external application, such as Wulong ointment. The record of "Kaibao Bencao" (Kaibao herbal) is: mainly treats fracture, mass and swelling, malignant sore, granulation promoting, lumbago relieving, acne removing, mastitis, anal swelling and pain. Record Shenxiao Qianju Gao from Yi Zong jin Jian: semen momordicae is used for treating sore and ulcer, early stage of furunculosis, scrofula and ecthyma, and arches of children: five ground woodlouse (hulled), four white and tender rosin (cleaned), one copper green ground into one money, two money for frankincense and myrrh, seven money for castor bean (hulled), five grains of croton meat and one money for almond (hulled). Mixing the above eight medicines, and pounding in stone mortar for three thousand times to obtain paste; taking up and soaking in cold water. When in use, the paste is rubbed into thin pieces with hands according to the size of the sore, stuck on the sore and covered with silk. Modern pharmacological research shows that the momordica cochinchinensis seed has the effects of detoxifying, relieving swelling and relieving pain.
Detailed Description
For better explanation of the present invention, the following detailed description of the present invention is provided for understanding.
Example 1, a traditional Chinese medicine compatible component for treating chronic wounds is prepared from the following components in parts by weight: 15 parts of lithospermum, 0.2 part of bezoar, 35 parts of borneol, 0.1 part of pearl powder, 0.3 part of amber powder, 30 parts of angelica, 70 parts of calcined calamine powder, 0.2 part of musk, 15 parts of dragon's blood, 7 parts of rhubarb, 7 parts of garden burnet, 12 parts of Japanese ampelopsis root, 5 parts of ground beeltle, 10 parts of honeysuckle, 1 part of momordica seed and 6 parts of borax.
In the embodiment 2, the traditional Chinese medicine compatible component for treating chronic wound is prepared from the following components in parts by weight: 20 parts of lithospermum, 0.5 part of bezoar, 45 parts of borneol, 0.3 part of pearl powder, 0.5 part of amber powder, 40 parts of angelica, 80 parts of calcined calamine powder, 0.3 part of musk, 20 parts of dragon's blood, 10 parts of rhubarb, 10 parts of sanguisorba, 15 parts of ampelopsis japonica, 10 parts of ground beeltle, 15 parts of honeysuckle, 2 parts of momordica cochinchinensis seeds and 10 parts of borax.
Embodiment 3, the traditional Chinese medicine compatible component for treating chronic wound is prepared from the following components in parts by weight: 35 parts of lithospermum, 5 parts of bezoar, 50 parts of borneol, 1.0 part of pearl powder, 5 parts of amber powder, 60 parts of angelica, 90 parts of calcined calamine powder, 0.6 part of musk, 35 parts of dragon's blood, 15 parts of rheum officinale, 18 parts of garden burnet root, 35 parts of ampelopsis japonica, 15 parts of ground beeltle, 35 parts of honeysuckle, 4 parts of momordica seed and 10 parts of borax.
Example 4, the traditional Chinese medicine compatible component for treating chronic wound is prepared from the following components in parts by weight: 25 parts of lithospermum, 0.7 part of bezoar, 40 parts of borneol, 0.5 part of pearl powder, 0.5 part of amber powder, 50 parts of angelica, 108.6 parts of calcined calamine powder, 0.4 part of musk, 25 parts of dragon's blood, 13 parts of rhubarb, 13 parts of sanguisorba, 25 parts of ampelopsis japonica, 10 parts of ground beeltle, 25 parts of honeysuckle, 3 parts of momordica cochinchinensis and 10 parts of borax.
The preparation method of each embodiment of the invention comprises the following steps:
s1: placing borax in a calcining pot according to the formula amount, heating with strong fire, calcining to form white snow, crisp and loose blocks, taking out, cooling, grinding, sieving with a 200-mesh sieve to obtain powder I, or adding appropriate amount of vaseline to obtain paste I;
s2: grinding Moschus, calculus bovis, radix et rhizoma Rhei, Succinum, sanguis Draxonis, Borneolum Syntheticum, radix Ampelopsis, Eupolyphaga Seu Steleophaga, and semen Momordicae into fine powder P1; pulverizing the calcined calamine powder with the formula amount into fine powder, heating 800g of vaseline and 60g of wool fat, heating to about 150 ℃, slowly adding the calcined calamine powder, stirring, cooling to about 50 ℃, adding the fine powder P1 with the formula amount, and stirring uniformly to form paste II;
s3: soaking radix Arnebiae, radix Angelicae sinensis, and flos Lonicerae in small amount of oleum Sesami for 15-30 days, boiling, cooling to 50 deg.C, keeping for about 20 min, and filtering to obtain extract III;
s4: parching radix Sangusorbae to brown, and grinding into powder IV;
s5: mixing paste I obtained from S1 or paste II obtained from powder I, S2, extract III obtained from S3 and powder IV obtained from S4 to obtain paste.
