CN213121958U - Specific protein measuring module and blood analyzer - Google Patents

Abstract

The application provides a specific protein measurement module, which comprises a shell, and a specific protein detection assembly and a preheating assembly which are fixed in the shell. The specific protein detection assembly comprises a reaction tank, a liquid inlet pipeline, an optical detection system and a laser control panel. The liquid inlet pipeline is communicated with the reaction tank and used for loading reaction reagents, the optical detection system comprises a front optical assembly and a rear optical assembly which are arranged on two sides of the reaction tank in a split mode, the laser control panel is used for controlling the front optical assembly to face the reaction tank to emit laser, and the rear optical assembly is used for receiving the laser transmitted or scattered by the reaction tank and forming photosensitive data. The preheating component is arranged relative to the path of the liquid inlet pipeline and used for preheating the reaction reagent, so that the specific protein measuring module has higher detection precision. The present application also relates to a blood analyzer.

Description

Specific protein measuring module and blood analyzer

Technical Field

The present application relates to the field of in vitro diagnostic analysis, in particular to a specific protein measurement module, and a blood analyzer.

Background

The specific protein measuring module is a modular detection device equipped on the blood analyzer, and is used for assisting the blood analyzer to realize the analysis and detection functions of specific proteins such as C-reactive protein (CRP), Serum Amyloid A (SAA) and the like. However, in order to realize more accurate and efficient detection operation in cooperation with a blood analyzer, the number of components for assisting detection, which need to be mounted on a specific protein measurement module itself, is also increased accordingly.

SUMMERY OF THE UTILITY MODEL

The application provides a specific protein measuring module with higher detection precision and a blood analyzer equipped with the specific protein measuring module. The application specifically comprises the following scheme:

the application provides a specific protein measuring module, include the casing and be fixed in specific protein determine module and preheating component in the casing, specific protein determine module includes reaction tank, liquid inlet pipeline, optics detecting system and laser instrument control panel, the liquid inlet pipeline communicate in the reaction tank is used for loading reactant, optics detecting system is including dividing the preceding optical assembly and the back optical assembly of reaction tank both sides, the laser instrument control panel is used for control preceding optical assembly orientation the reaction tank sends laser, back optical assembly is used for receiving the warp the laser of reaction tank transmission or scattering forms sensitization data, preheating component corresponds the route setting of liquid inlet pipeline is used for right reactant preheats.

Wherein, the subassembly of preheating includes the heating post, the feed liquor pipeline include the spiral around in the heating section of the surface of heating post.

Wherein, the subassembly of preheating still including coat in on the heating section and be used for the parcel the heat conduction glue of heating section.

Wherein, the subassembly of preheating still includes to enclose and locates the metal casing outside the heating section.

Wherein, the material of heating section is Teflon pipe.

Wherein, preheat the subassembly still including be fixed in heating column bottom and be used for to heat column transfer thermal heat-conducting plate, locate be used for heating in the heat-conducting plate the stick that generates heat of heat-conducting plate and be used for controlling the temperature controller of the heating power of the stick that generates heat.

The heating column is provided with a first temperature sensor, the first temperature sensor is electrically connected with the temperature controller, and the temperature controller controls the heating power of the heating rod based on a feedback signal of the first temperature sensor.

Wherein, the liquid inlet pipeline is including communicateing respectively the first liquid inlet pipeline and the second liquid inlet pipeline of reaction tank, first liquid inlet pipeline include the spiral encircle in the first heating section of heating post surface, the second liquid inlet pipeline include the spiral encircle in the second heating section of heating post surface, just first heating section with the second heating section is followed the length direction of heating post arranges.

Wherein the first temperature sensor is disposed between the first heating section and the second heating section.

The special protein detection device comprises a heat conducting plate, a heating rod, a mounting seat and a front light assembly, wherein the mounting seat is used for bearing and fixing the special protein detection assembly, the mounting seat and the heating rod are fixed on the heat conducting plate at intervals, the mounting seat is made of heat conducting materials, and the mounting seat is also used for transferring heat of the heat conducting plate to the front light assembly so as to keep the temperature of the front light assembly within a preset temperature range.

The mounting seat comprises a sealing cavity for accommodating the front light assembly, an accommodating cavity for accommodating the rear light assembly, and a sealing cover plate for matching the accommodating cavity to seal the rear light assembly.

Sealing rings for sealing are arranged between the light emergent surface of the front light assembly and the wall of the reaction tank and between the light incident surface of the rear light assembly and the wall of the reaction tank.

Wherein, preceding optical assembly includes laser instrument, collimating lens and diaphragm, the laser instrument with laser instrument control panel electric connection, collimating lens set up in the laser instrument with between the diaphragm, the sealing washer is concave to be located the diaphragm with on the surface of reaction tank laminating.

The backlight assembly comprises a transmission and scattering channel, a neutral density sheet for absorbing transmission light and a photosensitive board card for receiving scattered light, and the sealing ring is concavely arranged on the outer surface of the reaction tank, which is jointed with the transmission and scattering channel.

