CN112807387A - A Chinese medicinal composition and medical dressing for treating burn and scald - Google Patents
A Chinese medicinal composition and medical dressing for treating burn and scald Download PDFInfo
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- CN112807387A CN112807387A CN202110065966.3A CN202110065966A CN112807387A CN 112807387 A CN112807387 A CN 112807387A CN 202110065966 A CN202110065966 A CN 202110065966A CN 112807387 A CN112807387 A CN 112807387A
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Abstract
The invention discloses a traditional Chinese medicine composition and a medical dressing special for treating burns and scalds, belonging to the technical field of traditional Chinese medicine dressings for burns and scalds, wherein the traditional Chinese medicine composition comprises aniseed, giant knotweed rhizome, bletilla striata, sorghum rice, pine and cypress leaves, subprostrate sophora, dyers woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, radix rehmanniae elm powder, tea oil, eucalyptus oil and the like according to certain parts by weight; the traditional Chinese medicine composition specially used for treating burns and scalds is an external medicament improved by a Zhuang nationality secret recipe, can clear away heat and toxic materials, promote blood circulation to remove meridian obstruction, relieve swelling and pain, astringe and promote granulation, is quick in effect taking, and can feel cool within 5 minutes after the burn and scald part is coated with the traditional Chinese medicine composition, so that the effects of relieving pain and relieving swelling are achieved.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine dressings for burns and scalds, in particular to a traditional Chinese medicine composition and a medical dressing special for treating burns and scalds.
Background
The function of the skin is to prevent bacterial erosion and infection of the human body, regulate the body temperature and discharge body fluid and the like, is an organ with the largest area of the human body, and inevitably causes skin damage in daily life, wherein burn and scald are more difficult to treat than common wounds, and especially the treatment of large-area skin burn and scald is always a medical problem. The large-area skin burn and scald has a medical problem because the gas permeability of the skin is influenced after the burn and scald occurs, loss of tissue fluid and body fluid and loss of electrolytes and proteins are caused, contact rejection of tissues is damaged, and particularly, a series of complex pathological and physiological changes of the whole body can be caused when the large-area skin burn and scald occurs, such as imbalance of water, electrolytes and acid-base balance, shock, infection and septicemia.
The ideal clinical burn and scald dressing has the following functions besides isolating the wound from the outside and avoiding infection: the hemostatic property is good, and the tissue fluid secreted by the wound can be absorbed; effectively prevent bacteria from invading the wound; the air permeability is good, and the wound is kept moist; can adhere to healthy tissue but not to wound tissue, and the dressing can be easily removed from the wound without causing secondary damage to the patient, but to date, no wound dressing meets the requirements of the ideal dressing.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine composition and a medical dressing special for treating burns and scalds.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a traditional Chinese medicine composition specially used for treating burns and scalds comprises the following components in parts by weight: 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of giant knotweed, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 17-22 parts of tea oil, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 18-24 parts of eucalyptus oil, 8-12 parts of asarum, 8-12 parts of combed bone, 26-32 parts of sorghum rice, 18-23 parts of raw rhubarb, 12-16 parts of spora lygodii, 8-13 parts of Japanese butterflybush root, 7-11 parts of pricklyash peel, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora, 17-23 parts of honeysuckle, 9-12 parts of glossy privet, 46-52 parts of cotyledon ladysthumb, 26-33 parts of red cherokee rose root, 48-54 parts of rehmannia root.
The preferred traditional Chinese medicine composition comprises the following components in parts by weight: 30 parts of star anise, 20 parts of cassia bark, 20 parts of golden cypress, 15 parts of myrrh, 15 parts of safflower, 6 parts of coptis chinensis, 100 parts of giant knotweed, 50 parts of bletilla striata, 10 parts of rheum officinale, 20 parts of tea oil, 10 parts of liquorice, 10 parts of akebia stem, 20 parts of eucalyptus oil, 10 parts of asarum, 10 parts of combed bone, 30 parts of sorghum rice, 20 parts of raw rheum officinale, 15 parts of spora lygodii, 10 parts of shangshan, 10 parts of Chinese prickly ash, 20 parts of peach blossom, 20 parts of elephantopus scaber, 30 parts of pine-cypress leaf, 10 parts of subprostrate sophora, 20 parts of folium isatidis, 10 parts of honeysuckle, 50 parts of glossy privet leaf, 30 parts of cherokee rose root, 50 parts of raw sanguisorba.
The invention also discloses a preparation method of the traditional Chinese medicine composition for specially treating burns and scalds, which comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
according to the mass parts, 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of polygonum cuspidatum, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 8-12 parts of asarum, 8-12 parts of jatropha chinensis, 26-32 parts of sorghum rice, 18-23 parts of raw rheum officinale, 12-16 parts of spora lygodii, 8-13 parts of shansha tiger, 7-11 parts of pepper thorn, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora root, 17-23 parts of folium isatidis, 9-12 parts of honeysuckle, 46-52 parts of ligustrum leaves, 26-33 parts of radix rosae rubrum, 48-54 parts of radix rehmanniae powder and 8-12 parts of cassia seed are uniformly mixed to obtain a mixture;
and thirdly, adding 50-70 times of water by weight into the mixture obtained in the second step, boiling the mixture with strong fire, decocting the mixture with slow fire for 1-2 hours, filtering to remove residues, distilling the filtrate under reduced pressure to remove water to obtain a paste, adding 17-22 parts of tea oil and 18-24 parts of eucalyptus oil, and stirring to obtain a pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
The invention also comprises a medical dressing specially used for treating burns and scalds, the pasty traditional Chinese medicine extract takes acrylic acid modified chitosan as a medicine carrier, and nano short fibers are uniformly dispersed in the acrylic acid modified chitosan;
wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 40-50: 10-15: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 1000-5000: 5-20: 4-15: 0.5 to 1.
