CN117618508A - Antibacterial ointment for treating rhinitis and preparation method thereof - Google Patents
Antibacterial ointment for treating rhinitis and preparation method thereof Download PDFInfo
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- CN117618508A CN117618508A CN202311581964.5A CN202311581964A CN117618508A CN 117618508 A CN117618508 A CN 117618508A CN 202311581964 A CN202311581964 A CN 202311581964A CN 117618508 A CN117618508 A CN 117618508A
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- 206010039083 rhinitis Diseases 0.000 title claims abstract description 58
- 239000002674 ointment Substances 0.000 title claims abstract description 49
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
The invention discloses a bacteriostatic ointment for treating rhinitis and a preparation method thereof, wherein the bacteriostatic ointment for treating rhinitis is prepared from a traditional Chinese medicine composition, vaseline, lanolin and xanthium oil; the traditional Chinese medicine composition comprises the following components in parts by weight: 25-35 parts of fructus xanthil, 15-25 parts of radix sophorae flavescentis, 10-20 parts of aloe, 10-20 parts of cortex phellodendri, 8-12 parts of flos magnoliae, 8-12 parts of asarum, 4-6 parts of menthol, 4-6 parts of borneol and 10-20 parts of beeswax; according to the invention, by compounding the traditional Chinese medicine raw materials and combining the raw materials, the prepared antibacterial ointment has an excellent antibacterial effect, can rapidly eliminate inflammation in the nose and promote repair of nasal membrane injury, further achieves the purpose of treating rhinitis, and has the characteristics of remarkable treatment effect and quick response.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a bacteriostatic ointment for treating rhinitis and a preparation method thereof.
Background
Rhinitis, i.e. inflammatory diseases of the nasal cavity, is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physicochemical factors and certain systemic diseases. The main pathological changes of rhinitis are nasal mucosa congestion, swelling, exudation, hyperplasia, atrophy or necrosis.
At present, the products for treating rhinitis on the market comprise rhinitis cleaning liquid, wherein the rhinitis cleaning liquid is prepared into aqueous solution by sodium chloride, and the aqueous solution is sprayed to a lesion part by an electric nose washer, and has a certain anti-inflammatory effect, however, the cleaning liquid has poor effects of resisting viruses, sterilizing and eliminating mould.
In addition, most of the existing medicines for treating rhinitis are chemical medicines, and the medicines can only temporarily relieve symptoms and cannot fundamentally treat rhinitis.
Disclosure of Invention
The invention aims to provide a bacteriostatic ointment for treating rhinitis and a preparation method thereof, and the bacteriostatic ointment has excellent bacteriostatic and anti-inflammatory effects, can repair damaged tissues, further has an excellent treatment effect on rhinitis, and has quick and obvious curative effect.
In order to achieve the above object of the present invention, the following technical solutions are specifically adopted:
the invention provides a bacteriostatic ointment for treating rhinitis, which is prepared from a traditional Chinese medicine composition, vaseline, lanolin and xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
25-35 parts of fructus xanthil, 15-25 parts of radix sophorae flavescentis, 10-20 parts of aloe, 10-20 parts of cortex phellodendri, 8-12 parts of flos magnoliae, 8-12 parts of asarum, 4-6 parts of menthol, 4-6 parts of borneol and 10-20 parts of beeswax.
The raw materials adopted in the invention are as follows:
fructus Xanthii: sweet in nature and warm; enter lung and liver meridians; has effects of dispelling pathogenic wind, relieving pain, eliminating dampness, and killing parasite, and can be used for treating wind-cold headache, nasosinusitis, odontalgia, wind-cold-dampness arthralgia, limb spasm pain, scabies, and pruritus.
Radix Sophorae Flavescentis: bitter taste and cold nature; return to heart, liver, stomach, large intestine and bladder meridian; has effects of clearing heat, eliminating dampness, killing parasite, promoting urination, cooling blood, and removing toxic substances, and can be used for treating dysentery, hematochezia, jaundice, urine closure, leucorrhea with red and white discharge, yin swelling and pruritus vulvae, eczema, wet sore, skin pruritus, mange leprosy, trichomonas vaginitis, etc.
