CN112843147B - Ointment for treating arthralgia and preparation method thereof - Google Patents

Ointment for treating arthralgia and preparation method thereof Download PDF

Info

Publication number
CN112843147B
CN112843147B CN202110235550.1A CN202110235550A CN112843147B CN 112843147 B CN112843147 B CN 112843147B CN 202110235550 A CN202110235550 A CN 202110235550A CN 112843147 B CN112843147 B CN 112843147B
Authority
CN
China
Prior art keywords
parts
ointment
root
radix
raw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202110235550.1A
Other languages
Chinese (zh)
Other versions
CN112843147A (en
Inventor
史会建
薛新红
于爱兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Second Affiliated Hospital of Shandong First Medical University
Original Assignee
Second Affiliated Hospital of Shandong First Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Second Affiliated Hospital of Shandong First Medical University filed Critical Second Affiliated Hospital of Shandong First Medical University
Priority to CN202110235550.1A priority Critical patent/CN112843147B/en
Publication of CN112843147A publication Critical patent/CN112843147A/en
Application granted granted Critical
Publication of CN112843147B publication Critical patent/CN112843147B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses an ointment for treating arthralgia and a preparation method thereof, belonging to the field of traditional Chinese medicines. The ointment comprises the following components in parts by mass: 20-50 parts of white mustard seed, 7-16 parts of raw gardenia, 15-20 parts of raw rhubarb, 5-10 parts of borneol, 10-30 parts of kudzu root, 10-30 parts of medicinal cyathula root, 10-30 parts of pericarpium zanthoxyli, 10-30 parts of notopterygium root, 10-20 parts of garden balsam stem, 10-20 parts of rhizoma atractylodis, 10-20 parts of salvia miltiorrhiza, 10-20 parts of asarum, 5-15 parts of raw kusnezoff monkshood root and 5-15 parts of folium artemisiae argyi. Processing the above materials separately, decocting, concentrating, and making into unguent. The ointment prepared by the method has the advantages of short treatment course, quick response and obvious effect.

