CN112915152B - 一种治疗肿瘤分子靶向药物相关皮疹的中药面膜及制备方法 - Google Patents

一种治疗肿瘤分子靶向药物相关皮疹的中药面膜及制备方法 Download PDF

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CN112915152B
CN112915152B CN202110210921.0A CN202110210921A CN112915152B CN 112915152 B CN112915152 B CN 112915152B CN 202110210921 A CN202110210921 A CN 202110210921A CN 112915152 B CN112915152 B CN 112915152B
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廖荣荣
陈晶晶
陈连凤
曾灿辉
朱海慧
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TCM-INTEGRATED HOSPITAL OF SOUTHERN MEDICAL University
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Abstract

本发明公开了一种治疗肿瘤分子靶向药物相关皮疹的中药面膜及其制备方法，涉及中药面膜领域。所述中药面膜，包括以下质量组分原料：萆薢15‑20份、蛇床子15‑20份、紫花地丁15‑20份、萹蓄15‑20份、黄连15‑20份、黄柏15‑20份、黄芩15‑20份、青黛12‑22份、地榆15‑20份、苍术15‑20份、菊花15‑20份、土茯苓15‑20份、板蓝根15‑20份、地肤子15‑20份和苦参15‑20份。本发明的中药面膜为纯中药成分，萆薢、萹蓄利湿祛浊，黄连、黄柏、黄芩清三焦之热为主，青黛、菊花、板蓝根清热解毒，蛇床子，地肤子、苦参杀虫止痒。诸药合用，以健脾祛湿为根本，通过清热解毒、除湿止痒、敛疮生肌达到治疗皮疹之目的。

