CN112771067A - 包含基于SIRPα的嵌合蛋白的组合疗法 - Google Patents

包含基于SIRPα的嵌合蛋白的组合疗法 Download PDF

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Publication number
CN112771067A
CN112771067A CN201980063224.8A CN201980063224A CN112771067A CN 112771067 A CN112771067 A CN 112771067A CN 201980063224 A CN201980063224 A CN 201980063224A CN 112771067 A CN112771067 A CN 112771067A
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cancer
domain
binding
pharmaceutical composition
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Chinese (zh)
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T·施赖伯
G·弗罗姆
S·达西瓦
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Shattuck Labs Inc
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Shattuck Labs Inc
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN201980063224.8A 2018-08-29 2019-08-29 包含基于SIRPα的嵌合蛋白的组合疗法 Pending CN112771067A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862724600P 2018-08-29 2018-08-29
US62/724,600 2018-08-29
US201862734951P 2018-09-21 2018-09-21
US62/734,951 2018-09-21
US201962793235P 2019-01-16 2019-01-16
US62/793,235 2019-01-16
US201962832830P 2019-04-11 2019-04-11
US62/832,830 2019-04-11
US201962890217P 2019-08-22 2019-08-22
US62/890,217 2019-08-22
PCT/US2019/048913 WO2020047319A1 (en) 2018-08-29 2019-08-29 Combination therapies comprising sirp alpha-based chimeric proteins

Publications (1)

Publication Number Publication Date
CN112771067A true CN112771067A (zh) 2021-05-07

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CN201980063224.8A Pending CN112771067A (zh) 2018-08-29 2019-08-29 包含基于SIRPα的嵌合蛋白的组合疗法
CN201980067213.7A Pending CN112839952A (zh) 2018-08-29 2019-08-29 包含基于pd-1的嵌合蛋白的组合疗法

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CN201980067213.7A Pending CN112839952A (zh) 2018-08-29 2019-08-29 包含基于pd-1的嵌合蛋白的组合疗法

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US (2) US20210379153A1 (https=)
EP (2) EP3844176A4 (https=)
JP (2) JP2022512541A (https=)
CN (2) CN112771067A (https=)
AU (2) AU2019327494A1 (https=)
CA (2) CA3109346A1 (https=)
IL (2) IL281095A (https=)
MX (2) MX2021002294A (https=)
WO (2) WO2020047319A1 (https=)

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JP2022512541A (ja) * 2018-08-29 2022-02-07 シャタック ラボ，インコーポレイテッド Ｐｄ－１系キメラタンパク質を含む併用療法
US20210301019A1 (en) * 2020-03-26 2021-09-30 Aetio Biotherapy, Inc. Bi-specific fusion proteins for depletion of regulatory t cells
CN116615442A (zh) * 2020-09-08 2023-08-18 优特力克斯有限公司 程序性细胞死亡1多肽变体
JP2023541996A (ja) * 2020-09-17 2023-10-04 シャタック ラボ，インコーポレイテッド ＳＩＲＰ１αキメラタンパク質の臨床投与
AU2021378152A1 (en) * 2020-11-11 2023-06-22 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY
KR102618718B1 (ko) * 2021-01-11 2023-12-29 주식회사 유틸렉스 항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도
AU2022229900A1 (en) * 2021-03-05 2023-10-05 Shattuck Labs, Inc. Combination therapies with sirp alpha-based chimeric proteins
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases

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CN107857819A (zh) * 2017-07-03 2018-03-30 江苏西迪尔生物技术有限公司 多功能融合蛋白及其应用
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