CN112755867B - Micro-mixing chip and micro-mixing device - Google Patents
Micro-mixing chip and micro-mixing device Download PDFInfo
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- CN112755867B CN112755867B CN202011491648.5A CN202011491648A CN112755867B CN 112755867 B CN112755867 B CN 112755867B CN 202011491648 A CN202011491648 A CN 202011491648A CN 112755867 B CN112755867 B CN 112755867B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3017—Mixing chamber
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
Abstract
The invention discloses a micro-mixing chip and a micro-mixing device, wherein a mixing unit is arranged in the micro-mixing chip and comprises a gradual splitting channel, a mixing sub-channel, a liquid level amplification sub-channel, a composite channel and a flow dividing part, the flow dividing part divides the gradual splitting channel into the mixing sub-channel and the liquid level amplification sub-channel at the tail end of the gradual splitting channel, the width of the gradual splitting channel is firstly small and then large, the width of the mixing sub-channel is firstly large and then small, the width of the liquid level amplification sub-channel is gradually increased, and an outlet of the mixing sub-channel and an outlet of the liquid level amplification sub-channel are converged to the composite channel, so that fluid of the mixing sub-channel and fluid of the liquid level amplification sub-channel are mixed in a counter-flushing manner in the composite channel. Two or more flows needing to be mixed are converged into the progressive splitting channel, are split into two sub flows, respectively enter the mixing sub channel and the liquid level amplifying sub channel, and are mixed in a hedging mode in the composite channel, and mixing performance is improved. The invention can be widely applied to the technical field of biological chips.
Description
Technical Field
The invention relates to the technical field of biochips, in particular to a micro-mixing chip and a micro-mixing device.
Background
Microfluidic-based lab-on-a-chip devices and micro-total analysis systems have a great application prospect in the fields of drug delivery, biomedical detection, food, chemical engineering, etc., in various lab-on-a-chip devices and micro-total analysis systems, fluid mixing is considered as a key step, and the uniformity, stability and efficiency of mixing are one of the factors affecting the rapid and effective biochemical reaction effect. Due to the low Reynolds number characteristic (the Reynolds number is less than 10) of the microfluid under the microscale, the mixing of different fluids mainly depends on molecular diffusion, the time is consumed, the efficiency is low, the low mixing uniformity causes large limit noise, and the analysis result is influenced. Therefore, it is important to design high performance mixers to achieve fast and efficient mixing of two or even multi-phase liquids at the micro-scale.
Active and passive micromixers are commonly used to achieve mixing of liquids at the microscale. Compared with the active mixer, the passive micromixer has the advantages of economy, convenience, easy manufacture and assembly, no need of external force and an additional control system, and is widely applied, such as two-dimensional snakes, spirals, split-compound types and the like, and three-dimensional snakes, split-compound types, groove types and the like. Compared with three-dimensional and other two-dimensional passive micromixers, the two-dimensional improved Tesla micromixer has the advantages of high mixing efficiency under the condition of medium-high Reynolds number, easiness in manufacturing and the like, is a preferred scheme of the micromixer in various lab-on-a-chip equipment and micro total analysis systems, but has the advantages of improved mixing performance under the condition of low Reynolds number and higher requirement on manufacturing of a photoetching machine. There is a need for a passive micromixer that is both easy to manufacture and has good mixing performance over a range of reynolds numbers.
Disclosure of Invention
In order to solve at least one of the above technical problems and improve the mixing performance, the present invention provides a micro-mixing chip and a micro-mixing device, and the adopted technical scheme is as follows:
the invention provides a micro-mixing device, which comprises a substrate chip and a micro-mixing chip.
The invention provides a micro-mixing chip, wherein a mixing unit is arranged in the micro-mixing chip, the mixing unit comprises a progressive splitting channel, a mixing sub-channel, a liquid level amplification sub-channel, a composite channel and a flow dividing part, the flow dividing part divides the progressive splitting channel into the mixing sub-channel and the liquid level amplification sub-channel at the tail end of the progressive splitting channel, the width of the progressive splitting channel is firstly small and then large, the width of the mixing sub-channel is firstly large and then small, the width of the liquid level amplification sub-channel is gradually increased, and an outlet of the mixing sub-channel and an outlet of the liquid level amplification sub-channel are converged to the composite channel, so that fluid of the mixing sub-channel and fluid of the liquid level amplification sub-channel are mixed in a counter-flushing manner in the composite channel.