Description

一种治疗肿瘤分子靶向药物相关皮疹的中药面膜及制备方法
技术领域
本发明涉及中药面膜，尤其是一种治疗肿瘤分子靶向药物相关皮疹的中药面膜及其制备方法。
背景技术
当前，分子靶向药物被广泛应用于治疗肿瘤患者，此药物有助于阻碍肿瘤细胞的生长增殖，存在准确性以及高效性等特点。而且，分子靶向药物对正常组织毒负作用较弱，可以明显的减轻治疗痛苦。但是分子靶向药物在使用过程中存在一定的副作用，其中皮肤毒性是较为常见的一种不良反应。例如，吉非替尼皮肤反应发生率为41.4％～79.7％，主要为脓疱性皮疹、痤疮、脱皮等。好发于头面部及躯干部，伴有瘙痒、皮肤皲裂等，给患者带来不适，且影响形象。西医治疗常使用传统激素、消炎药膏，可引起过敏、色素沉着等。
也有一些中药方法，采取纱布湿敷局部的处理方式，取得良好效果，但是对于患者来说并不方便，湿敷时中药纱布滴水，容易弄湿衣物，特别对于出院患者，从医院带熬制好的中药保存期限短，自己在家熬制中药再进行湿敷相当麻烦。
发明内容
本发明旨在提供一种能够缓解肿瘤分子靶向药物所致皮疹，且携带和使用方便的中药面膜。
为了实现上述技术效果，本发明提供的技术方案是：
一种治疗肿瘤分子靶向药物相关皮疹的中药面膜，包括以下质量组分原料：萆薢15-20份、蛇床子15-20份、紫花地丁15-20份、萹蓄15-20份、黄连15-20 份、黄柏15-20份、黄芩15-20份、青黛12-22份、地榆15-20份、苍术15-20 份、菊花15-20份、土茯苓15-20份、板蓝根15-20份、地肤子15-20份和苦参 15-20份。
进一步地，包括以下质量组分原料：包括以下质量组分原料：萆薢18-20 份、蛇床子17-20份、紫花地丁18-20份、萹蓄18-20份、黄连18-20份、黄柏 18-20份、黄芩18-20份、青黛15-20份、地榆18-20份、苍术18-20份、菊花 18-20份、土茯苓18-20份、板蓝根15-20份、地肤子18-20份和苦参15-20份。
进一步地，包括以下质量组分原料：萆薢18-20份、蛇床子18-20份、紫花地丁18-20份、萹蓄18-20份、黄连18-20份、黄柏18-20份、黄芩18-20份、青黛18-20份、地榆18-20份、苍术18-20份、菊花18-20份、土茯苓18-20份、板蓝根18-20份、地肤子18-20份和苦参18-20份。
进一步地，包括以下质量组分原料：萆薢20份、蛇床子20份、紫花地丁 20份、萹蓄20份、黄连20份、黄柏20份、黄芩20份、青黛20份、地榆20 份、苍术20份、菊花20份、土茯苓20份、板蓝根20份、地肤子20份和苦参 20份。
本发明还提供了上述一种治疗肿瘤分子靶向药物相关皮疹的中药面膜的制备方法，包括以下步骤：
(1)按配方量将所述萆薢、蛇床子、萹蓄、黄连、黄柏、黄芩、地榆、苍术、土茯苓、板蓝根、地肤子、苦参加入清水中武火煎20～30分钟；
(2)再将紫花地丁、菊花、青黛加入，一起文火煎10～15分钟，熬制为中药水剂；
(3)50-80目筛网过滤，置于室温待中药水剂冷却，将面膜纸浸渍于中药水剂5～10分钟即可。
本发明与现有技术相比，具有以下优点：
1.中医认为皮肤不良反应的发生由气血阴阳与脏腑功能失调所致，靶向药物引起的皮疹属于“药毒疹”范畴，总的病因病机为素体禀赋不耐,药毒内侵，体内湿热所致，中医辨证湿热瘀毒。本发明的中药面膜为纯中药成分，萆薢、萹蓄利湿祛浊，黄连、黄柏、黄芩清三焦之热为主，青黛、菊花、板蓝根清热解毒，蛇床子，地肤子、苦参杀虫止痒。诸药合用，以健脾祛湿为根本，通过清热解毒、除湿止痒、敛疮生肌达到治疗皮疹之目的。
2.本发明的中药面膜不使用激素、化学药物，可以避免引起过敏、色素沉着等问题。
3.本发明的方法制得的中药面膜为纸质面膜，患者使用和携带都非常方便。
附图说明
图1为患者应用实施例1中的中药面膜前后的皮疹情况图；
图2是患者应用实施例2的中药面膜前后的皮疹情况图；
图3是患者应用实施例3的中药面膜前后的皮疹情况图。
具体实施方式
下面结合具体实施方式，对本发明的权利要求做进一步的详细说明，但不构成对本发明的任何限制，任何在本发明权利要求保护范围内所做的有限次修改，仍在本发明的权利要求保护范围内。
实施例1
萆薢15份、蛇床子15份、萹蓄20份、黄连20份、黄柏20份、黄芩20 份、地榆20份、苍术15份、土茯苓15份、板蓝根15份、地肤子20份和苦参 20份加入清水2000mL武火煎20分钟；紫花地丁15份、菊花15份、青黛22 份加入，一起文火煎10分钟，熬制为200mL的中药水剂，50-80目筛网过滤，置于室温1小时待中药水剂冷却，将面膜纸浸渍于中药水剂5分钟，使药液吸附于面膜纸上，制成包装密封的纸质片状面膜，4℃保存。1日两次，每次敷20-30 分钟，连用一周。
实施例2
萆薢18份、蛇床子17份、萹蓄20份、黄连20份、黄柏20份、黄芩20 份、地榆20份、苍术18份、土茯苓18份、板蓝根15份、地肤子18份和苦参 20份加入清水2000mL武火煎30分钟；紫花地丁18份、菊花20份、青黛15 份加入，一起文火煎10分钟，熬制为200mL的中药水剂，80目筛网过滤，置于室温1小时待中药水剂冷却，将面膜纸浸渍于中药水剂5分钟，使药液吸附于面膜纸上，制成包装密封的纸质片状面膜，4℃保存。1日两次，每次敷20-30 分钟，连用一周。
实施例3
萆薢20份、蛇床子20份、萹蓄20份、黄连20份、黄柏20份、黄芩20 份、地榆20份、苍术20份、土茯苓20份、板蓝根20份、地肤子20份和苦参 20份加入清水2000mL武火煎20分钟；紫花地丁20份、菊花20份、青黛20 份加入，一起文火煎10分钟，熬制为200mL的中药水剂，50-80目筛网过滤，置于室温1小时待中药水剂冷却，将面膜纸浸渍于中药水剂5分钟，使药液吸附于面膜纸上，制成包装密封的纸质片状面膜，4℃保存。1日两次，每次敷20-30 分钟，连用一周。
为了验证本发明的有效性，选取2020年10月—2021年1月应用靶向药物治疗的肿瘤患者22例，将11例患者作为对照组，按传统方法护理(局部予呋喃西林软膏、百多邦外用消炎，并予维生素E软膏保湿)，11例作为实验组，应用本发明实施例1～3的中药面膜，每日敷面膜2次，应用一周后进行观察疗效。干预前，两组性别、年龄，用药方案、剂量、周期有可比性。干预后结果显示，实验组效果明显优于对照组。具体如表1所示。
表1对照组与实验组的疗效比较
组别 治愈 有效 无效 总有效率
对照组(n＝11) 3(27.2) 4(36.4) 4(36.4) 7(63.6)
实验组<u>(n＝11)</u> 6(54.5) 4(36.4) 1(9.0) 10(90.9)
其中，皮疹分级标准根据以EGFRIS相关皮肤不良反应NCI-CTCAE标准 (3.0版)分级制定:皮疹消失为痊愈(治愈)；皮疹3/4级降为1/2级或皮疹明显减少为好转(有效)；皮疹无明显变化或增多为无效。
图1是本实施例中患者1应用面膜前后的皮疹情况图；图2是本实施例中患者2应用面膜前后的皮疹情况图；图3是本实施例中患者3应用面膜前后的皮疹情况图。图1～3三例患者为例，显示了应用面膜前后患者的皮疹情况明显好转。
以上所述的仅为本发明的较佳实施例，凡在本发明的精神和原则范围内所做的任何修改、等同修改和改进等，均应包含在本发明的保护范围内。

