CN101011549A - Medicament for nourishing liver and kidney, strengthening brain and developing intelligence and its preparation method - Google Patents
Medicament for nourishing liver and kidney, strengthening brain and developing intelligence and its preparation method Download PDFInfo
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- CN101011549A CN101011549A CN200710013432.6A CN200710013432A CN101011549A CN 101011549 A CN101011549 A CN 101011549A CN 200710013432 A CN200710013432 A CN 200710013432A CN 101011549 A CN101011549 A CN 101011549A
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Abstract
The invention relates to a medicament for tonifying liver, kidney and brain, and process for preparation, wherein the effective constituents comprise (by weight ratio) the following raw materials: mulberry 20-50g, fleece-flower root 20-50g, matrimony vine 8-16g, schisandra fruit 6-15g, ichih fruit 15-25g, wild or spiny jujuba seed 10-16g, arborviate seed 6-15g, mimosa-tree bark 10-16g, polygala root 10-16g, radix salvia miltiorrhiza 10-20g, Chinese angelica root 6-15g, kudzuvine root 8-16g, campanumaea pilosula 10-20g, Acorus calamus 8-16g, achyranthes and cyathula root 2-5g. The preparing process comprises steps of alcohol extracting and water extracting.
Description
(1) technical field
The present invention relates to a kind of liver and kidney tonifying, nourishing the brain and improving intelligence medicine and preparation method thereof, belong to technical field of Chinese medicine.
(2) background technology
Caused by liver and kidney deficiency, deficiency of heart-blood, forgetful insomnia, mind are dull, intellectual deterioration, memory decay, soreness of the waist and knees and senile encephalatrophy, cerebral arteriosclerosis, the high insufficiency of blood of brain, children's's congenital defect, hypoevolutism etc., be current frequently-occurring disease, but also do not have a kind of specific medicament now.
(3) summary of the invention
The present invention is in order to overcome the deficiency of above technology, and evident in efficacy, the liver and kidney tonifying of few side effects, the medicine of nourishing the brain and improving intelligence are provided.
Another object of the present invention is to provide manufacturing method for above mentioned medicine.
The medicine of liver and kidney tonifying of the present invention, nourishing the brain and improving intelligence, its active ingredient are to be made by following materials of weight proportions:
The Fructus Mori 20-50g Radix Polygoni Multiflori 20-50g Fructus Lycii 8-16g 6-15g Fructus Alpiniae Oxyphyllae 15-25g Semen Ziziphi Spinosae 10-16g Semen Platycladi 6-15g Cortex Albiziae 10-16g Radix Polygalae 10-16g Radix Salviae Miltiorrhizae 10-20g Radix Angelicae Sinensis 6-15g Radix Puerariae 8-16g Radix Codonopsis 10-20g Rhizoma Acori Graminei 8-16g Radix Achyranthis Bidentatae 2-5g that distinguishes the flavor of.
The medicine of liver and kidney tonifying of the present invention, nourishing the brain and improving intelligence, the optimum weight ratio of described raw material is:
Fructus Mori 30g Radix Polygoni Multiflori 30g Fructus Lycii 12g Fructus Schisandrae Chinensis 9g Fructus Alpiniae Oxyphyllae 19g Semen Ziziphi Spinosae 12g Semen Platycladi 9g Cortex Albiziae 12g Radix Polygalae 12g Radix Salviae Miltiorrhizae 15g Radix Angelicae Sinensis 9g Radix Puerariae 12g Radix Codonopsis 14g Rhizoma Acori Graminei 12g Radix Achyranthis Bidentatae 3g.
The medicine of liver and kidney tonifying of the present invention, nourishing the brain and improving intelligence generally is prepared into granule, tablet or capsule.
The preparation method of the invention described above medicine, adopt following steps:
(1) Radix Salviae Miltiorrhizae is with 95% alcohol reflux secondary, and the time was respectively 2 hours, 1 hour, filters, and filtrate recycling ethanol gets alcohol extract A, and medicinal residues A is standby;
(2) Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Puerariae, Fructus Schisandrae Chinensis four flavor Chinese medicines merge, and add 70% alcohol reflux secondary, and the time was respectively 2 hours, 1 hour, filtered, and merging filtrate reclaims ethanol, gets alcohol extract B, and medicinal residues B is standby;
(3) residue 10 flavor Chinese medicines and medicinal residues A, medicinal residues B medicinal residues merge, decoct with water secondary, time was respectively 2 hours, 1 hour, filtration, filtrate concentrate, and add ethanol precipitation, and precipitate and alcohol extract A, alcohol extract B merge, reclaim ethanol, be concentrated into the thick paste shape, add a certain amount of adjuvant, make required preparation.