Description

Ointment for treating arthralgia and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to an ointment for treating arthralgia and a preparation method thereof.
Background
Osteoarthritis is a chronic and degenerative change of bone joint structure, including a series of changes such as joint cartilage exfoliation, hyperosteogeny, meniscus injury, synovitis, etc., which is one of the main causes of knee joint pain, deformity and dysfunction in middle and old aged people. It has many different names, such as osteoarthritis, proliferative arthritis, degenerative arthritis, senile arthritis, etc.
The main clinical manifestations of osteoarthritis are slow onset of disease, morning stiffness does not exceed half an hour, the affected joints are mainly painful and pressure-painful, occasionally accompanied by soft tissue swelling around the joints, or transient periostitis, with fricative sound of the joints during movement, and joint deformity in severe cases. The pathological changes of cervical vertebra or lumbar vertebra can cause nerve compression or stimulation symptoms, and the symptoms of negative serum rheumatoid factor, non-rapid blood sedimentation and non-rising C-reactive protein are avoided.
At present, the medicines and the methods for treating osteoarthritis are many, and western medicine preparations are mainly used for relieving pain and eliminating inflammation, have large toxic and side effects, are not suitable for long-term administration, can only relieve pain and cannot completely cure the osteoarthritis; the traditional Chinese medicine has a certain treatment effect on the diseases, but has slow effect, long time, poor palatability and poor treatment effect on intractable pain patients.
Disclosure of Invention
The invention aims to provide the ointment for treating arthralgia and the preparation method thereof aiming at the defects of the prior art, and the ointment has the advantages of short treatment course, quick response and obvious effect.
In order to achieve the technical purpose, the invention provides the following technical scheme:
the ointment for treating arthralgia comprises the following components in parts by weight:
20-50 parts of white mustard seed, 7-16 parts of raw gardenia, 15-20 parts of raw rhubarb, 5-10 parts of borneol, 10-30 parts of kudzu root, 10-30 parts of medicinal cyathula root, 10-30 parts of pericarpium zanthoxyli, 10-30 parts of notopterygium root, 10-20 parts of garden balsam stem, 10-20 parts of rhizoma atractylodis, 10-20 parts of salvia miltiorrhiza, 10-20 parts of asarum, 5-15 parts of raw kusnezoff monkshood root and 5-15 parts of folium artemisiae argyi.
As further optimization, the ointment comprises the following components in parts by weight:
30 parts of white mustard seed, 10 parts of raw gardenia, 18 parts of raw rhubarb, 8 parts of borneol, 20 parts of kudzu root, 20 parts of medicinal cyathula root, 20 parts of pericarpium zanthoxyli, 20 parts of notopterygium root, 15 parts of garden balsam stem, 15 parts of rhizoma atractylodis, 15 parts of salvia miltiorrhiza, 15 parts of asarum, 10 parts of raw kusnezoff monkshood root and 10 parts of folium artemisiae argyi.
The invention also provides a preparation method of the ointment for treating arthralgia, which comprises the following steps:
1) adding yellow wine into radix et rhizoma Rhei, radix Cyathulae and Saviae Miltiorrhizae radix respectively, moistening, mixing radix Cyathulae and Saviae Miltiorrhizae radix when yellow wine is absorbed completely, parching with slow fire, taking out, and cooling; heating radix et rhizoma Rhei over water until radix et rhizoma Rhei is black, drying, mixing with air-cooled radix Cyathulae and Saviae Miltiorrhizae radix, and pulverizing to obtain powder A;
2) soaking radix Aconiti Kusnezoffii in water until there is no dry core, taking out, boiling in water, slicing, drying, and pulverizing to obtain powder B;
3) parching testa Tritici, adding radix Puerariae when smoking, parching until the medicinal powder turns brown, taking out, sieving to remove testa Tritici, cooling, and pulverizing to obtain powder C;
4) cutting notopterygium root, semen brassicae, raw gardenia, pericarpium zanthoxyli, garden balsam stem, asarum, rhizoma atractylodis and folium artemisiae argyi into pieces, cleaning, drying in the sun, crushing, and mixing with the powder A in the step 1), the powder B in the step 2), the powder C in the step 3) and the crushed borneol to obtain mixed powder;
5) adding the mixed powder obtained in the step 4) into water for decoction, filtering to obtain decoction, squeezing decoction dregs, mixing the squeezed liquid and the decoction, standing, and filtering to obtain filtrate;
6) heating and concentrating the filtrate obtained in the step 5) to obtain clear paste, adding refined honey, continuously heating, continuously stirring and removing foam on the liquid surface, taking out and cooling to obtain the ointment for treating arthralgia.
As a further optimization, the pulverization is carried out to a particle size of 70-80 μm.
For further optimization, the mass ratio of the raw rhubarb to the yellow wine in the step 1) is (8-12): 3; the mass ratio of the radix cyathulae to the yellow wine is (8-12): 1; the mass ratio of the red lead to the yellow wine is (8-12): 1.
for further optimization, in the step 2), the water content of the raw kusnezoff monkshood root is less than or equal to 10 percent, the total ash content is less than or equal to 5 percent, and the total alkali content is 0.10-0.30 percent.
