CN1127971C - Brain-tonifying intelligence-raising granules - Google Patents
Brain-tonifying intelligence-raising granules Download PDFInfo
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- CN1127971C CN1127971C CN01121542A CN01121542A CN1127971C CN 1127971 C CN1127971 C CN 1127971C CN 01121542 A CN01121542 A CN 01121542A CN 01121542 A CN01121542 A CN 01121542A CN 1127971 C CN1127971 C CN 1127971C
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Abstract
The present invention relates to a pure Chinese preparation, namely 'brain tonifying and intelligence raising granule ' used for treating dementia. The medicine is composed of fleece-flower root, rhubarb, hawthorn fruit, matrimony vine, Chinese arborvitae kernel, arillus longan, ginseng, milkvetch root, epimedium herb, Chinese date, solomonseal rhizome, notoginseng, earthworm, leech, walnut kernel and sharpleaf galangal fruit. The present invention is prepared according to a specific technology. The present invention has the optimized weight proportion of the medical composition (by weight portions) that 100 of fleece-flower root, 100 of rhubarb, 100 of hawthorn fruit, 100 of matrimony vine, 100 of Chinese arborvitae kernel, 100 of arillus longan, 60 of ginseng, 60 of milkvetch root, 50 of epimedium herb, 50 of Chinese date, 50 of solomonseal rhizome, 50 of notoginseng, 50 of earthworm, 50 of leech, 50 of walnut kernel and 50 of sharpleaf galangal fruit. The medicine has the prevention and therapeutical effect on senile dementia.
Description
Senile dementia sporadically appears among " dizzy " and " forgetful " category of Chinese medicine, the old people is owing to the influence of decline and pathological factor naturally, deficiency of kidney-essence, brain mistake are filled, function day by day fails, the defeated cloth of qi-blood-body fluid operation is not normal, YANG-orifices failing to be nourished, sudden inspiration is slow-witted blunt, and deficiency of kidney-essence is not enough for falling ill originally.Thereby bradykinesia, instability of gait, hypomnesis occur, even disease such as can't take care of oneself." interior warp " thought: " the brain being the reservoir of the marrow ", " the brain being the house of mentality ", there are important relation in the intravital QI and blood of senile dementia and people, kidney essense, brain, it is the malfunction that the stasis of blood stagnates in material base qi-blood-body fluid, marrow deficiency, the blood, the thick friendship resistance of expectorant produces god, cause deficiency of marrow-reservoir at last, the generation of dementia disease.
Senile dementia is hypomnesis and the identification ability obstacle that the nerve degeneration sexual maladjustment causes.The diseases related western medical treatment mainly comprises: the psychostimulant of cholinomimetic, potassium channel antagonists, glutamate receptor adjusting control agent, 5-HT receptor antagonist and medium action intensity etc.But uncertain therapeutic efficacy is cut, and side effect is bigger, and costs an arm and a leg.
The report of relevant in recent years primary disease Chinese medicine is more, but contrast property, perspective study are wide, mostly are retrospective analysis.Surplus at many decades according to motherland's theory of medicine, the kidney being the origin of congenital constitution, the root of life; The spleen being the foundation of acquired constitution, source of generating QI and blood; The heart is the big masters of the vital organs of the human body; This theory of the brain being the house of mentality.Through the many decades clinical research, sum up and develop a kind of medicine for the treatment of senile dementia, be used for clinically, will obtain significant curative effect as long as adhere to taking.
Radix Polygoni Multiflori in the side, sweet in the mouth add the smart marrow of mending, with the nourishing essence in kidney make that kidney essense abundance, brain get that it is supported, brain is full of, not atrophy of brain, people are quick on the draw, mind is clear, energetic.The Radix Ginseng sweet in the mouth, tonifying QI to produce body fluid, QI invigorating is led blood operation with the general, " interior warp " cloud: " the capable then blood of gas is capable ", promote the production of body fluid to replenish the composition in the blood, " essence can be changed blood, blood generating essence ", Radix Ginseng is that the operation of blood plays a part guide and participation, make blood can on give in brain, for the needs of brain.The Radix Et Rhizoma Rhei bitter in the mouth is weeded out the old and bring forth the new, and dispels in the blood stasis of blood and stagnates, for the moving row of blood is removed the obstacles.Fructus Crataegi is carnivorous greasy, stagnant key medicine for mill disappears, blood circulation promoting and blood stasis dispelling, and it is turbid to dispel in the blood expectorant, purifies the blood, and it is normally also flowed.Reuse Herba Epimedii in the side, with kidney tonifying, essence replenishing benefit marrow.Select vital energy benefiting and the kidney invigorating in the side for use, all medicines of Radix Polygoni Multiflori, Fructus Crataegi, Radix Notoginseng, Radix Et Rhizoma Rhei, Hirudo of blood circulation promoting and blood stasis dispelling dehumidifying resolve phlegm effect stop the AS formation and development, stop hyperlipidemia to form and reach.The people participates in the same usefulness of Radix Et Rhizoma Rhei in the side, and invigorating middle warmer has rushes down, and sets upright first, eliminating evil first, has magazine report to think rhubarb powder, obeys 0.3 gram for each person every day, participates in the human body intracellular metabolic, and the effect of anti-ageing anti-old, life lengthening is arranged." the brain being the reservoir of the marrow ", with Radix Polygoni Multiflori and Fructus Crataegi, the kidney invigorating first, blood stasis dispelling is to give in brain on blood, essence, the marrow first, and advantageous conditions is provided.All medicines share, and focusing on conditioning essence, marrow, god, looking the heart, brain, kidney is one, play the effect of kidney tonifying, essence replenishing benefit marrow, the refreshment of complement kidney tonifying altogether, and the sufficient brain of kidney essense must be supported, and the mind must be pacified, QI and blood and freely.