Claims (5)

1.一种治疗肿瘤分子靶向药物相关皮疹的中药面膜，其特征在于，由以下质量组分原料制成：萆薢15-20份、蛇床子15-20份、紫花地丁15-20份、萹蓄15-20份、黄连15-20份、黄柏15-20份、黄芩15-20份、青黛12-22份、地榆15-20份、苍术15-20份、菊花15-20份、土茯苓15-20份、板蓝根15-20份、地肤子15-20份和苦参15-20份。
2.根据权利要求1所述的一种治疗肿瘤分子靶向药物相关皮疹的中药面膜，其特征在于，由以下质量组分原料制成：萆薢18-20份、蛇床子17-20份、紫花地丁18-20份、萹蓄18-20份、黄连18-20份、黄柏18-20份、黄芩18-20份、青黛15-20份、地榆18-20份、苍术18-20份、菊花18-20份、土茯苓18-20份、板蓝根15-20份、地肤子18-20份和苦参15-20份。
3.根据权利要求1所述的一种治疗肿瘤分子靶向药物相关皮疹的中药面膜，其特征在于，由以下质量组分原料制成：萆薢18-20份、蛇床子18-20份、紫花地丁18-20份、萹蓄18-20份、黄连18-20份、黄柏18-20份、黄芩18-20份、青黛18-20份、地榆18-20份、苍术18-20份、菊花18-20份、土茯苓18-20份、板蓝根18-20份、地肤子18-20份和苦参18-20份。
4.根据权利要求1-3任一所述的一种治疗肿瘤分子靶向药物相关皮疹的中药面膜，其特征在于，由以下质量组分原料制成：萆薢20份、蛇床子20份、紫花地丁20份、萹蓄20份、黄连20份、黄柏20份、黄芩20份、青黛20份、地榆20份、苍术20份、菊花20份、土茯苓20份、板蓝根20份、地肤子20份和苦参20份。
5.一种根据权利要求1所述的治疗肿瘤分子靶向药物相关皮疹的中药面膜的制备方法，其特征在于，包括以下步骤：
（1）将所述萆薢、蛇床子、萹蓄、黄连、黄柏、黄芩、地榆、苍术、土茯苓、板蓝根、地肤子、苦参加入清水中武火煎20~30分钟；
（2）再将紫花地丁、菊花、青黛加入，一起文火煎10~15分钟，熬制为中药水剂；
（3）50-80目筛网过滤，置于室温待中药水剂冷却，将面膜纸浸渍于中药水剂5~10分钟即可。
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CN1768812A (zh) * 2005-10-24 2006-05-10 高欲林 一种用于除湿止痒的药物组合物及其制备方法和用途

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