CN112881719B

CN112881719B - Blood analyzer and detecting device

Info

Publication number: CN112881719B
Application number: CN201911209219.1A
Authority: CN
Inventors: 郭俊游
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2019-11-30
Filing date: 2019-11-30
Publication date: 2024-01-16
Anticipated expiration: 2039-11-30
Also published as: CN112881719A

Abstract

The invention provides a blood analyzer and a detection device, wherein the detection assembly comprises a vertical frame, a heating assembly, a detection assembly and an optical detection pool, the heating assembly is fixed on the vertical frame and comprises a heating block, the heating block is provided with an assembly cavity for receiving the optical detection pool, the detection assembly is fixed with the heating block, the detection assembly comprises a base body, the base body is provided with a notch part which is clamped and matched with the heating block, and the optical detection pool is arranged in the notch part and is assembled into the assembly cavity through the bearing of the base body. The detection device provided by the invention has novel structure, the optical detection pool is arranged in the notch part and is arranged in the assembly cavity through the support of the matrix, and the detection device is convenient to assemble and disassemble and is beneficial to maintenance.

Description

Blood analyzer and detecting device

Technical Field

The invention relates to the technical field of sample analysis, in particular to a blood analyzer and a detection device.

Background

The full-automatic analyzer has been widely used in hospitals, medical inspection laboratories and area detection centers due to its high measurement speed, high accuracy and small consumption of reagents.

The full-automatic analyzer is internally provided with a detection device, and the detection device detects a sample in the optical detection cell in an optical detection mode.

However, the existing detection device has a complex structure, is inconvenient to assemble and disassemble, and is not beneficial to maintenance.

Disclosure of Invention

The application provides an analyzer, detection device to survey device structure complicacy, dismouting inconvenience among the solution prior art, be unfavorable for the problem of maintenance.

In order to solve the technical problems, one technical scheme adopted by the application is as follows: there is provided a detection apparatus including:

a vertical frame;

the heating assembly is fixed on the vertical frame and comprises a heating block, and the heating block is provided with an assembly cavity for receiving the optical detection pool;

the detection assembly is fixed with the heating block and comprises a base body, and the base body is provided with a notch part which is clamped and matched with the heating block;

the optical detection pool is arranged in the notch part and is arranged in the assembly cavity through the support of the base body.

The beneficial effects of this application are: compared with the prior art, the detection device provided by the invention has the advantages that the structure is novel, the optical detection pool is arranged in the notch part and is arranged in the assembly cavity through the support of the matrix, and the assembly and disassembly are convenient, so that the maintenance is facilitated.

Drawings

FIG. 1 is a schematic view of a partial planar structure of an analyzer according to an embodiment of the present invention;

FIG. 2 is a schematic perspective view of a detection device of the analyzer shown in FIG. 1;

FIG. 3 is a schematic view of a partial perspective view of the inside of an analyzer according to an embodiment of the present invention;

FIG. 4 is a schematic perspective view of a heating assembly of the detection device shown in FIG. 2;

FIG. 5 is a schematic view of an exploded construction of the heating assembly shown in FIG. 4;

FIG. 6 is a schematic perspective view of a heating block of the heating assembly shown in FIG. 5;

FIG. 7 is a schematic perspective view of a detection assembly of the detection device shown in FIG. 2;

FIG. 8 is a schematic view of an exploded construction of the detection assembly shown in FIG. 7;

FIG. 9A is a schematic perspective view of an optical detection cell of the detection device shown in FIG. 2;

FIG. 9B is a schematic diagram of an exploded structure of the optical detection cell shown in FIG. 9A;

FIG. 10A is a schematic side view of another embodiment of an optical detection cell;

FIG. 10B is a schematic cross-sectional structure of the optical detection cell shown in FIG. 10A;

FIG. 10C is a schematic diagram of a side of another embodiment of an optical detection cell;

FIG. 10D is a schematic view of the other side of the optical detection cell shown in FIG. 10C;

FIG. 11 is a schematic perspective view of the mount of the analyzer shown in FIG. 1;

FIG. 12 is a schematic view of an exploded construction of the mount shown in FIG. 11;

FIG. 13 is a schematic side elevational view of the mount shown in FIG. 11;

fig. 14 is a schematic perspective view of the mixing tank shown in fig. 12;

FIG. 15 is a schematic cross-sectional view of the mixing tank shown in FIG. 14;

FIG. 16 is an exploded view of the preheating tank shown in FIG. 12;

FIG. 17 is a schematic perspective view of a winding tube according to an embodiment of the present invention;

figure 18 is a schematic side elevational view of the winding tube shown in figure 17;

FIG. 19 is a schematic perspective view of a pipe heating assembly according to an embodiment of the present invention;

FIG. 20 is a schematic cross-sectional view of the heating assembly of the conduit shown in FIG. 19;

FIG. 21 is a schematic view of the exploded construction of the heating assembly of FIG. 19;

FIGS. 22-26 are schematic structural views of a detection assembly provided by an embodiment of the present invention;

fig. 27-30 are simplified schematic structural diagrams of a detection device according to an embodiment of the present invention.

Detailed Description

The technical solutions of the following embodiments can be combined with each other.

In a first embodiment, the present embodiment provides a detection apparatus, as shown in fig. 1 to 6, which includes a stand 100, a heating assembly, a detection assembly, and an optical detection cell 120.

As shown in fig. 2, the stand 100 may be a metal bracket or a plastic bracket, and is fixedly assembled in a housing of the analyzer, the heating assembly may be obliquely fixed on the stand 100, and the heating assembly includes a heating block 110, where the heating block 110 may be made of aluminum or copper, the heating block 110 is provided with a plurality of assembly cavities 113 for receiving the optical detection cells 120, the volumes of the assembly cavities 113 are matched with the volumes of the optical detection cells 120, the assembly cavities 113 form a complete enclosure for the optical detection cells 120, only the bottom end surfaces of the optical detection cells 120 are exposed, the contact area between the heating block 110 and the optical detection cells 120 is large, the heat conduction effect is good, and the liquid to be measured in the optical detection cells 120 can be well temperature-controlled. The detection assembly is fixed with the heating block 110, the detection assembly comprises a base 130, the base 130 is provided with a notch 134 which is clamped and matched with the heating block 110, and the optical detection pool 120 is arranged in the notch 134 and is installed in the assembly cavity 113 through the support of the base 130.

As shown in fig. 2, 7 and 8, the heating block 110 is further provided with a light-passing hole 114 penetrating the assembly cavity 113, the base 130 is further provided with a light-entering channel 133, a first light-exiting channel 131 and a second light-exiting channel 132, the notch 134 is arranged between the light-entering channel 133 and the first light-exiting channel 131 and between the light-exiting channel 132, the light-entering channel 133 is aligned with the first light-exiting channel 131, the axis of the second light-exiting channel 132 is inclined relative to the axis of the first light-exiting channel 131, and the light-passing hole 114 is aligned with the light-entering channel 133 when the detection assembly is fixed with the heating block 110.

In order to facilitate the fixing of the detection assembly to the heating block 110, the base 130 integrally extends to form a mounting plate 136 on one side of the notch 134 near the light incident channel 133, a first mounting hole 137 is formed in the mounting plate 136, a first connecting hole 111 is formed in the side wall of the heating block 110 corresponding to the first mounting hole 137, the detection assembly can be locked relative to the heating block 110 by penetrating the first mounting hole 137 through a screw and screwing in the first connecting hole 111, and the first connecting hole 111 is located at the side edge of the light passing hole 114.