The function of medicine of the present invention: liver and kidney tonifying, replenishing blood for nourishing heart, invigorating brain and relieving mental uneasiness, invigorate blood circulation sensible.
Cure mainly: caused by liver and kidney deficiency, deficiency of heart-blood, forgetful insomnia, mind are dull, intellectual deterioration, memory decay, soreness of the waist and knees and senile encephalatrophy, cerebral arteriosclerosis, the high insufficiency of blood of brain, children's's congenital defect, hypoevolutism auxiliary treatment.
The side separates: prescription with Fructus Mori, Radix Polygoni Multiflori nourishing the liver and kidney, nourishing blood and replenishing essence, to fill the marrow supplementing the brain be monarch drug altogether; Fructus Lycii, Fructus Schisandrae Chinensis, nourishing the liver and kidney, the benefit that nourishes blood is smart and be auxilliary; Assistant is with Fructus Alpiniae Oxyphyllae the kidney warming spermatogenesis; Semen Ziziphi Spinosae, Semen Platycladi, Cortex Albiziae, Radix Polygalae nourishing blood to tranquillize the mind are tired of; Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Puerariae promoting blood circulation to remove obstruction in the collateral; Rhizoma Acori Graminei is had one's ideas straightened out and eliminates the phlegm; The foundation of acquired constitution is mended in the invigorating middle warmer of Radix Codonopsis QI invigorating, and the source of inflationization life is an adjuvant drug in order to the generation of essence and blood altogether.Radix Achyranthis Bidentatae: invigorating the liver and kidney, priming return through, make for it.Liver and kidney tonifying, replenishing blood for nourishing heart, invigorating brain and relieving mental uneasiness are played, the sensible merit of invigorating blood circulation altogether by full side.
Medicine of the present invention has advantage evident in efficacy, few side effects.Its preparation method has the pure height of extraction, the advantage that drug loss is few.
(4) specific embodiment
Below in conjunction with specific embodiment the present invention is made specific description.
Embodiment 1:
Prescription: Fructus Mori 30g Radix Polygoni Multiflori 30g Fructus Lycii 12g Fructus Schisandrae Chinensis 9g Fructus Alpiniae Oxyphyllae 19g Semen Ziziphi Spinosae 12g Semen Platycladi 9g Cortex Albiziae 12g Radix Polygalae 12g Radix Salviae Miltiorrhizae 15g Radix Angelicae Sinensis 9g Radix Puerariae 12g Radix Codonopsis 14g Rhizoma Acori Graminei 12g Radix Achyranthis Bidentatae 3g
2. preparation:
Get Radix Salviae Miltiorrhizae with 95% alcohol reflux secondary (2 hours, 1 hour), filtration, filtrate are waited until recovery ethanol, and medicinal residues are incorporated in the decocting in water Chinese medicine.Other gets Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Puerariae, Fructus Schisandrae Chinensis four flavor Chinese medicines, add 70% alcohol reflux secondary (2 hours, 1 hour) filter, merging filtrate ethanol to be recycled, medicinal residues are incorporated in the decocting in water Chinese medicine, the medicinal residues merging decocted with water secondary (2 hours after other got the alcohol extraction of 10 flavor Chinese medicines such as all the other Semen Ziziphi Spinosaes and four flavors such as Radix Salviae Miltiorrhizae and Radix Polygoni Multiflori, 1 hour), filter, filtrate is concentrated into finite concentration, adds ethanol precipitation, the clear liquid of elimination precipitation, alcohol precipitation clear liquids with 4 flavors such as above-mentioned tanshinol extracting solution and Radix Polygoni Multiflori, merge and reclaim ethanol, be concentrated into the thick paste shape, add appropriate amount of auxiliary materials, make granule, oven dry, make the 230g granule, packing, every bag 10 gram dress.
Usage and consumption: oral, three times on the one, a 10～20g.