As a further optimization, the mass ratio of the kudzuvine root to the wheat bran in the step 3) is (8-11): 3.
As further optimization, the decocting times in the step 5) are 2-3 times, and the decocting time is 2-3 h.
As a further optimization, the mass ratio of the clear paste to the refined honey in the step 6) is 1: (1-2).
As further optimization, the heating temperature in the step 6) is 90-100 ℃, and the heating time is 1-1.5 h.
White mustard seed: pungent and warm. Enter lung and warm meridians. Promoting qi and removing obstruction in channels, dissipating stagnation and relieving swelling: can be used for treating carbuncle of yin type, multiple abscess, numbness of limbs, and arthralgia.
Raw gardenia: belongs to one of heat-clearing medicines, has bitter and cold property, and has the effects of purging fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood, removing toxic substances, relieving swelling and alleviating pain. The raw gardenia has the strongest anti-inflammatory effect, and the anti-inflammatory effect is obviously weakened after being processed by different methods.
Raw rhubarb: belongs to the field of traditional Chinese medicine purgatives and has the effects of purging and eliminating accumulation, clearing away heat and fire, detoxifying, activating blood and dissolving stasis. Mixing radix et rhizoma Rhei with yellow wine, sealing, stewing in water until the interior and exterior are black brown, and drying to obtain cooked radix et rhizoma Rhei with enhanced blood circulation promoting and blood stasis dispelling effects, which is especially suitable for the elderly with asthenia and blood stasis syndrome.
Borneol: colorless transparent or white translucent flaky crisp crystals; fragrant smell, pungent and cool taste, opening orifices, dispelling stagnated fire, removing nebula, improving eyesight, relieving swelling and pain. Can inhibit central nervous system, has obvious sedative and analgesic effects, and can promote growth and division of glial cells; has antiinflammatory, antibacterial, and antifertility effects, and can interact with other medicines such as tetramethylpyrazine and salicylic acid. The topical application has slight irritation to sensory nerve, and has analgesic and antiseptic effects.
Kudzu root: sweet and pungent in flavor and cool in nature. Has effects in softening tissue and relaxing joint. The puerarin content is obviously increased after processing.
Radix cyathulae: sweet, slightly bitter and neutral in nature; entering liver and kidney meridians; dispersing and descending, and has effects of promoting blood circulation, dredging channels, dispelling pathogenic wind, removing dampness, promoting articulation, and inducing diuresis for treating stranguria. Radix Cyathulae crude drug has the main actions of removing blood stasis and dredging channels, and is used for amenorrhea, abdominal mass, retained afterbirth, traumatic injury and other symptoms. After being processed with wine, the medicinal liquor can enhance the functions of removing blood stasis, dredging channels and relaxing joints, and is used for treating arthralgia, flaccidity of feet, contracture of muscles, traumatic injury, kidney deficiency, lumbago and the like.
Pericarpium zanthoxyli: pungent and warm. It enters spleen, stomach and kidney meridians. Warm middle energizer to alleviate pain, kill parasites to relieve itching.
Notopterygium root: pungent and bitter with warm nature. Relieve exterior syndrome, dispel cold, expel wind and remove dampness, and alleviate pain.
Garden balsam stem: pungent flavor and warm nature. Dispelling pathogenic wind and removing dampness, relieving rigidity of muscles and promoting blood circulation, removing blood stasis and detumescence, removing toxic substance and relieving pain.
Rhizoma atractylodis: pungent and bitter with warm nature. Dry dampness and invigorate spleen, dispel wind and cold, improve vision. Raw rhizoma atractylodis has strong warm and dry property and is mainly used for treating rheumatic arthralgia, while the dryness of rhizoma atractylodis is weakened after being fried, the effect of pungent and fragrant for activating spleen is enhanced, and the rhizoma atractylodis can be used for treating spleen and stomach diseases such as spleen and stomach cold-dampness. Rhizoma atractylodis has better effect on treating arthralgia than stir-fried rhizoma atractylodis.
Red sage root: bitter and slightly cold in taste. Promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. The wine red sage root has mild cold and cool nature, and has the functions of promoting blood circulation to disperse blood clots, regulating menstruation and relieving pain.
Asarum: pungent and warm with slight toxicity. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifices, warming lung, and eliminating phlegm.
Raw kusnezoff monkshood root: bitter and hot; it is toxic. It enters heart, liver, kidney and spleen meridians. Dispel wind and dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia, and pain due to anesthesia. The raw material is toxic and mostly used externally to dispel cold, alleviate pain and relieve swelling. The toxicity is greatly reduced after processing.
Folium artemisiae argyi: pungent, bitter and warm. Warming channels to stop bleeding, dispelling cold and relieving pain; externally used for eliminating dampness and relieving itching.