Further, the base 130 is further provided with a second assembly hole 138 penetrating to the bottom of the notch 134, the bottom end of the heating block 110 is provided with a second connection hole 112 corresponding to the second assembly hole 138, the detection assembly can be locked relative to the heating block 110 by penetrating the second assembly hole 138 through a screw and screwing into the second connection hole 112, and the second connection hole 112 is located at the side edge of the assembly cavity 113.

In the embodiment of the present invention, the number of the assembly cavities 113 is a plurality of parallel and spaced, for example, 6 of the assembly cavities shown in fig. 2, the number of the detection assemblies and the number of the optical detection cells 120 are all a plurality of, and a plurality of groups of guide ribs 115 are further arranged on the side wall of the heating block 110 in parallel and spaced manner, so that the notch 134 of the base 130 and the assembly plate 136 are aligned and clamped with the heating block 110, and the extending direction of the guide ribs 115 is parallel to the extending direction of the assembly cavities 113.

As shown in fig. 2 and fig. 4 to 10, the detection device further includes a waterproof sealing ring 101, the optical detection tank 120 includes a tank body 121 and a liquid injection tube 125, a through hole 116 communicating with the assembly cavity 113 to allow the liquid injection tube 125 to extend is provided at the top end of the heating block 110, and the waterproof sealing ring 101 is located in the assembly cavity 113 and sleeved on the periphery of the liquid injection tube 125 and is sandwiched between the optical detection tank 120 and the heating block 110, so that external liquid can be prevented from entering the optical detection tank 120 to affect the detection result.

As shown in fig. 1 and 2, the heating block 110 is obliquely fixed to the stand 100 such that the assembly chamber 113 is obliquely disposed, and the optical detection cell 120 and the detection assembly are obliquely disposed with respect to the horizontal plane.

The detection device further comprises a pipeline heating assembly 300, the pipeline heating assembly 300 is used for winding a pipeline and heating the pipeline, the stand 100 comprises a first support arm 102 and a second support arm 104, the heating block 110 is fixed through the first support arm 102, the pipeline heating assembly 300 is arranged on the side edge of the heating block 110 through the second support arm 104, and the pipeline heating assembly 300 is lower than the position of the liquid injection pipe 125, so that the pipeline wound on the pipeline heating assembly 300 can be turned and butted with the liquid injection pipe 125 in a smaller curvature mode when being led out, the problem of bubbles can be reduced by facilitating the air bubble discharge, and if the pipeline heating assembly 300 is higher than the position of the liquid injection pipe 125, the pipeline wound on the pipeline heating assembly 300 is turned and butted with the liquid injection pipe 125 in a larger curvature mode when being led out, and the bubbles are not easy to discharge, so that the problem of relatively serious bubbles can be generated.

As shown in fig. 4 to 6, the heating assembly further includes a heating film 117, a temperature sensor 118 and an overtemperature protection switch 119, the heating block 110 may be made of a material with good heat conduction performance, such as aluminum or copper, the heating film 117 is adhered to the surface of the heating block 110, and the temperature sensor 118 and the overtemperature protection switch 119 are embedded and assembled in the heating block 110. The mounting holes 103 can be formed at two ends of the heating block 110 to be fixed with the first support arm 102 of the vertical frame 100, the surface of the heating block 110, which is used for attaching the heating film 117, can be provided with the protruding portion 106, the protruding portion 106 enables the section of the heating block 110 to be L-shaped, and the over-temperature protection switch 119 can be embedded and assembled in the protruding portion 106, so that the heating block 110 is compact in structure.

The detection device provided in this embodiment has novel structure, the optical detection tank 120 is arranged in the notch 134 and is installed in the assembly cavity through the support of the base 130, so that the assembly and disassembly are convenient, the maintenance is facilitated, the influence of water leakage on the detection device can be reduced, and the bubble problem can be reduced. The embodiment also provides a sample analyzer, which comprises the detection device.

In a second embodiment, the present embodiment provides a detection assembly, as shown in fig. 7 to 8, which includes a base 130, an optical receiver, and a fixing assembly. In one embodiment, the securing assembly includes a securing member 139 and a sealing ring 140.

Wherein, the base 130 may be made of plastic or metal, the fixing piece 139 is fixed with the base 130 to assemble the light receiver in the base 130, and the sealing ring 140 is sandwiched between the fixing piece 139 and the light receiver.

Specifically, as shown in fig. 8, the base 130 is provided with a first light-emitting channel 131 and a second light-emitting channel 132, the axis of the second light-emitting channel 132 is inclined with respect to the axis of the first light-emitting channel 131, the sides of the first light-emitting channel 131 and the second light-emitting channel 132 are provided with first fixing holes 143, the fixing piece 139 is a fixing plate, and the fixing plate is fixed with the base 130 by screws.

The light receiver includes a first photodiode 141 and a second photodiode 142, the first photodiode 141 is assembled in the first light-emitting channel 131, the second photodiode 142 is assembled in the second light-emitting channel 132, the detection assembly further includes a transmission light filter block 144, a lens fixing block 145 and a lens 146, the transmission light filter block 144 is disposed in the first light-emitting channel 131 and is located at the light-incident side of the first photodiode 141, the lens fixing block 145 and the lens 146 are disposed in the second light-emitting channel 132, and the lens 146 is fixed by the lens fixing block 145 and is located at the light-incident side of the second photodiode 142.

The base 130 is further provided with a notch 134, the notch 134 is communicated with the first light-emitting channel 131 and the second light-emitting channel 132, the notch 134 is used for accommodating the optical detection cell 120, an arc-shaped groove 135 is formed in one side, close to the first light-emitting channel 131 and the second light-emitting channel 132, of the notch 134, a second fixing hole 147 is formed in the side edge of the arc-shaped groove 135, the second fixing hole 147 is used for fixing a light barrier (not shown in the figure), and the light barrier is used for blocking light at two ends of the arc-shaped groove 135.

The detecting assembly further includes a first diaphragm 148, where the first diaphragm 148 is fixed to the substrate 130 and extends into one side of the notch 134 near the first light-emitting channel 131 and the second light-emitting channel 132, and the first diaphragm 148 is provided with a light-passing slot 149, where the light-passing slot 149 is aligned with the first light-emitting channel 131 and the second light-emitting channel 132.

The base 130 integrally extends on one side of the notch 134 away from the first light-emitting channel 131 and the second light-emitting channel 132 to form a mounting plate 136, the mounting plate 136 is provided with a first mounting hole 137, the first mounting hole 137 is used for supporting the base 130 to be fixedly mounted, and as can be easily understood in conjunction with fig. 2, the mounting plate 136 can be slidably matched with a chute formed by two guide ribs 115, and the detection assembly can be locked relative to the heating block 110 by passing a screw through the first mounting hole 137 and screwing into the first connecting hole 111.

As shown in fig. 8, the detection assembly further includes a laser 156 and a second diaphragm 150, the substrate 130 is further provided with an light-entering channel 133, the light-entering channel 133 is communicated with the notch 134 and aligned with the first light-exiting channel 131, and the laser 156 and the second diaphragm 150 are installed in the light-entering channel 133. The number of the second diaphragms 150 may be one, two or three, and the first diaphragm 148 and the second diaphragm 150 both have the function of transmitting light and the function of blocking light.

As shown in fig. 2, 7 and 8, the base 130 is further provided with a first slot 151 and a second slot 152, the first slot 151 is disposed near the outer end of the light-entering channel 133 so that one end of the base 130 forms a clamping block 153, the second slot 152 is disposed on the clamping block 153 and is communicated with the light-entering channel 133, two sides of the clamping block 153 are provided with through connecting holes 154, and the connecting holes 154 are used for setting screws so that the clamping block 153 clamps or unclamps the laser 156.

As shown in fig. 7 and 8, the fixing plate is provided with a slot 155 to allow the leads of the first photodiode 141 and the second photodiode 142 to be led out.