Embodiment 2:
Prescription: Fructus Mori 40g Radix Polygoni Multiflori 25g Fructus Lycii 15g Fructus Schisandrae Chinensis 12g Fructus Alpiniae Oxyphyllae 16g Semen Ziziphi Spinosae 10g Semen Platycladi 14g Cortex Albiziae 15g Radix Polygalae 10g Radix Salviae Miltiorrhizae 18g Radix Angelicae Sinensis 7g Radix Puerariae 16g Radix Codonopsis 12g Rhizoma Acori Graminei 16g Radix Achyranthis Bidentatae 2g.
2. preparation:
Get Radix Salviae Miltiorrhizae with 95% alcohol reflux secondary (1.5 hours, 1 hour), filtration, filtrate are waited until recovery ethanol, and medicinal residues are incorporated in the decocting in water Chinese medicine.Other gets Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Puerariae, Fructus Schisandrae Chinensis four flavor Chinese medicines, add 75% alcohol reflux secondary (1.5 hours, 1 hour) filter, merging filtrate ethanol to be recycled, medicinal residues are incorporated in the decocting in water Chinese medicine, the medicinal residues merging decocted with water secondary (1.5 hours after other got the alcohol extraction of 10 flavor Chinese medicines such as all the other Semen Ziziphi Spinosaes and four flavors such as Radix Salviae Miltiorrhizae and Radix Polygoni Multiflori, 1 hour), filter, filtrate is concentrated into finite concentration, adds ethanol precipitation, the clear liquid of elimination precipitation, alcohol precipitation clear liquids with 4 flavors such as above-mentioned tanshinol extracting solution and Radix Polygoni Multiflori merge and reclaim ethanol, are concentrated into the thick paste shape, add appropriate amount of auxiliary materials, granulate, be pressed into the 57.5g tablet, every 0.5g, packing is finished product.
Usage and consumption: oral, three times on the one, a 5-10 sheet.
Test case 1: to the influence of learning and memory function
1. to the influence of experimental mouse aging school grade
72 of mices, ↑ ↓ half and half, be divided into the normal control group at random by the sex body weight, model group, the piracetam group, the nourishing brain pill group, electuary 6g/kg 12g/kg organizes (embodiments of the invention 1), except that the normal control group, other mice is all to 10%D one galactose (the real agent T in Shanghai, lot number 920416) 0.25ml.Sc * 60d gives 58d, 1h adopts the school grade of diving tower method (stop doun test) mice after the last administration, mice passes to the 40V electric current after putting combination diving tower instrument endoadaptation 3min, surveys errors number in the real 5min, reduce as school grade raising, result such as table 1 with errors number
Raising x ± the s of table 1 pair mouse aging school grade
| Group | The Mus number | The 5min errors number | The P value |
| Normal control | 12 | 1.01±1.42 | |
| Model group | 12 | 2.18±1.20 | ＜0.01 (with the normal group ratio) |
| Electuary 6g/kg | 12 | 0.71±1.10 | ＜0.01 (with the model group ratio) |
| Electuary 12g/kg | 12 | 1.00±0.60 | ＜0.01 (with the model group ratio) |
| Nourishing brain pill | 12 | 1.82±1.57 | ＜0.05 (with the model group ratio) |
| Piracetam | 12 | 1.08±1.31 | ＜0.05 (with the model group ratio) |
2. to the influence of experimental mouse aging memory function, respectively organize mice after 24 hours after the real intact school grade of survey, incubation period occurs, result such as table 2 by errors number and mistake in the diving tower method mensuration 5min:
Protective effect x ± the s of table 2 pair mouse aging memory function
| Group | The Mus number | Incubation period min | Number of times |
| Normal control | 12 | 4.58±0.76※ | 0.27±0.45 |
| Model group | 12 | 3.47±1.85 | 0.82±0.29 |
| Electuary 6g/kg | 12 | 4.55±1.19※ | 0.09±0.29※※△△ |
| Electuary 12g/kg | 12 | 4.82±0.99※※ | 0.21±0.41※△ |
| Nourishing brain pill | 12 | 3.74±1.42 | 0.63±0.17 |
| Piracetam | 12 | 4.65±1.24※ | 0.07±0.26※※※ |
Compare with model group: ※ P＜0.05 ※ ※＞0.01
Compare with the nourishing brain pill group: △ P＜0.05 △ △ P＜0.01
Experimental result points out medicine of the present invention that the learning and memory function of mouse aging is all had significant protective effect, improves the school grade and the memory function of mouse aging.