In some embodiments of the invention, the progressively splitting channel comprises a first planar wall, a first arcuate wall, a second planar wall, a third arcuate wall, and a third planar wall, the first arcuate wall, and the second planar wall being connected in series to form one sidewall of the progressively splitting channel, the third arcuate wall and the third planar wall being connected in series to form the other sidewall of the progressively splitting channel.
In some embodiments of the present invention, the mixing sub-passage is provided with a curved flow path having a width that is larger first and smaller second, the mixing sub-passage includes a fourth arc-shaped wall that constitutes one side wall of the curved flow path and a fifth arc-shaped wall that constitutes the other side wall of the curved flow path, the fifth arc-shaped wall being provided on the flow dividing portion.
In some embodiments of the invention, the mixing sub-passageway comprises a fourth planar wall and a sixth planar wall, the fourth planar wall and the sixth planar wall forming a flow path therebetween for communicating the curved flow path with the progressively splitting passageway, the fourth planar wall being disposed on the flow splitting section.
In some embodiments of the present invention, a width of a flow path formed between the fourth plane wall and the sixth plane wall is gradually increased.
In some embodiments of the present invention, the liquid level amplification sub-passage includes a fifth planar wall and a sixth arc-shaped wall, the fifth planar wall constitutes one side wall of the liquid level amplification sub-passage, the sixth arc-shaped wall constitutes the other side wall of the liquid level amplification sub-passage, and the fifth planar wall is provided on the flow dividing portion.
In some embodiments of the invention, the fourth and fifth planar walls form a V-shape for separating the mixing sub-channel and the level amplifying sub-channel from the progressive splitting channel.
The invention provides a micro-mixing chip, wherein a plurality of mixing units are arranged in the micro-mixing chip, each mixing unit is arranged in series, and in two adjacent mixing units, the composite channel outlet of the previous mixing unit is communicated with the inlet of the progressive splitting channel of the next mixing unit.
In some embodiments of the present invention, a confluence channel and at least two input ports are disposed in the micro-mixing chip, each input port is connected to the confluence channel, the confluence channel is connected to the first mixing unit, and an output port is disposed in the micro-mixing chip and is used for flowing out the fluid processed by the last mixing unit.
The embodiment of the invention has at least the following beneficial effects: two or more flows needing to be mixed are converged into the progressive splitting channel, are split into two sub flows, respectively enter the mixing sub channel and the liquid level amplifying sub channel, and are mixed in a hedging mode in the composite channel, and mixing performance is improved. The invention can be widely applied to the technical field of biological chips.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic diagram of a micro-hybrid chip, showing the micro-hybrid chip as square;
FIG. 2 is a schematic view of a mixing unit;
fig. 3 is a schematic diagram of a frame structure of the mixing unit.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it is to be understood that, if the terms "central", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc. are used in the orientation or positional relationship indicated in the drawings, this is for convenience of description and simplicity of description only, and does not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. The features defined as "first" and "second" are used to distinguish feature names rather than having a special meaning, and further, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The invention relates to a micro-mixing device, which comprises a substrate chip and a micro-mixing chip. The micro-mixing chip is used for mixing different types of fluids based on unbalanced convergence, divergence, splitting and reverse-hedging-recombination, can realize the high-efficiency mixing of two or more strands of liquids in a wider Reynolds number range under microscale, particularly improves the mixing performance in a lower Reynolds number range, and has the characteristics of convenient process, reduced manufacturing precision requirement, easy processing and the like.
The micro-hybrid chip and the substrate chip are designed to be square or round. Furthermore, the micro-hybrid chip is made of organic glass or polydimethylsiloxane, and the substrate chip is made of organic glass or polydimethylsiloxane.
Other configurations and operations of the micro-hybrid device are known to those of ordinary skill in the art and will not be described in detail herein, and the structure of the micro-hybrid chip will be described below.
The invention relates to a micro-mixing chip, wherein a mixing unit 100 is arranged in the micro-mixing chip, the mixing unit 100 is used for progressively splitting, shunting and mixing fluid and carrying out opposite impact type compounding, and the capacity of the micro-mixing chip can be adjusted by changing the width and the depth of a channel of the mixing unit 100.