Aloe: bitter taste and cold nature; liver and large intestine channels; has purgative, liver heat removing, parasite killing, and antiinflammatory effects, and can be used for treating constipation due to heat accumulation, headache due to liver fire, conjunctival congestion, infantile convulsion, abdominal pain due to insect accumulation, scabies, tinea, hemorrhoid and fistula.
Cortex Phellodendri: bitter taste and cold nature; kidney and bladder meridian; has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substances, and treating sore; can be used for treating damp-heat diarrhea, jaundice, dark urine, itching and leukorrhagia, heat stranguria, tinea pedis, night sweat, spermatorrhea, pyocutaneous disease, swelling and toxin, and eczema. Salted phellodendron bark, cortex Phellodendri, radix Phellodendri, has the effect of nourishing yin to reduce pathogenic fire. Is used for treating night sweat and bone steaming due to yin deficiency and fire excess.
Flos Magnoliae: pungent and warm; enter lung and stomach meridians; has effects of dispelling pathogenic wind and cold, and relieving stuffy nose; can be used for treating common cold due to wind-cold, nasal obstruction, and nasosinusitis.
Asarum herb: pungent and warm; return to heart, lung and kidney meridians; has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, inducing resuscitation, warming lung, and resolving fluid retention; can be used for treating common cold due to wind-cold, headache, toothache, rheumatalgia, nasosinusitis, cough due to lung cold, etc.
Menthol: pungent taste; cooling; has effects of dispelling pathogenic wind and clearing heat; can be used for treating common cold, headache, conjunctival congestion, laryngopharynx swelling and pain, odontalgia, and skin pruritus.
Borneol: borneol is pungent and bitter and slightly cold; return to heart, liver and lung meridians; has the effects of inducing resuscitation, clearing heat, removing toxic substances, improving eyesight, and removing nebula, and can be used for treating fever with high fever, unconsciousness, apoplexy, phlegm syncope, convulsion, summer-heat dampness, clearing orifices, throat obstruction, deafness, aphtha, odontopathy, carbuncle, infantile hemorrhoid, conjunctival congestion, swelling and pain, nebula, and eye obstruction.
Beeswax: sweet taste and slightly warm nature; spleen meridian tropism; has effects in removing toxic materials, healing sore, promoting granulation, and relieving pain; can be used for treating ulcer, ecthyma erosion, traumatic ulcer, burn, scald, etc.
According to the invention, by compounding the traditional Chinese medicine raw materials and combining the raw materials, the prepared antibacterial ointment has an excellent antibacterial effect, can rapidly eliminate inflammation in the nose and promote repair of nasal membrane injury, further achieves the purpose of treating rhinitis, and has the characteristics of remarkable treatment effect and quick response.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight:
30 parts of fructus xanthil, 20 parts of radix sophorae flavescentis, 15 parts of aloe, 15 parts of cortex phellodendri, 10 parts of flos magnoliae, 10 parts of asarum, 5 parts of menthol, 5 parts of borneol and 15 parts of beeswax.
Preferably, the antibacterial ointment for treating rhinitis is prepared from the following raw materials in parts by weight:
18-22 parts of traditional Chinese medicine composition, 8-12 parts of Vaseline, 8-12 parts of lanolin and 18-22 parts of cocklebur oil.
Preferably, the antibacterial ointment for treating rhinitis is prepared from the following raw materials in parts by weight:
20 parts of traditional Chinese medicine composition, 10 parts of Vaseline, 10 parts of lanolin and 20 parts of cocklebur oil.
Preferably, the xanthium oil is prepared by the following method:
pulverizing fructus Xanthii, frying in oleum Sesami to brown, and filtering to obtain the final product.
Preferably, 35-45 fructus Xanthii is added to 50g of sesame oil.
The second aspect of the invention provides a preparation method of the antibacterial ointment for treating rhinitis, which comprises the following steps:
(a) Pulverizing and sieving the components in the traditional Chinese medicine composition respectively, collecting undersize to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition;
(b) Mixing vaseline, xanthium oil and lanoline, and heating to completely melt to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 70-80 ℃ to obtain the antibacterial ointment for treating rhinitis.