The preferable medical dressing specially used for treating burns and scalds is prepared from the following components in parts by mass of a traditional Chinese medicine extract, nano short fibers and acrylic acid modified chitosan, wherein the mass ratio of the traditional Chinese medicine extract to the nano short fibers is 45: 12: 100.
the invention also comprises a preparation method of the medical dressing special for treating burns and scalds, which comprises the following steps:
preparing polyhydroxypropionate into nanofibers with the diameters of 200-300 nm by adopting an electrostatic spinning method, then placing the nanofibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 1-2 hours, and crushing and sieving the nanofibers by using a high-speed crusher to obtain nano short fibers with the lengths of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract, stirring and dispersing for at least 1 hour, then adding the nano short fibers obtained in the step, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold, freezing and molding, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 1-5%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 600-2000: 40-50: 10 to 15.
The preparation method is preferably characterized in that the electrostatic spinning method is operated by heating polyhydroxypropionate into molten liquid, spraying the molten liquid through a capillary by adopting electrostatic spinning equipment, and drawing the molten liquid through potential difference of a high-voltage electrostatic field of 8-12 kv to obtain the nano-fiber with the diameter of 200-300 nm.
In the preferable preparation method, the mass concentration of the acetic acid solution is 4 percent; the mass ratio of the acrylic acid modified chitosan to the acetic acid solution is 100: 1000.
compared with the prior art, the invention has the following advantages:
the traditional Chinese medicine composition specially used for treating burns and scalds is an external medicament improved by a Zhuang nationality secret recipe, can clear away heat and toxic materials, promote blood circulation to remove meridian obstruction, relieve swelling and pain, astringe and promote granulation, is quick in effect taking, and can feel cool within 5 minutes after the burn and scald part is coated with the traditional Chinese medicine composition, so that the effects of relieving pain and relieving swelling are achieved.
The traditional Chinese medicine composition specially used for treating burns and scalds has no pain when being applied to the affected part of a patient, and can be directly applied without cutting eschar and blisters of the wound surface when in use; the skin care product can quickly absorb tissue fluid, prevent skin from drying and scabbing, promote skin cells to be soft and quickly form new skin epidermal tissues; the burn and scald ointment has the advantages of short cure period, quick response, no scar, no need of being combined with other antibiotics when in use, and capability of independently treating the burn and scald;
the traditional Chinese medicine composition specially used for treating burns and scalds is mild to I-II degree burns and scalds or general symptoms, and a patient can be healed within 5 days generally after rescue is timely performed; the burn and scald of III degree can be cured within 15 days, and no scar is left after the cure; the first aid can be used for the first aid of the initial wound part, and can also be used for the affected part of the skin which can not be cured for a long time, the clinical statistics is carried out on 200 patients, and the cure rate reaches 100 percent.
Detailed Description
The invention aims to provide a traditional Chinese medicine composition and a medical dressing special for treating burns and scalds, which are realized by the following technical scheme:
a traditional Chinese medicine composition specially used for treating burns and scalds comprises the following components in parts by weight: 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of giant knotweed, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 17-22 parts of tea oil, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 18-24 parts of eucalyptus oil, 8-12 parts of asarum, 8-12 parts of combed bone, 26-32 parts of sorghum rice, 18-23 parts of raw rhubarb, 12-16 parts of spora lygodii, 8-13 parts of Japanese butterflybush root, 7-11 parts of pricklyash peel, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora, 17-23 parts of honeysuckle, 9-12 parts of glossy privet, 46-52 parts of cotyledon ladysthumb, 26-33 parts of red cherokee rose root, 48-54 parts of rehmannia root.
The function of part of the components in the invention is explained as follows:
rhizoma Polygoni Cuspidati has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving cough, dispelling pathogenic wind, promoting diuresis, removing blood stasis, relieving pain, relieving cough, and eliminating phlegm. Can be used for treating arthralgia, jaundice due to damp-heat pathogen, amenorrhea, abdominal mass, scald due to hot water or fire, traumatic injury, carbuncle, suppurative sore, cough, and excessive phlegm;
bletilla striata is bitter and pungent in flavor, mild in smell, slightly cold in nature, and also yin in yang. Enter the lung meridian. It can astringe and stop bleeding. It can be used for both ulcer due to abortion and necrotic tissue. Apply on mountain root to stop epistaxis. Scabies and tinea are applied, and parasites are killed;
the tea oil has effects of improving blood circulation, clearing away heat and toxic materials, relieving inflammation and swelling, and relieving pain and pathogenic fire. The tea oil is directly applied to the affected part to achieve the effects of quickly activating blood circulation to dissipate blood stasis, and reducing swelling and eliminating redness;
the oleum Eucalypti is volatile oil obtained by steam distillation of Eucalyptus globulus Labill of Myrtaceae, Cinnamomum camphora of Lauraceae, or other plants of the same genus of the above two families. Has effects of dispelling pathogenic wind and relieving pain. The external ointment is mainly used for treating skin itch and neuralgia, can effectively treat skin itch of burn and scald patients after being added, and reduces pain of the patients;
the pine and cypress leaves can dispel wind and dry dampness; killing parasites and relieving itching; promoting blood circulation and tranquilizing. Wind-damp arthralgia; beriberi; eczema; tinea; rubella with pruritus; traumatic injury; the decoction contains quercetin and tannin, and has effects of remarkably shortening bleeding time and blood coagulation time, relieving cough, eliminating phlegm, relieving asthma, and tranquilizing mind. In vitro experiments show that the product has inhibitory effect on Staphylococcus aureus, Catalpa, Shigella dysenteriae, Salmonella typhi, and Corynebacterium diphtheriae.