The detection assembly provided in this embodiment can improve the assembly accuracy by providing the sealing ring 140 between the fixing member 139 and the light receiver, so that the receiving plane of the light receiver is relatively flat.

In another embodiment, the fixing component is a small circuit board, the light receiver is welded on one surface of the circuit board, the circuit board is fixed with the base 130 through a screw or an adhesive, a terminal is arranged on the other surface of the circuit board, and a signal of the light receiver can be led out through the terminal and connected to a main control circuit board of the analyzer through a wire for processing. The embodiment also provides a sample analyzer, which comprises the detection assembly.

Third embodiment as shown in fig. 9A and 9B, the present embodiment provides an optical detection cell 120, the optical detection cell 120 including a cell body 121 and a light-transmitting plate 124.

Wherein, the cell body 121 is provided with a linear through groove 122 penetrating through two opposite surfaces of the cell body 121 and a liquid injection channel 123 communicated with the through groove 122, and a light-transmitting plate 124 is fixed with the cell body 121 and seals the outer end of the through groove 122. The optical detection tank 120 adopts a split design, so that the problem of high difficulty in manufacturing by adopting a glass integrated design can be avoided, specifically, the through groove 122 of the tank body 121 can be directly formed by a numerical control drilling or numerical control milling groove mode, and the liquid injection channel 123 can be formed by a numerical control drilling mode.

Specifically, the tank 121 may be a metal tank, a ceramic tank, a glass tank, or a plastic tank. The light-transmitting plate 124 may be a glass plate or a plastic plate. The light-transmitting plate 124 and the cell body 121 may be fixed by glue bonding, laser welding or screw fixation.

The tank body 121 may be provided with a convex column, a flange 126, a surrounding edge or a concave area for positioning and assembling the light-transmitting plate 124, and the flange 126 may be straight or L-shaped as shown in fig. 10.

In an embodiment, the optical detection cell 120 may be rectangular, and the optical detection cell 120 has a pair of first side surfaces, a pair of second side surfaces, and a pair of third side surfaces with sequentially smaller areas, the through groove 122 penetrates the pair of first side surfaces, and the outer opening end of the liquid injection channel 123 is located on one of the third side surfaces.

The tank body 121 is provided with two liquid injection channels 123, and the two liquid injection channels 123 are vertically arranged and are respectively close to opposite end angles of the third surface so as to reduce the volume of the product. The two pouring channels 123 are respectively connected with a pouring tube 125.

The cross section of the through groove 122 may be circular, oval, racetrack, rectangular or regular polygon, and the racetrack is a shape surrounded by two parallel sides and two arc sides.

The optical detection cell 120 provided in this embodiment is assembled after split processing and manufacturing, so that the processing difficulty is greatly simplified, the processing efficiency is improved, the production cost is reduced, and the problem of high difficulty in designing and manufacturing by adopting glass integrated type can be avoided.

As shown in fig. 10A and 10D, the present embodiment also provides an optical detection cell, which includes a cell body 121, a light-transmitting plate (not shown, refer to the aforementioned light-transmitting plate 124), and a pour tube 125.

Wherein the tank 121 is provided with a straight through groove 122 penetrating through two opposite surfaces of the tank 121, a liquid injection passage (not shown, refer to the liquid injection passage 123 described above) communicating with the through groove 122, an opening end of the liquid injection passage being located on an abutting surface between the two opposite surfaces, and a liquid guiding groove 127. The through groove 122 of the tank body 121 can be directly formed by numerical control drilling or numerical control milling, the liquid injection channel 123 can be formed by numerical control drilling, the liquid guide groove 127 can be formed by numerical control milling, and the processing is convenient, the shape is regular and the precision is high.

The cell body 121 may be a metal cell body 121, a ceramic cell body 121, a glass cell body 121, or a plastic cell body 121. The cell body 121 may have a rectangular body shape or a stepped shape as shown in fig. 10B and 10C, i.e., including a relatively thin lower portion and a relatively thick upper portion. The cross section of the through groove 122 may be in a racetrack shape as shown in fig. 10A, the areas of the two ends of the through groove 122 may be the same or different, the bottom side of the through groove 122 in the longitudinal section of the through groove 122 may be horizontally disposed or inclined as shown in fig. 10B, in other embodiments, the cross section of the through groove 122 may be a round hole shape (as shown in fig. 10D) or a square hole shape, when the areas of the two ends of the through groove 122 are different, for example, the longitudinal sections of the through groove 122 shown in fig. 10A and 10B are right trapezoid, the internal volume of the optical detection cell may be reduced, air bubbles may be prevented, the angle of the hypotenuse of the through groove 122 is consistent with the angle of the scattered light, the scattered light may be emitted through the aforementioned second light emitting channel 132, the angle may effectively shield the stray light, and the bottom side of the through groove 122 may be inclined with respect to the horizontal plane, the included angle range is less than or equal to 35 degrees, for example, 21 degrees, 23 degrees, 23.5 degrees, 24 degrees, 26 degrees, 28 degrees, etc. The through groove 122 may be provided at a thinner lower portion of the cell body 121, and the area of the corresponding light-transmitting plate may be reduced, and flush-assembled with the step-shaped cell body 121.

The liquid guiding groove 127 communicates the through groove 122 with the liquid injecting channel, the liquid guiding groove 127 is connected with the liquid injecting channel in an inclined way, and the liquid guiding groove 127 is connected with the top end of the through groove 122 so as to facilitate the discharge of bubbles in the tank body 121, and the angle range of the acute angle formed by the liquid guiding groove 127 relative to the vertical direction is less than or equal to 30 degrees, for example, 23 degrees, 24 degrees, 25 degrees, 26 degrees, 27 degrees and the like. The drain groove 127 is concave in two opposite surfaces of the cell body 121, one end of the drain groove 127 is communicated with the end part of the through groove 122, the other end of the drain groove 127 is communicated with the liquid injection channel, the liquid injection channel is connected with the liquid injection pipe 125, the liquid injection pipe 125 and the through groove 122 can be arranged in a staggered mode, the drain groove 127 communicated with the through groove 122 and the liquid injection channel can be arranged in an inclined mode, bubbles are not prone to accumulating in the cell body 121 due to the drain groove arranged in an inclined mode, and the liquid injection channel and the liquid injection pipe 125 are two in quantity and are arranged diagonally and diagonally so that the product structure is compact.

The light-transmitting plate is fixed to the cell body 121 and closes the outer end of the through groove 122. The light-transmitting plate is a glass plate or a plastic plate. The light-transmitting plate is fixed with the cell body 121 by glue bonding, laser welding or screw fixing. The cell body 121 may be provided with a post, a flange, a rim or a recessed area to position and assemble the light-transmitting plate.

The optical detection tank 120 of the embodiment adopts a split design, so that the problem of high difficulty in manufacturing due to the adoption of glass integrated design can be avoided, meanwhile, the accurate control of the volume and the shape of the inner cavity of the optical detection tank 120 is facilitated, the requirements of regular and small shapes of the inner cavity and the local inclined plane of the inner cavity are easily met, the difficulty and the cost of generation are reduced, meanwhile, the influence of bubbles is reduced due to the optimized structural design, the detection condition is further optimized, and the detection precision is improved.

The embodiment also provides a sample analyzer, which comprises the optical detection tank 120, a mixing tank and a detection assembly, wherein the mixing tank is communicated with the optical detection tank, the detection assembly is provided with a notch part for accommodating the optical detection tank, and the detection assembly further comprises a laser and a light receiver which are respectively arranged at two sides of the notch part. Wherein the mixing tank and detection assembly refer to other embodiments.

