CN112804993A - 氯法齐明的组合物,含它们的组合,它们的制备方法,含它们的用途和方法 - Google Patents

氯法齐明的组合物,含它们的组合,它们的制备方法,含它们的用途和方法 Download PDF

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Publication number
CN112804993A
CN112804993A CN201980064766.7A CN201980064766A CN112804993A CN 112804993 A CN112804993 A CN 112804993A CN 201980064766 A CN201980064766 A CN 201980064766A CN 112804993 A CN112804993 A CN 112804993A
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CN
China
Prior art keywords
clofazimine
pharmaceutical composition
infection
suspension
mycobacterium
Prior art date
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Pending
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CN201980064766.7A
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English (en)
Chinese (zh)
Inventor
托马斯·霍夫曼
斯蒂芬·厄弗
凯文·斯泰普勒顿
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Mankind
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Mankind
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Publication of CN112804993A publication Critical patent/CN112804993A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
CN201980064766.7A 2018-08-23 2019-04-03 氯法齐明的组合物,含它们的组合,它们的制备方法,含它们的用途和方法 Pending CN112804993A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862722048P 2018-08-23 2018-08-23
US62/722,048 2018-08-23
US201962796822P 2019-01-25 2019-01-25
US62/796,822 2019-01-25
PCT/US2019/025538 WO2020040818A1 (en) 2018-08-23 2019-04-03 Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them

Publications (1)

Publication Number Publication Date
CN112804993A true CN112804993A (zh) 2021-05-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980064766.7A Pending CN112804993A (zh) 2018-08-23 2019-04-03 氯法齐明的组合物,含它们的组合,它们的制备方法,含它们的用途和方法

Country Status (7)

Country Link
EP (1) EP3840737A1 (ko)
JP (2) JP7377259B2 (ko)
KR (1) KR20210090607A (ko)
CN (1) CN112804993A (ko)
AU (1) AU2019324330A1 (ko)
CA (1) CA3109572A1 (ko)
WO (1) WO2020040818A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114507189A (zh) * 2021-12-08 2022-05-17 余述南 一种化学合成的原料药及其治疗结核病及耐药性结核病的用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4054524A1 (en) * 2019-11-06 2022-09-14 MannKind Corporation Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods of treatment comprising them
CN111634940B (zh) * 2020-05-27 2021-10-29 中国地质大学(武汉) 一种单质金均匀负载钛酸盐纳米材料的制备方法
CN112521339A (zh) * 2020-11-20 2021-03-19 山西立业制药有限公司 一种氯苯吩嗪的制备方法
US11793808B2 (en) * 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
CN115737560A (zh) * 2022-12-27 2023-03-07 四川农业大学 一种酸响应的一氧化氮/活性氧纳米发生器及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114507189A (zh) * 2021-12-08 2022-05-17 余述南 一种化学合成的原料药及其治疗结核病及耐药性结核病的用途

Also Published As

Publication number Publication date
JP2021535124A (ja) 2021-12-16
KR20210090607A (ko) 2021-07-20
WO2020040818A1 (en) 2020-02-27
CA3109572A1 (en) 2020-02-27
JP2024012393A (ja) 2024-01-30
EP3840737A1 (en) 2021-06-30
AU2019324330A1 (en) 2021-03-04
JP7377259B2 (ja) 2023-11-09

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