The mixing unit 100 includes a progressive splitting channel 101, a mixing sub-channel 102, a liquid level amplification sub-channel 103, a compound channel 104, and a flow dividing portion 105 that divides the progressive splitting channel 101 into the mixing sub-channel 102 and the liquid level amplification sub-channel 103 at the end of the progressive splitting channel 101. The outlets of the mixing sub-channel 102 and the liquid level amplifying sub-channel 103 converge to the composite channel 104, so that the fluid of the mixing sub-channel 102 and the fluid of the liquid level amplifying sub-channel 103 are oppositely collided and compounded in the composite channel 104, and are reversely, oppositely collided and recombined in the composite channel 104, and the interface area and the mass transfer effect of recombination and mixing of the two fluids are increased through repeated collision of the fluids and the wall surfaces and multiple vortexes generated, and the mixing performance is enhanced.
The fluid generates secondary flow and vortex flow in the progressive splitting passage 101, the width of the progressive splitting passage 101 is first small and then large, the progressive splitting passage 101 has the functions of converging and diverging the fluid, the fluid is converged in the flow passage with the small width, the fluid is diverged in the flow passage with the large width, and the fluid is split by combining the structure of the flow dividing part 105.
The progressively splitting channel 101 comprises a first planar wall 201, a first arced wall 301, a second planar wall 202, a third arced wall 303, and a third planar wall 203, the first planar wall 201, the first arced wall 301, and the second planar wall 202 being in series to form one sidewall of the progressively splitting channel 101, and the third arced wall 303 and the third planar wall 203 being in series to form the other sidewall of the progressively splitting channel 101. It can be understood that the fluid of the progressive splitting passage 101 is divided into two flows by the flow dividing portion 105 after colliding with the first arc-shaped wall 301 and the second plane wall 202 to generate the secondary flow and the vortex flow to change the direction of the fluid.
The width of the mixing sub-channel 102 is first larger and then smaller, and the mixing sub-channel 102 has a diverging, converging, and curved structure, and expanding vortex and dean vortex are generated in the mixing sub-channel 102 to improve fluid mixing performance. Specifically, the mixing sub-channel 102 is provided with a curved flow path, the width of which is first larger and then smaller, so as to increase the acting area of the centrifugal inertia force of the fluid in the fluid mixing process, and simultaneously fold the compressed fluid to improve the mixing performance. The mixing sub-passageway 102 includes a fourth arcuate wall 304 and a fifth arcuate wall 305, the fourth arcuate wall 304 forming one sidewall of the curved flow path and the fifth arcuate wall 305 forming the other sidewall of the curved flow path.
The mixing sub-passageway 102 includes a fourth planar wall 204 and a sixth planar wall 206, the flow path defined between the fourth planar wall 204 and the sixth planar wall 206 for communicating the tortuous flow path with the progressively splitting passageway 101. Further, the width of the flow path formed between the fourth planar wall 204 and the sixth planar wall 206 gradually increases.
The liquid level amplification sub-channel 103 has a divergent structure, and the width of the liquid level amplification sub-channel 103 is gradually increased, so that the acting area of collision of two streams of fluid is increased, and the flow resistance is reduced. The liquid level amplification sub-channel 103 comprises a fifth plane wall 205 and a sixth arc-shaped wall 306, the fifth plane wall 205 forms one side wall of the liquid level amplification sub-channel 103, and the sixth arc-shaped wall 306 forms the other side wall of the liquid level amplification sub-channel 103. Referring to the drawings, the fifth curved wall 305 is provided on the flow dividing portion 105, the fourth planar wall 204 is provided on the flow dividing portion 105, and the fifth planar wall 205 is provided on the flow dividing portion 105. The fourth planar wall 204 and the fifth planar wall 205 form a V-shaped portion for separating the mixing sub-channel 102 and the level amplifying sub-channel 103 from the progressive splitting channel 101.