Fourth embodiment, the present embodiment provides a fitting seat, as shown in fig. 11 to 16, which includes a first fitting body 210, the first fitting body 210 having first and second fitting grooves 211 and 212 provided on the opposite surfaces thereof, respectively, the first and second fitting grooves 211 and 212 being used to provide mixing and preheating tanks 240 and 250, respectively, the number of the first and second fitting grooves 211 and 212 being single or laterally expanded to a plurality (for example, 6 as shown in fig. 12), the first fitting groove 211 being located higher than the second fitting groove 212 so that the mixing tank 240 is located higher than the preheating tank 250. When the liquid in the preheating tank 250 is heated to generate bubbles, the bubbles are easier to be discharged out of the preheating tank 250 along with the output of the liquid under the condition that the mixing tank 250 is higher than the preheating tank 250 due to the smaller density of the bubbles when the liquid in the preheating tank 250 is required to be conveyed into the mixing tank 240 for reaction.

As shown in fig. 13, the first assembly 210 is stepped and includes a connecting portion 214, a first assembly portion 216 extending upward from one side of the connecting portion 214, and a second assembly portion 218 extending downward from the other side of the connecting portion 214, wherein the first assembly groove 211 is recessed in the first assembly portion 216 and the connecting portion 214, and the second assembly groove 212 is recessed in the second assembly groove 212 and the connecting portion 214.

As shown in fig. 12, the assembly base further includes a second assembly 220 and a third assembly 230, the second assembly 220 is provided with a third assembly groove 221 and is buckled with the first assembly groove 211 to provide a mixing pool 240, and the third assembly 230 is provided with a fourth assembly groove 231 and is buckled with the second assembly groove 212 to provide a preheating pool 250. The first assembly 210, the second assembly 220, and the third assembly 230 are all made of a material with good heat conductivity, such as an aluminum material or a copper material.

Of course, in other embodiments, the mounting base may be a single piece, and the first mounting groove 211 and the second mounting groove 212 may be cavities provided inside the first mounting body 210 and matched with the mixing tank 240 and the preheating tank 250, thereby reducing material costs.

As shown in fig. 12, this embodiment further provides a heating assembly, which includes a mixing tank 240, a preheating tank 250, a first heating body 261, a second heating body 262, and the foregoing assembly base, where the mixing tank 240 and the preheating tank 250 are made of corrosion-resistant materials, and heat conducting materials are used to fill between the mixing tank 240, the preheating tank 250, and the assembly base, and the first heating body 261 and the second heating body 262 are respectively used to heat the mixing tank 240 and the preheating tank 250.

As shown in fig. 14 and 15, a first liquid outlet pipe 241 and a waste discharge pipe 242 are disposed at the bottom of the mixing tank 240, a first liquid inlet pipe 243 is disposed at a position of the mixing tank 240 near the top, and a first reinforcing block 244 and a second reinforcing block 245 are disposed at the positions of the first liquid outlet pipe 241 and the first liquid inlet pipe 243 of the mixing tank 240. When the mixing tank 240 is not in use, the liquid needs to be soaked in the liquid, if the position of the first liquid inlet pipe 243 is low, the liquid in the mixing tank 240 is easy to contact with the reagent in the first liquid inlet pipe 243 to pollute the reagent, so the position of the first liquid inlet pipe 243 is higher than the height of the soaking liquid.

The first liquid inlet pipe 243 is inclined with respect to the mixing tank 240, and the included angle of the first liquid inlet pipe 243 with respect to the axis of the mixing tank 240 may be 30±15 degrees.

The bottom of the preheating tank 250 is provided with a second liquid inlet pipe 251, the top of the preheating tank 250 is provided with a second liquid outlet pipe 252, and the position of the second liquid outlet pipe 252 is lower than that of the first liquid inlet pipe 243. The top of the preheating tank 250 is also provided with a plug 253.

The heating element further includes an over-temperature protection switch 263, a temperature sensor 264, a first mounting bracket, a second mounting bracket and a top cover 276, the over-temperature protection switch 263 and the temperature sensor 264 are installed in the first assembly 210, the first mounting bracket includes a first connecting plate 271, a second connecting plate 272 and a third connecting plate 273 which are sequentially connected, the first connecting plate 271 is connected with the first assembly 210 and parallel to the third connecting plate 273, the second mounting bracket includes a fourth connecting plate 274 and a fifth connecting plate 275 which are connected with each other in L-shaped cross section, the fourth connecting plate 274 is used for supporting and connecting the bottom of the first assembly 210, the fifth connecting plate 275 and the third connecting plate are located on the same plane, the top cover 276 is provided with a fixing hole 278 corresponding to the fixing holes 213 and 232 and a through hole 277 corresponding to the second liquid outlet pipe 252 of the preheating tank, and the top cover 276 is convenient to be fixedly installed.

The heating element that this embodiment provided compact structure, convenient assembling, heat conduction efficiency are better, and the first feed liquor pipe 243 of mixing tank 240 sets up the position relatively higher and is the slope setting, and the reagent is difficult for receiving the pollution, and the reagent of entering is difficult for splashing on the pool wall of mixing tank 240, heats mixing tank 240, preheating tank 250 respectively through first heating member 261, second heating member 262, can control different heating power, reaches different heating effect, and then improves the accuracy of detection. The embodiment also provides a sample analyzer, which comprises the heating assembly.

In a fifth embodiment, as shown in fig. 17 to 21, the present embodiment provides a pipe heating assembly 300, where the pipe heating assembly 300 includes a heating cylinder 301, a pipe penetrating channel 302 penetrating through an arc wall of the heating cylinder 301 is provided on an outer circumferential surface of the heating cylinder 301, the outer circumferential surface of the heating cylinder 301 is used for winding a pipe, and the pipe penetrating channel 302 is used for passing the pipe and forming an anti-drop limit for the pipe.

Wherein, the tube-passing channel 302 may be straight or curved. The through pipe passage 302 is distant from the diameter of the heating cylinder 301 and is close to the outer peripheral surface of the heating cylinder 301. If the pipe passage 302 is directly opened on the diameter of the heating cylinder 301, the angle of the pipe is larger, which is not beneficial to the transmission of the internal reagent.

The opening size of one end of the pipe penetrating channel 302 is larger than that of the other end so as to facilitate pipe penetrating operation, the pipe penetrating channel is convenient to operate by penetrating from the larger end of the opening, and the limiting effect is good by penetrating from the smaller end of the opening.

The heating cylinder 301 is provided with a plurality of flanges 303, for example, three through pipe channels 302 are shown in fig. 17, and are arranged close to the flanges 303, two through pipe channels 302 are arranged between two adjacent flanges for winding a coil of pipeline, and two leading-out ends of the pipeline respectively pass through the two through pipe channels 302, so that the pipeline can be well prevented from being loosened.

As shown in fig. 21, the pipe heating assembly 300 further includes a fixing clip 310, and the fixing clip 310 is disposed at the outer circumference of the heating cylinder 301 and provided with an opening 312 corresponding to the pipe penetration passage 302 to allow the pipes (304, 305) to be drawn out. The fixing clamp plate 310 may have two fixing clamp plates, and each fixing clamp plate 310 may include an arc portion and a flat plate portion, and the flat plate portion is provided with a locking hole for locking a screw. The pipe heating assembly 300 further comprises heat insulation cotton 330, the heat insulation cotton 330 is sleeved on the periphery of the fixed clamping plate 310 and is provided with a cutting part 332 corresponding to the opening 312 to allow the pipe (304, 305) to be led out, one end of the heat insulation cotton 330 is further provided with extension cotton 334, the end part of the heating cylinder 301 is at least partially covered by the extension cotton 334 to improve the heat insulation effect, and meanwhile the extension cotton 334 can play a role in limiting assembly, so that the heat insulation cotton 330 and the fixed clamping plate 310 are not easy to relatively shift.