The glossy privet leaf has the effects of dispelling wind and blood, and relieving swelling and pain. For dizziness and pain, all kinds of malignant sores and ulcers, as well as honing sores and ulcerations, it is often replaced by boiling with water or hot paste, or it is also done by boiling with rice vinegar. Sores in the mouth and tongue, swelling and swelling of tongue, pounding juice to soak and spit saliva; it can be used for external application to stop bleeding due to injury, diminish inflammation and relieve swelling, and is indicated for fire injury. It can be orally administered to relieve cough and hematemesis.
The radix rehmanniae and elm powder can cool blood and stop bleeding, clear away heat and toxic material, reduce swelling and heal wound.
Preferably, the composition comprises the following components in parts by weight: 30 parts of star anise, 20 parts of cassia bark, 20 parts of golden cypress, 15 parts of myrrh, 15 parts of safflower, 6 parts of coptis chinensis, 100 parts of giant knotweed, 50 parts of bletilla striata, 10 parts of rheum officinale, 20 parts of tea oil, 10 parts of liquorice, 10 parts of akebia stem, 20 parts of eucalyptus oil, 10 parts of asarum, 10 parts of combed bone, 30 parts of sorghum rice, 20 parts of raw rheum officinale, 15 parts of spora lygodii, 10 parts of shangshan, 10 parts of Chinese prickly ash, 20 parts of peach blossom, 20 parts of elephantopus scaber, 30 parts of pine-cypress leaf, 10 parts of subprostrate sophora, 20 parts of folium isatidis, 10 parts of honeysuckle, 50 parts of glossy privet leaf, 30 parts of cherokee rose root, 50 parts of raw sanguisorba.
The invention also comprises a preparation method of the traditional Chinese medicine composition specially used for treating burns and scalds, which comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
according to the mass parts, 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of polygonum cuspidatum, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 8-12 parts of asarum, 8-12 parts of jatropha chinensis, 26-32 parts of sorghum rice, 18-23 parts of raw rheum officinale, 12-16 parts of spora lygodii, 8-13 parts of shansha tiger, 7-11 parts of pepper thorn, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora root, 17-23 parts of folium isatidis, 9-12 parts of honeysuckle, 46-52 parts of ligustrum leaves, 26-33 parts of radix rosae rubrum, 48-54 parts of radix rehmanniae powder and 8-12 parts of cassia seed are uniformly mixed to obtain a mixture;
and thirdly, adding 50-70 times of water by weight into the mixture obtained in the second step, boiling the mixture with strong fire, decocting the mixture with slow fire for 1-2 hours, filtering to remove residues, distilling the filtrate under reduced pressure to remove water to obtain a paste, adding 17-22 parts of tea oil and 18-24 parts of eucalyptus oil, and stirring to obtain a pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
A medical dressing for treating burn and scald comprises pasty Chinese medicinal extract with acrylic acid modified chitosan as medicinal carrier, wherein nanometer short fiber is uniformly dispersed in the acrylic acid modified chitosan;
wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 40-50: 10-15: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 1000-5000: 5-20: 4-15: 0.5 to 1; the amount of dimethyl sulfoxide is the same in the two times;
the pasty traditional Chinese medicine extract is prepared by the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
according to the mass parts, 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of polygonum cuspidatum, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 8-12 parts of asarum, 8-12 parts of jatropha chinensis, 26-32 parts of sorghum rice, 18-23 parts of raw rheum officinale, 12-16 parts of spora lygodii, 8-13 parts of shansha tiger, 7-11 parts of pepper thorn, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora root, 17-23 parts of folium isatidis, 9-12 parts of honeysuckle, 46-52 parts of ligustrum leaves, 26-33 parts of radix rosae rubrum, 48-54 parts of radix rehmanniae powder and 8-12 parts of cassia seed are uniformly mixed to obtain a mixture;
and thirdly, adding 50-70 times of water by weight into the mixture obtained in the second step, boiling the mixture with strong fire, decocting the mixture with slow fire for 1-2 hours, filtering to remove residues, distilling the filtrate under reduced pressure to remove water to obtain paste, adding 17-22 parts of tea oil and 18-24 parts of eucalyptus oil, and stirring to obtain a pasty traditional Chinese medicine extract.