The invention relates to a micro-hybrid chip, which is provided with a plurality of mixing units 100, wherein the mixing units 100 are arranged in series, and the mixing performance is enhanced in a multi-stage mode. In two adjacent mixing units 100, the counter-flushing outlet of the compound channel 104 of the previous mixing unit 100 is used for communicating with the inlet of the progressively splitting channel 101 of the next mixing unit 100. It is understood that two adjacent mixing units 100 communicate with each other through the composite channel 104 and the progressively splitting channel 101. Referring to the drawings, the side walls of the composite channel 104 are arranged in an arc-shaped structure to reduce the manufacturing accuracy, and specifically, the composite channel 104 can be regarded as an inlet flow path of the progressively splitting channel 101, in which the first planar wall 201 and the third arc-shaped wall 303 are two side walls of the composite channel 104, respectively.
The arcuate flow path formed by the compound channel 104 and the progressively splitting channel 101 forms an inward corner at the entrance of the progressively splitting channel 101 that may act to facilitate the fluid impinging on the sidewall, which may form secondary flows and vortices as the fluid impinges on the second planar wall 202, enhancing mixing performance. Referring to the figures, the second planar wall 202 of the progressively splitting channel 101 interfaces with the sixth planar wall 206 of the mixing sub-channel 102 through a second arcuate wall 302.
With reference to the accompanying drawings, a confluence channel 106 and at least two input ports 107 are arranged in the micro-mixing chip, the input ports 107 are provided as through holes penetrating through the micro-mixing chip, each input port 107 is communicated to the confluence channel 106, the confluence channel 106 is communicated to the mixing unit 100 arranged at the head, an output port 108 is arranged in the micro-mixing chip, the output port 108 is used for flowing out the fluid processed by the mixing unit 100 arranged at the tail, and the output port 108 is provided as a through hole penetrating through the micro-mixing chip. It is understood that different types of fluids enter the respective input ports 107, are collected in the collecting channel 106, undergo progressive splitting, split mixing, and combined counter flushing, and then are discharged from the output port 108.
In some examples, the micro-mixing chip has two input ports 107, two flows of deionized water and a fluorescein solution with a solubility of 0.04mM/L are respectively provided, the two flows are fed from the two input ports 107 at a flow rate of 0.001-0.100 mL/min (Reynolds number of 0.1-10), and are merged in the confluence channel 106, wherein the distribution range of the fluorescein concentration in the mixed flow is 0-0.04mM/L, and the mixed flow sequentially passes through the multi-stage mixing unit 100 and then flows out from the output port 108. At a reynolds number of 0.50 (flow rates of 0.005mL/min, respectively) at the micro-scale, the fluorescein mixing index at the output port 108 in this example is 0.71, compared to 0.59 for the two-dimensional modified tesla micromixer; when the reynolds number is 1.25 (the flow rates are 0.0125mL/min, respectively) at the microscale, the mixing index of fluorescein at the output port 108 in this embodiment is 0.51, compared with that of a two-dimensional modified tesla micromixer which is 0.38; when the reynolds number is 2.5 (the flow rates are 0.025mL/min, respectively) at the micro scale, the fluorescein mixing index at the output port 108 in this embodiment is 0.53, compared with the mixing index of 0.43 in the two-dimensional improved tesla micromixer; at a reynolds number of 10.0 (flow rates of 0.1mL/min, respectively) at the micro-scale, the fluorescein mixing index at the output port 108 in this example was 0.96 compared to 0.83 for the two-dimensional modified tesla micromixer. By comparison, the larger the mixing index, the better the mixing performance.
In the description herein, references to the terms "one embodiment," "some examples," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" or the like, if any, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While the embodiments of the present invention have been described in detail with reference to the drawings, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (9)
1. A micro-hybrid chip, comprising: the micro-mixing chip is provided with a mixing unit (100), the mixing unit (100) comprises a progressive splitting channel (101), a mixing sub-channel (102), a liquid level amplification sub-channel (103), a composite channel (104) and a flow dividing part (105), the flow divider (105) divides the progressively splitting channel (101) into the mixing sub-channel (102) and the liquid level amplification sub-channel (103) at the end of the progressively splitting channel (101), the width of the gradual splitting channel (101) is firstly small and then large, the width of the mixing sub-channel (102) is firstly large and then small, the width of the liquid level amplification sub-channel (103) is gradually increased, the outlet of the mixing sub-channel (102) and the outlet of the liquid level amplifying sub-channel (103) are converged to the composite channel (104), so that the fluid of the mixing sub-channel (102) and the fluid of the liquid level amplification sub-channel (103) are mixed in the compound channel (104) in an opposite flushing mode;
the liquid level amplification sub-channel (103) comprises a fifth plane wall (205) and a sixth arc-shaped wall (306), wherein the fifth plane wall (205) forms one side wall of the liquid level amplification sub-channel (103), and the sixth arc-shaped wall (306) forms the other side wall of the liquid level amplification sub-channel (103);
the mixing units (100) are arranged in a plurality, each mixing unit (100) is arranged in series, and in two adjacent mixing units (100), the outlet of the composite channel (104) of the previous mixing unit (100) is used for communicating with the inlet of the progressive splitting channel (101) of the next mixing unit (100); the side wall of the composite channel (104) is arranged to be an arc-shaped structure, and the composite channel (104) and the progressive splitting channel (101) form an arc-shaped flow path.