The sealing cavity is internally provided with a second temperature sensor, the second temperature sensor is electrically connected with the temperature controller, and the temperature controller controls the heating power of the heating rod based on a feedback signal of the second temperature sensor.

The specific protein detection assembly further comprises a data processing board which is electrically connected to the rear light assembly and used for receiving the photosensitive data and then calculating a specific protein detection result.

Wherein, the shell is internally provided with a heat-insulating layer and/or

The shell is made of a heat-insulating material.

The special protein measuring module comprises a shell, a connecting piece and a special protein measuring module, wherein the special protein measuring module is fixed on the shell, and the connecting piece is fixed with a blood analyzer through a screw so as to fix the special protein measuring module on the blood analyzer.

The connecting piece is provided with a sliding sleeve which is inserted into the corresponding opening of the shell and an adjusting component which is used for adjusting the depth of the opening into which the sliding sleeve extends.

The adjusting assembly comprises a positioning rod which is elastically connected to the connecting piece along the length direction parallel to the sliding sleeve, and a jackscrew which is used for locking and fixing the positioning rod.

The specific protein detection assembly further comprises a liquid discharge pipeline, and the liquid discharge pipeline comprises a first liquid discharge pipe and a second liquid discharge pipe, wherein the first liquid discharge pipe corresponds to the bottom of the reaction tank, and the second liquid discharge pipe corresponds to the overflow liquid collection structure at the top of the reaction tank.

The present application also provides a blood analyzer, comprising:

a sampling device for collecting a blood sample;

the liquid inlet and outlet system is used for loading a reaction reagent and discharging the detected reaction liquid; and

the specific protein measurement module described above.

A specific protein measurement module of the present application, housing the specific protein detection assembly and the pre-heating assembly through the housing. The specific protein detection assembly controls the front light assembly to emit laser towards the reaction pool loaded with the reaction reagent through the laser control board, and receives the laser transmitted by the reaction pool through the rear light assembly to form photosensitive data. Meanwhile, the preheating assembly is correspondingly arranged on the path of the liquid inlet pipeline, so that the function of preheating the reaction reagent is achieved. The specific protein measuring module of the application also has higher detection precision. The detection precision of the blood analyzer equipped with the specific protein measurement module is improved.

Drawings

FIG. 1 is a schematic diagram of the structure of a specific protein measurement module provided in an embodiment of the present application;

FIG. 2 is a schematic diagram of the internal structure of a specific protein measurement module provided in an embodiment of the present application;

FIG. 3 is a schematic diagram of the internal structure of a specific protein measurement module provided in an embodiment of the present application;

FIG. 4 is a schematic cross-sectional view of a specific protein measurement module provided in an embodiment of the present application;

FIG. 5 is a schematic partial cross-sectional view of a specific protein measurement module provided in an embodiment of the present application;

FIG. 6 is a schematic view of another aspect of a specific protein measurement module provided in an embodiment of the present application;

FIG. 7 is a schematic representation of another embodiment of a specific protein measurement module provided in embodiments herein;

FIG. 8 is a schematic diagram of a linker in a specific protein measurement module provided in embodiments of the present application;

fig. 9 is a schematic view of an internal structural framework of a blood analyzer according to an embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be described clearly and completely with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings). In the description of the present application, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present application and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be considered as limiting the present application.

In this application, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through intervening media. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

Please refer to FIG. 1-FIG. 3 for a schematic diagram of a specific protein measurement module 100 of the present application. Where FIG. 1 illustrates the external structure of a particular protein measurement module 100 of the present application, it can be seen that the particular protein measurement module 100 has a housing 10. Fig. 2 and 3 show the internal configuration of the specific protein measurement module 100 after the housing 10 is removed. It can be seen that the specific protein measurement module 100 further includes a specific protein detection assembly 20 and a preheating assembly 30 fixed within the housing 10.

The specific protein measurement module 100 may be equipped on the blood analyzer 200 (see fig. 9) of the present application, and is used to assist the blood analyzer 200 to implement the analysis and detection functions of specific proteins such as C-reactive protein (CRP), serum amyloid a (saa), and the like. Thus, in addition to the components described above, a particular protein measurement module 100 may include numerous interfaces to connect and communicate with a hematology analyzer 200. For example, a connection structure (see "connector 80" in fig. 7) that fixes specific protein measurement module 100 to blood analyzer 200; a reagent line interface for communicating with a reagent container of the blood analyzer 200 to obtain a reagent for detection; a liquid inlet and outlet port for obtaining a sample from the blood analyzer 200 and discharging the reaction liquid after completion of the detection to a waste liquid discharge line of the blood analyzer 200; a power interface for taking electricity from the blood analyzer 200; a communication interface for communicating with the blood analyzer 200 and transmitting and receiving commands and detection signals, and the like.

Of course, besides the necessary connection structure, liquid inlet and outlet interface and communication interface, the specific protein measurement module 100 may also integrate components such as a reagent container and/or a battery for detection into the housing 10, so as to omit a reagent pipeline interface and/or a power supply interface. The specific protein measurement module 100 of the present application does not particularly limit the type, number, specification, and the like of each interface, as long as the specific protein measurement module 100 is equipped on the blood analyzer 200, and after completing the connection with each interface of the blood analyzer 200, can obtain a complete working environment required for detection, and realize the analysis and detection function of the auxiliary blood analyzer 200.