Test case 2: clinical experiment
1. age and sex: observe 85 examples altogether.Age: 40 years old-55 years old: 30 examples; 60 years old-70 years old: 55 examples.Sex: man: 73 examples; Woman: 10 examples.Be divided into treatment group 85 example and matched group 30 examples at random.See Table 3
Table 3: sex, age (year)
2. the Chinese medical discrimination typing of disordered brain function and case are selected: and dialectical reference standard that have an informal discussion meeting work out old according to the whole nation, 199010 Beijing on days can be divided into: 1. 2. 3. 4. resistance type in the congestion of turbid phlegm blocking the clear orifices type of spleen kidney deficiency type of the hepatic and renal YIN deficiency, deficiency of marrow-reservoir type.
3. the attending effectiveness because of " medicine of the present invention " is: liver and kidney tonifying, nourishing the brain and improving intelligence are main, and the nourshing blood and promoting blood circulation collateral dredging is arranged, the function of eliminating the phlegm and having one's ideas straightened out, and therefore, so 85 examples are organized in treatment, matched group 30 examples are all selected the hepatic and renal YIN deficiency, deficiency of marrow-reservoir type patient.See Table 4
Case is selected
4. auxiliary examination: treatment group and matched group each patient have carried out the Webster recall tests, and cranium brain CT examination, brain visual evoked potential are checked.Its result: cerebral infarction accounts for 35%, and brain A sclerosis accounts for 40%; Patient's memory quotient is between 80-89, and memory level is a middle and lower level, sees Table 5
Table 5 auxiliary examination result
| Group | The example number | The brain CT examination | Visual evoked potential is checked | |||
| Cerebral infarction | Brain A sclerosis | Normally | The mild damage | Normally | ||
| The treatment group | 85 | 35.30％ | 29.41％ | 35.29％ | 64.71％ | 35.29％ |
| Matched group | 30 | 16.67％ | 50％ | 33.33％ | 33.33％ | 66.67％ |
| The Webster memory is measured | |
| Memory quotient | Memory level |
| 80-89 | In down |
5. treat and curative effect
One. the instructions about how to take medicine and the course of treatment
Treatment group: " medicine of the present invention " adult secondary every day, each 30 grams.Sooner or later boiled water is taken after mixing it with water.
Matched group: nourishing brain pill is produced by the Qingdao pharmaceutical factory of traditional Chinese medicine, be grown up one time 15, every day three times.Be 2 months two courses of treatment
Two. curative effect judging standard and result
1. the symptom curative effect is judged and the result:
Primary symptom: dizziness and tinnitus, forgetfully become deaf, bradykinesia, insomnia and dreamful sleep.
Inferior disease: flushed cheeks night sweat, heel pain, frequent micturition.
Produce effects: three primary symptoms are improved, and one time disease is improved.
Effectively: the binomial primary symptom is improved, and binomial time disease is improved.
Invalid: primary symptom does not have improvement, and inferior disease has improvement or do not have improvement.
The patient of treatment group and matched group, by treatment in 2 months, its every clinical symptoms all had improvement, and the total effective rate of treatment group all is better than matched group, and its total effective rate is 98%.See Table 6
Two groups of clinical symptoms of table 6 improve the result:
2. auxiliary examination criterion and result＜criterion 〉
(1) cranium brain CT examination: infarct area is dwindled or no change all belongs to effective category
(2) brain visual evoked potential: effectively: have infringement to disappear.Invalid: no change
(3) the Webster memory is surveyed real:
A. produce effects: memory quotient two standard deviations that rise, promptly memory level is risen to above the average by middle and lower level.
B. effective: standard deviation of memory quotient rising, promptly memory level rises to medium level by middle and lower level.
C. invalid: memory quotient does not have rising.
＜result 〉
1. to the observation of cranium brain CT:
Medicine group of the present invention 85 examples and nourishing brain pill group 30 example treatment front and back have been checked cranium brain CT respectively, and wherein cerebral infarction kitchen range scope is not slightly dwindled the person, and the treatment group accounts for 10 examples, matched group account for 1 example.
2. to the observation of brain visual evoked potential:
Before the treatment two groups of patients have all been done the inspection of brain visual evoked potential, wherein by slight visual impairment, gone to normal person, the treatment group accounts for 20 examples, and matched group accounts for 1 example.
