CN112772682A - Environmental disinfectant and preparation method and application thereof - Google Patents
Environmental disinfectant and preparation method and application thereof Download PDFInfo
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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Abstract
The disclosure relates to the field of disinfectant formulas, and particularly provides an environmental disinfectant, and a preparation method and application thereof. The environmental disinfectant comprises folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae. According to the theories of traditional Chinese medicine fumigation method, solvent extraction method and supercritical extraction method, the disinfectant is prepared into sachets or incense spices, portable disinfectant and essential oil. The problem of chemical disinfectant among the prior art often need ventilate for a long time after using, the practicality is relatively poor, and important disinfectant does not do the environmental disinfection usually is solved.
Description
Technical Field
The disclosure relates to the field of disinfectant formulas, and particularly provides an environmental disinfectant, and a preparation method and application thereof.
Background
The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art.
The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved.
The disinfectants in the prior art mainly comprise 84 disinfectant, hydrogen peroxide disinfectant, chlorine, quicklime, ethanol and the like, generally have large smell, are harmful to human bodies, need to be ventilated for a long time after being used, and have poor practicability in practical application.
The traditional Chinese medicine fumigation for epidemic prevention is a unique creation of ancient doctors and people, and is proved to be an effective epidemic prevention measure in ancient epidemic prevention practice. It is widely used during the occurrence period of epidemic diseases in the past generations, and fully plays the role of the traditional Chinese medicinal materials in epidemic prevention and treatment. However, the inventor finds that the traditional Chinese medicine disinfectant in the prior art is only used for preventing mosquito bites or healing wounds, and the fumigation perfume is often used as a nerve-concentrating medicine, so that the disinfection function is neglected.
Disclosure of Invention
The problem that chemical disinfectants in the prior art often need long-term ventilation after being used and have poor practicability, and important disinfectants are not used for environmental disinfection usually is solved.
In one or some embodiments of the present disclosure, there is provided an environmental disinfectant, comprising the following components: folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae.
In one or some embodiments of the present disclosure, there is provided an environmental disinfectant sachet or fragrance, comprising the above-described environmental disinfectant.
In one or more embodiments of the present disclosure, there is provided a method for preparing the above-mentioned environment sterilizing sachet or incense spice, comprising the steps of: 1) respectively pulverizing folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae into powder;
2) respectively grabbing the prepared powder according to the mass ratio, and uniformly mixing the prepared powder;
3) putting the mixed traditional Chinese medicines into a non-woven bag to prepare a traditional Chinese medicine disinfection sachet; or making into incense.
In one or more embodiments of the present disclosure, a portable environmental sanitizer spray is provided that includes the above-described environmental sanitizer.
In one or more embodiments of the present disclosure, a method for preparing the portable environmental disinfectant spray is provided, which includes the following steps: 1, putting folium artemisiae argyi, calamus, rhizoma atractylodis, clove, notopterygium root and radix angelicae into a high-pressure container, and adding clear water for boiling;
2, decocting clear water for a period of time and filtering; taking the medicinal juice for later use;
and 3, clarifying the medicinal juice, taking supernatant after clarification, and performing pressure sealing packaging in a sterile environment to prepare the portable environment sterilization spray.
In one or some embodiments of the present disclosure, there is provided a disinfectant essential oil comprising an extract of the above-mentioned environmental disinfectant.
In one or some embodiments of the present disclosure, a method for preparing the disinfecting essential oil is provided, which includes the following steps:
(1) vacuum drying folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae respectively, pulverizing, sieving, and selecting 40-50 mesh material;
(2) weighing raw materials in proportion, then putting the raw materials into an extraction material barrel, sealing the extraction material barrel, and putting the sealed extraction material barrel into a supercritical fluid extraction device;
(3) after extraction, taking clear grease from the supernatant, putting the grease into a high-temperature sterilized tan glass bottle, and storing the grease in a dark place.
In one or more embodiments of the present disclosure, there is provided an application of the above-mentioned environmental disinfectant, or the above-mentioned environmental disinfecting sachet, or the above-mentioned incense perfume, or the product obtained by the above-mentioned method for preparing the environmental disinfecting sachet, or the above-mentioned portable environmental disinfecting spray, or the above-mentioned essential oil, or the above-mentioned product obtained by the above-mentioned method for preparing the essential oil, in antibiosis.
In one or some embodiments of the present disclosure, there is provided an environmental disinfection method, comprising the steps of: carrying the environment-disinfecting sachet or incense perfume or the product prepared by the preparation method of the environment-disinfecting sachet or incense perfume with a person or fumigating;
or spraying the portable environment disinfection spraying agent or the product prepared by the preparation method of the portable environment disinfection spraying agent;
or smearing or diluting the above disinfectant essential oil or the product prepared by the above disinfectant essential oil preparation method, spraying or heating for fumigation.
One or some of the above technical solutions have the following advantages or beneficial effects:
1) the invention provides an environment disinfection spray with pure traditional Chinese medicine components, which is harmless to human bodies and avoids the problems that 84 disinfectant, hydrogen peroxide disinfectant, chlorine, quicklime, ethanol and the like in the prior art are harmful to human bodies and need to ventilate for a long time after being used.
2) The present disclosure provides three different dosage forms, which can be reasonably selected according to different use conditions, and the three different dosage forms have better sterilization effects than single-component extracts.
Detailed Description
The technical solutions in the embodiments of the present disclosure will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present disclosure, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the disclosure without making any creative effort, shall fall within the protection scope of the disclosure.
The problem that chemical disinfectants in the prior art often need long-term ventilation after being used and have poor practicability, and important disinfectants are not used for environmental disinfection usually is solved.
The inventor thinks that: the method has the advantages that a killing scheme with the characteristics of the traditional Chinese medicine is formulated, the killing effect of the traditional Chinese medicine under different concentrations is determined, research results are combined with the modern technology, the environment friendliness and safety of the traditional Chinese medicine killing are improved, the social medical environment pressure is relieved, and economic, effective and convenient traditional Chinese medicine killing measures are provided for hospitals and common people.
In one or some embodiments of the present disclosure, there is provided an environmental disinfectant, comprising the following components: folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae.
Preferably, the weight ratio of each component is as follows: 1-1.5 parts of folium artemisiae argyi, 1-1.5 parts of calamus, 1-1.5 parts of rhizoma atractylodis, 1-1.5 parts of clove, 1-1.5 parts of notopterygium root and 1-1.5 parts of radix angelicae, preferably 1 part of folium artemisiae argyi, 1 part of calamus, 1 part of rhizoma atractylodis, 1 part of clove, 1 part of notopterygium root and 1 part of radix angelicae.
In one or some embodiments of the present disclosure, there is provided an environmental disinfectant sachet or fragrance, comprising the above-described environmental disinfectant.
In one or more embodiments of the present disclosure, there is provided a method for preparing the above-mentioned environment sterilizing sachet or incense spice, comprising the steps of: 1) respectively pulverizing folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae into powder;
2) respectively grabbing the prepared powder according to the mass ratio, and uniformly mixing the prepared powder;
3) putting the mixed traditional Chinese medicines into a non-woven bag to prepare a traditional Chinese medicine disinfection sachet; or making into incense.
Preferably, in the step 1), the milling is carried out in a wall-breaking milling machine;
preferably, in the step 2), the raw materials are grabbed according to the equal parts by mass of all the raw materials.
The manufacturing process of the incense spice comprises the following steps: the coarse granules of the above Chinese medicinal powder can be mixed with water to obtain sticky powder, and made into pure Chinese medicinal incense with antibacterial effect, which can be used in small space such as toilet by burning incense for sterilization.
In one or more embodiments of the present disclosure, a portable environmental sanitizer spray is provided that includes the above-described environmental sanitizer.
In one or more embodiments of the present disclosure, a method for preparing the portable environmental disinfectant spray is provided, which includes the following steps: 1, putting folium artemisiae argyi, calamus, rhizoma atractylodis, clove, notopterygium root and radix angelicae into a high-pressure container, and adding clear water for boiling;
2, decocting clear water for a period of time and filtering; taking the medicinal juice for later use;
3, clarifying the medicine juice, taking supernatant after clarification, and performing pressure sealing packaging under a sterile environment to prepare the portable environment sterilization spray;
preferably, in the step 1>, the clear water amount is 4-6 times of the volume of the traditional Chinese medicine, and is further preferably 5 times;
preferably, in the step 2>, when the clear water is 1-1.5 times of the volume of the traditional Chinese medicine, the filtration is carried out.
In one or some embodiments of the present disclosure, there is provided a disinfectant essential oil comprising an extract of the above-mentioned environmental disinfectant.
In one or some embodiments of the present disclosure, a method for preparing the disinfecting essential oil is provided, which includes the following steps:
(1) vacuum drying folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae respectively, pulverizing, sieving, and selecting 40-50 mesh material;
(2) weighing raw materials in proportion, then putting the raw materials into an extraction material barrel, sealing the extraction material barrel, and putting the sealed extraction material barrel into a supercritical fluid extraction device;
(3) after extraction is finished, taking clear grease from the supernatant, filling the clear grease into a high-temperature sterilized tan glass bottle, and storing the clear grease in a dark place;
preferably, in the step (2), the extraction temperature is set to 50 ℃, the pressure is set to 26MPa, and the extraction time is set to 1 hour.
In one or more embodiments of the present disclosure, there is provided an application of the above-mentioned environmental disinfectant, or the above-mentioned environmental disinfecting sachet, or the above-mentioned incense perfume, or the product obtained by the above-mentioned method for preparing the environmental disinfecting sachet, or the above-mentioned portable environmental disinfecting spray, or the product obtained by the above-mentioned method for preparing the portable environmental disinfecting spray, or the above-mentioned essential oil, or the product obtained by the above-mentioned method for preparing the essential oil, in antibiosis;
preferably, the bacteria are one or more of escherichia coli, staphylococcus epidermidis, staphylococcus aureus and diplococcus pneumoniae.
In one or some embodiments of the present disclosure, there is provided an environmental disinfection method, comprising the steps of: carrying the environment-disinfecting sachet or incense perfume or the product prepared by the preparation method of the environment-disinfecting sachet or incense perfume with a person or fumigating;
or spraying the portable environment disinfection spraying agent or the product prepared by the preparation method of the portable environment disinfection spraying agent;
or smearing or diluting the above disinfectant essential oil or the product prepared by the above disinfectant essential oil preparation method, spraying or heating for fumigation.
Example 1
The embodiment of the method for preparing the environment disinfection sachet or the incense spice according to the principle of the traditional Chinese medicine fumigation method comprises the following steps:
grabbing the argyi leaf, the calamus, the rhizoma atractylodis, the clove, the notopterygium root and the radix angelicae according to equal parts, respectively putting the grabbed materials into a multifunctional grinding pulverizer, and operating equipment. Preparing into coarse particle powder, and manually sieving with 100 mesh sieve;
further processing the mixture by a 220-mesh airflow type grinder after preliminary milling to prepare superfine powder;
respectively marking and weighing the prepared traditional Chinese medicine powder, and taking 5g of rhizoma atractylodis, 5g of clove, 3g of folium artemisiae argyi, 3g of calamus, 3g of notopterygium root and 3g of angelica dahurica;
making the mixed Chinese medicinal materials into Chinese medicinal incense powder, and packaging into non-woven bag to prevent the medicinal powder from spilling, and making into Chinese medicinal sterilizing sachet or incense perfume.
Example 2
The embodiment of the portable environment disinfection spray prepared according to the principle of the solvent extraction method comprises the following steps:
putting 5g of rhizoma atractylodis, 5g of clove, 3g of folium artemisiae argyi, 3g of calamus, 3g of notopterygium root and 3g of angelica dahurica into a high-pressure container, and adding 5 times of clear water for boiling;
decocting 5 times of clear water for 1 time, and filtering; taking the medicinal juice for later use;
clarifying the medicinal liquid, collecting supernatant, and packaging under aseptic condition under pressure.
Example 3
The present example prepares the essential oil for disinfection according to the principle of supercritical extraction method, which comprises the following steps:
preparing materials: 100g of folium artemisiae argyi, calamus, rhizoma atractylodis, clove, notopterygium root and angelica dahurica (raw medicinal materials) respectively; HA220-50-06 supercritical fluid extraction device; FA2004B electronic analytical balance; DHG-9123A vacuum drying oven; an electronic scale; a test sieve; a plurality of measuring cups, droppers, test tubes, grinding pestles and the like
Drying, pulverizing and sieving the medicinal materials respectively, and selecting 40-50 mesh materials;
weighing 30g of folium artemisiae argyi, 30g of calamus, 50g of rhizoma atractylodis, 50g of clove, 30g of notopterygium root and 30g of angelica dahurica;
weighing 220g of raw materials, putting the raw materials into an extraction charging barrel, sealing the extraction charging barrel, putting the raw materials into extraction equipment, setting the extraction temperature to be 50 ℃, the pressure to be 26MPa and the extraction time to be 1 hour;
and (4) after extraction is finished, taking the clarified oil in the separator I, filling the clarified oil into a high-temperature sterilized tan glass bottle, and storing the clarified oil in a dark place.
Example 4
The experiment of the bacteriostatic effect of the disinfectants prepared in the different formulations in examples 1 to 3 is provided in the example below:
experimental strains: escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, Diplococcus pneumoniae
Bacterial culture and serial dilution:
(1) and (3) bacterial culture: the Fast-T1 chemosensory cells (E.coli) were removed from a freezer at-80 ℃ and thawed slowly on ice for 1-2 minutes, and 100. mu.l of E.coli was aspirated and placed in 100ml of LB Broth medium and shake-cultured in a water bath at 37 ℃ and 100rpm for 20 hours.
(2) Serial dilution: putting the escherichia coli liquid into a super clean bench which is sterilized for 15-20 minutes in advance, and performing serial dilution. Sucking 1ml of escherichia coli liquid, adding the liquid into a test tube filled with 9ml of sterile water, diluting by 10 times, and repeating the step for 1 time, wherein the concentration of the liquid is 10-2 of that of the original liquid.
(3) The culture method and dilution method of Staphylococcus epidermidis, Staphylococcus aureus and Diplococcus pneumoniae are the same as above.
The test method comprises the following steps: a blank group, a control group and an experimental group are set. Only adding bacterial liquid into the blank group culture dish for sealing; adding bacteria solution and extracts of folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae into control group culture dish, and sealing with sealing film; the experiment group was added with bacterial solution, the disinfectants of different formulations prepared in examples 1-3 were poured on the other side of the petri dish, respectively, and after spreading, the petri dish was covered with a piece of white paper, and after the bacteria solution and the traditional Chinese medicine-added petri dish were closed, the edge was sealed with a sealing film. And marking.
The results of culturing E.coli for 14h and 30h are shown in Table 1:
TABLE 1
The results of 14h and 30h incubation of Staphylococcus epidermidis are shown in Table 2:
TABLE 2
The results of the staphylococcus aureus culture after 14h and 30h are shown in table 3:
TABLE 3
The results of 14h and 30h incubation of pneumococci are shown in Table 4:
TABLE 4
The test result shows that: the disinfectant based on the traditional Chinese medicine external treatment method has obvious bactericidal effect on escherichia coli, staphylococcus epidermidis, staphylococcus aureus and diplococcus pneumoniae.
The disinfectant based on the traditional Chinese medicine external treatment theory consists of 6 traditional Chinese medicinal materials. The inventor proves that the folium artemisiae argyi water decoction and the compound folium artemisiae argyi water extract have obvious antibacterial effects on diplococcus pneumoniae, escherichia coli, staphylococcus epidermidis and staphylococcus aureus through experiments; the cineole and 4-terpinene in the folium artemisiae argyi volatile oil have antibacterial activity on 5 fungi including penicillium, phytophthora, aspergillus niger, alternaria and pinkish polyporus, and the antibacterial activity is enhanced along with the increase of the concentration of the folium artemisiae argyi volatile oil.
Experimental results show that the rhizoma acori graminei volatile oil has an antibacterial effect, the antibacterial effect on staphylococcus epidermidis and group A streptococcus is strongest, and candida albicans and staphylococcus aureus are the second.
The rhizoma atractylodis water extract has obvious inhibiting effect on staphylococcus aureus, helicobacter pylori, certain influenza A virus, influenza B virus and other bacteria and viruses; the rhizoma Atractylodis volatile oil has effect in killing various pathogenic bacteria such as rhinovirus and measles virus.
Eugenol in flos Caryophylli extract can inhibit Staphylococcus aureus, Staphylococcus epidermidis and Corynebacterium acnes, and flos Caryophylli water extract or flos Caryophylli decoction has inhibitory effect on various pathogenic fungi such as Trichophyton and Candida albicans, and eugenol has certain transdermal property.
The hairpin diol contained in Notopterygii rhizoma has inhibitory effect on Staphylococcus aureus.
The radix Angelicae Dahuricae has strong antibacterial effect, and can inhibit Escherichia coli, Bacillus dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, gram-positive bacteria, and human type Bacillus tuberculosis.
However, from the data results in tables 1-4, although each extract has a certain antibacterial effect, the mixture of the three dosage forms of the present disclosure has a better effect, and it is obvious that the mixture of the present disclosure significantly improves the antibacterial effect.
The three preparation modes of the invention can effectively retain the effective components of the Chinese herbal medicine, have no addition of other chemical substances, and are safe and non-toxic.
The disclosure of the present invention is not limited to the specific embodiments, but rather to the specific embodiments, the disclosure is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An environmental disinfectant is characterized by comprising the following components: folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae.
2. The environmental disinfectant as set forth in claim 1, wherein the weight ratio of each component is as follows: 1-1.5 parts of folium artemisiae argyi, 1-1.5 parts of calamus, 1-1.5 parts of rhizoma atractylodis, 1-1.5 parts of clove, 1-1.5 parts of notopterygium root and 1-1.5 parts of radix angelicae, preferably 1 part of folium artemisiae argyi, 1 part of calamus, 1 part of rhizoma atractylodis, 1 part of clove, 1 part of notopterygium root and 1 part of radix angelicae.
3. An environmental disinfectant sachet or fragrance comprising an environmental disinfectant according to claim 1 or 2.
4. A method of making an environmental disinfecting sachet or incense fragrance as claimed in claim 3 comprising the steps of: 1) respectively pulverizing folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae into powder;
2) respectively grabbing the prepared powder according to the mass ratio, and uniformly mixing the prepared powder;
3) putting the mixed traditional Chinese medicines into a non-woven bag to prepare a traditional Chinese medicine disinfection sachet; or making into incense perfume;
preferably, in the step 1), the milling is carried out in a wall-breaking milling machine;
preferably, in the step 2), the raw materials are grabbed according to the equal parts by mass of all the raw materials.
5. A portable environmental sanitizer spray comprising the environmental sanitizer of claim 1 or 2.
6. The method of making a portable environmental sanitizer spray according to claim 5, comprising the steps of: 1, putting folium artemisiae argyi, calamus, rhizoma atractylodis, clove, notopterygium root and radix angelicae into a high-pressure container, and adding clear water for boiling;
2, decocting clear water for a period of time and filtering; taking the medicinal juice for later use;
3, clarifying the medicine juice, taking supernatant after clarification, and performing pressure sealing packaging under a sterile environment to prepare the portable environment sterilization spray;
preferably, in the step 1>, the clear water amount is 4-6 times of the volume of the traditional Chinese medicine, and is further preferably 5 times;
preferably, in the step 2>, when the clear water is 1-1.5 times of the volume of the traditional Chinese medicine, the filtration is carried out.
7. A disinfecting essential oil comprising an extract of the environmental disinfectant of claim 1 or 2.
8. The method of producing a disinfecting essential oil of claim 7, comprising the steps of:
(1) vacuum drying folium Artemisiae Argyi, rhizoma Acori Calami, rhizoma Atractylodis, flos Caryophylli, Notopterygii rhizoma, and radix Angelicae Dahuricae respectively, pulverizing, sieving, and selecting 40-50 mesh material;
(2) weighing raw materials in proportion, then putting the raw materials into an extraction material barrel, sealing the extraction material barrel, and putting the sealed extraction material barrel into a supercritical fluid extraction device;
(3) after extraction is finished, taking clear grease from the supernatant, filling the clear grease into a high-temperature sterilized tan glass bottle, and storing the clear grease in a dark place;
preferably, in the step (2), the extraction temperature is set to 50 ℃, the pressure is set to 26MPa, and the extraction time is set to 1 hour.
9. Use of the environmental sanitizer of claim 1 or 2 or the environmental sanitizer sachet or fragrance fumigant of claim 3 or the product of the process for the preparation of the environmental sanitizer sachet or fragrance fumigant of claim 4 or the portable environmental sanitizer spray of claim 5 or the portable environmental sanitizer spray of claim 6 or the sanitizing essential oil of claim 7 or the product of the process for the preparation of the sanitizing essential oil of claim 8 for antimicrobial applications;
preferably, the bacteria are one or more of escherichia coli, staphylococcus epidermidis, staphylococcus aureus and diplococcus pneumoniae.
10. An environmental disinfection method, comprising the steps of: carrying or fumigating the environment disinfecting sachet or incense spice of claim 3 or the product prepared by the method for preparing the environment disinfecting sachet or incense spice of claim 4;
or, spraying the portable environmental disinfectant spray of claim 5 or the product of the process for preparing the portable environmental disinfectant spray of claim 6;
or, the disinfectant essential oil of claim 7 or the product obtained by the preparation method of the disinfectant essential oil of claim 8 is applied or diluted and then sprayed or heated and fumigated.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113767938A (en) * | 2021-08-30 | 2021-12-10 | 柳州市中医医院(柳州市壮医医院) | Zhuang nationality medicine air disinfectant |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2948570A1 (en) * | 2009-07-31 | 2011-02-04 | Addevista | Composition, useful e.g. treating diseases, disorders and/or infections of skin, appendages and mucous membranes, preferably fungi including e.g. candidiasis, comprises a fruit extract of Citrus medica L. var Risso |
| CN102258063A (en) * | 2011-04-28 | 2011-11-30 | 张志明 | Chinese medicinal air freshening bactericide |
| CN105230679A (en) * | 2015-11-09 | 2016-01-13 | 王热勤 | Traditional Chinese medicine combination for indoor air disinfection of hospital outpatient clinics |
| CN106035420A (en) * | 2016-05-30 | 2016-10-26 | 宿州天雨养殖（集团）有限公司 | Chinese herbal medicine formula for sterilizing indoor environment of farm |
| WO2018004490A1 (en) * | 2016-07-01 | 2018-01-04 | Bioarge Bitiksel Kozmetik Arastirma Gelistirme Muhendislik Ltd. Sti. | Enhanced oil dispersion and transdermal delivery |
| CN111685135A (en) * | 2020-07-03 | 2020-09-22 | 广州本心生物医药科技有限公司 | Traditional Chinese medicine plant extract with disinfection effect, preparation method and disinfectant |
-
2021
- 2021-01-25 CN CN202110096626.7A patent/CN112772682A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2948570A1 (en) * | 2009-07-31 | 2011-02-04 | Addevista | Composition, useful e.g. treating diseases, disorders and/or infections of skin, appendages and mucous membranes, preferably fungi including e.g. candidiasis, comprises a fruit extract of Citrus medica L. var Risso |
| CN102258063A (en) * | 2011-04-28 | 2011-11-30 | 张志明 | Chinese medicinal air freshening bactericide |
| CN105230679A (en) * | 2015-11-09 | 2016-01-13 | 王热勤 | Traditional Chinese medicine combination for indoor air disinfection of hospital outpatient clinics |
| CN106035420A (en) * | 2016-05-30 | 2016-10-26 | 宿州天雨养殖（集团）有限公司 | Chinese herbal medicine formula for sterilizing indoor environment of farm |
| WO2018004490A1 (en) * | 2016-07-01 | 2018-01-04 | Bioarge Bitiksel Kozmetik Arastirma Gelistirme Muhendislik Ltd. Sti. | Enhanced oil dispersion and transdermal delivery |
| CN111685135A (en) * | 2020-07-03 | 2020-09-22 | 广州本心生物医药科技有限公司 | Traditional Chinese medicine plant extract with disinfection effect, preparation method and disinfectant |
Non-Patent Citations (3)
| Title |
|---|
| 周秋丽 等主编: "《现代中药基础研究与临床》", 30 June 2012, 天津科技翻译出版公司 * |
| 徐晓玉 主编: "《中药药理学》", 31 January 2010, 中国中医药出版社 * |
| 谢盘根 主编: "《十二经临床用药手册》", 31 January 1994, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113767938A (en) * | 2021-08-30 | 2021-12-10 | 柳州市中医医院(柳州市壮医医院) | Zhuang nationality medicine air disinfectant |
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