Preferably, in the step (a), the sieve used in the sieving has a sieve diameter of 150 mesh.
Preferably, in the step (b), the temperature of the mixed solution is 90 to 100 ℃.
Compared with the prior art, the invention has the beneficial effects that at least:
according to the invention, by compounding the traditional Chinese medicine raw materials and combining the raw materials, the prepared antibacterial ointment has an excellent antibacterial effect, can rapidly eliminate inflammation in the nose and promote repair of nasal membrane injury, further achieves the purpose of treating rhinitis, and has the characteristics of remarkable treatment effect and quick response. A step of
The preparation raw material of the antibacterial ointment for treating rhinitis is natural Chinese herbal medicines, has no toxic or side effect on human bodies, can treat both symptoms and root causes of rhinitis, can realize rapid improvement of rhinitis symptoms, and achieves the aim of curing rhinitis.
Detailed Description
Embodiments of the technical scheme of the present invention will be described in detail below with reference to the embodiments. The following examples are only for more clearly illustrating the technical aspects of the present invention, and thus are merely examples, and are not intended to limit the scope of the present invention.
It is noted that unless otherwise indicated, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.
Example 1
The embodiment is a bacteriostatic ointment for treating rhinitis, which is prepared from the following raw materials in parts by weight:
18 parts of a traditional Chinese medicine composition, 12 parts of Vaseline, 8 parts of lanolin and 18 parts of xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
35 parts of fructus xanthil, 15 parts of radix sophorae flavescentis, 20 parts of aloe, 10 parts of cortex phellodendri, 12 parts of flos magnoliae, 8 parts of asarum, 6 parts of menthol, 4 parts of borneol and 20 parts of beeswax.
The preparation method of the antibacterial ointment for treating rhinitis comprises the following steps:
(a) Adding 35 fructus Xanthii into 50g of sesame oil, pulverizing fructus Xanthii, frying in sesame oil to brown, and filtering to obtain oleum Xanthii; pulverizing the components in the traditional Chinese medicine composition, sieving with a 150-mesh sieve, collecting undersize products to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition for standby;
(b) Mixing vaseline, xanthium oil and lanolin, heating to 100deg.C, and completely melting to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 80 ℃ to obtain the antibacterial ointment for treating rhinitis.
Example 2
The embodiment is a bacteriostatic ointment for treating rhinitis, which is prepared from the following raw materials in parts by weight:
22 parts of traditional Chinese medicine composition, 8 parts of Vaseline, 12 parts of lanolin and 22 parts of xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
25 parts of fructus xanthil, 25 parts of radix sophorae flavescentis, 10 parts of aloe, 20 parts of cortex phellodendri, 8 parts of flos magnoliae, 8 parts of asarum, 4 parts of menthol, 6 parts of borneol and 10 parts of beeswax.
The preparation method of the antibacterial ointment for treating rhinitis comprises the following steps:
(a) Adding 45 fructus Xanthii into 50g of sesame oil, pulverizing fructus Xanthii, frying in sesame oil to brown, and filtering to obtain oleum Xanthii; pulverizing the components in the traditional Chinese medicine composition, sieving with a 150-mesh sieve, collecting undersize products to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition for standby;
(b) Mixing vaseline, xanthium oil and lanoline, heating to 90deg.C, and completely melting to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 70 ℃, thus obtaining the antibacterial ointment for treating rhinitis.
Example 3
The embodiment is a bacteriostatic ointment for treating rhinitis, which is prepared from the following raw materials in parts by weight:
20 parts of a traditional Chinese medicine composition, 10 parts of Vaseline, 10 parts of lanolin and 20 parts of xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
30 parts of fructus xanthil, 20 parts of radix sophorae flavescentis, 15 parts of aloe, 15 parts of cortex phellodendri, 10 parts of flos magnoliae, 10 parts of asarum, 5 parts of menthol, 5 parts of borneol and 15 parts of beeswax.
The preparation method of the antibacterial ointment for treating rhinitis comprises the following steps:
(a) Adding 40 fructus Xanthii into 50g of sesame oil, pulverizing fructus Xanthii, frying in sesame oil to brown, and filtering to obtain oleum Xanthii; pulverizing the components in the traditional Chinese medicine composition, sieving with a 150-mesh sieve, collecting undersize products to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition for standby;
(b) Mixing vaseline, xanthium oil and lanolin, heating to 95deg.C, and completely melting to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 75 ℃ to obtain the antibacterial ointment for treating rhinitis.
Comparative example 1
The comparative example is a bacteriostatic ointment for treating rhinitis, which is prepared from the following raw materials in parts by weight:
20 parts of a traditional Chinese medicine composition, 10 parts of Vaseline, 10 parts of lanolin and 20 parts of xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of cocklebur fruit, 10 parts of kuh-seng, 25 parts of aloe, 25 parts of phellodendron, 20 parts of magnolia flower, 5 parts of asarum, 5 parts of menthol, 5 parts of borneol and 15 parts of beeswax.
The preparation method of the antibacterial ointment for treating rhinitis comprises the following steps:
(a) Adding 40 fructus Xanthii into 50g of sesame oil, pulverizing fructus Xanthii, frying in sesame oil to brown, and filtering to obtain oleum Xanthii; pulverizing the components in the traditional Chinese medicine composition, sieving with a 150-mesh sieve, collecting undersize products to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition for standby;
(b) Mixing vaseline, xanthium oil and lanolin, heating to 95deg.C, and completely melting to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 75 ℃ to obtain the antibacterial ointment for treating rhinitis.
Comparative example 2
The comparative example is a bacteriostatic ointment for treating rhinitis, which is prepared from the following raw materials in parts by weight:
20 parts of a traditional Chinese medicine composition, 10 parts of Vaseline, 10 parts of lanolin and 20 parts of xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
30 parts of fructus xanthil, 20 parts of radix sophorae flavescentis, 15 parts of aloe, 30 parts of cortex phellodendri, 10 parts of flos magnoliae, 10 parts of asarum, 5 parts of menthol and 5 parts of borneol.
The preparation method of the antibacterial ointment for treating rhinitis comprises the following steps:
(a) Adding 40 fructus Xanthii into 50g of sesame oil, pulverizing fructus Xanthii, frying in sesame oil to brown, and filtering to obtain oleum Xanthii; pulverizing the components in the traditional Chinese medicine composition, sieving with a 150-mesh sieve, collecting undersize products to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition for standby;
(b) Mixing vaseline, xanthium oil and lanolin, heating to 95deg.C, and completely melting to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 75 ℃ to obtain the antibacterial ointment for treating rhinitis.
Experimental example
Antibacterial ointments for treating rhinitis prepared in example 3 and comparative examples 1 to 2 were obtained, respectively;
the antibacterial ointment for treating rhinitis is used for treating rhinitis patients, and symptoms of sneeze, nasal discharge, nasal obstruction, dizziness, hyposmia and the like are symptoms; wherein, the antibacterial ointment of example 3 cumulatively treats 63 cases of allergic rhinitis, 168 cases of nasosinusitis and 52 cases of dry rhinitis; the antibacterial ointment of comparative example 1 cumulatively treats 41 cases of allergic rhinitis, 129 cases of sinusitis and 37 cases of rhinitis sicca; the antibacterial ointment of comparative example 2 cumulatively treats 36 cases of allergic rhinitis, 85 cases of sinusitis and 28 cases of rhinitis sicca;
the treatment method comprises the following steps:
the ointment is smeared on the affected part of the nasal cavity by using a cotton swab for 2 times per day; continuously smearing for 20 days, and then follow-up treatment effect;
curative effect judgment standard:
and (3) curing: all clinical symptoms disappear, and no recurrence occurs within half a year;
the effect is shown: more than two thirds of clinical symptoms disappear;
the method is effective: clinical symptoms are relieved;
invalidation: the clinical symptoms are unchanged or aggravated.