The invention relates to a traditional Chinese medicine ointment for treating osteoarthritis, which is mainly used for treating pain and tenderness, occasionally the pain is severe and can cause swelling of peripheral soft tissues, therefore, the traditional Chinese medicine ointment provided by the invention has the advantages that pericarpium zanthoxyli, notopterygium root, asarum, raw kusnezoff monkshood root and white mustard seed are used for warming channels to relieve pain, the salvia miltiorrhiza and folium artemisiae argyi are used for activating blood and dissolving stasis, the garden balsam stem and the rhizoma atractylodis are used for dispelling the swelling and relieving pain, the raw gardenia, the raw rhubarb and borneol are used for diminishing swelling and relieving pain, the purpose of healing is gradually realized according to the condition of a patient, and the ointment is prepared by adding refined honey after the treatment of important components, so that the treatment time of the medicine can be prolonged, the occurrence of an allergic phenomenon is reduced, the defects of poor palatability of oral traditional Chinese medicines and large side effect of western medicines are avoided, the swelling and pain relieving are completed in one step, the bone and joint pain can be quickly and effectively treated, and a patient can walk quickly and normally.
Compared with the prior art, the invention has the beneficial effects that:
1) the ointment provided by the invention has the effects of warming channels, relieving pain, promoting blood circulation, removing blood stasis, and relieving swelling and pain, and can be used for quickly and effectively treating arthralgia.
2) The ointment of the invention is a pure traditional Chinese medicine formula, has no discomfort during use, no toxic or side effect, can treat internal diseases by external treatment, and is safe and convenient.
3) Low cost, quick effect, short treatment course, high cure rate and lasting effect.
Detailed Description
Reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Further, for numerical ranges in this disclosure, it is understood that each intervening value, between the upper and lower limit of that range, is also specifically disclosed. Every smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference herein for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the present disclosure without departing from the scope or spirit of the disclosure. Other embodiments will be apparent to those skilled in the art from consideration of the specification. The specification and examples are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are open-ended terms that mean including, but not limited to.
Example 1
The ointment for treating arthralgia comprises the following components in parts by weight:
30 parts of white mustard seed, 10 parts of raw gardenia, 18 parts of raw rhubarb, 8 parts of borneol, 20 parts of kudzu root, 20 parts of medicinal cyathula root, 20 parts of pericarpium zanthoxyli, 20 parts of notopterygium root, 15 parts of garden balsam stem, 15 parts of rhizoma atractylodis, 15 parts of salvia miltiorrhiza, 15 parts of asarum, 10 parts of raw kusnezoff monkshood root and 10 parts of folium artemisiae argyi.
The preparation method comprises the following steps:
1) adding yellow wine into radix et rhizoma Rhei, radix Cyathulae and Saviae Miltiorrhizae radix respectively, moistening, mixing radix Cyathulae and Saviae Miltiorrhizae radix when yellow wine is absorbed completely, parching with slow fire, taking out, and cooling; heating radix et rhizoma Rhei over water until radix et rhizoma Rhei is black, drying, mixing with air-cooled radix Cyathulae and Saviae Miltiorrhizae radix, and pulverizing to obtain powder A; wherein the mass ratio of the raw rhubarb to the yellow wine is 10:3, the mass ratio of the medicinal cyathula root to the yellow wine is 10:1, and the mass ratio of the salvia miltiorrhiza to the yellow wine is 10: 1;
2) soaking radix Aconiti Kusnezoffii in water until there is no dry core, taking out, boiling in water, slicing, drying, and pulverizing to obtain powder B;
3) parching testa Tritici, adding radix Puerariae when smoking, parching until the medicinal powder turns brown, taking out, sieving to remove testa Tritici, cooling, and pulverizing to obtain powder C; wherein the mass ratio of the kudzu root to the wheat bran is 10: 3;
4) cutting notopterygium root, semen brassicae, raw gardenia, pericarpium zanthoxyli, garden balsam stem, asarum, rhizoma atractylodis and folium artemisiae argyi into pieces, cleaning, drying in the sun, crushing, and mixing with the powder A in the step 1), the powder B in the step 2), the powder C in the step 3) and the crushed borneol to obtain mixed powder;
5) adding the mixed powder obtained in the step 4) into water, decocting for 3 times, each time for 2.5h, filtering to obtain decoction, squeezing decoction dregs, mixing the squeezed liquid and the decoction, standing, and filtering to obtain filtrate;
6) heating and concentrating the filtrate obtained in the step 5) for 1h to obtain clear paste, adding refined honey, continuously heating at 90 ℃ for 1h with the mass ratio of the clear paste to the refined honey being 1:2, continuously stirring and removing foam on the liquid surface, cooling when the clear paste is viscous, taking out and cooling to obtain the ointment for treating arthralgia.
All ingredients were crushed to a particle size of 75 microns.
Example 2
The ointment for treating arthralgia comprises the following components in parts by weight:
50 parts of white mustard seed, 8 parts of raw gardenia, 5 parts of raw rhubarb, 10 parts of borneol, 30 parts of kudzu root, 10 parts of medicinal cyathula root, 10 parts of pericarpium zanthoxyli, 30 parts of notopterygium root, 15 parts of garden balsam stem, 10 parts of rhizoma atractylodis, 20 parts of salvia miltiorrhiza, 10 parts of asarum, 15 parts of raw kusnezoff monkshood root and 5 parts of folium artemisiae argyi.
The preparation method is the same as example 1.
Example 3
The ointment for treating arthralgia comprises the following components in parts by weight:
20 parts of white mustard seed, 7 parts of raw gardenia, 15 parts of raw rhubarb, 5 parts of borneol, 30 parts of kudzu root, 30 parts of medicinal cyathula root, 20 parts of pericarpium zanthoxyli, 12 parts of notopterygium root, 19 parts of garden balsam stem, 22 parts of rhizoma atractylodis, 13 parts of salvia miltiorrhiza, 20 parts of asarum, 5 parts of raw kusnezoff monkshood root and 15 parts of folium artemisiae argyi.
The preparation method is the same as example 1.
Example 4
The ointment composition for treating joint pain was the same as in example 1.
The preparation method comprises the following steps:
1) adding yellow wine into radix et rhizoma Rhei, radix Cyathulae and Saviae Miltiorrhizae radix respectively, moistening, mixing radix Cyathulae and Saviae Miltiorrhizae radix when yellow wine is absorbed completely, parching with slow fire, taking out, and cooling; heating radix et rhizoma Rhei over water until radix et rhizoma Rhei is black, drying, mixing with air-cooled radix Cyathulae and Saviae Miltiorrhizae radix, and pulverizing to obtain powder A; wherein the mass ratio of the raw rhubarb to the yellow wine is 8:3, the mass ratio of the medicinal cyathula root to the yellow wine is 10:1, and the mass ratio of the salvia miltiorrhiza to the yellow wine is 12: 1;
2) soaking radix Aconiti Kusnezoffii in water until there is no dry core, taking out, boiling in water, slicing, drying, and pulverizing to obtain powder B;
3) parching testa Tritici, adding radix Puerariae when smoking, parching until the medicinal powder turns brown, taking out, sieving to remove testa Tritici, cooling, and pulverizing to obtain powder C; wherein the mass ratio of the kudzu root to the wheat bran is 8: 3;
4) cutting notopterygium root, semen brassicae, raw gardenia, pericarpium zanthoxyli, garden balsam stem, asarum, rhizoma atractylodis and folium artemisiae argyi into pieces, cleaning, drying in the sun, crushing, and mixing with the powder A in the step 1), the powder B in the step 2), the powder C in the step 3) and the crushed borneol to obtain mixed powder;
5) adding the mixed powder obtained in the step 4) into water, decocting for 3 times, each time for 2.5h, filtering to obtain decoction, squeezing decoction dregs, mixing the squeezed liquid and the decoction, standing, and filtering to obtain filtrate;
6) heating and concentrating the filtrate obtained in the step 5) for 1h to obtain clear paste, adding refined honey, continuously heating at 95 ℃ for 1h with the mass ratio of the clear paste to the refined honey being 1:1, continuously stirring and removing foam on the liquid surface, cooling when the clear paste is viscous, taking out and cooling to obtain the ointment for treating arthralgia.
All ingredients were crushed to a particle size of 80 microns.
Example 5
The ointment composition for treating joint pain was the same as in example 1.
The preparation method comprises the following steps:
1) adding yellow wine into radix et rhizoma Rhei, radix Cyathulae and Saviae Miltiorrhizae radix respectively, moistening, mixing radix Cyathulae and Saviae Miltiorrhizae radix when yellow wine is absorbed completely, parching with slow fire, taking out, and cooling; heating radix et rhizoma Rhei over water until radix et rhizoma Rhei is black, drying, mixing with air-cooled radix Cyathulae and Saviae Miltiorrhizae radix, and pulverizing to obtain powder A; wherein the mass ratio of the raw rhubarb to the yellow wine is 12:3, the mass ratio of the medicinal cyathula root to the yellow wine is 12:1, and the mass ratio of the salvia miltiorrhiza to the yellow wine is 10: 1;
2) soaking radix Aconiti Kusnezoffii in water until there is no dry core, taking out, boiling in water, slicing, drying, and pulverizing to obtain powder B;
3) parching testa Tritici, adding radix Puerariae when smoking, parching until the medicinal powder turns brown, taking out, sieving to remove testa Tritici, cooling, and pulverizing to obtain powder C; wherein the mass ratio of the kudzu root to the wheat bran is 11: 3;
4) cutting notopterygium root, semen brassicae, raw gardenia, pericarpium zanthoxyli, garden balsam stem, asarum, rhizoma atractylodis and folium artemisiae argyi into pieces, cleaning, drying in the sun, crushing, and mixing with the powder A in the step 1), the powder B in the step 2), the powder C in the step 3) and the crushed borneol to obtain mixed powder;
5) adding the mixed powder obtained in the step 4) into water, decocting for 3 times, each time for 2.5h, filtering to obtain decoction, squeezing decoction dregs, mixing the squeezed liquid and the decoction, standing, and filtering to obtain filtrate;
6) heating and concentrating the filtrate obtained in the step 5) for 1h to obtain clear paste, adding refined honey, continuously heating at 92 ℃ for 1h while continuously stirring and removing foam on the liquid surface, cooling when the clear paste is viscous, and taking out and cooling to obtain the ointment for treating arthralgia.
All ingredients were crushed to a particle size of 70 microns.
Comparative example 1