The traditional Chinese medicine compatible component preparation for treating the chronic wound is an ointment, and an equal amount of Jingwanhong ointment is added for mixing.
The application of the traditional Chinese medicine compatible components for treating chronic wound surfaces can be added with sulfadiazine ointment with the same amount to improve the antiviral effect of the ointment.
The traditional Chinese medicine compatible component for treating the chronic wound is prepared into paste and patches.
The traditional Chinese medicine compatible components are applied to treating chronic wounds.
The traditional Chinese medicine compatible components for treating chronic wounds are clinically used from 1988, and no systemic allergy or local allergy is found in more than 30 years, and no case of damage to important organs of the whole body exists. The invention has more remarkable effect on the recovery of chronic wound surfaces, the dressing change interval is reduced from 2 times a day to once every 3 to 4 days, and the clinical application conditions are as follows:
1. use of infections in diabetic patients, lower limbs or other parts of the body
(1) The fasting blood sugar of the patient is controlled below 8;
(2) applying the medicine after removing necrotic tissues;
(3) the granulation tissue grows fast, no scar is left after healing, and the healing time is 2/3 time faster than normal;
(4) the application patient is close to 200.
2. Application of anorectal patients
(1) Is suitable for perianal abscess incision and after intestinal atrophy (wilting tube excision)
(2) The granulation grows rapidly, the healing time is shortened, the local inflammatory reaction disappears rapidly, and the healing time is shortened;
(3) approximately 300 patients were used.
3. Ulcer of lower limb caused by great saphenous vein varicosity
(1) Ligature of great saphenous vein and sectional stripping of varicose vein
(2) Applying medicine to ulcer part of lower limb after operation, the ulcer healing is rapid
(3) The number of applied patients is more than 100.
4. Application of bedsore patient
(1) Bedsore of long-term bedridden patients
(2) The necrotic tissues and the hardened tissues are clear, the medicine is applied, the granulation grows rapidly and the healing process is accelerated 1/2 time according to the normal bedsore nursing rule.
(3) The number of cases was 26.
5. Wound at far end of limb, wound with poor blood stain and long-term infection
(1) Wound of always cleaning up
(2) Applying the medicine, healing is obviously accelerated
(3) The number of cases is about 200.
6. Application of burn and scald patient
(1) The medicine is applied after I degree and shallow II degree injuries, the healing time is shortened, and no scar is left
(2) Deep II degree burn, the water seepage period is finished, the application is carried out after debridement, and the wet dressing can obviously inhibit infection, accelerate granulation growth and accelerate the falling separation of necrotic tissues;
(3) the number of application examples is more than 200.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents, and thus the embodiments of the present invention are intended to be merely illustrative examples of the invention and are not to be construed as limiting the invention in any way.

Claims (9)

1. A traditional Chinese medicine compatible component for treating chronic wound is characterized in that: the composition is prepared from the following components in parts by weight: 10-50 parts of lithospermum, 0.1-10 parts of bezoar, 30-90 parts of borneol, 0.1-1.0 part of pearl powder, 0.2-5 parts of amber powder, 30-80 parts of angelica, 50-120 parts of calcined calamine powder, 0.1-0.8 part of musk, 10-40 parts of dragon's blood, 5-20 parts of rheum officinale, 5-20 parts of garden burnet root, 10-40 parts of Japanese ampelopsis root, 1-20 parts of ground beetle, 10-40 parts of honeysuckle, 1-5 parts of momordica cochinchinensis seed and 5-20 parts of borax.
2. The traditional Chinese medicine compatible component for treating chronic wounds according to claim 1 is characterized in that: the composition is prepared from the following components in parts by weight: 15-40 parts of lithospermum, 0.3-10 parts of bezoar, 40-80 parts of borneol, 0.3-0.7 part of pearl powder, 0.2-3 parts of amber powder, 40-60 parts of angelica, 70-100 parts of calcined calamine powder, 0.2-0.4 part of musk, 15-30 parts of dragon's blood, 8-18 parts of rheum officinale, 10-20 parts of garden burnet root, 15-30 parts of Japanese ampelopsis root, 5-15 parts of ground beetle, 15-30 parts of honeysuckle, 1-5 parts of momordica seed and 10 parts of borax.
3. The traditional Chinese medicine compatible component for treating chronic wounds according to claim 1 is characterized in that: the composition is prepared from the following components in parts by weight: 15-30 parts of lithospermum, 0.3-10 parts of bezoar, 30-50 parts of borneol, 0.3-0.7 part of pearl powder, 0.2-3 parts of amber powder, 40-60 parts of angelica, 90-110 parts of calcined calamine powder, 0.2-0.4 part of musk, 18-28 parts of dragon's blood, 10-15 parts of rheum officinale, 10-15 parts of garden burnet root, 20-30 parts of Japanese ampelopsis root, 8-15 parts of ground beetle, 20-30 parts of honeysuckle, 1-5 parts of momordica seed and 10 parts of borax.