3. real result is surveyed in memory to Webster:
Medicine of the present invention 85 example treatments are after 2 months, and the test respectively that 10 real projects are surveyed in memory is improved, 1-100 in the intelligence wherein, and 100-1 adds up, and re-recognizes, carries on the back several three tables and improve respectively significantly.After seeing Table the 30 example treatments of 7 nourishing brain pill matched groups, except that picture, association, understanding slightly descend, all the other projects also all have raising in various degree.See Table 8
Table 7 treatment group is divided measurement result to Wechsler Memory Scale
| Project | Memory quotient n=85 |
| Before the treatment | 84.25±3.71 |
| After the treatment | 90.26±8.38 |
| The P value | ＜0.001 |
Table 8 matched group divides measurement result to Wechsler Memory Scale
| Project | Memory quotient n=30 |
| Before the treatment | 84.1±3.48 |
| After the treatment | 86.4±6.68 |
| The P value | ＜0.05 |
Above result shows that treatment group and matched group all have the dysmnesia for the treatment of middle-aged and elderly people and being caused owing to cerebral infarction, brain A sclerosis, the effect of bradyphrenia.But clinical efficacy contrast difference highly significant behind two groups of medicines.The treatment group is better than matched group, P value＜0.001.See Table 9
Clinical efficacy contrast behind the table 9 liang group medicine
| Treatment group n=85 | Before the medicine | Behind the medicine | P | Two groups of contrasts |
| 84.25±3.71 | 90.26±8.38 | ＜0.001 | P＜0.001 | |
| Matched group n=30 | 84.1±3.48 | 86.8±6.68 | ＜0.05 |
Tackle the observation of reaction:
Treatment group: do not have any untoward reaction, wherein original 55 routine constipation persons, free movement of the bowels after taking medicine.
Matched group: no obvious adverse reaction, wherein 10 routine patient's reflections, after taking medicine, the sleep increased frequency.
Claims (4)
1. the medicine of a liver and kidney tonifying, nourishing the brain and improving intelligence, it is characterized in that: its active ingredient is to be made by following materials of weight proportions,
Fructus Mori 20-50g Radix Polygoni Multiflori 20-50g Fructus Lycii 8-16g Fructus Schisandrae Chinensis 6-15g Fructus Alpiniae Oxyphyllae 15-25g Semen Ziziphi Spinosae 10-16g Semen Platycladi 6-15g Cortex Albiziae 10-16g Radix Polygalae 10-16g Radix Salviae Miltiorrhizae 10-20g Radix Angelicae Sinensis 6-15g Radix Puerariae 8-16g Radix Codonopsis 10-20g Rhizoma Acori Graminei 8-16g Radix Achyranthis Bidentatae 2-5g.
2. the medicine of liver and kidney tonifying according to claim 1, nourishing the brain and improving intelligence is characterized in that: the weight ratio of described raw material is,
The Fructus Mori 30g Radix Polygoni Multiflori 30g Fructus Lycii 12g 9g Fructus Alpiniae Oxyphyllae 19g Semen Ziziphi Spinosae 12g Semen Platycladi 9g Cortex Albiziae 12g Radix Polygalae 12g Radix Salviae Miltiorrhizae 15g Radix Angelicae Sinensis 9g Radix Puerariae 12g Radix Codonopsis 14g Rhizoma Acori Graminei 12g Radix Achyranthis Bidentatae 3g that distinguishes the flavor of.
3. the medicine of liver and kidney tonifying according to claim 1 and 2, nourishing the brain and improving intelligence is characterized in that:
Described medicine is granule, tablet or capsule.
4. the preparation method of the described medicine of claim 3 is characterized in that adopting following steps:
(1) Radix Salviae Miltiorrhizae is with 95% alcohol reflux secondary, and the time was respectively 2 hours, 1 hour, filters, and filtrate recycling ethanol gets alcohol extract A, and medicinal residues A is standby;
(2) Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Puerariae, Fructus Schisandrae Chinensis four flavor Chinese medicines merge, and add 70% alcohol reflux secondary, and the time was respectively 2 hours, 1 hour, filtered, and merging filtrate reclaims ethanol, gets alcohol extract B, and medicinal residues B is standby;
(3) residue 10 flavor Chinese medicines and medicinal residues A, medicinal residues B medicinal residues merge, decoct with water secondary, time was respectively 2 hours, 1 hour, filtration, filtrate concentrate, and add ethanol precipitation, and precipitate and alcohol extract A, alcohol extract B merge, reclaim ethanol, be concentrated into the thick paste shape, add a certain amount of adjuvant, make required preparation.
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