The medical dressing specially used for treating burns and scalds takes the acrylic acid modified chitosan as the carrier of the traditional Chinese medicine extract, and compared with the traditional Chinese medicine extract directly coated on the surface of the skin of a wound while the efficacy of the traditional Chinese medicine composition is exerted, the medical dressing can overcome the defect that the traditional Chinese medicine extract is not easy to remove when being adhered to the tissue of the wound for dressing change; the acrylic acid modified chitosan is adopted, so that the dressing has good hydrophilicity and biocompatibility, the mechanical strength of the dressing after the traditional Chinese medicine extract is dispersed in the carrier can be increased, and the clinical requirement can be better met; on the other hand, the acrylic acid modified chitosan is also uniformly dispersed with the polyhydroxypropionate nanometer short fibers, when tissue fluid or blood needs to be absorbed clinically, the acrylic acid modified chitosan becomes hydrophilic and soft, the polyhydroxypropionate hydrophobic is kept unchanged, a soft and hard section energy storage structure is formed, the tensile strength, the radial supporting force and the resilience of the dressing after the tissue fluid is absorbed are remarkably increased, the medical dressing can form gel in an integral form after the tissue fluid is absorbed, the gel is easy to remove, and secondary wound to a patient is avoided.
Preferably, the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 45: 12: 100.
the invention also comprises a preparation method of the medical dressing special for treating burns and scalds, which comprises the following steps:
preparing polyhydroxypropionate into nanofibers with the diameters of 200-300 nm by adopting an electrostatic spinning method, then placing the nanofibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 1-2 hours, and crushing and sieving the nanofibers by using a high-speed crusher to obtain nano short fibers with the lengths of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract, stirring and dispersing for at least 1 hour, then adding the nano short fibers obtained in the step, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold, freezing and molding, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 1-5%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 600-2000: 40-50: 10 to 15.
The preferred electrostatic spinning method is to add the polyhydroxy propionic acid ester into dioxane to prepare a solution with the mass concentration of 8 percent or heat the polyhydroxy propionic acid ester into a molten liquid, spray the solution by a capillary tube by adopting electrostatic spinning equipment, and draw and stretch the solution by the potential difference of a high-voltage electrostatic field of 10kv to obtain the nano-fiber with the diameter of 200-300 nm.
In the preferable preparation method, the mass concentration of the acetic acid solution is 4 percent; the mass ratio of the acrylic acid modified chitosan to the acetic acid solution is 100: 1000.
in the development process, glutaraldehyde cross-linked chitosan is used as a carrier of the traditional Chinese medicine extract, and polyhydroxypropionate is dispersed in the glutaraldehyde cross-linked chitosan by the same operation, but after the dressing absorbs water, the glutaraldehyde cross-linked chitosan is broken into gel, is easy to disperse and is not suitable for being used as a clinical dressing, so that the common glutaraldehyde cross-linked chitosan is not suitable for being used as a carrier of the traditional Chinese medicine extract.
Acrylic acid modified chitosan is used as a carrier of the traditional Chinese medicine extract, wherein the polyhydroxypropionate nanometer short fiber is not dispersed, but is in a broken gel state after the dressing absorbs water, is easy to disperse and is not suitable for being used as a clinical dressing, so that the mechanical property of the medical dressing can be improved by dispersing the polyhydroxypropionate nanometer short fiber, and the dressing can be better uncovered.
Acrylic acid modified chitosan is used as a carrier of a traditional Chinese medicine extract, polyester materials of the nano short fibers are modified into materials such as polyglycolide, polylactide, polytrimethylene carbonate and the like, but due to the structural problem of the polyester materials, other polyester materials cannot be well dispersed in a traditional Chinese medicine composition and an acrylic acid modified chitosan-acetic acid mixed solution in the preparation process, a dispersing agent needs to be added, but the biocompatibility of the dressing to a wound is affected after the dispersing agent is added, and the wound is easy to feel itch, so that polyhydroxypropionate with good dispersion degree is used as the material of the nano short fibers.
The invention is further described with reference to specific examples.
Example 1
A Chinese medicinal composition for treating burn and scald comprises the following components: 28g of star anise, 16g of cassia bark, 18g of golden cypress, 12g of myrrh, 14g of safflower, 4g of coptis chinensis, 90g of giant knotweed, 46g of bletilla striata, 8g of rheum officinale, 17g of tea oil, 6g of liquorice, 8g of akebia stem, 18g of eucalyptus oil, 8g of asarum, 8g of combed bone, 26g of sorghum rice, 18g of raw rhubarb, 12g of spora lygodii, 8g of shansha tiger, 7g of prickly ash, 18g of peach blossom, 18g of elephantopus scaber, 27g of pine cypress leaf, 8g of subprostrate sophora, 17g of dyers woad leaf, 9g of honeysuckle, 46g of glossy privet, 26g of cherokee rose root, 48g of raw sanguisorba.
Example 2
A Chinese medicinal composition for treating burn and scald comprises the following components: 32g of star anise, 22g of cassia bark, 24g of golden cypress, 18g of myrrh, 16g of safflower, 8g of coptis chinensis, 105g of giant knotweed, 52g of bletilla striata, 12g of rheum officinale, 22g of tea oil, 12g of liquorice, 11g of akebia stem, 24g of eucalyptus oil, 12g of asarum, 12g of combed bone, 32g of sorghum rice, 23g of raw rhubarb, 16g of spora lygodii, 13g of shansha tiger, 11g of Chinese prickly ash, 24g of peach blossom, 22g of elephantopus scaber, 32g of pine cypress leaf, 12g of subprostrate sophora, 23g of dyers woad leaf, 12g of honeysuckle, 52g of glossy privet, 33g of red cherokee rose root, 54g of raw sanguisorba.