4. The traditional Chinese medicine compatible component for treating chronic wounds according to claim 1 is characterized in that: the composition is prepared from the following components in parts by weight: 25 parts of lithospermum, 0.7 part of bezoar, 40 parts of borneol, 0.5 part of pearl powder, 0.5 part of amber powder, 50 parts of angelica, 108.6 parts of calcined calamine powder, 0.4 part of musk, 25 parts of dragon's blood, 13 parts of rhubarb, 13 parts of sanguisorba, 25 parts of ampelopsis japonica, 10 parts of ground beeltle, 25 parts of honeysuckle, 3 parts of momordica cochinchinensis and 10 parts of borax.
5. The process for preparing a Chinese medicinal composition for treating chronic wounds according to any one of claims 1 to 4, wherein: the method comprises the following steps:
s1: placing borax in a calcining pot according to the formula amount, heating with strong fire, calcining to form white snow, crisp and loose blocks, taking out, cooling, grinding, sieving with a 200-mesh sieve to obtain powder I, or adding appropriate amount of vaseline to obtain paste I;
s2: grinding Moschus, calculus bovis, radix et rhizoma Rhei, Succinum, sanguis Draxonis, Borneolum Syntheticum, radix Ampelopsis, Eupolyphaga Seu Steleophaga, and semen Momordicae into fine powder P1; pulverizing the calcined calamine powder with the formula amount into fine powder, heating 800g of vaseline and 60g of wool fat, heating to about 150 ℃, slowly adding the calcined calamine powder, stirring, cooling to about 50 ℃, adding the fine powder P1 with the formula amount, and stirring uniformly to form paste II;
s3: soaking radix Arnebiae, radix Angelicae sinensis, and flos Lonicerae in small amount of oleum Sesami for 15-30 days, boiling, cooling to 50 deg.C, keeping for about 20 min, and filtering to obtain extract III;
s4: parching radix Sangusorbae to brown, and grinding into powder IV;
s5: mixing paste I obtained from S1 or paste II obtained from powder I, S2, extract III obtained from S3 and powder IV obtained from S4 to obtain paste.
6. The use of the compatible ingredients of chinese herbs for the treatment of chronic wounds according to any one of claims 1 to 4, wherein: the traditional Chinese medicine compatible component preparation is ointment, and the same amount of Jingwanhong ointment is added for mixing.
7. The use of the compatible ingredients of chinese herbs for the treatment of chronic wounds as claimed in claim 6, wherein: sulfadiazine ointment may also be added to raise the antiviral effect of the ointment.
8. A herbal formulation for use in the treatment of chronic wounds, according to any one of claims 1 to 4, wherein: the Chinese medicinal compatible component preparation is paste or patch.
9. The use of the herbal compatible ingredients of any one of claims 1 to 4 for the treatment of chronic wounds.
CN202010164496.1A 2020-03-11 2020-03-11 Traditional Chinese medicine compatible component for treating chronic wound Pending CN112933169A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1640437A (en) * 2004-01-18 2005-07-20 中国人民解放军军事医学科学院毒物药物研究所 Medicinal composition for treating gastro intestinal tract disease
CN108619362A (en) * 2018-06-29 2018-10-09 利辛县运杰家庭农场 A kind of acne cream and preparation method thereof
CN109200159A (en) * 2018-10-30 2019-01-15 王心海 A kind of ointment for burns and scalds and preparation method thereof
CN110179900A (en) * 2018-03-26 2019-08-30 何本仁 A kind of ointment for treating burn and scald and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1640437A (en) * 2004-01-18 2005-07-20 中国人民解放军军事医学科学院毒物药物研究所 Medicinal composition for treating gastro intestinal tract disease
CN110179900A (en) * 2018-03-26 2019-08-30 何本仁 A kind of ointment for treating burn and scald and preparation method thereof
CN108619362A (en) * 2018-06-29 2018-10-09 利辛县运杰家庭农场 A kind of acne cream and preparation method thereof
CN109200159A (en) * 2018-10-30 2019-01-15 王心海 A kind of ointment for burns and scalds and preparation method thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
中国医药公司: "《药品养护》", 31 March 1982, 中国财政经济出版社 *
任胜林: "关于11例烧烫伤患者的疗效观察", 《中国医药指南》 *
周美儿: "麝香痔疮膏治疗Ⅱ～Ⅲ度褥疮17例体会", 《现代中西医结合杂志》 *
王淑霞 等: "马应龙麝香痔疮膏在小面积深Ⅱ°烧伤患者中的应用", 《中国中医药现代远程教育》 *
程慧洁 等: "马应龙麝香痔疮膏临床新用", 《浙江中医杂志》 *
马振友 等: "《新编中西皮肤药物手册》", 31 January 2019, 河南科学技术出版社 *

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Application publication date: 20210611