Therefore medicine of the present invention is to be the Chinese patent medicine that feedstock production forms with following pharmaceutical composition: Radix Polygoni Multiflori 100-200 gram, Radix Et Rhizoma Rhei 100-200 gram, Fructus Crataegi 100-200 gram, Fructus Lycii 100-200 gram, Semen Platycladi 100-200 gram, first meat 100-200 gram, Radix Ginseng 60-100 gram, Radix Astragali 60-100 gram, Herba Epimedii 50-100 gram, Fructus Jujubae 50-100 gram, Rhizoma Polygonati 50-100 gram, Radix Notoginseng 50-100 gram, Pheretima 50-100 gram, Hirudo 50-100 gram, Semen Juglandis 50-100 gram, Fructus Alpiniae Oxyphyllae 50-100 gram.
The preferred weight proportioning of pharmaceutical composition of the present invention is: Radix Polygoni Multiflori 100, Radix Et Rhizoma Rhei 100, Fructus Crataegi 100, Fructus Lycii 100, Semen Platycladi 100, first meat 100, Radix Ginseng 60, the Radix Astragali 60, Herba Epimedii 50, Fructus Jujubae 50, Rhizoma Polygonati 50, Radix Notoginseng 50, Pheretima 50, Hirudo 50, Semen Juglandis 50, Fructus Alpiniae Oxyphyllae 50.
Medicine of the present invention can be prepared into any pharmaceutical preparation that is suitable for using clinically according to conventional formulation technology, as: tablet, powder, pill, granule, capsule, oral liquid etc.
Pharmaceutical composition of the present invention can directly prepare patent medicine, also can extract respectively each compositions, prepares patent medicine then, and these are all within protection scope of the present invention.
Process for preparing medicine of the present invention is:
One, selected crude drug: selected high-quality Chinese crude drug, to remove impurity, and differentiate and the run-of-the-mill check by pharmacopeia regulation, defective medical material such as of poor quality, as to go bad, damage by worms, go mouldy must not use.
Two; polish: with Radix Polygoni Multiflori; Radix Et Rhizoma Rhei; Fructus Crataegi; Fructus Lycii; Semen Platycladi; unit's meat; Radix Ginseng; the Radix Astragali; Herba Epimedii; Fructus Jujubae; Rhizoma Polygonati; Pheretima; Semen Juglandis; Fructus Alpiniae Oxyphyllae adds 8 times of water loggings or does not have powder 2-3cm; heating decocts 2 hours after-filtration; medicinal residues add 4 times of amounts of water; heating for the second time decocts and filtered in 1 hour again; the merging filtrate low-temperature evaporation; be concentrated into half amount of original volume; adding 95% ethanol equivalent mixing spends the night; make the sedimentation supernatant that inclines, steam to slip and reclaim ethanol, revaporization concentrates; putting cold place filtered precipitation in 24 hours fully; Radix Notoginseng; Hirudo is ground into powder and is blended into, and the filtrate low-temperature evaporation adds an amount of excipient mixing to dense shape (water content 20%); make soft material with 70% ethanol; move to granulation machine 12 orders and granulate, put in the baking oven dry, encapsulated standby again under the low temperature.Per 1 gram contains crude drug 2 grams.
Clinical research:
One, clinical matched group and the treatment group of being divided into, the patient amounts to 210 examples.The treatment group: 140 examples, male 108 examples, women 32 examples, age 63-79 year, average (71.62 ± 7.45) year, the course of disease 10 months to 5.7 years, average (2.3 ± 0.5).Matched group (piracetam) 70 examples: male 54 examples, women 16 examples, age 61.5-83, mean age (72.53 ± 7.62), the course of disease 1 month to 5.5 years, average (2.4 ± 0.6) year.Two groups of every situations compare, difference that there are no significant, and (P＞0.05) has comparability.