The pipe heating assembly 300 further includes a temperature protection switch 342, a temperature sensor 344, and a heating rod 346, and the end of the heating cylinder 301 is provided with an assembly groove 341, and the assembly groove 341 is used for assembling the temperature protection switch 342, the temperature sensor 344, and the heating rod 346. The pipe heating assembly 300 further includes a mounting plate 350, the mounting plate 350 being secured to one end of the heating cartridge 301 for fixedly assembling the heating cartridge 301.

The pipeline heating assembly 300 provided by the embodiment can perform accurate temperature control on the reagent conveying path, avoids heat loss of the reagent in the conveying process, and improves heating efficiency and detection precision. The present embodiment also provides a sample analyzer including the aforementioned pipe heating assembly 300.

In a sixth embodiment, as shown in fig. 1 to 12, the present embodiment provides a detection apparatus including a mixing tank 240, a preheating tank 250, a dilution liquid tank 270, an optical detection tank 120, a first heating body 261, a second heating body 262, a third heating body 263, and a heating assembly.

Wherein the first heating body 261 is attached to the outer side of the mixing tank 240 for heating the mixing tank 240, the preheating tank 250 is attached to the side of the mixing tank 240 and is communicated with the mixing tank 240 through a pipeline, the second heating body 262 is attached to the outer side of the preheating tank 250 for heating the preheating tank 250, the dilution liquid tank 270 is attached to the side of the mixing tank 240 and is communicated with the mixing tank 240 through a pipeline, the third heating body 263 is attached to the outer side of the dilution liquid tank 270 for heating the dilution liquid tank 270,

The optical detection tank 120 is arranged at the side of the mixing tank 240 and is communicated with the mixing tank 240 through a pipeline, the heating assembly comprises a heating block 110, and the heating block 110 is coated on the outer side of the optical detection tank 120 and is used for heating the optical detection tank 120.

As shown in fig. 17 to 21, the inspection assembly further includes a pipe heating assembly 300, the pipe heating assembly 300 including a heating cylinder 301, an outer circumferential surface of the heating cylinder 301 for winding a pipe to heat the pipe. The outer peripheral surface of the heating cylinder 301 is provided with a pipe penetrating channel 302 penetrating through the arc-shaped wall of the heating cylinder 301, and the pipe penetrating channel 302 is used for allowing a pipeline to pass through and forming an anti-falling limit for the pipeline. The heating cylinder 301 is provided with a plurality of flanges 303, and the pipe penetrating channel 302 is arranged close to the flanges 303.

As shown in fig. 11 to 16, the detecting assembly further includes an assembly seat through which the preheating tank 250 and the mixing tank 240 are assembled, the assembly seat including a first assembly body 210, the first assembly body 210 having first and second assembly grooves 211 and 212 provided on opposite surfaces thereof, respectively, the first and second assembly grooves 211 and 212 being used to set the mixing tank 240 and the preheating tank 250, respectively, the first assembly groove 211 being located higher than the second assembly groove 212 so that the mixing tank 240 is located higher than the preheating tank 250.

The first assembly 210 is a step assembly, and includes a connection portion 214, a first assembly portion 216 extending upward from one side of the connection portion 214, and a second assembly portion 218 extending downward from the other side of the connection portion 214, wherein the first assembly groove 211 is recessed in the first assembly portion 216 and the connection portion 214, and the second assembly groove 212 is recessed in the second assembly groove 212 and the connection portion 214.

The assembly base further comprises a second assembly 220 and a third assembly 230, wherein the second assembly 220 is provided with a third assembly groove 221 and is buckled with the first assembly groove 211 to form a mixing pool 240, and the third assembly 230 is provided with a fourth assembly groove 231 and is buckled with the second assembly groove 212 to form a preheating pool 250.

As shown in fig. 5, the heating assembly includes a heating block 110 and a heating film 117 attached to a side of the heating block 110, and the heating block 110 is provided with an assembly cavity 113 for receiving the optical detection cell 120.

As shown in fig. 2 and 8, the detection device further includes a stand 100 and a detection assembly.

Wherein the stand 100 comprises a first support arm 102 and a second support arm 104, the heating component is fixed by the first support arm 102, the pipeline heating component 300 is arranged at the side of the heating block 110 by the second support arm 104,

the detection assembly also includes a substrate 130, a laser 156, and an optical receiver.

Wherein, the base 130 is fixed with the heating block 110, the base 130 is provided with a notch 134, a light-in channel 133, a first light-out channel 131 and a second light-out channel 132 which are clamped and matched with the heating block 110, the notch 134 is arranged between the light-in channel 133 and the first light-out channel 131 and the second light-out channel 132, the light-in channel 133 is aligned with the first light-out channel 131, the axis of the second light-out channel 132 is inclined relative to the axis of the first light-out channel 131, the laser 156 is arranged in the light-in channel 133, the light receiver comprises a first photodiode 141 and a second photodiode 142, the first photodiode 141 is assembled in the first light-out channel 131, and the second photodiode 142 is assembled in the second light-out channel 132.

The detection device provided by the embodiment heats the plurality of pools respectively through the plurality of heating bodies, the temperatures of the plurality of heating bodies can be set to be different to provide corresponding temperature demands, rapid heating can be realized, accurate heat preservation is realized, and detection precision is improved. The embodiment also provides a sample analyzer, which comprises the detection device.

The embodiment also provides a detection device, which comprises an optical detection tank, a first heater and a second heater, wherein the first heater is used for heating the optical detection tank; the second heater is used for heating the reagent input into the optical detection cell; the heating temperatures of the first heater and the second heater are set differently, for example, the heating temperature of the second heater is 1-7 degrees higher than the heating temperature of the first heater, and of course, in other test working conditions, the heating temperature of the second heater can be lower than the heating temperature of the first heater, and the actual reagent detection needs to be determined. In one embodiment, the heating temperature of the optical detection tank can be set to 34-36 degrees, the heating temperature of the preheating tank and the mixing tank can be set to 40-42 degrees, the heating temperature of the dilution tank can be set to 36-38 degrees, and the heating temperature of the pipeline heating component can be set to 34-36 degrees.

According to the detection device provided by the invention, the optical detection tank and the reagent input into the optical detection tank are heated respectively through the at least two heaters, and the temperatures of the at least two heaters are arranged in a differential mode, so that the rapid heating of the reagent can be realized, the optical detection tank is accurately insulated, and the detection efficiency and the detection precision are improved.

The second heater includes an antibody reagent heater for heating the antibody reagent inputted into the optical detection cell, and since the antibody reagent is usually called from a refrigerating state, the second heater with a relatively high heating temperature is used to heat the antibody reagent alone, so that the heating time can be shortened, and the heating efficiency can be improved, wherein the antibody reagent can be heated in a pipeline (such as the pipeline heating assembly 300 described below), or in a cell body (such as the mixing tank 240 described above). The second heater may comprise a hemolysis reagent heater for heating the hemolysis reagent fed into the optical detection cell, which may be heated in a tube (e.g., using the tube heating assembly 300 described below), or in a cell body (e.g., the mixing cell 240 described above). The second heater may further include a diluent heater for heating the diluent input to the optical detection cell, which may be heated in a pipe (as with the pipe heating assembly 300 described below), or in a cell body, and the diluent heater may refer to the third heater 263 in fig. 3.

The detection device further comprises a pipeline and a tank body which are directly or indirectly communicated with the optical detection tank, wherein the pipeline is naturally bent or coiled, and the pipeline can be heated by adopting the pipeline heating assembly 300 when the pipeline is coiled.