2. The micro-hybrid chip of claim 1, wherein: the progressive splitting channel (101) comprises a first plane wall (201), a first arc-shaped wall (301), a second plane wall (202), a third arc-shaped wall (303) and a third plane wall (203), wherein the first plane wall (201), the first arc-shaped wall (301) and the second plane wall (202) are connected in series to form one side wall of the progressive splitting channel (101), and the third arc-shaped wall (303) and the third plane wall (203) are connected in series to form the other side wall of the progressive splitting channel (101).
3. The micro-hybrid chip of claim 1, wherein: the mixing sub-channel (102) is provided with a curved flow path having a width that is first larger and then smaller, the mixing sub-channel (102) includes a fourth curved wall (304) and a fifth curved wall (305), the fourth curved wall (304) constitutes one side wall of the curved flow path, the fifth curved wall (305) constitutes the other side wall of the curved flow path, and the fifth curved wall (305) is provided on the flow dividing portion (105).
4. The micro-hybrid chip of claim 3, wherein: the mixing sub-channel (102) comprises a fourth planar wall (204) and a sixth planar wall (206), a flow path formed between the fourth planar wall (204) and the sixth planar wall (206) is used for communicating the curved flow path with the progressively splitting channel (101), and the fourth planar wall (204) is arranged on the flow dividing part (105).
5. The micro-hybrid chip of claim 4, wherein: the width of the flow path formed between the fourth plane wall (204) and the sixth plane wall (206) is gradually increased.
6. The micro-hybrid chip of claim 4 or 5, wherein: the fifth plane wall (205) is provided on the flow dividing portion (105).
7. The micro-hybrid chip of claim 6, wherein: the fourth planar wall (204) and the fifth planar wall (205) form a V-shaped portion for separating the mixing sub-channel (102) and the level amplifying sub-channel (103) from the progressive splitting channel (101).
8. The micro-hybrid chip of claim 1, wherein: the micro-mixing chip is provided with a confluence channel (106) and at least two input ports (107), each input port (107) is communicated with the confluence channel (106), the confluence channel (106) is communicated with the mixing unit (100) arranged at the head, the micro-mixing chip is provided with an output port (108), and the output port (108) is used for flowing out the fluid processed by the mixing unit (100) arranged at the tail.
9. A micro-mixing device, characterized by: comprising a substrate chip and a micro-hybrid chip according to any of claims 1 to 8.
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| CN113952993B (en) * | 2021-11-23 | 2022-09-20 | 中北大学 | Multistage inertial microfluidic blood sample processing chip integrating micro mixer and Tesla valve |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8430558B1 (en) * | 2008-09-05 | 2013-04-30 | University Of Central Florida Research Foundation, Inc. | Microfluidic mixer having channel width variation for enhanced fluid mixing |
| CN105664773B (en) * | 2016-01-22 | 2017-09-19 | 苏州汶颢芯片科技有限公司 | Plane passive type micro-mixer |
| CN109001269B (en) * | 2018-09-19 | 2021-03-02 | 重庆大学 | Bacterial chip integrating DEP separation, magnetic microsphere selective enrichment and EIS in-situ detection and detection method thereof |
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-
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Non-Patent Citations (1)
| Title |
|---|
| Tesla微混合器结构参数对混合强度的影响;夏国栋等;《工程热物理学报》;20110331;第32卷(第3期);第432-436页 * |
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