Two, diagnostic criteria: according to May nineteen ninety, " the senile dementia diagnosis evaluation criteria " of Beijing senile dementia symposium revision.
Three, Therapeutic Method: the treatment group is taken a kind of medicine for the treatment of senile dementia, and each 6, day 3 times, one month one course of treatment; Matched group is taken piracetam (Minsheng Pharmaceutical Factory, Hangzhou City. produces, lot number 980405), each 4, day 3 times, warm water delivery service, one month one course of treatment.
Four, observational technique: scale is measured.(Zhang Mingyuan; The application of scale in diagnosis of dementias, practical tcm internal medicine magazine, 1993 (6) 337), all cases adopt (1) simple intelligent tables (MMSE, U.S. FOISTEIN, 1975 establishments) can detect whether obstacle of intelligence.
Five, other: plasma SOD (adopts pyrogallol autoxidation method; LPO adopts the thiobarbituricacid colorimetry), and blood, routine urinalysis, liver, renal function.Each experimenter measures above test item before taking medicine, and checks above-mentioned every inspection full 3 months the time in taking medicine.
Six, criterion of therapeutical effect; Efficacy assessment standard is carried out by " the senile dementia efficacy assessment standard " of Chinese Chinese medicine Gerontological Society of association and Society of Internal Medicine's revision in May nineteen ninety.
Seven, therapeutic outcome: (seeing Table 1-table 3)
Table 1: two groups of clinical total effectses relatively
| Group | N | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 140 | 20 | 104 | 16 | 88.57 |
| Matched group | 70 | 6 | 34 | 30 | 57.15 |
Annotate: compare with matched group (P＜0.05)
Table 2: two groups of scale integral results are (X ± S) relatively
| Group | N | MMSE | HOS | ADL | |
| The treatment group | 140 | Before the treatment | 12.50±6.73 | 12.80±54.2 | 40.38±8.21 |
| After the treatment | 19.90±6.81 | 19.32±6.59 | 31.29±7.78 | ||
| Difference | 5.08±2.61 | 5.80±4.35 | -9.10±7.30 | ||
| Matched group | 70 | Before the treatment | 13.40±7.05 | 13.85±5.21 | 37.60±6.22 |
| After the treatment | 16.62±6.94 | 15.27±5.39 | 69.53±6.08 | ||
| Difference | 3.11±1.07 | 1.80±1.16 | -3.87±2.04 |
Annotate: compare P＜0.05 before and after the treatment, compare P＜0.01 with matched group
Table 3: plasma SOD and the comparison of LPO content before and after two groups of treatments (X ± S)
| Group | N | SOD(U/M1) | LPO(UMO1/L) | |
| The treatment group | 140 | Before the treatment | 11.50±5.12 | 2.58±0.63 |
| After the treatment | 17.55±3.40 | 1.64±0.02 | ||
| Difference | 5.08±2.61 | 0.89±0.57 | ||
| Matched group | 70 | Before the treatment | 12.58±2.79 | 2.31±0.49 |
| After the treatment | 13.97±2.15 | 2.02±0.56 | ||
| Difference | 1.27±0.96 | -0.21±0.09 | ||
Annotate: compare P＜0.05 before and after the treatment, P＜0.01 and matched group be Δ P＜0.01 relatively
Significantly discomfort appears in two groups of objects of observation during treating, all carry out liver, kidney function test before and after the inpatients treatment, does not see significant change.Point out all safety of two medicines, no obvious toxic-side effects.
Embodiment:
Prescription: Radix Polygoni Multiflori 100 grams, Radix Et Rhizoma Rhei 100 grams, Fructus Crataegi 100 grams, Fructus Lycii 100 grams, Semen Platycladi 100 grams, first meat 100 grams, Radix Ginseng 60 grams, the Radix Astragali 60 grams, Herba Epimedii 50 grams, Fructus Jujubae 50 grams, Rhizoma Polygonati 50 grams, Radix Notoginseng 50 grams, Pheretima 50 grams, Hirudo 50 grams, Semen Juglandis 50 grams, Fructus Alpiniae Oxyphyllae 50 grams (weight portion).
Technology
Defective medical materials such as 1, crude drug check after choosing is clean, is removed impurity, and differentiated by the pharmacopeia regulation, and is of poor quality, as to go bad, damage by worms, go mouldy must not use.