The cell body includes the mixing pond, mixing pond and optical detection pond intercommunication, and the mixing pond is used for importing antibody reagent, and the second heater heats the mixing pond and then heats antibody reagent. Or the tank body comprises a mixing tank, the mixing tank and the optical detection tank are a mixing and detection integrated tank, in other words, the optical detection tank is used for receiving the mixed reagent or is used for receiving the reagent and carrying out reagent mixing in the optical detection tank, and the optical detection tank bears the detection function and the mixing function. The tank body can also comprise a preheating tank, wherein the preheating tank is used for inputting hemolysis reagent, and the preheating tank is communicated with the mixing tank or communicated with the mixing and detecting integrated tank.

The first heater and the second heater are heat conducting substrates provided with heating rods or heating films, and the heat conducting substrates are in a block shape, a step shape (such as the assembly seat described in the fourth embodiment), a cylinder shape (such as the pipeline heating assembly 300 described below) or a box shape.

As shown in fig. 22, the present embodiment also provides a detecting apparatus including a preheating tank 411, a mixing tank 412, an optical detecting tank 413, a mixing line 414, a diluent line 415, a first heater 511, a second heater 512, a third heater 513, and a fourth heater 514.

Wherein, the mixing pool 412 is communicated with the preheating pool 411; the optical detection pool 413 is communicated with the mixing pool 412; the preheating tank 411 and the mixing tank 412 are arranged in the second heater 512, and the second heater 512 is used for heating the preheating tank 411 and the mixing tank 412. The optical detection cell 413 is disposed in the first heater 511, and the first heater 511 is used for heating the optical detection cell 413, wherein the temperature of the second heater 512 may be 1-3 degrees higher than the temperature of the first heater 511 to perform a rapid heating effect. The mixing pipeline 414 is communicated with the optical detection pool 413 and is arranged in the third heater 513, the third heater 513 is used for heating the mixing pipeline 414, and the temperature of the third heater 513 can be 1-2 degrees higher than the temperature of the first heater 511 so as to achieve a good heat preservation effect. The diluent line 415 is in communication with the mixing line 414, and the fourth heater 514 is configured to heat the diluent line 415, where the fourth heater 514 may be 1-3 degrees higher than the temperature of the first heater 511 to provide a rapid heating effect.

As shown in fig. 23, the present embodiment further includes a detection device including a preheating tank 421, a mixing tank 422, an optical detection tank 423, a buffer tank 424, a first heater 521, a second heater 522, and an antibody reagent storage device 426.

The antibody reagent storage device 426 is communicated with the mixing tank 422 through a pipeline and is used for inputting antibody reagent into the mixing tank 422, and the mixing tank 422 is communicated with the preheating tank 421; the optical detection pool 423 is communicated with the mixing pool 422; the preheating tank 421 and the mixing tank 422 are arranged in the second heater 522, and the second heater 522 is used for heating the preheating tank 421 and the mixing tank 422. The buffer tank 424 is communicated with the optical detection tank 423 and is disposed in the first heater 521, and the temperature of the second heater 522 may be 1-3 degrees higher than the temperature of the first heater 521 to achieve a rapid heating effect.

As shown in fig. 24, the present embodiment further includes a detection device including a preheating tank 431, a mixing detection integrated tank 430, a mixing pipeline 434, a first heater 531, a second heater 532, and an antibody reagent tank 436.

Wherein the optical detection tank and the mixing tank share a first tank body 430; the antibody reagent storage device 436 is communicated with the first tank 430 through a pipeline and is used for inputting antibody reagent to the first tank 430, the preheating tank 431 is communicated with the first tank 430 and is arranged in the first heater 531, and the first heater 531 is used for heating the preheating tank 431 and the first tank 430. The mixing pipeline 434 is communicated with the first tank 430 and is arranged in the second heater 532, and the temperature of the second heater 532 can be 1-2 degrees higher than the temperature of the first heater 531 so as to achieve a better heat preservation effect.

As shown in fig. 25, the present embodiment also provides a detection apparatus including a preheating tank 441, a mixing tank 442, an optical detection tank 443, a mixing line 444 (or buffer tank), a diluent line 445, a first heater 541, and a second heater 542.

Wherein the mixing pool 442 is communicated with the preheating pool 441; the optical detection pool 443 is communicated with the mixing pool 442, and the mixing pipeline 444 is communicated with the optical detection pool 443; the preheating tank 441, the mixing tank 442, the optical detection tank 443, and the mixing pipeline 444 are disposed in the first heater 541, and the first heater 541 is used for heating the preheating tank 441, the mixing tank 442, the optical detection tank 443, and the mixing pipeline 444. The diluent line 445 is in communication with the blending line 444, and the second heater 542 is configured to heat the diluent line 445, and the temperature of the second heater 542 may be 1-3 degrees higher than the temperature of the first heater 541 to provide a rapid heating effect.

As shown in fig. 26, the present embodiment further includes a detection device including a preheating tank 451, a mixing tank, an optical detection tank, a mixing line 454, a first heater 551, and an antibody reagent tank 456.

The optical detection tank and the mixing tank share the first tank body 450, and the antibody reagent tank 456 is communicated with the first tank body 450 through a pipeline and is used for inputting antibody reagent to the first tank body 450, and the preheating tank 451, the first tank body 450 and the mixing pipeline 454 (or the buffer tank) are jointly arranged in the first heater 551.

In the above embodiments, the first heater is a heat conductive substrate provided with a heating rod or a heating film, heat conductive by direct contact or heat conductive by air. The invention also provides a sample analyzer, which comprises the detection device in any embodiment.

Seventh embodiment the present embodiment provides a detection apparatus, as shown in fig. 1 to 21, comprising a preheating tank 250, a mixing tank 240, a dilution tank 270, and an optical detection tank 120, and a pipe heating assembly 300, wherein the preheating tank 250, the mixing tank 240, the dilution tank 270, and the optical detection tank 120 are connected by pipes, the pipe heating assembly 300 comprises a heating cylinder 301, and the outer circumferential surface of the heating cylinder 301 is used for winding a pipe to heat the pipe.

As shown in fig. 17 to 21, the outer peripheral surface of the heating cylinder 301 is provided with a pipe penetrating passage 302 penetrating through the arc-shaped wall of the heating cylinder 301, and the pipe penetrating passage 302 is used for the pipe to pass through and form an anti-falling limit for the pipe. The through-tube channel 302 is straight or curved. The through pipe passage 302 is distant from the diameter of the heating cylinder 301 and is close to the outer peripheral surface of the heating cylinder 301. The heating cylinder 301 is provided with a plurality of flanges 303, and the pipe penetrating channel 302 is arranged close to the flanges 303.

The detection device further comprises an assembly seat, the preheating tank 250 and the mixing tank 240 are assembled through the assembly seat, the assembly seat comprises a first assembly body 210, a first assembly groove 211 and a second assembly groove 212 are respectively formed in two surfaces, which are away from each other, of the first assembly body 210, the first assembly groove 211 and the second assembly groove 212 are respectively used for arranging the mixing tank 240 and the preheating tank 250, and the position of the first assembly groove 211 is higher than that of the second assembly groove 212 so that the mixing tank 240 is higher than that of the preheating tank 250.

As shown in fig. 12, the first assembly 210 is a step assembly, and includes a connection portion 214, a first assembly portion 216 extending upward from one side of the connection portion 214, and a second assembly portion 218 extending downward from the other side of the connection portion 214, wherein the first assembly groove 211 is recessed in the first assembly portion 216 and the connection portion 214, and the second assembly groove 212 is recessed in the second assembly groove 212 and the connection portion 214.