The difference from example 1 is that pueraria root and cyathula root are not processed.
Comparative example 2
The difference from example 1 is that the Danshen root is not processed.
Comparative example 3
The difference from example 1 is that raw rhubarb is not processed.
Comparative example 4
The ointment composition for treating joint pain was the same as in example 1.
The preparation method comprises the following steps:
1) adding yellow wine into radix et rhizoma Rhei, radix Cyathulae and Saviae Miltiorrhizae radix respectively, moistening, mixing radix Cyathulae and Saviae Miltiorrhizae radix when yellow wine is absorbed completely, parching with slow fire, taking out, and cooling; heating radix et rhizoma Rhei over water until radix et rhizoma Rhei is black, drying, mixing with air-cooled radix Cyathulae and Saviae Miltiorrhizae radix, and pulverizing to obtain powder A; wherein the mass ratio of the raw rhubarb to the yellow wine is 10:3, the mass ratio of the medicinal cyathula root to the yellow wine is 10:1, and the mass ratio of the salvia miltiorrhiza to the yellow wine is 10: 1;
2) soaking radix Aconiti Kusnezoffii in water until there is no dry core, taking out, boiling in water, slicing, drying, and pulverizing to obtain powder B;
3) parching testa Tritici, adding radix Puerariae when smoking, parching until the medicinal powder turns brown, taking out, sieving to remove testa Tritici, cooling, and pulverizing to obtain powder C; wherein the mass ratio of the kudzu root to the wheat bran is 10: 3;
4) cutting notopterygium root, semen brassicae, raw gardenia, pericarpium zanthoxyli, garden balsam stem, asarum, rhizoma atractylodis and folium artemisiae argyi into pieces, cleaning, drying in the sun, crushing, and mixing with the powder A in the step 1), the powder B in the step 2), the powder C in the step 3) and the crushed borneol to obtain mixed powder;
adding the coarse powder and vinegar into the mixed powder to prepare ointment.
Clinical data:
the effect of the ointments of the invention (examples 1-5) and the control ointments (comparative examples 1-4) and the drugs for osteoarthritis sold in the pharmacy (control) on the treatment of joint pain were observed and verified.
600 patients with joint pain and swelling due to various types of arthritis were divided into 10 groups of 60 patients at random. There was no statistical difference in age, sex, course of disease, cause of disease, and level of joint pain for each group (p > 0.05).
The treatment method comprises the following steps:
the ointment is uniformly applied to joints for 1 time a day, and a treatment course is five days.
And (3) judging standard:
1. and (3) healing: the pain of the joints disappears or basically disappears, the joint movement returns to normal, and the joint swelling phenomenon does not exist;
2. the method has the following advantages: the joint pain is improved, the joint movement is slightly limited, and the slight joint swelling phenomenon can be accompanied;
3. and (4) invalidation: joint pain is not obviously improved or even aggravated, joint movement is limited, operation is strong, and severe joint swelling can be caused.
And (3) test results:
the statistical results of the clinical efficacy of each test group after 5 days of treatment are shown in table 1 below.
TABLE 1 statistical table of clinical efficacy of each test group
Recovery method Is effective Invalidation High efficiency
Example 1 60 0 0 100％
Example 2 58 0 2 97％
Example 3 56 3 1 98％
Example 4 59 0 1 98％
Example 5 58 2 0 100％
Comparative example 1 43 4 13 78％
Comparative example 2 49 1 10 83％
Comparative example 3 40 7 13 78％
Comparative example 4 35 9 16 73％
Control group 24 13 23 62％
As can be seen from Table 1, after a short treatment period of 5 days, the patients who used the ointment of the present invention were substantially healed, while the comparative examples 1 to 4 of the ointment which was not prepared according to the preparation method of the present invention had significantly reduced effects, indicating that some of the components in the ointment of the present invention for treating osteoarthritis had better effects after being processed. The treatment effect of the medicament for treating osteoarthritis sold in a pharmacy within 5 days is obviously poor.
Case (2):
li Shi, male, 40 years old, suffered from osteoarthritis, and has no significant curative effect when taking Chinese and western medicines. The ointment is applied to the affected part 1 time a day, the pain is relieved after 3 days, the symptoms are obviously improved after the ointment is continuously used for 10 days, the pain basically disappears, and the symptoms disappear after the ointment is continuously used for one month.
Wangzhi, female age 48, suffering from osteoarthritis for 8 years, pain in joints of limbs, inconvenient movement and great pain. After the ointment of the invention is used for 5 days, the swelling disappears, the pain is relieved, and after the ointment is used for 10 days, the normal state is recovered, the general arthralgia is improved, the waist can be straightened, and the clinical cure of the patient is realized.
Zhangqi, male age 40, suffered from osteoarthritis for 2 years, and had fricative sound in joints during movement. After the ointment is used for 5 days, the fricative sound is reduced, the pain disappears, and after the ointment is continuously treated for 5 days, the fricative sound completely disappears.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included therein.

