CN112888673B - 新颖mct4抑制剂及其用途 - Google Patents

新颖mct4抑制剂及其用途 Download PDF

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Publication number
CN112888673B
CN112888673B CN201980035699.6A CN201980035699A CN112888673B CN 112888673 B CN112888673 B CN 112888673B CN 201980035699 A CN201980035699 A CN 201980035699A CN 112888673 B CN112888673 B CN 112888673B
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mct4
cancer
subject
cells
pharmaceutical composition
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Chinese (zh)
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CN112888673A (zh
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吴勇
杰伊·瓦德加玛
黄志敏
吴珂
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Charles Drew University Of Medical Sciences
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Charles Drew University Of Medical Sciences
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980035699.6A 2018-04-25 2019-04-25 新颖mct4抑制剂及其用途 Active CN112888673B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862662637P 2018-04-25 2018-04-25
US62/662,637 2018-04-25
PCT/US2019/029192 WO2020033019A2 (en) 2018-04-25 2019-04-25 Novel mct4 inhibitors and uses thereof

Publications (2)

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CN112888673A CN112888673A (zh) 2021-06-01
CN112888673B true CN112888673B (zh) 2022-07-29

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US (1) US10919878B2 (https=)
EP (1) EP3784650B1 (https=)
JP (1) JP7115671B2 (https=)
CN (1) CN112888673B (https=)
AU (1) AU2019317518B2 (https=)
CA (1) CA3098189C (https=)
WO (1) WO2020033019A2 (https=)

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Publication number Priority date Publication date Assignee Title
US12544375B2 (en) * 2019-09-05 2026-02-10 The Board Of Trustees Of The Leland Junior University Small molecule therapeutic for parkinson's disease paired with a biomarker of therapeutic activity
WO2021249969A1 (en) * 2020-06-10 2021-12-16 Merck Patent Gmbh Combination product for the treatment of cancer diseases
WO2022243573A1 (en) 2021-05-21 2022-11-24 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 1,2,4-triazolo[1,5-a]pyrimidine-based slc16a3 inhibitors and their therapeutic use
WO2022243574A1 (en) 2021-05-21 2022-11-24 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 3-(phthalazin-1-yl)benzenesulfonamide-based slc16a3 inhibitors and their therapeutic use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101291917A (zh) * 2003-11-28 2008-10-22 诺瓦提斯公司 治疗蛋白激酶依赖性疾病的二芳基脲衍生物
WO2010089580A1 (en) * 2009-02-06 2010-08-12 Astrazeneca Ab Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4
CN102731413A (zh) * 2011-04-15 2012-10-17 上海医药工业研究院 一种脲类化合物、其制备方法、其中间体及其应用
CN107635404A (zh) * 2015-06-12 2018-01-26 威特瑞有限公司 用于治疗疾病的mct4抑制剂
CN108368060A (zh) * 2017-12-21 2018-08-03 中国科学院合肥物质科学研究院 一类新型的嘧啶类衍生物激酶抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226438A (https=) 1968-12-03 1971-03-31
TW200804349A (en) * 2005-12-23 2008-01-16 Kalypsys Inc Novel substituted pyrimidinyloxy ureas as inhibitors of protein kinases
CN105263484B (zh) 2013-05-24 2018-08-03 株式会社加龄.营养研究所 包含二甲双胍和二氢槲皮素的药物组合及其用于治疗癌症的用途
CN107406390B (zh) * 2014-11-17 2021-04-16 奈吉治疗公司 单羧酸转运蛋白调节剂及其用途
EP3247349B1 (en) * 2015-01-22 2019-12-11 The Scripps Research Institute Chromenone inhibitors of monocarboxylate transporters
US10328078B2 (en) * 2015-01-22 2019-06-25 The Scripps Research Institute Pteridine dione monocarboxylate transporter inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101291917A (zh) * 2003-11-28 2008-10-22 诺瓦提斯公司 治疗蛋白激酶依赖性疾病的二芳基脲衍生物
WO2010089580A1 (en) * 2009-02-06 2010-08-12 Astrazeneca Ab Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4
CN102731413A (zh) * 2011-04-15 2012-10-17 上海医药工业研究院 一种脲类化合物、其制备方法、其中间体及其应用
CN107635404A (zh) * 2015-06-12 2018-01-26 威特瑞有限公司 用于治疗疾病的mct4抑制剂
CN108368060A (zh) * 2017-12-21 2018-08-03 中国科学院合肥物质科学研究院 一类新型的嘧啶类衍生物激酶抑制剂

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AU2019317518A1 (en) 2020-12-17
EP3784650A4 (en) 2022-01-26
CA3098189C (en) 2025-05-13
AU2019317518B2 (en) 2023-05-25
EP3784650C0 (en) 2023-09-06
WO2020033019A3 (en) 2020-04-02
US10919878B2 (en) 2021-02-16
CA3098189A1 (en) 2020-02-13
WO2020033019A2 (en) 2020-02-13
JP2021522345A (ja) 2021-08-30
EP3784650A2 (en) 2021-03-03
JP7115671B2 (ja) 2022-08-09
US20190352282A1 (en) 2019-11-21
EP3784650B1 (en) 2023-09-06
CN112888673A (zh) 2021-06-01

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