The detection device includes a first heating body 261, a second heating body 262 and a third heating body 263, where the first heating body 261 is attached to the outer surface of the second assembly seat and is used for heating the mixing pool 240, the second heating body 262 is attached to the outer surface of the third assembly seat and is used for heating the preheating pool 250, and the third heating body 263 is attached to the outer surface of the dilution liquid pool 270 and is used for heating the dilution liquid pool 270. The detection device provided in this embodiment can heat and preserve heat to the reagent in the pipeline by adding the pipeline heating assembly 300, and can improve the detection precision.

In an eighth embodiment, as shown in fig. 27 and 28, the present embodiment provides a detection apparatus, which includes a heating element 410, a container 420, a hydrodynamic device 430, and a reagent tube 440, where the reagent tube 440 is connected between the container 420 and the hydrodynamic device 430, at least a part of the reagent tube 440 is densely wound around and disposed on the heating element 410, the reagent tube 440 is used for transmitting a reagent to the container 420 through the hydrodynamic device 430, or the hydrodynamic device 430 is used for sucking and spitting a mixed reagent, and the reagent is heated by the heating element 410 during the transmission or sucking and spitting and mixing process of the hydrodynamic device 430. Of course, the detection device also includes other components such as a sampling needle, a reversing valve, etc., and the details of the detection device are not described in the present application.

Wherein, the hydrodynamic device 430 may be a syringe, a quantitative pump or an air pump in the analyzer, and the heating element 410 and the container 420 may be the same device or different devices.

Specifically, when the heating element 410 and the container 420 are different devices, reference may be made to fig. 27, that is, the heating element 410 is an independent heating device, and may be specially used for heating the reagent tube 440, especially, the reagent may be heated by the independent heating element 410 during the process of sucking, spitting and mixing the reagent by the hydrodynamic device 430. When the heating element 410 and the container 420 are the same device, as shown in fig. 28, that is, the container 420 has a heat conduction function due to the heating element 410, and the reagent tube 440 is densely wound around the outer periphery of the container 420, so that a heating effect can be obtained.

In one embodiment, the heating element 410 is an independent heating tube, and the independent heating tube includes a winding tube base (refer to the heating tube 301 described above) for winding the reagent tube 440 and a heating element (refer to the heating rod 346 described above) disposed in the winding tube base or attached to the outside of the reagent tube 440. The heating element can be a heating rod inserted into the winding base body, or a heating film attached to the outer side of the pipeline.

The outer surface of the winding tube matrix is provided with a tube binding structure, and the tube binding structure can be a tube penetrating channel (refer to the tube penetrating channel 302) or a tube clamping groove which is arranged on the surface of the winding tube matrix, the tube clamping groove is in a closing-in groove, is concaved on the surface of the winding tube matrix, and can be pressed and kept in the tube clamping groove through the deformation of the reagent pipeline 440.

The reagent tube 440 may be spirally wound in a cylindrical shape, or the reagent tube 440 may be spirally wound in a disk shape, or the reagent tube 440 may be spirally wound in an S shape, and the heat generating body 410 may be planar when the reagent tube 440 is spirally wound in a disk shape or wound in an S shape.

The container 420 may include an optical detection cell 120, and the reagent conduit 440 includes a diluent conduit for transporting a diluent, the diluent conduit being disposed between the optical detection cell 120 and the hydrodynamic device 430. The container 420 may also include a mixing tank, and the reagent conduit 440 includes an antibody reagent conduit for transporting an antibody reagent, the antibody reagent conduit being disposed between the mixing tank and the hydrodynamic device 430. The container 420 may further include a pre-heat reservoir, and the reagent conduit 440 may include a hemolysis reagent conduit for transporting a hemolysis reagent, the hemolysis reagent conduit being disposed between the pre-heat reservoir and the hydrodynamic device 430.

Referring to fig. 29, the detecting device may include a heating element 410, a container 420, a hydrodynamic device 430, a reagent tube 440, a reversing valve 450, a temperature control system 460, a waste liquid treatment device 470, a reagent bottle 480, etc.

The reagent pipe 440 is connected between the container 420 and the liquid power device 430, at least part of the reagent pipe 440 is wound around and disposed on the heating element 410, for example, part of the pipe C, D is wound around the heating element 410, the reagent pipe 440 is used for transmitting reagent to the container 420 through the liquid power device 430, the liquid power device 430 is also used for sucking and spitting the mixed reagent, the reagent is heated through the heating element 410 in the sucking and spitting mixing process of the liquid power device 430, the reagent is also heated through the heating element 410 in the transmitting process of the liquid power device 430 to the container 420, the heating element 410 can be a heating tube, and the temperature control system 460 can comprise a temperature sensor, a heating rod, a temperature control switch and the like.

Wherein the reagent can be hemolysis reagent, antibody reagent, diluent and the mixture of two or three of them. Correspondingly, the reagent bottles 480 are multiple and are respectively used for containing reagents such as hemolysis reagent, antibody reagent and diluent, the reagent bottles 480 are connected with the container 420 and the hydrodynamic device 430 through the reversing valve 450, the number of the reversing valve 450 and the hydrodynamic device 430 can be one or more, according to the actual liquid path requirement, the hemolysis reagent and the antibody reagent can be heated through the heating body 410 when being conveyed to the container 420 in the reagent pipeline 440, the heating time is relatively short, the reagent activity deterioration caused by long-time heating can be avoided, the detection is influenced, the structure is simplified, a corresponding preheating pool is not required to be arranged independently, the diluent can be prevented from entering the container 420 with relatively high temperature through the heating body 410 when being conveyed to the container 420 in the reagent pipeline 440, the temperature of the container 420 can be reduced, and the rapid detection of the next sample can be facilitated.

Referring to fig. 30, the detecting device includes a heating element 410, a container 420, a hydrodynamic device, at least one reversing valve and a plurality of reagent pipelines, at least part of the reagent pipelines are connected between the container 420 and the hydrodynamic device and are wound on the heating element 410 to form a winding section; at least part of the reagent pipeline is used for sucking reagent through the liquid power device and the reversing valve, and the reagent enters the winding section and is heated through the heating body 410 in the reagent sucking process of the liquid power device; or at least a portion of the reagent conduit is used to push and draw reagent through the hydrodynamic device and the reversing valve to the container 420, where the reagent enters the winding section to be heated by the heater 410 during the push and draw of reagent by the hydrodynamic device.

Wherein, heat-generating body 410 is independent heating tube, and independent heating tube is including twining a tub base member and heating element, twines the tub base member and is used for supplying the reagent pipeline to twine, and the heating element sets up in twining a tub base member or pastes and establish the reagent pipeline outside, and the heating element is for inserting the heating rod that locates twining in the tub base member, or the heating element is the cladding and pastes the heating film of locating the winding section periphery, twines the surface of tub base member and is equipped with the restraint tube structure, restraints the tube structure for locating the poling passageway or the card pipe groove of twining tub base member surface, and the reagent pipeline can be the teflon.

In an embodiment, the reagent conduit comprises a first reagent suction conduit G, a first reagent push conduit BF, and a first common conduit I; the reversing valve comprises a first reversing valve 1; the hydrodynamic device includes a first hydrodynamic device 431; a first common conduit I connects the common port of the first reversing valve 1 with the first hydrodynamic device 431; one end of the first reagent sucking pipeline G is connected with a split reversing port of the first reversing valve 1, the other end of the first reagent sucking pipeline G is used for being connected with a first reagent bottle, such as a reagent bottle filled with diluent, and the first liquid power device 431 sucks reagent through the first public pipeline I, the first reversing valve 1 and the first reagent sucking pipeline G; the first reagent pushing pipeline BF is wound on the heating body 410 and connects the other sub-reversing opening of the first reversing valve 1 with the container 420, the first hydrodynamic device 431 pushes reagent through the first public pipeline I, the first reversing valve 1 and the first reagent pushing pipeline BF or pushes reagent to reach the effect of sucking and spitting and mixing, the reagent is heated through the heating body 410 after entering the winding section, and before the next reagent sucking or pushing operation in the first reagent bottle, the former operation can lead the reagent to exist in the first reagent pushing pipeline BF, and the gap time of the reagent before the next operation is heated.

In an embodiment, the reagent conduit comprises a second reagent suction conduit H, a second reagent push conduit and a second common conduit E; the reversing valve comprises a second reversing valve 2; the hydrodynamic device includes a second hydrodynamic device 432; a second common conduit E connects the common port of the second reversing valve 2 with the second hydrodynamic device 432; one end of the second reagent sucking pipeline H is connected with one split reversing port of the second reversing valve 2, the other end of the second reagent sucking pipeline H is used for being connected with a second reagent bottle, such as a reagent bottle filled with a hemolytic agent, and the second liquid power device 432 sucks reagent through the second public pipeline E, the second reversing valve 2 and the second reagent sucking pipeline H; the second reagent pushing pipe is wound on the heating body 410 and connects the other sub-reversing port of the second reversing valve 2 with the container 420, and the second hydrodynamic device 432 pushes the reagent through the second common pipe E, the second reversing valve 2 and the second reagent pushing pipe or pushes the reagent to reach the effect of sucking and spitting, and the reagent is heated through the heating body 410 after entering the winding section. Wherein the second reagent pushing conduit may be a single tube or a plurality of tubes in the embodiments described below.

In one embodiment, the reagent tubes include a second reagent suction tube H, a third reagent tube suction tube J, a second common tube E, a third common tube CD, and a fourth common tube a; the reversing valve comprises a second reversing valve 2 and a third reversing valve 3; the hydrodynamic device includes a second hydrodynamic device 432; one end of the second reagent sucking pipeline H is connected with one split reversing port of the second reversing valve 2, the other end of the second reagent sucking pipeline H is used for being connected with a second reagent bottle, such as a reagent bottle filled with a hemolytic agent, and the second liquid power device 432 sucks reagent through the second public pipeline E, the second reversing valve 2 and the second reagent sucking pipeline H; one end of the third reagent tube sucking pipeline J is connected with a split reversing port of the third reversing valve 3, and the other end of the third reagent tube sucking pipeline J is used for connecting a third reagent bottle, such as a reagent bottle for containing an antibody liquid; a second common conduit E connects the common port of the second reversing valve 2 with the second hydrodynamic device 432; a third common pipe CD is wound on the heating body 410 and connects the other sub-reversing port of the second reversing valve 2 with the common port of the third reversing valve 3; the third common line CD connects the other split-port of the third directional valve 3 with the container 420.

The second hydrodynamic device 432 pushes or sucks the reagent through the second common line E, the second direction valve 2, the third common line CD, the third direction valve 3, and the fourth common line a to achieve the suction/discharge mixing effect, the reagent is heated by the heating body 410 after entering the winding section,

the second liquid power device 432 sucks reagent through the second common line E, the second reversing valve 2, the third common line CD, the third reversing valve 3 and the third reagent tube suction line J, at which time reagent enters the winding section and is heated by the heating body 410, and since reagent sucking or reagent pushing in the second reagent bottle has been previously performed, the second common line E, the third common line CD and the fourth common line a are filled with reagent before the next operation, wherein the line relatively near the end of the second liquid power device 432 is mainly filled with reagent in the second reagent bottle, and thus when reagent in the third reagent bottle is sucked, reagent in the second reagent bottle near the end of the second liquid power device 432 and reagent in the third reagent bottle near the end of the third reversing valve 3 are contained in the third common line CD, and both reagents can be heated simultaneously in the winding section at a gap time before the next operation. The number of structural components is reduced through pipeline multiplexing, reversing valve multiplexing and heating body multiplexing, the pipeline layout is optimized, the reagent temperature control effect is improved, the temperature fluctuation of the container 410 can be reduced, and the detection stability is improved. The embodiment also provides a sample analyzer, which comprises the detection device. In the scheme provided by the invention, the reagent is heated by the heating body 410 in the process of sucking, spitting and mixing the liquid power device 430, so that the reagent in the reagent pipeline 440 can be heated and kept warm, and the detection precision is improved.

Claims

1. A detection device for a blood analyzer, the detection device comprising:

a vertical frame;

the detection assembly is fixed with the heating block and comprises a base body, and the base body is provided with a notch part which is clamped and matched with the heating block; the detection assembly further comprises a light receiver and a laser, wherein the light receiver and the laser are arranged on the substrate;

the optical detection pool is arranged in the notch part and is arranged in the assembly cavity through the support of the matrix; the optical detection pool comprises a pool body and a light-transmitting plate, and the pool body is fixed with the light-transmitting plate.

2. The detecting device according to claim 1, wherein the heating block is further provided with a light-passing hole penetrating the assembly cavity, the base body is further provided with a light-entering channel, a first light-exiting channel and a second light-exiting channel, the notch portion is arranged between the light-entering channel and the first light-exiting channel and between the light-exiting channel and the second light-exiting channel, the light-entering channel is aligned with the first light-exiting channel, an axis of the second light-exiting channel is inclined with respect to an axis of the first light-exiting channel, and the light-passing hole is aligned with the light-entering channel when the detecting component is fixed with the heating block.

3. The detecting device according to claim 2, wherein the base body integrally extends on a side of the notch portion, which is close to the light entrance channel, to form a mounting plate, a first mounting hole is formed in the mounting plate, a first connecting hole is formed in a side wall of the heating block corresponding to the first mounting hole, and the first connecting hole is located on a side edge of the light passing hole.

4. The detecting device according to claim 1, wherein the base body is further provided with a second fitting hole penetrating to the bottom of the notch portion, the bottom end of the heating block is provided with a second connecting hole corresponding to the second fitting hole, and the second connecting hole is located at a side edge of the fitting cavity.

5. The detecting device according to claim 1, wherein the assembly chamber is a plurality of parallel and spaced apart, the detecting assembly and the optical detecting pool are a plurality of, a plurality of groups of guide ribs are further arranged on the side wall of the heating block at parallel and spaced apart so that the notch part of the base body is aligned and clamped with the heating block, and the extending direction of the guide ribs is parallel to the extending direction of the assembly chamber.

6. The detection device according to claim 1, further comprising a waterproof sealing ring, wherein the optical detection tank further comprises a liquid injection pipe, a through hole communicated with the assembly cavity to allow the liquid injection pipe to extend is formed in the top end of the heating block, and the waterproof sealing ring is located in the assembly cavity, sleeved on the periphery of the liquid injection pipe and clamped between the optical detection tank and the heating block.

7. The detection device according to claim 1, wherein the heating block is obliquely fixed on the stand so that the assembly cavity is obliquely arranged, and the optical detection cell and the detection assembly are obliquely arranged relative to a horizontal plane.

8. The apparatus according to claim 6, further comprising a pipe heating assembly for winding a pipe and heating the pipe, wherein the stand includes a first arm and a second arm, the heating block is fixed by the first arm, the pipe heating assembly is provided on a side of the heating block by the second arm, and the pipe heating assembly is lower than the liquid filling pipe.

9. The detecting device according to claim 1, wherein the heating assembly further comprises a heating film, a temperature sensor and an overtemperature protection switch, the heating block is an aluminum block or a copper block, the heating film is attached to the surface of the heating block, and the temperature sensor and the overtemperature protection switch are embedded and assembled in the heating block.

10. A blood analyser, characterized in that it comprises a detection device according to any one of claims 1-9.