2; get and handle clean medical material; take by weighing weight by prescription, be ground into coarse powder and add 8 times of water loggings or do not have powder 2-3cm, heating decocts filtered in 2 hours; medicinal residues add 4 times of amounts of water, 1 hour after-filtration of heating decoction for the second time again; low-temperature evaporation is concentrated into half of original volume and measures, and adds 95% ethanol equivalent mixing; spend the night and make sedimentation; the supernatant that inclines steams to slip and reclaims ethanol, and revaporization concentrates and put cold place 24 hours; precipitation is filtered fully; the filtrate low-temperature evaporation is to dense shape (water content 20%), Radix Notoginseng; Hirudo is ground into powder and is blended into, and adds an amount of excipient mixing; make soft material with 70% ethanol; move to granulation machine 12 orders and granulate, put in the baking oven dry, encapsulated standby again under the low temperature.
Claims (3)
1, a kind of medicine for the treatment of senile dementia is characterized in that it is made by the following weight proportion raw material: Radix Polygoni Multiflori 100-200 gram, Radix Et Rhizoma Rhei 100-200 gram, Fructus Crataegi 100-200 gram, Fructus Lycii 100-200 gram, Semen Platycladi 100-200 gram, first meat 100-200 gram, Radix Ginseng 60-100 gram, Radix Astragali 60-100 gram, Herba Epimedii 50-100 gram, Fructus Jujubae 50-100 gram, Rhizoma Polygonati 50-100 gram, Radix Notoginseng 50-100 gram, Pheretima 50-100 gram, Hirudo 50-100 gram, Semen Juglandis 50-100 gram, Fructus Alpiniae Oxyphyllae 50-100 gram.
2, require the medicine of 1 described treatment senile dementia according to power, wherein the weight proportion of each raw material is: Radix Polygoni Multiflori 100 grams, Radix Et Rhizoma Rhei 100 grams, Fructus Crataegi 100 grams, Fructus Lycii 100 grams, Semen Platycladi 100 grams, first meat 100 grams, Radix Ginseng 60 grams, the Radix Astragali 60 grams, Herba Epimedii 50 grams, Fructus Jujubae 50 grams, Rhizoma Polygonati 50 grams, Radix Notoginseng 50 grams, Pheretima 50 grams, Hirudo 50 grams, Semen Juglandis 50 grams, Fructus Alpiniae Oxyphyllae 50 grams.
3, the medicine of treatment senile dementia according to claim 1 and 2, the dosage form that it is characterized in that this medicine are any of tablet, powder, pill, granule, capsule, oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01121542A CN1127971C (en) | 2001-06-15 | 2001-06-15 | Brain-tonifying intelligence-raising granules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01121542A CN1127971C (en) | 2001-06-15 | 2001-06-15 | Brain-tonifying intelligence-raising granules |
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| CN1341432A CN1341432A (en) | 2002-03-27 |
| CN1127971C true CN1127971C (en) | 2003-11-19 |
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| CN01121542A Expired - Fee Related CN1127971C (en) | 2001-06-15 | 2001-06-15 | Brain-tonifying intelligence-raising granules |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008020127A1 (en) * | 2008-04-22 | 2009-11-05 | Merz Pharma Gmbh & Co. Kgaa | Compartment-specific plant extract combination of ginkgo biloba and ginseng extract with tandem action |
| CN101347557B (en) * | 2008-08-14 | 2010-12-08 | 于宝锋 | Medicament composition for refreshment and intelligence development and preparation and use thereof |
| CN101473943B (en) * | 2008-12-12 | 2012-01-04 | 广西中医学院 | Health-care food for improving memory function and preparation method thereof |
| CN103371385A (en) * | 2013-07-26 | 2013-10-30 | 哈尔滨膳宝酒业有限公司 | Formula and production method of pine nut brain tonic soup base for intelligence development |
| CN103445156A (en) * | 2013-07-31 | 2013-12-18 | 宫中林 | Compound brain oral liquid of rhodiola rosea and walnut |
| CN103719493B (en) * | 2013-12-31 | 2016-01-27 | 青岛市市立医院 | Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof |
| CN104719767A (en) * | 2014-12-18 | 2015-06-24 | 陈正梅 | Dietetic therapy formula for preventing and treating senile dementia |
| CN105233207B (en) * | 2015-10-19 | 2020-10-13 | 南阳医学高等专科学校 | Traditional Chinese medicine composition for relieving pressure, soothing heart, strengthening brain and improving intelligence |
| CN107582947A (en) * | 2017-09-30 | 2018-01-16 | 莱芜房干康复医院 | A kind of Chinese medicine composition of intelligence development cerebrum tonifying and preparation method thereof |
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- 2001-06-15 CN CN01121542A patent/CN1127971C/en not_active Expired - Fee Related
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