The statistical curative effects are shown in tables 1 to 3:
TABLE 1 allergic rhinitis
| Group of | Healing | Has obvious effect | Effective and effective | Invalidation of |
| Example 3 | 42 | 17 | 4 | 0 |
| Comparative example 1 | 21 | 14 | 5 | 1 |
| Comparative example 2 | 19 | 9 | 8 | 0 |
TABLE 2 sinusitis
| Group of | Healing | Has obvious effect | Effective and effective | Invalidation of |
| Example 3 | 124 | 27 | 15 | 2 |
| Comparative example 1 | 58 | 31 | 34 | 6 |
| Comparative example 2 | 37 | 26 | 17 | 5 |
TABLE 3 Dry rhinitis
| Group of | Healing | Has obvious effect | Effective and effective | Invalidation of |
| Example 3 | 33 | 14 | 5 | 0 |
| Comparative example 1 | 12 | 16 | 8 | 1 |
| Comparative example 2 | 6 | 19 | 3 | 0 |
As can be seen from tables 1 to 3:
the antibacterial ointment prepared by the technical scheme and the comparative example has a certain treatment effect on rhinitis, and compared with the comparative example, the antibacterial ointment prepared by the technical scheme has a remarkable treatment effect on rhinitis.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention, and are intended to be included within the scope of the appended claims and description.
Claims (9)
1. The antibacterial ointment for treating rhinitis is characterized by being prepared from a traditional Chinese medicine composition, vaseline, lanolin and xanthium oil;
the traditional Chinese medicine composition comprises the following components in parts by weight:
25-35 parts of fructus xanthil, 15-25 parts of radix sophorae flavescentis, 10-20 parts of aloe, 10-20 parts of cortex phellodendri, 8-12 parts of flos magnoliae, 8-12 parts of asarum, 4-6 parts of menthol, 4-6 parts of borneol and 10-20 parts of beeswax.
2. The antibacterial ointment for treating rhinitis according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight:
30 parts of fructus xanthil, 20 parts of radix sophorae flavescentis, 15 parts of aloe, 15 parts of cortex phellodendri, 10 parts of flos magnoliae, 10 parts of asarum, 5 parts of menthol, 5 parts of borneol and 15 parts of beeswax.
3. The antibacterial ointment for treating rhinitis according to claim 1, wherein the antibacterial ointment for treating rhinitis is prepared from the following raw materials in parts by weight:
18-22 parts of traditional Chinese medicine composition, 8-12 parts of Vaseline, 8-12 parts of lanolin and 18-22 parts of cocklebur oil.
4. The antibacterial ointment for treating rhinitis according to claim 1, wherein the antibacterial ointment for treating rhinitis is prepared from the following raw materials in parts by weight:
20 parts of traditional Chinese medicine composition, 10 parts of Vaseline, 10 parts of lanolin and 20 parts of cocklebur oil.
5. The antibacterial ointment for treating rhinitis according to claim 1, wherein the xanthium oil is prepared by the following method:
pulverizing fructus Xanthii, frying in oleum Sesami to brown, and filtering to obtain the final product.
6. The antibacterial ointment for treating rhinitis according to claim 5, wherein 35 to 45 cocklebur fruits are added per 50g of sesame oil.
7. The method for preparing the antibacterial ointment for treating rhinitis according to any one of claims 1 to 6, which comprises the following steps:
(a) Pulverizing and sieving the components in the traditional Chinese medicine composition respectively, collecting undersize to obtain traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder according to parts by weight to obtain the traditional Chinese medicine composition;
(b) Mixing vaseline, xanthium oil and lanoline, and heating to completely melt to obtain mixed solution;
(c) And (3) adding the traditional Chinese medicine composition and stirring uniformly when the mixed solution is cooled to 70-80 ℃ to obtain the antibacterial ointment for treating rhinitis.
8. The method of claim 6, wherein in step (a), the sieve used for sieving has a mesh size of 150 mesh.
9. The method according to claim 6, wherein in the step (b), the temperature of the mixed solution is 90 to 100 ℃.
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