CN112839662A - 用于治疗口腔粘膜炎的方法和组合物 - Google Patents

用于治疗口腔粘膜炎的方法和组合物 Download PDF

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Publication number
CN112839662A
CN112839662A CN201980068116.XA CN201980068116A CN112839662A CN 112839662 A CN112839662 A CN 112839662A CN 201980068116 A CN201980068116 A CN 201980068116A CN 112839662 A CN112839662 A CN 112839662A
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Prior art keywords
pharmaceutical composition
present disclosure
pharmaceutically acceptable
patient
compound
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Pending
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CN201980068116.XA
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English (en)
Chinese (zh)
Inventor
S·A·凯茨
S·帕金森
P·C·奥康纳
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Lakewood Amedex Inc
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Lakewood Amedex Inc
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Publication of CN112839662A publication Critical patent/CN112839662A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
CN201980068116.XA 2018-10-17 2019-10-17 用于治疗口腔粘膜炎的方法和组合物 Pending CN112839662A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862746943P 2018-10-17 2018-10-17
US62/746,943 2018-10-17
PCT/US2019/056772 WO2020081839A1 (en) 2018-10-17 2019-10-17 Methods and compositions for treating oral mucositis

Publications (1)

Publication Number Publication Date
CN112839662A true CN112839662A (zh) 2021-05-25

Family

ID=70281364

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980068116.XA Pending CN112839662A (zh) 2018-10-17 2019-10-17 用于治疗口腔粘膜炎的方法和组合物

Country Status (12)

Country Link
US (2) US11123357B2 (https=)
EP (1) EP3866810A4 (https=)
JP (1) JP2022503733A (https=)
KR (1) KR20210075968A (https=)
CN (1) CN112839662A (https=)
AU (1) AU2019361999A1 (https=)
BR (1) BR112021006954A2 (https=)
CA (1) CA3116157A1 (https=)
IL (1) IL282100A (https=)
MX (1) MX2021004396A (https=)
SG (1) SG11202103180QA (https=)
WO (1) WO2020081839A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12030908B2 (en) 2017-03-10 2024-07-09 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
US11795192B2 (en) * 2017-03-10 2023-10-24 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
WO2024129985A2 (en) * 2022-12-14 2024-06-20 Lakewood Amedex, Inc. Antiviral compounds, compositions, and uses thereof
WO2025179296A1 (en) * 2024-02-22 2025-08-28 Lakewood Amedex, Inc. Crystalline forms of nu-3 and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035096A1 (en) * 1999-09-14 2002-03-21 Lawter James Ronald Formulations for treating or preventing mucositis
TW200402301A (en) * 2002-05-21 2004-02-16 Abbott Lab Treatment of mucositis
CN1687100A (zh) * 2005-04-05 2005-10-26 奥林格斯技术有限公司 修饰性核苷酸及其用途
US20110135713A1 (en) * 1998-12-30 2011-06-09 Lakewood-Amedex, Inc. Antimicrobial and Antiviral Compounds and Methods for Their Use
WO2012017434A2 (en) * 2010-08-03 2012-02-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compounds for treating bacterial infections
CN104583182A (zh) * 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 用于治疗粘膜炎的组合物和方法
WO2018165673A1 (en) * 2017-03-10 2018-09-13 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
CN110753549A (zh) * 2017-06-12 2020-02-04 莱克伍德阿美达克斯股份有限公司 双磷脂素凝胶制剂及其用途

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US4421769A (en) 1981-09-29 1983-12-20 The Procter & Gamble Company Skin conditioning composition
US5167950A (en) 1991-03-28 1992-12-01 S. C. Johnson & Son High alcohol content aerosol antimicrobial mousse
WO1995024179A1 (en) 1994-03-11 1995-09-14 The Procter & Gamble Company LOW pH, HYDROLYTICALLY STABLE, COSMETIC COMPOSITIONS CONTAINING ACIDIC ACTIVES
US6211349B1 (en) 1998-12-30 2001-04-03 Oligos Etc., Inc. Protonated/acidified nucleic acids and methods of use
US20020032164A1 (en) 1998-12-30 2002-03-14 Dale Roderic M. K. Antimicrobial compounds and methods for their use
US6211162B1 (en) 1998-12-30 2001-04-03 Oligos Etc. Inc. Pulmonary delivery of protonated/acidified nucleic acids
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
WO2003032909A2 (en) 2001-10-18 2003-04-24 Ilex Products, Inc. Methods of treating skin with diphosphonate derivatives
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
US8884000B2 (en) 2010-02-17 2014-11-11 Albert Einstein College Of Medicine Of Yeshiva University Saporin-L1 inhibitors and uses thereof
WO2014124430A1 (en) 2013-02-11 2014-08-14 Emory University Nucleotide and nucleoside therapeutic compositions and uses related thereto
WO2015075406A1 (en) 2013-11-19 2015-05-28 Lipopeptide Ab New treatment of chronic ulcers
EP3215126A1 (en) 2014-10-30 2017-09-13 Biomet Manufacturing, LLC Methods of preventing surgical site infections
US10172786B2 (en) 2014-12-16 2019-01-08 Axim Biotechnologies, Inc. Oral care composition comprising cannabinoids
US20200306119A1 (en) * 2016-03-23 2020-10-01 University Of Utah Research Foundation Spinal traction device

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110135713A1 (en) * 1998-12-30 2011-06-09 Lakewood-Amedex, Inc. Antimicrobial and Antiviral Compounds and Methods for Their Use
US20020035096A1 (en) * 1999-09-14 2002-03-21 Lawter James Ronald Formulations for treating or preventing mucositis
TW200402301A (en) * 2002-05-21 2004-02-16 Abbott Lab Treatment of mucositis
CN1687100A (zh) * 2005-04-05 2005-10-26 奥林格斯技术有限公司 修饰性核苷酸及其用途
WO2012017434A2 (en) * 2010-08-03 2012-02-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compounds for treating bacterial infections
CN104583182A (zh) * 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 用于治疗粘膜炎的组合物和方法
WO2018165673A1 (en) * 2017-03-10 2018-09-13 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
CN110753549A (zh) * 2017-06-12 2020-02-04 莱克伍德阿美达克斯股份有限公司 双磷脂素凝胶制剂及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DONNELLY等: "Antimicrobial therapy to prevent or treat oral mucositis", LANCET INFECTIOUS DISEASES, pages 405 - 412 *
WONG等: "Bisphosphocins: novel antimicrobials for enhanced killing of drug-resistant and biofilm-forming bacteria", FUTURE MICROBIOLOGY, pages 1751 - 1758 *

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Publication number Publication date
EP3866810A1 (en) 2021-08-25
AU2019361999A1 (en) 2021-02-25
JP2022503733A (ja) 2022-01-12
US20210393666A1 (en) 2021-12-23
US11123357B2 (en) 2021-09-21
KR20210075968A (ko) 2021-06-23
EP3866810A4 (en) 2022-07-27
US20200121708A1 (en) 2020-04-23
IL282100A (en) 2021-05-31
MX2021004396A (es) 2021-06-04
CA3116157A1 (en) 2020-04-23
SG11202103180QA (en) 2021-05-28
WO2020081839A1 (en) 2020-04-23
BR112021006954A2 (pt) 2021-07-20

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