Example 3
A Chinese medicinal composition for treating burn and scald comprises the following components: 31g of star anise, 18g of cassia bark, 22g of golden cypress, 14g of myrrh, 15g of safflower, 7g of coptis chinensis, 95g of giant knotweed, 48g of bletilla striata, 9g of rheum officinale, 19g of tea oil, 8g of liquorice, 10g of akebia stem, 20g of eucalyptus oil, 9g of asarum, 9g of combed bone, 28g of sorghum rice, 21g of raw rhubarb, 14g of lygodium japonicum, 11g of shansha tiger, 8g of pepper thorn, 22g of peach blossom, 19g of elephantopus scaber, 28g of pine cypress leaf, 11g of subprostrate sophora, 22g of dyers woad leaf, 11g of honeysuckle, 48g of glossy privet fruit, 28g of cherokee rose root, 52g of raw garden burnet root.
Example 4
A Chinese medicinal composition for treating burn and scald comprises the following components: 30g of star anise, 20g of cassia bark, 20g of golden cypress, 15g of myrrh, 15g of safflower, 6g of coptis chinensis, 100g of giant knotweed, 50g of bletilla striata, 10g of rheum officinale, 20g of tea oil, 10g of liquorice, 10g of akebia stem, 20g of eucalyptus oil, 10g of asarum, 10g of combed bone, 30g of sorghum rice, 20g of raw rheum officinale, 15g of spora lygodii, 10g of shansha tiger, 10g of Chinese prickly ash, 20g of peach blossom, 20g of elephantopus scaber, 30g of pine cypress leaf, 10g of subprostrate sophora, 20g of folium isatidis, 10g of honeysuckle, 50g of glossy privet leaf, 30g of cherokee rose root, 50g of raw sanguisorba.
Example 5
The preparation method of the traditional Chinese medicine composition specially used for treating burns and scalds in the embodiment 1 comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
secondly, uniformly mixing 28g of star anise, 16g of cassia bark, 18g of golden cypress, 12g of myrrh, 14g of safflower, 4g of coptis chinensis, 90g of giant knotweed, 46g of bletilla striata, 8g of rheum officinale, 6g of liquorice, 8g of akebiaquinata, 8g of asarum, 8g of combos bone, 26g of sorghum rice, 18g of raw rheum officinale, 12g of spora lygodii, 8g of shansha tiger, 7g of prickly ash, 18g of rose mallow, 18g of elephantopus scaber, 27g of pine cypress leaf, 8g of subprostrate sophora, 17g of dyers woad leaf, 9g of honeysuckle, 46g of glossy privet fruit, 26g of cherokee rose root, 48g of raw sanguisorba powder and 8g of concha haliotidis;
and thirdly, adding 50 times of water by weight into the mixture obtained in the second step, boiling the mixture with strong fire, decocting the mixture with slow fire for 1 hour, filtering the decoction dregs, removing water by reduced pressure distillation of the filtrate to obtain paste, adding 17g of tea oil and 18g of eucalyptus oil, and stirring the mixture to obtain pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
Example 6
The preparation method of the traditional Chinese medicine composition specially used for treating burns and scalds in the embodiment 2 comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
secondly, crushing 32g of star anise, 22g of cassia bark, 24g of golden cypress, 18g of myrrh, 16g of safflower, 8g of coptis chinensis, 105g of giant knotweed, 52g of bletilla striata, 12g of rheum officinale, 12g of liquorice, 11g of akebiaquinata, 12g of asarum, 12g of combos bone, 32g of sorghum rice, 23g of raw rheum officinale, 16g of spora lygodii, 13g of shansha tiger, 11g of prickly ash, 24g of rose mallow, 22g of elephantopus scaber, 32g of pine cypress leaf, 12g of subprostrate sophora, 23g of dyers woad leaf, 12g of honeysuckle, 52g of glossy privet fruit, 33g of cherokee rose root, 54g of raw garden burnet root powder and 12g of abalone shell to obtain a mixture;
and thirdly, adding water with the weight being 70 times of that of the mixture obtained in the second step into the mixture obtained in the third step, boiling the mixture by strong fire, then decocting the mixture by slow fire for 2 hours, filtering the decoction dregs, filtering the decoction, removing water by reduced pressure distillation to obtain paste, then adding 22g of tea oil and 24g of eucalyptus oil, and stirring the mixture to obtain pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
Example 7
The preparation method of the traditional Chinese medicine composition specially used for treating burns and scalds in the embodiment 3 comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
② mixing 31g of anise, 18g of cassia bark, 22g of phellodendron, 14g of myrrh, 15g of safflower, 7g of coptis, 95g of giant knotweed, 48g of bletilla striata, 9g of rhubarb, 8g of liquorice, 10g of akebia stem, 9g of asarum, 9g of combos bone, 28g of sorghum rice, 21g of raw rhubarb, 14g of spora lygodii, 11g of shansha tiger, 8g of prickly ash, 22g of rose mallow, 19g of elephantopus scaber, 28g of pine cypress leaf, 11g of subprostrate sophora, 22g of dyers woad leaf, 11g of honeysuckle, 48g of glossy privet fruit, 28g of cherokee rose root, 52g of raw garden burnet root powder and 11g of abalone shell uniformly to obtain a mixture;
and thirdly, adding 65 times of water by weight into the mixture obtained in the second step, boiling the mixture with strong fire, decocting the mixture with slow fire for 1.5 hours, filtering the decoction dregs, removing water into paste by reduced pressure distillation of the filtrate, then adding 19g of tea oil and 20g of eucalyptus oil, and stirring the mixture to obtain pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
Example 8
The preparation method of the traditional Chinese medicine composition specially used for treating burns and scalds in the embodiment 4 comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
secondly, 30g of star anise, 20g of cassia bark, 20g of golden cypress, 15g of myrrh, 15g of safflower, 6g of coptis chinensis, 100g of giant knotweed, 50g of bletilla striata, 10g of rheum officinale, 10g of liquorice, 10g of akebia stem, 10g of asarum, 10g of combos bone, 30g of sorghum rice, 20g of raw rheum officinale, 15g of spora lygodii, 10g of shansha tiger, 10g of Chinese prickly ash, 20g of rose mallow, 20g of elephantopus scaber, 30g of pine cypress leaf, 10g of subprostrate sophora, 20g of dyers woad leaf, 10g of honeysuckle, 50g of glossy privet leaf, 30g of cherokee rose root, 50g of fresh rehmannia elm powder and 10 g;
adding 55 times of water into the mixture obtained in the step II, boiling the mixture with strong fire, decocting the mixture with slow fire for 1.2 hours, filtering the decoction dregs, removing the residue by filtration, distilling the filtrate under reduced pressure to remove water to obtain paste, then adding 20g of tea oil and 20g of eucalyptus oil, and stirring to obtain pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
Example 9
A medical dressing specially used for treating burns and scalds, the traditional Chinese medicine extract of the embodiment 5 takes acrylic acid modified chitosan as a medicine carrier, and nano short fibers are uniformly dispersed in the acrylic acid modified chitosan; wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 40: 15: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 1000: 5: 4: 0.5.
example 10
A medical dressing specially used for treating burns and scalds, the traditional Chinese medicine extract of the embodiment 6 takes acrylic acid modified chitosan as a medicine carrier, and nano short fibers are uniformly dispersed in the acrylic acid modified chitosan; wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 50: 10: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 5000: 20: 15: 1.
example 11
A medical dressing specially used for treating burns and scalds, the traditional Chinese medicine extract of example 7 takes acrylic acid modified chitosan as a medicine carrier, and nano short fibers are uniformly dispersed in the acrylic acid modified chitosan; wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 42: 14: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 2000: 8: 6: 1.
example 12
A medical dressing specially used for treating burns and scalds, the traditional Chinese medicine extract of the embodiment 8 takes acrylic acid modified chitosan as a medicine carrier, and nano short fibers are uniformly dispersed in the acrylic acid modified chitosan; wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 45: 12: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 3000: 15: 10: 0.8.
example 13
The preparation method of the medical dressing special for treating burns and scalds in the embodiment 9 comprises the following steps:
preparing polyhydroxypropionate into nano-fibers with diameters of 200-300 nm by adopting an electrostatic spinning method, then placing the nano-fibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 1 hour, crushing the nano-fibers by a high-speed crusher, and then sieving the crushed nano-fibers to obtain nano-short fibers with lengths of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract into the acetic acid solution, stirring and dispersing for 1 hour, then adding the nano short fibers obtained in the step into the acetic acid solution, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold for freeze forming, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 1%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 2000: 40: 15.
example 14
The preparation method of the medical dressing special for treating burns and scalds in the embodiment 10 comprises the following steps:
heating polyhydroxypropionate into molten liquid, spraying the molten liquid through a capillary by using electrostatic spinning equipment, drawing and stretching the molten liquid through a potential difference of a high-voltage electrostatic field of 8kv to obtain nano fibers with the diameter of 200-300 nm, then placing the nano fibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 2 hours, and crushing and sieving the nano fibers by using a high-speed crusher to obtain nano short fibers with the length of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract, stirring and dispersing for 1.5 hours, then adding the obtained nano short fibers, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold, freezing and molding, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 5%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 600: 50: 10.
example 15
The preparation method of the medical dressing special for treating burns and scalds in the embodiment 11 comprises the following steps:
heating polyhydroxypropionate into molten liquid, spraying the molten liquid through a capillary by using electrostatic spinning equipment, drawing and stretching the molten liquid through a potential difference of a high-voltage electrostatic field of 12kv to obtain nano fibers with the diameter of 200-300 nm, then placing the nano fibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 1.5 hours, and crushing the nano fibers by using a high-speed crusher and then sieving the crushed nano fibers to obtain nano short fibers with the length of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract, stirring and dispersing for 1.5 hours, then adding the obtained nano short fibers, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold, freezing and molding, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 3%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 1500: 42: 14.
example 16
The preparation method of the medical dressing special for treating burns and scalds in the embodiment 12 comprises the following steps:
heating polyhydroxypropionate into molten liquid, spraying the molten liquid through a capillary by using electrostatic spinning equipment, drawing and stretching the molten liquid through a potential difference of a high-voltage electrostatic field of 10kv to obtain nano fibers with the diameter of 200-300 nm, then placing the nano fibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 1.2 hours, and crushing and sieving the nano fibers by using a high-speed crusher to obtain nano short fibers with the length of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract, stirring and dispersing for at least 1 hour, then adding the nano short fibers obtained in the step, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold, freezing and molding, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 4%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 1000: 45: 12.
clinical trial
96 patients with burn or scald cases are treated by the traditional Chinese medicine composition special for treating burn and scald (examples 1-4) before 19 years and 12 months, the burn or scald parts of the patients are coated with the traditional Chinese medicine composition special for treating burn and scald, the medicine is changed once a day, the depth of each burn and scald and the corresponding sign performance are shown in table 1, and the observation and statistical results after treatment are shown in table 2.
TABLE 1 corresponding table of depth of burn and scald and local physical signs
Table 2 treatment conditions of patients with the Chinese medicinal composition for treating burns and scalds of the present invention
The traditional Chinese medicine composition specially used for treating burns and scalds for patients with burns or scalds has an excellent treatment effect, but patients with deep II degrees or III degrees have the defect that the traditional Chinese medicine composition is not easy to remove when dressing change is carried out on wound tissues, partial residues are not easy to remove, and the dressing change time is long, so that the traditional Chinese medicine composition is combined with a medical high polymer material, a proper carrier suitable for the traditional Chinese medicine extract is tried to be explored, acrylic acid modified chitosan is used as the carrier of the traditional Chinese medicine extract after 19 years and 12 months, the medical dressing specially used for treating burns and scalds as shown in examples 9-12 is obtained and used for clinical practice, the dressing change time is modified into 2 times per day, and the observation and statistical results after 58 clinical patients are treated are shown in table 3.
TABLE 3 treatment of patients with the medical dressing of the present invention for treating burns and scalds
The results in table 3 show that the medical dressing of the present invention has no change to the body feeling of the patient compared with the previous traditional Chinese medicine composition, but the dressing change times are increased, so the medical dressing is more favorable for the healing of the skin wound surface.
Typical patient treatment situation
If Li Yi and women are 65 years old, the arms are scalded by hot water, the burn area reaches 35%, the skin breaking condition occurs, the skin temperature is low, the wound surface at the scalded position is light red or red and white, and reticular embolism blood vessels can be seen, after the medical dressing of the embodiment 12 of the invention is applied, the wound feels cool and has no itching symptom, the dressing change is carried out twice a day in the first 2 days, and the dressing change is carried out once a day in the last 4 days, so that the wound is healed, and no scar is left on the affected part.
When a certain Zhao, male and a 14-month old are scalded by hot soup for about 85% of the area of the back of the right hand, the wound surface is light red or red and white alternately, reticular embolism blood vessels can be seen, and the crying is still, the crying stops after the medical dressing of the embodiment 12 of the invention is applied for 20 minutes, the crying is stopped after the dressing is changed twice a day, the affected part is healed in 4 days, and no scar is left.
Wu Chi, male, age 22, has serious leg burn, the affected part has signs of rot after a period of treatment in hospital, the patient has no pain, and the pain can be relieved only by using the pain killer, the medical dressing of the invention example 12 is adopted, the dressing is changed for 2 times every day, the wound feels cool and has no pruritus after being applied, the wound is obviously improved after 3 days, new tissues gradually cover the affected part after 6 days, and the patient is cured after 12 days without scars.
Claims (8)
1. A traditional Chinese medicine composition specially used for treating burns and scalds is characterized in that: the composition comprises the following components in parts by weight: 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of giant knotweed, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 17-22 parts of tea oil, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 18-24 parts of eucalyptus oil, 8-12 parts of asarum, 8-12 parts of combed bone, 26-32 parts of sorghum rice, 18-23 parts of raw rhubarb, 12-16 parts of spora lygodii, 8-13 parts of Japanese butterflybush root, 7-11 parts of pricklyash peel, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora, 17-23 parts of honeysuckle, 9-12 parts of glossy privet, 46-52 parts of cotyledon ladysthumb, 26-33 parts of red cherokee rose root, 48-54 parts of rehmannia root.
2. The traditional Chinese medicine composition special for treating burns and scalds as claimed in claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 30 parts of star anise, 20 parts of cassia bark, 20 parts of golden cypress, 15 parts of myrrh, 15 parts of safflower, 6 parts of coptis chinensis, 100 parts of giant knotweed, 50 parts of bletilla striata, 10 parts of rheum officinale, 20 parts of tea oil, 10 parts of liquorice, 10 parts of akebia stem, 20 parts of eucalyptus oil, 10 parts of asarum, 10 parts of combed bone, 30 parts of sorghum rice, 20 parts of raw rheum officinale, 15 parts of spora lygodii, 10 parts of shangshan, 10 parts of Chinese prickly ash, 20 parts of peach blossom, 20 parts of elephantopus scaber, 30 parts of pine-cypress leaf, 10 parts of subprostrate sophora, 20 parts of folium isatidis, 10 parts of honeysuckle, 50 parts of glossy privet leaf, 30 parts of cherokee rose root, 50 parts of raw sanguisorba.
3. The preparation method of the Chinese medicinal composition for treating burns and scalds according to claim 1, which is characterized by comprising the following steps: the method comprises the following steps:
pulverizing anise, cassia bark, golden cypress, myrrh, safflower, coptis chinensis, giant knotweed rhizome, bletilla striata, rhubarb, liquorice, akebiaquinata, asarum, combed bone, sorghum rice, raw rhubarb, lygodium japonicum, Japanese ardisia, pricklyash peel, rose mallow, elephantopus scaber, pine and cypress leaf, subprostrate sophora, dyer woad leaf, honeysuckle, glossy privet leaf, cherokee rose root, raw sanguisorba powder and concha haliotidis to more than 100 meshes respectively for later use;
according to the mass parts, 28-32 parts of star anise, 16-22 parts of cassia bark, 18-24 parts of golden cypress, 12-18 parts of myrrh, 14-16 parts of safflower, 4-8 parts of coptis chinensis, 90-105 parts of polygonum cuspidatum, 46-52 parts of bletilla striata, 8-12 parts of rheum officinale, 6-12 parts of liquorice, 8-11 parts of akebiaquinata, 8-12 parts of asarum, 8-12 parts of jatropha chinensis, 26-32 parts of sorghum rice, 18-23 parts of raw rheum officinale, 12-16 parts of spora lygodii, 8-13 parts of shansha tiger, 7-11 parts of pepper thorn, 18-24 parts of prunus persica flower, 18-22 parts of elephantopus scaber, 27-32 parts of pine cypress leaf, 8-12 parts of subprostrate sophora root, 17-23 parts of folium isatidis, 9-12 parts of honeysuckle, 46-52 parts of ligustrum leaves, 26-33 parts of radix rosae rubrum, 48-54 parts of radix rehmanniae powder and 8-12 parts of cassia seed are uniformly mixed to obtain a mixture;
and thirdly, adding 50-70 times of water by weight into the mixture obtained in the second step, boiling the mixture with strong fire, decocting the mixture with slow fire for 1-2 hours, filtering to remove residues, distilling the filtrate under reduced pressure to remove water to obtain a paste, adding 17-22 parts of tea oil and 18-24 parts of eucalyptus oil, and stirring to obtain a pasty traditional Chinese medicine extract, namely the traditional Chinese medicine composition special for treating burns and scalds.
4. A medical dressing specially used for treating burns and scalds is characterized in that: the pasty traditional Chinese medicine extract obtained by the method of claim 3 takes acrylic acid modified chitosan as a medicine carrier, and nano short fibers are uniformly dispersed in the acrylic acid modified chitosan;
wherein the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 40-50: 10-15: 100, respectively;
the nano short fiber is polyhydroxy propionate with the diameter of 200-300 nm and the length of 50-60 mu m;
the acrylic acid modified chitosan is prepared by the following steps:
adding chitosan into dimethyl sulfoxide, then sequentially adding acrylic acid, diisopropylcarbodiimide and potassium tert-butoxide, reacting for 1 hour under reflux, pouring the obtained mixed solution into water while the mixed solution is hot, stirring, standing, filtering, washing a filter cake with dimethyl sulfoxide, and drying to obtain acrylic acid modified chitosan;
wherein the mass ratio of chitosan, dimethyl sulfoxide, acrylic acid, diisopropyl carbodiimide and potassium tert-butoxide is 100: 1000-5000: 5-20: 4-15: 0.5 to 1.
5. The medical dressing special for treating burns and scalds according to claim 4, wherein: the mass ratio of the traditional Chinese medicine extract to the nano short fiber to the acrylic acid modified chitosan is 45: 12: 100.
6. the preparation method of the medical dressing special for treating burns and scalds as claimed in claim 4, is characterized in that: the method comprises the following steps:
preparing polyhydroxypropionate into nanofibers with the diameters of 200-300 nm by adopting an electrostatic spinning method, then placing the nanofibers in liquid nitrogen at the temperature of below-50 ℃ for deep cooling for 1-2 hours, and crushing and sieving the nanofibers by using a high-speed crusher to obtain nano short fibers with the lengths of 50-60 mu m;
dissolving and dispersing acrylic acid modified chitosan into an acetic acid solution, adding a traditional Chinese medicine extract, stirring and dispersing for at least 1 hour, then adding the nano short fibers obtained in the step, stirring and dispersing uniformly to obtain a mixed solution, adding the mixed solution into a mold, freezing and molding, and then placing the mold into a freeze dryer for freeze drying to remove a solvent, so as to obtain the medical dressing special for treating burns and scalds;
the mass concentration of the acetic acid solution is 1-5%;
the mass ratio of the acrylic acid modified chitosan to the acetic acid solution to the traditional Chinese medicine extract to the nano short fibers is 100: 600-2000: 40-50: 10 to 15.
7. The preparation method of the medical dressing special for treating burns and scalds according to claim 6, characterized in that: the electrostatic spinning method is operated by heating polyhydroxypropionate into molten liquid, spraying the molten liquid through a capillary by adopting electrostatic spinning equipment, and drawing the molten liquid through potential difference of a high-voltage electrostatic field of 8-12 kv to obtain the nano-fiber with the diameter of 200-300 nm.
8. The preparation method of the medical dressing special for treating burns and scalds according to claim 6, characterized in that: the mass concentration of the acetic acid solution is 4%; the mass ratio of the acrylic acid modified chitosan to the acetic acid solution is 100: 1000.
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