Claims (7)

1. The ointment for treating arthralgia is characterized by being prepared from the following traditional Chinese medicine components in parts by weight: 20-50 parts of white mustard seed, 7-16 parts of raw gardenia, 15-20 parts of raw rhubarb, 5-10 parts of borneol, 10-30 parts of kudzu root, 10-30 parts of medicinal cyathula root, 10-30 parts of pericarpium zanthoxyli, 10-30 parts of notopterygium root, 10-20 parts of garden balsam stem, 10-20 parts of rhizoma atractylodis, 10-20 parts of salvia miltiorrhiza, 10-20 parts of asarum, 5-15 parts of raw kusnezoff monkshood root and 5-15 parts of folium artemisiae argyi;
the preparation method of the ointment for treating arthralgia comprises the following steps:
1) adding yellow wine into radix et rhizoma Rhei, radix Cyathulae and Saviae Miltiorrhizae radix respectively, moistening, mixing radix Cyathulae and Saviae Miltiorrhizae radix when yellow wine is absorbed completely, parching with slow fire, taking out, and cooling; heating radix et rhizoma Rhei over water until radix et rhizoma Rhei is black, drying, mixing with air-cooled radix Cyathulae and Saviae Miltiorrhizae radix, and pulverizing to obtain powder A;
2) soaking radix Aconiti Kusnezoffii in water until there is no dry core, taking out, boiling in water, slicing, drying, and pulverizing to obtain powder B;
3) parching testa Tritici, adding radix Puerariae when smoking, parching until the medicinal powder turns brown, taking out, sieving to remove testa Tritici, cooling, and pulverizing to obtain powder C;
4) cutting notopterygium root, semen brassicae, raw gardenia, pericarpium zanthoxyli, garden balsam stem, asarum, rhizoma atractylodis and folium artemisiae argyi into pieces, cleaning, drying in the sun, crushing, and mixing with the powder A in the step 1), the powder B in the step 2), the powder C in the step 3) and the crushed borneol to obtain mixed powder;
5) adding the mixed powder obtained in the step 4) into water for decoction, filtering to obtain decoction, squeezing decoction dregs, mixing the squeezed liquid and the decoction, standing, and filtering to obtain filtrate;
6) heating and concentrating the filtrate obtained in the step 5) to obtain clear paste, adding refined honey, continuously heating, continuously stirring and removing foam on the liquid surface, taking out and cooling to obtain the ointment for treating arthralgia;
the mass ratio of the raw rhubarb to the yellow wine in the step 1) is (8-12): 3; the mass ratio of the radix cyathulae to the yellow wine is (8-12): 1; the mass ratio of the red lead to the yellow wine is (8-12): 1;
in the step 3), the mass ratio of the kudzuvine root to the wheat bran is (8-11) to 3.
2. The ointment of claim 1, wherein the ointment is prepared from the following traditional Chinese medicine components in parts by weight: 30 parts of white mustard seed, 10 parts of raw gardenia, 18 parts of raw rhubarb, 8 parts of borneol, 20 parts of kudzu root, 20 parts of medicinal cyathula root, 20 parts of pericarpium zanthoxyli, 20 parts of notopterygium root, 15 parts of garden balsam stem, 15 parts of rhizoma atractylodis, 15 parts of salvia miltiorrhiza, 15 parts of asarum, 10 parts of raw kusnezoff monkshood root and 10 parts of folium artemisiae argyi.
3. The ointment of claim 1, wherein the pulverization is to a particle size of 70 to 80 μm.
4. The ointment of claim 1, wherein in step 2), the water content of the raw kusnezoff monkshood root is less than or equal to 10%, the total ash content is less than or equal to 5%, and the total alkali content is 0.10-0.30%.
5. The ointment of claim 1, wherein the number of the decoction times in the step 5) is 2-3 times, and the decoction time is 2-3 hours.
6. The ointment of claim 1, wherein the mass ratio of the clear paste to the refined honey in the step 6) is 1: (1-2).
7. The ointment of claim 1, wherein the heating temperature in step 6) is 90-100 ℃ and the heating time is 1-1.5 h.
CN202110235550.1A 2021-03-03 2021-03-03 Ointment for treating arthralgia and preparation method thereof Active CN112843147B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110235550.1A CN112843147B (en) 2021-03-03 2021-03-03 Ointment for treating arthralgia and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110235550.1A CN112843147B (en) 2021-03-03 2021-03-03 Ointment for treating arthralgia and preparation method thereof