Fig. 4 shows the cross-sectional structure of the specific protein detection module 20 and the preheating module 30. The specific protein detection assembly 20 comprises a reaction tank 21, a liquid inlet pipeline 22, an optical detection system 23 and a laser control panel 24. The reaction cell 21 is used for carrying a reaction solution for detection prepared from a sample and a reaction reagent. The liquid inlet pipe 22 is connected to the inner cavity of the reaction cell 21 and is used for loading the reaction reagent into the inner cavity of the reaction cell 21. The optical detection system 23 includes a front light assembly 231 and a rear light assembly 232. Wherein the front light assembly 231 and the rear light assembly 232 are arranged at two sides of the reaction cell 21, the front light assembly 231 is used for emitting laser towards the reaction cell 21, and the rear light assembly 232 is used for receiving the laser transmitted or scattered by the reaction cell 21 and forming photosensitive data. It is understood that the sensed data is the detection data detected by the specific protein measurement module 100 of the present application. The laser control board 24 is electrically connected to the front light assembly 231, and the laser control board 24 is used for controlling the front light assembly 231 to emit laser toward the reaction cell 21.

The specific protein measurement module 100 may send the sensitization data to the blood analyzer 200 to calculate the result of the specific protein detection, so that the specific protein measurement module 100 of the present application assists the blood analyzer 200 to realize the analysis and detection functions of the specific proteins such as C-reactive protein (CRP), serum amyloid a (saa), and the like.

The reaction cell 21 has an opening 211 at the top, and the blood analyzer 200 generally loads a sample into the reaction cell 21 from the position of the opening 211 for preparing a reaction solution for detection. The liquid inlet pipeline 22 is used for injecting the reaction reagent into the reaction tank 21, and is also used for uniformly mixing the sample and the reaction reagent in the reaction tank 21, so as to improve the accuracy of the specific protein detection. On the other hand, in order to obtain higher detection accuracy, it is also necessary that the reaction solution to be detected be maintained within a certain temperature range to eliminate the difference in detection data due to the temperature difference of the reaction solution. Because the reaction solution is formed by mixing the sample and the reagent, the temperature control of the reaction solution can be decomposed into temperature control of the sample and temperature control of the reagent before the reaction solution is prepared; in the preparation process of the reaction liquid, only the temperature of the reaction liquid needs to be controlled. Because the act of loading the sample is performed by hematology analyzer 200, sample control can be performed on the side of hematology analyzer 200. When the blood analyzer 200 is not provided with the function of preheating the sample, the temperature control of the reaction solution can be performed entirely on the side of the specific protein measurement module 100.

In the specific protein measurement module 100 of the present application, the preheating assembly 30 is disposed corresponding to the infusion path of the liquid inlet pipeline 22, and is configured to preheat the reagent during the reagent loading process, so that the reagent reaches a preset temperature and then is mixed with the sample to configure the reaction liquid. It can be understood that, when the preheating assembly 30 preheats the reagent, the preheating temperature of the reagent can be appropriately raised based on the volume ratio between the reagent configuring the reaction solution and the sample, and then the temperature of the reaction solution obtained by mixing the reagent and the sample is lowered to reach the preset temperature range by using the characteristic that the temperature of the sample is relatively low in the process of mixing the reagent and the sample.

In other embodiments, the preheating assembly 30 can also heat the reaction liquid sucked in the liquid inlet pipe 22 to directly heat the reaction liquid to a temperature range required for detection. Specifically, the liquid inlet pipeline 22 is communicated to the inner cavity of the reaction tank 21, after the reagent and the sample are loaded in the reaction tank 21, the reagent and the sample in the reaction tank 21 can be sucked into the liquid inlet pipeline 22 together, the reagent and the sample reach a section correspondingly heated by the preheating assembly 30, the sample and the reagent are simultaneously heated by the preheating assembly 30, the temperature of the sample and the reagent reaches the temperature range required by detection, and the preheated reagent and the sample are discharged back to the reaction tank 21 together through the liquid inlet pipeline 22. It can be understood that the liquid inlet pipeline 22 can suck and spit the sample and the reagent, and can also uniformly mix the sample and the reagent, thereby improving the quality of the reaction liquid.

Therefore, the specific protein measuring module 100 of the present application has a function of analyzing and detecting a specific protein due to the arrangement of the specific protein detecting component 20. And through preheating the corresponding setting of subassembly 30 and the liquid inlet pipe way 22 in the specific albumen detecting element 20 for the reaction liquid that accepts the detection can keep in predetermineeing the temperature range, and obtain better mixing effect, has possessed higher specific albumen and has detected the analysis precision from this.

In one embodiment, with continued reference to fig. 4, the preheating assembly 30 includes a heating column 31, and the liquid inlet pipe 22 includes a heating section 221 disposed corresponding to the heating column 31. The heating section 221 is attached to the heating column 31 to directly transfer the heat of the heating column 31 into the heating section 221. Further, the heating section 221 also spirally surrounds the outer surface of the heating column 31, so that the contact area between the heating section 221 and the heating column 31 can be increased, and the overall volume of the preheating assembly 30 and the heating section 221 can be controlled. The number of spiral winding turns of the heating section 221 on the heating column 31 is not particularly limited, and it is understood that the larger the number of spiral winding turns of the heating section 221 on the heating column 31, the longer the heating column 31 can correspond to the heated heating section 221, and the larger the dose of the reagent or the reaction solution that can be heated by the heating column 31.

In one embodiment, the heating column 31 is made of a metal material to obtain better heat conduction. In one embodiment, the heating section 221 is further made of teflon. It should be noted that, in order to ensure the relative position between the liquid inlet pipeline 22 and the reaction tank 21, the pipeline of the liquid inlet pipeline 22, which is communicated with one end of the reaction tank 21, may be a steel pipe 222 (as shown in fig. 3), on the side of the liquid inlet pipeline 22 close to the reaction tank 21. The heating section 221 is connected to a reagent container (not shown) of the blood analyzer 200 and a steel tube 222 at the head end and the tail end, respectively. The reagent thus taken from the reagent vessel can be preheated by the heating column 31 through the heating section 221 and then injected into the reaction tank 21 through the steel pipe 222.

In one embodiment, as shown in fig. 3, in order to increase the heating effect of the preheating assembly 30 on the heating section 221, a heat conductive glue 50 may be filled between the heating column 31 and the heating section 221. Since the heating section 221 has a generally cylindrical shape, after it is spirally wound on the heating column 31, a large gap is left between the heating section 221 and the heating column 31, so that the actual contact area between the heating section 221 and the heating column 31 is limited. After the heat conductive adhesive 50 is filled between the heating column 31 and the heating section 221, the gap can be filled with the heat conductive adhesive 50, so that the area between the heating section 221 and the heating column 31 which is indirectly contacted with the gap through the heat conductive adhesive 50 is increased. Based on the heat conduction property of the heat conductive glue 50, the heating effect of the heating column 31 on the heating section 221 can be improved.

Meanwhile, the heat conducting glue 50 can also be coated on the outer surface of the heating section 221 to wrap the heating section 221, so that the heat preservation effect of the heating section 221 is realized, and the heating efficiency of the preheating assembly 30 on the liquid inlet pipeline 22 is further improved.

Referring to fig. 4, the preheating assembly 30 is provided with a metal casing 32, and the metal casing 32 is disposed around the heating section 221 for accommodating the heating section 221 and the heating column 31. The accommodating space formed by the metal shell 32 can also insulate the heating column 31 and the heating section 221, thereby improving the heating efficiency of the preheating assembly 30 on the liquid inlet pipeline 22.

In one embodiment, the preheating assembly 30 further includes a heat-conducting plate 33, a heat-generating rod 34, and a temperature controller 35. Wherein the heat conducting plate 33 is fixed at the bottom of the heating column 31 and is in contact with the heating column 31, and the heating rod 34 is arranged in the inner cavity of the heat conducting plate 33. The heating rod 34 is used for supplying electricity and heating, and the heat conducting plate 33 is made of a heat conducting material such as metal and is used for conducting heat emitted from the heating rod 34 to the heating column 31. The temperature controller 35 may also be disposed in the heat conducting plate 33, and the temperature controller 35 is used for controlling the heating power of the heating rod 34 to ensure that the heat generated by the preheating assembly 30 through the heating rod 34 can maintain the reagent or the reaction liquid in the heating section 221 within the temperature range required for detection after being transferred to the heating section 221 through the heat conducting plate 33 and the heating column 31. In the illustrated illustration, the temperature controller 35 is also configured as a wire for transmitting a control signal, and in this embodiment the function of the temperature controller 35 may be implemented by a controller on the blood analyzer 200, or by the wire the temperature control function is implemented by the remaining control units connected to the specific protein measurement module 100, thereby saving internal resources of the specific protein measurement module 100 and reducing the number of chips used.

The heating rod 34 is fixed in the heat conducting plate 33, and the heat is transferred to the heating column 31 through the heat conducting plate 33, so that the phenomenon that the heating rod 34 directly acts on the heating column 31 and the heating column 31 is thermally deformed due to the heating rod 34 after long-term use can be avoided. It can be understood that, because the heating section 221 is spirally wound around the outer surface of the heating column 31, if the heating column 31 is thermally deformed by the action of the heating rod 34, the heating section 221 is extruded and deformed, and even the flow of the reagent in the heating section 221 is affected. Therefore, by heat conduction of the heat conducting plate 33, the heating column 31 can be protected, and the service life of the specific protein measuring module 100 of the present application can be prolonged.

In one embodiment, the control of the heating power of the heating rod 34 by the temperature controller 35 can be realized by combining the first temperature sensor 81 disposed on the heating column 31. Specifically, the first temperature sensor 81 is fixed on the heating column 31, and is used for monitoring the temperature of the heating column 31 in real time and forming a feedback signal. The first temperature sensor 81 is also electrically connected with the temperature controller 35, the first temperature sensor 81 sends a feedback signal obtained by real-time monitoring to the temperature controller 35, and the temperature controller 35 controls the heating power of the heating rod 34 in real time based on the received feedback signal so as to ensure that the temperature of the heating column 31 is kept stable, thereby ensuring that the reaction solution is in a temperature range required by monitoring.

In one embodiment, the preheating module 30 is required to heat the liquid inlet pipe 22 to a temperature of 37 ℃ ± 3 ℃ in the reaction tank 21, and the temperature of the reaction liquid is required to be controlled not to exceed 50 ℃.

In one embodiment, since there may be more than one reagent type for disposing the reaction solution for detection, the liquid inlet line 22 may further include a first liquid inlet line 22a and a second liquid inlet line 22b which are respectively communicated with the reaction cell 21. The other end of the first liquid inlet line 22a opposite to the reaction cell 21 is connected to a first reagent container (not shown) of the blood analyzer 200, and the other end of the second liquid inlet line 22b opposite to the reaction cell 21 is connected to a second reagent container (not shown) of the blood analyzer 200. It is understood that the first and second reagent containers of hematology analyzer 200 can carry different types of reagents. For example, a hemolytic agent is carried in the first reagent container, and latex or the like is carried in the second reagent container. Different reagents may correspond to different specific protein detection items for implementing the hematology analyzer 200.

Thus, the first liquid inlet pipe 22a includes a first heating section 221a spirally wound around the outer surface of the heating column 31, and the second liquid inlet pipe 22b includes a second heating section 221b spirally wound around the outer surface of the heating column 31. The first heating section 221a and the second heating section 221b are arranged along the length direction of the heating column 31. It can be seen that the aperture diameter between the first liquid inlet line 22a and the second liquid inlet line 22b is also differently set because different reagents require different dosages when the reaction solution is prepared. Since the bottom of the heating column 31 is directly connected to the heat conductive plate 33, the preheating temperature thereof is slightly higher than that of the top of the heating column 31. The heating section 221 with a larger aperture has a larger capacity for holding the reagent, and the heating quantity is higher, so that in order to obtain a better heating effect, the heating section 221 with a larger aperture of the liquid inlet pipeline 22 can be disposed at a position close to the heat conducting plate 33, i.e. the heating section 221 with a larger aperture is preferably disposed at the bottom of the heating column 31.

In one embodiment, in view of the possible temperature difference at the top and bottom of the heating column 31 and the spiral shape of the first heating section 221a and the second heating section 221b around the outer surface of the heating column 31, the first temperature sensor 81 is preferably disposed between the first heating section 221a and the second heating section 221b, i.e., at a position close to the midpoint of the heating column 31 in the length direction, so as to obtain a feedback signal corresponding to the temperature of the heating column 31 at the middle position, and further reflect the actual temperature state of the heating column 31.

In one embodiment, the specific protein measurement module 100 of the present application further includes a mount 70. The mounting seat 70 is also fixed to the heat conductive plate 33, and the mounting seat 70 is spaced apart from the heating column 31. The mounting seat 70 is used to carry and hold the specific protein detection assembly 20. The mounting seat 70 is also made of a heat conductive material, and the mounting seat 70 is further configured to transfer heat of the heat conducting plate 33 to the front light assembly 231 to keep the working temperature of the front light assembly 231 stable, so as to ensure the consistency of the laser beam emitted by the front light assembly 231.

Referring to fig. 5, the mounting base 70 includes a sealing cavity 71, a receiving cavity 72, and a sealing cover 73. The reaction tank 21 is also accommodated in the mounting seat 70. The sealing cavity 71 and the accommodating cavity 72 are respectively arranged at two sides of the reaction chamber 21, and the sealing cavity 71 is used for accommodating the front light assembly 231 and sealing the front light assembly 231. The receiving cavity 72 is used for receiving the backlight assembly 232, but since the occupied volume of the backlight assembly 232 is large and extends out of the outer surface of the mounting base 70, the receiving cavity 72 needs to be matched with the sealing cover plate 73 to seal the backlight assembly 232. The sealing protection of the front light assembly 231 and the rear light assembly 232 by the mounting seat 70 can prevent external dust or overflowing liquid generated by the reaction cell 21 from entering the detection light path, thereby maintaining the long-term stable operation of the specific protein detection assembly 20.

In one embodiment, the sealing rings 51 for sealing are disposed between the light emitting surface of the front light assembly 231 and the cell wall 212 of the reaction cell 21, and between the light incident surface of the back light assembly 232 and the cell wall 212 of the reaction cell 21. The sealing ring 51 can be used to prevent the overflow liquid flowing down from the top of the reaction tank 21 from possibly polluting the optical path.

In one embodiment, the front light assembly 231 includes a laser 2311, a collimating lens 2312, and a diaphragm 2313 arranged in that order along the optical path. The laser 2311 is electrically connected to the laser control board 24, and the laser 2311 emits laser light to the collimating lens 2312 under the control of the laser control board 24. The collimating lens 2312 is disposed between the laser 2311 and the diaphragm 2313, and is configured to collimate laser light emitted from the laser 2311 to form a parallel beam, and emit the parallel beam toward the diaphragm 2313. The diaphragm 2313 is used for receiving the parallel light beams emitted by the collimating lens 2312 and controlling the size of the laser spot entering the reaction cell 21.

Because the diaphragm 2313 is attached to the reaction chamber 21, the light-emitting surface of the front light assembly 231 is disposed on the diaphragm 2313, and the sealing ring 51 is disposed on the surface of the diaphragm 2313 attached to the reaction chamber 21, or the sealing ring 51 on one side of the front light assembly 231 is recessed on the outer surface of the diaphragm 2313 attached to the reaction chamber 21.

In one embodiment, the backlight assembly 232 includes a light-transmitting and scattering channel 2321, a neutral density patch 2322 and a photosensitive board card 2323. The transmission and scattering channel 2321 is used for transmitting the laser beam transmitted through the reaction cell 21 and transmitting the laser beam scattered through the reaction cell 21, respectively. The laser beam transmitted through the reaction cell 21 is absorbed by the neutral density plate 2322, and the laser beam scattered through the reaction cell 21 is received by the photosensitive board 2323. The photosensitive board 2323 receives the laser beam scattered by the reaction cell 21 and then forms corresponding photosensitive data. The sensitive data is the detection data detected by the specific protein measuring module 100 of the present application.

Since the transmission/scattering channel 2321 is actually a through hole formed in the mounting seat 70, the sealing ring 51 on the side of the rear light assembly 232 is recessed into the mounting seat 70 forming the transmission/scattering channel 2321 and is attached to the outer surface of the reaction cell 21.

In addition, the sealing ring 51 on the side of the front light assembly 231 is preferably formed in a circular ring shape along with the outer shape of the diaphragm 2313, and the sealing ring 51 on the side of the rear light assembly 232 is preferably formed in a rectangular shape along with the outer shape of the reaction cell 21.

In one embodiment, a second temperature sensor 82 is disposed in the sealed cavity 71, the second temperature sensor 82 is electrically connected to the temperature controller 35, and the temperature controller 35 controls the heating power of the heating rod 34 based on a feedback signal of the second temperature sensor 82. The sealed cavity 71 is used for hermetically receiving the front light assembly 231, and therefore the second temperature sensor 82 is used for monitoring the temperature in the sealed cavity 71, i.e. for monitoring the temperature of the front light assembly 231. As mentioned above, in order to maintain the uniformity of the laser light emitted from the front light assembly 231, it is necessary to keep the temperature of the front light assembly 231 relatively stable. The temperature in the sealed chamber 71 is the temperature of the heat conducting plate 33 conducted through the mount 70, and the temperature of the heat conducting plate 33 depends on the heat generating power of the heat generating rod 34. The temperature controller 35 can also maintain the temperature of the front light assembly 231 stable by controlling the heating power of the heating rod 24.

It should be noted that in some embodiments, when the first temperature sensor 81 and the second temperature sensor 82 are provided at the same time, the temperature controller 35 receives two different feedback signals at the same time. In this case, the temperature controller 35 needs to perform control based on two different feedback signals to simultaneously ensure that the temperature of the heating column 31 and the temperature of the sealing ring 71 are stable.

In one embodiment, the specific protein detection assembly 20 further comprises a data processing board 25. The data processing board 25 is electrically connected to the backlight assembly 232, and specifically, the data processing board 25 is electrically connected to the photo card 2323 in the backlight assembly 232. The data processing board 25 is configured to receive the sensitization data obtained by the sensitization board 2323 and calculate the sensitization data, so that the specific protein measurement module 100 of the present application can calculate a result of specific protein detection and directly send the detection result to the blood analyzer 200, thereby omitting a step of calculating the sensitization data by the blood analyzer 200.

It should be noted that, in the above embodiments and the schematic illustration of the drawings, the number of the specific protein detection assemblies 20 and the number of the preheating assemblies 30 in the specific protein measurement module 100 of the present application are not limited to one. One skilled in the art can arrange multiple sets of specific protein detection assemblies 20 and pre-heating assemblies 30 within the housing 10 to work in cooperation with each other according to the actual detection needs of the blood analyzer 200. For example, in the illustrated embodiment, the number of the specific protein detection assemblies 20 is two, and each of the specific protein detection assemblies 20 is further provided with a preheating assembly 30 for heating the reagent or the reaction solution. Further, each set of the cooperative specific protein detection module 20 and the pre-heating module 30 can be used for detecting different kinds of specific proteins.

Referring to FIG. 6, in order to maintain the temperature of the specific protein measurement module 100 of the present application, an insulating layer 11 is further provided within the housing 10, and/or the housing 10 is made of an insulating material. Therefore, the shell 10 has a heat preservation function, and heat emitted by the preheating assembly 30 is prevented from being lost.

Referring to fig. 7 and 8, in one embodiment, the specific protein measurement module 100 further includes a connector 60 fixed to the housing 10. The connector 60 is provided with a plurality of screw holes 65, and the connector 60 is fixed to the blood analyzer 200 by screws passing through the screw holes 65, thereby fixing the specific protein measuring module 100 to the blood analyzer 200.

In one embodiment, the connecting member 60 is further provided with a sliding sleeve 63 for inserting into the housing 10 in the connecting structure of the connecting member 60 and the housing 10. Referring back to fig. 6, the housing 10 is provided with an opening 12 corresponding to the sliding sleeve 63, and the sliding sleeve 63 extends into the opening 12 to be inserted into the housing 10. The link 60 is further provided with an adjustment assembly comprising a positioning rod 62, a spring 61 and a jack screw 64. The adjustment assembly is used to adjust the depth of the sliding sleeve 63 extending into the opening 12 to adjust the size of the particular protein measurement module 100 that is equipped with the blood analyzer 200.

The blood analyzer 200 needs to send the sample into the reaction cell 21 from the opening 211 of the reaction cell 21. The sample is typically introduced into reaction cell 21 by aligning a sample needle (not shown) with opening 211. However, due to system and individual tolerances of the blood analyzers 200 and assembly tolerances of the specific protein measurement module 100, misalignment of the sample needle with the opening 211 may occur after the specific protein measurement module 100 is fixed to a different blood analyzer 200. To this end, the dimensions of the particular protein measurement module 100 equipped with the hematology analyzer 200 can be adjusted by the adjustment assembly described above to overcome the system tolerance effects described above, thereby ensuring that the sample needle is aligned with the opening 211.

In one embodiment, the positioning rod 62 is disposed parallel to the length direction of the sliding sleeve 63, and the positioning rod 62 is telescopically connected to the body of the connecting member 60. The spring 61 is disposed between the body of the connecting member 60 and the positioning rod 62, and is used for providing an elastic force for moving the positioning rod 62 toward the side away from the body of the connecting member 60. The jackscrew 64 is disposed through the body of the connecting member 60 and is used for abutting against and locking the positioning rod 62 to determine the moving distance of the positioning rod relative to the body of the connecting member 60.

After the connector 60 is fixed on the blood analyzer 200, the sliding sleeve 63 of the connector 60 is aligned with the opening 12 of the housing 10 and slid into the corresponding opening 12, the body of the connector 60 moves toward the housing 10 along with the sliding movement of the sliding sleeve 63 in the opening 12, and the positioning rod 62 will abut against the outer surface of the housing 10 during the sliding movement of the sliding sleeve 63 into the opening 12, and further compress the spring 61 along with the abutting of the housing 10 until the sample needle is aligned with the opening 211. After the sample needle is aligned with opening 211, threading jackscrew 64 locks positioning rod 62. It is thereby possible to determine the depth to which the sliding sleeve 63 protrudes into the opening 12, thereby fixing the size of the specific protein measurement module 100 equipped on the blood analyzer 200.

In one embodiment, the specific protein detection assembly 20 is further provided with a drain line 26. A drain line 26 may be connected to a drain passage of the blood analyzer 200 for discharging the reaction solution for completing the detection, the cleaning solution for cleaning the reaction cell 21, and the like out of the reaction cell 21. The drain line 26 includes a first drain pipe (used as an indication drain line 26 in fig. 4) provided corresponding to the bottom of the reaction well 21, and a second drain pipe (not shown) provided corresponding to the overflow collecting structure 213 (shown in fig. 2) at the top of the reaction well 21.

Referring to fig. 9, the present application further provides a blood analyzer 200, which includes a sampling device 201, a fluid inlet and outlet system 202, and the specific protein measurement module 100. Wherein the sampling device 201 is used to collect a blood sample, the sampling device 201 may also be used to load the sample towards a specific protein measurement module 100. The inlet and outlet system 202 may be respectively connected to the inlet pipe 22 and the outlet pipe 26 of the specific protein measuring module 100, and is used for providing reagents required for detection to the specific protein measuring module 100 and discharging the reaction solution after detection out of the specific protein measuring module 100. It can be understood that the blood analyzer 200 of the present application has higher detection accuracy due to the provision of the specific protein measurement module 100 described above. The blood analyzer 200 of the present application is further developed based on the above-mentioned specific protein measurement module 100, and the detection reliability and the service life thereof are improved to a certain extent.

The above-described embodiments do not limit the scope of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the above-described embodiments should be included in the protection scope of the technical solution.

Claims (22)

1. The specific protein measuring module is characterized by comprising a shell, a specific protein detecting assembly and a preheating assembly, wherein the specific protein detecting assembly and the preheating assembly are fixed in the shell, the specific protein detecting assembly comprises a reaction pool, a liquid inlet pipeline, an optical detecting system and a laser control board, the liquid inlet pipeline is communicated with the reaction pool and used for loading a reaction reagent, the optical detecting system comprises a front light assembly and a rear light assembly which are arranged on two sides of the reaction pool in a split mode, the laser control board is used for controlling the front light assembly to emit laser towards the reaction pool, the rear light assembly is used for receiving the laser transmitted or scattered by the reaction pool and forming photosensitive data, and the preheating assembly corresponds to a path of the liquid inlet pipeline and is used for preheating the reaction reagent.

2. The specific protein measurement module of claim 1, wherein the pre-heating assembly comprises a heating column, and the liquid inlet line comprises a heating section helically wrapped around an outer surface of the heating column.

3. The specific protein measurement module of claim 2, wherein the pre-heating assembly further comprises a thermally conductive adhesive coated on the heating section and adapted to wrap the heating section.

4. The specific protein measurement module of claim 2, wherein the pre-heating assembly further comprises a metal housing disposed about the heating section.

5. The specific protein measurement module according to any one of claims 2-4, wherein the heating section is made of Teflon tubing.

6. The specific protein measurement module according to claim 5, wherein the preheating assembly further comprises a heat conducting plate fixed to the bottom of the heating column for transferring heat to the heating column, a heat generating rod disposed in the heat conducting plate for heating the heat conducting plate, and a temperature controller for controlling a heating power of the heat generating rod.

7. The specific protein measurement module according to claim 6, wherein a first temperature sensor is disposed on the heating column, the first temperature sensor is electrically connected to the temperature controller, and the temperature controller controls the heating power of the heating rod based on a feedback signal of the first temperature sensor.

8. The specific protein measurement module according to claim 7, wherein the liquid inlet line comprises a first liquid inlet line and a second liquid inlet line respectively communicating with the reaction cell, the first liquid inlet line comprises a first heating section spirally wound around the outer surface of the heating column, the second liquid inlet line comprises a second heating section spirally wound around the outer surface of the heating column, and the first heating section and the second heating section are arranged along the length direction of the heating column.

9. The specific protein measurement module of claim 8, wherein the first temperature sensor is disposed between the first heating segment and the second heating segment.

10. The specific protein measurement module of claim 6, further comprising a mounting seat for carrying and securing the specific protein detection component, the mounting seat being secured to the heat conductive plate in spaced relation to the heating column, the mounting seat being made of a thermally conductive material, the mounting seat further being adapted to transfer heat from the heat conductive plate to the front light component to maintain the temperature of the front light component within a predetermined temperature range.

11. The specific protein measurement module according to claim 10, wherein the mounting base comprises a sealing cavity for receiving the front-light assembly, a receiving cavity for receiving the rear-light assembly, and a sealing cover plate for sealing the rear-light assembly in cooperation with the receiving cavity.

12. The specific protein measurement module according to claim 11, wherein sealing rings are disposed between the light emitting surface of the front light assembly and the cell wall of the reaction cell, and between the light incident surface of the rear light assembly and the cell wall of the reaction cell.

13. The specific protein measurement module according to claim 12, wherein the front light assembly comprises a laser, a collimating lens and a diaphragm, the laser is electrically connected to the laser control board, the collimating lens is disposed between the laser and the diaphragm, and the sealing ring is concavely disposed on an outer surface of the diaphragm, which is attached to the reaction cell.

14. The specific protein measurement module of claim 12, wherein the rear light assembly comprises a transmission and scattering channel, a neutral density plate for absorbing transmission light, and a photosensitive plate for receiving scattered light, and the sealing ring is recessed on the transmission and scattering channel and is adhered to the outer surface of the reaction cell.

15. The specific protein measurement module according to claim 11, wherein a second temperature sensor is disposed in the sealed chamber, the second temperature sensor is electrically connected to the temperature controller, and the temperature controller controls the heating power of the heating rod based on a feedback signal from the second temperature sensor.

16. The specific protein measurement module according to claim 1, wherein the specific protein detection assembly further comprises a data processing board electrically connected to the backlight assembly for receiving the light-sensitive data and calculating the specific protein detection result.

17. The specific protein measurement module according to claim 4, wherein an insulating layer is provided inside the housing, and/or,

the shell is made of a heat-insulating material.

18. The specific protein measurement module according to claim 4, further comprising a connector fixed to the housing, the connector being fixed to a blood analyzer by a screw to fix the specific protein measurement module to the blood analyzer.

19. The specific protein measurement module of claim 18, wherein said connector is provided with a sliding sleeve for insertion into a corresponding opening of said housing, and an adjustment assembly for adjusting the depth to which said sliding sleeve extends into said opening.

20. The specific protein measurement module of claim 19, wherein the adjustment assembly comprises a positioning rod elastically connected to the connection member in a direction parallel to the length direction of the sliding sleeve, and a top thread for locking the positioning rod.

21. The specific protein measurement module according to claim 1, wherein the specific protein detection assembly further comprises a drain line, the drain line comprising a first drain pipe disposed corresponding to a bottom of the reaction well and a second drain pipe disposed corresponding to a overflow collecting structure at a top of the reaction well.

22. A blood analyzer, comprising:

a sampling device for collecting a blood sample;

the liquid inlet and outlet system is used for loading a reaction reagent and discharging the detected reaction liquid; and the number of the first and second groups,

the specific protein measurement module of any one of claims 1-21.

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