Publications (2)

Publication Number Publication Date
CN112843147A CN112843147A (en) 2021-05-28
CN112843147B true CN112843147B (en) 2022-03-11

Family

ID=75991341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110235550.1A Active CN112843147B (en) 2021-03-03 2021-03-03 Ointment for treating arthralgia and preparation method thereof

Country Status (1)

Country Link
CN (1) CN112843147B (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中药内服外敷加牵引治疗颈椎病89例疗效观察;翁炎佳;《中国社区医师(医学专业)》;20121231(第20期);214-215 *
中药内服外敷治疗颈椎病101例观察;王家芳;《实用中医药杂志》;20011231;第17卷(第10期);6 *

Also Published As

Publication number Publication date
CN112843147A (en) 2021-05-28

Similar Documents

Publication Publication Date Title
CN107184782A (en) External medicine composition, preparation method and applications
CN105687587B (en) Plaster for warming channels, dredging collaterals and relieving pain
CN110652544A (en) Pharmaceutical composition for treating rhinitis and preparation method thereof
CN112843147B (en) Ointment for treating arthralgia and preparation method thereof
CN105535822A (en) Traditional Chinese medicine composition for treating haemorrhoids and preparation method thereof
CN109381627B (en) Medicine for treating uremia and preparation method thereof
CN113332407A (en) External application agent for dispelling cold, eliminating dampness, promoting blood circulation and removing meridian obstruction
CN105998495A (en) Traditional Chinese medicine composition for treating scald and preparation method thereof
CN105561270A (en) Analgesic Chinese herbal medicine for external application and preparation method thereof
CN102416049B (en) Small square type rheumatoid swelling diminishing and pain eliminating plaster and preparation method thereof
CN111358915A (en) Traditional Chinese medicine for treating congenital muscular torticollis and preparation method thereof
CN111419924A (en) A topical Chinese medicinal composition for treating various muscle and bone diseases, and its preparation device
CN1089845A (en) A kind of oral medicine and medicine for external use and production method thereof for the treatment of bone disease
CN115120690B (en) Traditional Chinese medicine composition for treating precocious puberty and application thereof
CN103735851A (en) Traditional Chinese medicine preparation for treating fracture
CN1772117A (en) Nephrosis treating Chinese medicine boneyed bolus and its prepn process
CN105853760A (en) Orthopedic plaster and preparation method thereof
CN105194205A (en) Chinese herbal medicine composition for treating fracture and joint soft tissue injury
CN105169342A (en) Traditional Chinese medicine composition for treating eczema and preparation method thereof
CN1070063C (en) Quick action powder medicine for reunion of broken bone
CN118806821A (en) A spray with repercussive and analgesic effects, and its preparation method
CN114404494A (en) External medicament for removing blood stasis and relieving pain and preparation method thereof
CN118340860A (en) Medicated wine for treating rheumatic arthritis and preparation method thereof
CN103566117A (en) Ointment for external use for bone-injury hemorrhagic disease and preparation method thereof
CN116585411A (en) Edible traditional Chinese medicine for dispelling wind, removing dampness, relaxing tendons, promoting blood circulation and removing blood stasis and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant