CN214438545U

CN214438545U - Micro-mixing chip and micro-mixing device

Info

Publication number: CN214438545U
Application number: CN202023087842.5U
Authority: CN
Inventors: 邹丽丽; 龚尧; 伊翔; 陈龙胜
Original assignee: GUANGDONG INSTITUTE OF MEDICAL INSTRUMENTS
Current assignee: Institute Of Health Medicine Guangdong Academy Of Sciences; Institute of Biological and Medical Engineering of Guangdong Academy of Sciences
Priority date: 2020-12-17
Filing date: 2020-12-17
Publication date: 2021-10-22
Anticipated expiration: 2030-12-17

Abstract

The utility model discloses a mix chip a little, little mixing arrangement, be provided with mixed unit in the little mixed chip, mixed unit is including dividing the passageway gradually, mix the subchannel, the subchannel is enlarged to the liquid level, compound channel and reposition of redundant personnel portion, reposition of redundant personnel portion will divide into gradually at the end that divides the passageway gradually and mix subchannel and liquid level and enlarge the subchannel, the width that divides the passageway gradually is big after little earlier, mix the width that the subchannel is big after little earlier, the width that the subchannel is enlarged to the liquid level increases gradually, the export that the subchannel was enlarged to compound channel with the liquid level's export converges to compound channel, so that the fluid that mixes the subchannel and the fluid that the liquid level enlarged the subchannel in compound channel offset and mix. Two or more flows needing to be mixed are converged into the progressive splitting channel, are split into two sub flows, respectively enter the mixing sub channel and the liquid level amplifying sub channel, and are mixed in a hedging mode in the composite channel, and mixing performance is improved. The utility model can be widely applied to the technical field of biological chips.

Description

Micro-mixing chip and micro-mixing device

Technical Field

The utility model relates to a biochip technical field, in particular to little hybrid chip, little mixing arrangement.

Background

Microfluidic-based lab-on-a-chip devices and micro-total analysis systems have great application prospects in the fields of drug delivery, biomedical detection, food, chemical engineering, etc., fluid mixing is considered as a key step in various lab-on-a-chip devices and micro-total analysis systems, and uniformity, stability and high efficiency of mixing are one of the factors influencing the rapid and effective biochemical reaction effect. Due to the low reynolds number characteristic (reynolds number less than 10) of the microfluid at the microscale, the mixing of different fluids mainly depends on molecular diffusion, time is consumed, efficiency is low, and the low mixing uniformity causes high limit noise, thereby influencing the analysis result. Therefore, it is important to design a high performance mixer to achieve fast and efficient mixing of two-phase or even multi-phase liquids at the micro-scale.

Active and passive micromixers are commonly used to achieve mixing of liquids at the microscale. Compared with the active mixer, the passive micromixer has the advantages of economy, convenience, easy manufacture and assembly, no need of external force and an additional control system, and is widely applied, such as two-dimensional snakes, spirals, split-compound types and the like, and three-dimensional snakes, split-compound types, groove types and the like. Compared with three-dimensional and other two-dimensional passive micromixers, the two-dimensional improved Tesla micromixer has the advantages of high mixing efficiency under the condition of medium-high Reynolds number, easiness in manufacturing and the like, is a preferred scheme of the micromixer in various lab-on-a-chip equipment and micro total analysis systems, but has the advantages of improved mixing performance under the condition of low Reynolds number and higher requirement on manufacturing of a photoetching machine. There is a need for a passive micromixer that is easy to manufacture and has good mixing performance over a range of reynolds numbers.

SUMMERY OF THE UTILITY MODEL

For at least one among the above-mentioned technical problem of solution, improve the mixing performance, the utility model provides a little hybrid chip, little mixing arrangement, the technical scheme who adopts as follows:

the utility model provides a micro-mixing device, micro-mixing device include basement chip and micro-mixing chip.

The utility model provides a little mixed chip is provided with mixed unit in the little mixed chip, mixed unit is including dividing gradually the passageway, mixing sub-channel, liquid level amplification sub-channel, compound channel and reposition of redundant personnel portion, reposition of redundant personnel portion is in gradually the end of dividing gradually the passageway will divide into gradually the mixture sub-channel with liquid level amplification sub-channel, gradually divide the width of passageway little earlier big back big, mix sub-channel's width big back little earlier, liquid level amplification sub-channel's width increases gradually, mix sub-channel's export with liquid level amplification sub-channel's export converge extremely compound channel, so that mix sub-channel's fluid with liquid level amplification sub-channel's fluid is in the hedging mixes in the compound channel.

In certain embodiments of the present invention, the progressively splitting channel comprises a first planar wall, a first arcuate wall, a second planar wall, a third arcuate wall and a third planar wall, the first arcuate wall and the second planar wall being serially connected to form a sidewall of the progressively splitting channel, the third arcuate wall and the third planar wall being serially connected to form another sidewall of the progressively splitting channel.

The utility model discloses a certain embodiments, the mixed subchannel is provided with crooked flow path, the width of crooked flow path is big before last little, the mixed subchannel includes fourth arc wall and fifth arc wall, the fourth arc wall constitutes a lateral wall of crooked flow path, fifth arc wall constitutes another lateral wall of crooked flow path, fifth arc wall sets up on the reposition of redundant personnel portion.

In some embodiments of the present invention, the mixing sub-channel includes a fourth planar wall and a sixth planar wall, the fourth planar wall and the flow path formed between the sixth planar wall are used for communicating the curved flow path with the progressive splitting channel, the fourth planar wall is disposed on the flow dividing portion.

In some embodiments of the present invention, a width of the flow path formed between the fourth plane wall and the sixth plane wall is gradually increased.

In some embodiments of the present invention, the liquid level amplification sub-channel includes a fifth plane wall and a sixth arc wall, the fifth plane wall constitutes a side wall of the liquid level amplification sub-channel, the sixth arc wall constitutes another side wall of the liquid level amplification sub-channel, and the fifth plane wall is disposed on the flow dividing portion.

In certain embodiments of the present invention, the fourth planar wall and the fifth planar wall form a V-shaped portion for separating the mixing sub-channel and the liquid level amplifying sub-channel from the progressive splitting channel.

The utility model provides a little hybrid chip is provided with a plurality of as before mixing unit, each in the little hybrid chip mixing unit series connection sets up, adjacent two in the mixing unit, the former one mixing unit's compound passageway export is used for with the latter mixing unit's gradual division passageway entry intercommunication.

The utility model discloses a certain embodiment, be provided with confluence passageway and two at least input ports in the little hybrid chip, each the input port communicates to the confluence passageway, the confluence passageway communicates to arrange at first the mixing unit, be provided with the delivery outlet in the little hybrid chip, the delivery outlet is used for flowing out arrange at last the fluid after the mixing unit is handled.

The embodiment of the utility model has the following beneficial effect at least: two or more flows needing to be mixed are converged into the progressive splitting channel, are split into two sub flows, respectively enter the mixing sub channel and the liquid level amplifying sub channel, and are mixed in a hedging mode in the composite channel, and mixing performance is improved. The utility model can be widely applied to the technical field of biological chips.

Drawings

The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:

FIG. 1 is a schematic diagram of a micro-hybrid chip, showing the micro-hybrid chip as square;

FIG. 2 is a schematic structural diagram of a mixing unit;

fig. 3 is a schematic diagram of a frame structure of the mixing unit.

Detailed Description

Embodiments of the invention, examples of which are illustrated in the accompanying drawings, are described in detail below with reference to fig. 1 to 3, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present invention, and should not be construed as limiting the present invention.

In the description of the present invention, it should be understood that if the terms "center", "middle", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc. are used to indicate an orientation or positional relationship based on that shown in the drawings, it is only for convenience of description and simplicity of description, and it is not intended to indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention. The features defined as "first" and "second" are used to distinguish feature names rather than having a special meaning, and further, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The utility model relates to a little mixing arrangement, little mixing arrangement include basement chip and little mixing chip, and it can be understood that little mixing arrangement still includes power pump, stock solution device and connects the micropump. The micro-mixing chip is used for mixing different types of fluids based on unbalanced convergence, divergence, splitting and reverse-hedging-recombination, can realize the high-efficiency mixing of two or more strands of liquids in a wider Reynolds number range under microscale, particularly improves the mixing performance in a lower Reynolds number range, and has the characteristics of convenient process, reduced manufacturing precision requirement, easy processing and the like.

The micro-hybrid chip and the substrate chip are designed to be square or round. Furthermore, the micro-hybrid chip is made of organic glass or polydimethylsiloxane, and the substrate chip is made of organic glass or polydimethylsiloxane.

Other configurations and operations of the micro-hybrid device are known to those of ordinary skill in the art and will not be described in detail herein, and the structure of the micro-hybrid chip will be described below.

The utility model relates to a little hybrid chip is provided with mixing unit 100 in the little hybrid chip, and mixing unit 100 is used for the fluid progressive splitting, the reposition of redundant personnel mixes and the offset formula is compound, through changing mixing unit 100's channel width and degree of depth, the capacity of adjustable little hybrid chip.

The mixing unit 100 includes a progressive splitting channel 101, a mixing sub-channel 102, a liquid level amplification sub-channel 103, a compound channel 104, and a flow dividing portion 105 that divides the progressive splitting channel 101 into the mixing sub-channel 102 and the liquid level amplification sub-channel 103 at the end of the progressive splitting channel 101. The outlets of the mixing sub-channel 102 and the liquid level amplifying sub-channel 103 converge to the composite channel 104, so that the fluid of the mixing sub-channel 102 and the fluid of the liquid level amplifying sub-channel 103 are oppositely collided and compounded in the composite channel 104, and are reversely, oppositely collided and recombined in the composite channel 104, and the interface area and the mass transfer effect of recombination and mixing of the two fluids are increased through repeated collision of the fluids and the wall surface and multiple vortexes generated, so that the mixing performance is enhanced.

The fluid generates secondary flow and vortex flow in the progressive splitting channel 101, the width of the progressive splitting channel 101 is small firstly and then large, the progressive splitting channel 101 has the functions of converging and diverging the fluid, the fluid is converged in a flow path with small width, the fluid is diverged in a flow path with large width, and the fluid is split by combining the structure of the flow dividing part 105.

The progressively splitting tunnel 101 includes a first planar wall 201, a first arcuate wall 301, a second planar wall 202, a third arcuate wall 303, and a third planar wall 203, the first planar wall 201, the first arcuate wall 301, and the second planar wall 202 in series forming one sidewall of the progressively splitting tunnel 101, and the third arcuate wall 303 and the third planar wall 203 in series forming the other sidewall of the progressively splitting tunnel 101. It can be understood that the fluid of the gradually-splitting passage 101 is divided into two by the flow dividing portion 105 after colliding with the first arc-shaped wall 301 and the second plane wall 202 to generate the secondary flow and the vortex flow changes the direction of the fluid.

The width of the mixing sub-channel 102 is first larger and then smaller, and the mixing sub-channel 102 has a diverging, converging, and curved structure, and expanding vortex and dean vortex are generated in the mixing sub-channel 102 to improve fluid mixing performance. Specifically, the mixing sub-channel 102 is provided with a curved flow path, the width of which is first larger and then smaller, so as to increase the acting area of the centrifugal inertia force of the fluid in the fluid mixing process, and simultaneously fold the compressed fluid to improve the mixing performance. The mixing sub-passageway 102 includes a fourth arcuate wall 304 and a fifth arcuate wall 305, the fourth arcuate wall 304 forming one sidewall of the curved flow path and the fifth arcuate wall 305 forming the other sidewall of the curved flow path.

The mixing sub-passageway 102 includes a fourth planar wall 204 and a sixth planar wall 206, the flow path defined between the fourth planar wall 204 and the sixth planar wall 206 for communicating the tortuous flow path with the progressively splitting passageway 101. Further, the width of the flow path formed between the fourth planar wall 204 and the sixth planar wall 206 gradually increases.

The liquid level amplification sub-channel 103 has a divergent structure, and the width of the liquid level amplification sub-channel 103 is gradually increased, so that the acting area of collision of two streams of fluid is increased, and the flow resistance is reduced. The liquid level amplification sub-channel 103 comprises a fifth plane wall 205 and a sixth arc-shaped wall 306, wherein the fifth plane wall 205 forms one side wall of the liquid level amplification sub-channel 103, and the sixth arc-shaped wall 306 forms the other side wall of the liquid level amplification sub-channel 103. Referring to the drawings, a fifth arc-shaped wall 305 is provided on the flow dividing portion 105, a fourth plane wall 204 is provided on the flow dividing portion 105, and a fifth plane wall 205 is provided on the flow dividing portion 105. The fourth planar wall 204 and the fifth planar wall 205 form a V-shaped portion for separating the mixing sub-channel 102 and the level amplifying sub-channel 103 from the progressive splitting channel 101.

The utility model relates to a little hybrid chip is provided with a plurality of as before on the little hybrid chip hybrid unit 100, each hybrid unit 100 establishes ties and sets up, adopts multistage mode reinforcing mixing performance. In two adjacent mixing units 100, the counter-flushing outlet of the compound channel 104 of the previous mixing unit 100 is used for communicating with the inlet of the progressively splitting channel 101 of the next mixing unit 100. It is understood that two adjacent mixing units 100 communicate with each other through the composite channel 104 and the progressively splitting channel 101. Referring to the drawings, the side walls of the composite channel 104 are provided with arc-shaped structures to reduce the manufacturing accuracy, and in particular, the composite channel 104 can be regarded as an inlet flow path of the gradually-splitting channel 101, wherein the first planar wall 201 and the third arc-shaped wall 303 are two side walls of the composite channel 104 respectively.

The arcuate flow path formed by the compound channel 104 and the progressively splitting channel 101 forms an inward corner at the entrance of the progressively splitting channel 101 that may serve to facilitate fluid impinging on the sidewall, which may form secondary flows and vortices against the second planar wall 202, enhancing mixing performance. Referring to the figures, the second planar wall 202 of the progressively splitting channel 101 interfaces with the sixth planar wall 206 of the mixing sub-channel 102 through a second arcuate wall 302.

With reference to the drawings, a confluence channel 106 and at least two input ports 107 are arranged in the micro-mixing chip, the input ports 107 are provided as through holes penetrating through the micro-mixing chip, each input port 107 is communicated with the confluence channel 106, the confluence channel 106 is communicated with the mixing unit 100 arranged at the head, an output port 108 is arranged in the micro-mixing chip, the output port 108 is used for flowing out the fluid processed by the mixing unit 100 arranged at the tail, and the output port 108 is provided as a through hole penetrating through the micro-mixing chip. It is understood that different types of fluids enter the respective input ports 107, are collected in the collecting channel 106, undergo progressive splitting, split mixing, and combined counter flushing, and then are discharged from the output port 108.

In some examples, the micro-mixing chip has two input ports 107, two flows of deionized water and a fluorescein solution with a solubility of 0.04mM/L are respectively provided, the two flows are fed from the two input ports 107 at a flow rate of 0.001-0.100 mL/min (Reynolds number of 0.1-10), and are merged in the confluence channel 106, wherein the distribution range of the fluorescein concentration in the mixed flow is 0-0.04mM/L, and the mixed flow sequentially passes through the multi-stage mixing unit 100 and then flows out from the output port 108. At a reynolds number of 0.50 (flow rates of 0.005mL/min, respectively) at the micro-scale, the fluorescein mixing index at the output port 108 in this example was 0.71, compared to 0.59 for the two-dimensional modified tesla micromixer; when the reynolds number is 1.25 (the flow rates are 0.0125mL/min, respectively) at the microscale, the mixing index of fluorescein at the output port 108 in this embodiment is 0.51, compared with that of a two-dimensional modified tesla micromixer which is 0.38; when the reynolds number is 2.5 (the flow rates are 0.025mL/min, respectively) at the micro scale, the fluorescein mixing index at the output port 108 in this embodiment is 0.53, compared with the mixing index of 0.43 in the two-dimensional improved tesla micromixer; at a reynolds number of 10.0 (flow rates of 0.1mL/min, respectively) at the micro-scale, the fluorescein mixing index at the output port 108 in this example was 0.96 compared to 0.83 for the two-dimensional modified tesla micromixer. By comparison, the larger the mixing index, the better the mixing performance.

In the description herein, references to the terms "one embodiment," "some examples," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" or the like, if any, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.

Claims

1. A micro-hybrid chip, comprising: the micro-mixing chip is internally provided with a mixing unit (100), the mixing unit (100) comprises a progressive splitting channel (101), a mixing sub-channel (102), a liquid level amplification sub-channel (103), a composite channel (104) and a flow dividing part (105), the flow divider (105) divides the progressively splitting channel (101) into the mixing sub-channel (102) and the liquid level amplification sub-channel (103) at the end of the progressively splitting channel (101), the width of the gradual splitting channel (101) is firstly small and then large, the width of the mixing sub-channel (102) is firstly large and then small, the width of the liquid level amplification sub-channel (103) is gradually increased, the outlet of the mixing sub-channel (102) and the outlet of the liquid level amplifying sub-channel (103) are converged to the composite channel (104), so that the fluid of the mixing sub-channel (102) and the fluid of the liquid level amplifying sub-channel (103) are mixed in the compound channel (104) in an opposite flushing mode.

2. The micro-hybrid chip of claim 1, wherein: the progressive splitting channel (101) comprises a first plane wall (201), a first arc-shaped wall (301), a second plane wall (202), a third arc-shaped wall (303) and a third plane wall (203), wherein the first plane wall (201), the first arc-shaped wall (301) and the second plane wall (202) are connected in series to form one side wall of the progressive splitting channel (101), and the third arc-shaped wall (303) and the third plane wall (203) are connected in series to form the other side wall of the progressive splitting channel (101).

3. The micro-hybrid chip of claim 1, wherein: the mixing sub-channel (102) is provided with a curved flow path having a width that is first larger and then smaller, the mixing sub-channel (102) includes a fourth curved wall (304) and a fifth curved wall (305), the fourth curved wall (304) constitutes one side wall of the curved flow path, the fifth curved wall (305) constitutes the other side wall of the curved flow path, and the fifth curved wall (305) is provided on the flow dividing portion (105).

4. The micro-hybrid chip of claim 3, wherein: the mixing sub-channel (102) comprises a fourth plane wall (204) and a sixth plane wall (206), a flow path formed between the fourth plane wall (204) and the sixth plane wall (206) is used for communicating the curved flow path with the gradual splitting channel (101), and the fourth plane wall (204) is arranged on the flow dividing part (105).

5. The micro-hybrid chip of claim 4, wherein: the width of the flow path formed between the fourth plane wall (204) and the sixth plane wall (206) is gradually increased.

6. The micro-hybrid chip of claim 4 or 5, wherein: the liquid level amplification sub-channel (103) comprises a fifth plane wall (205) and a sixth arc-shaped wall (306), the fifth plane wall (205) forms one side wall of the liquid level amplification sub-channel (103), the sixth arc-shaped wall (306) forms the other side wall of the liquid level amplification sub-channel (103), and the fifth plane wall (205) is arranged on the flow dividing part (105).

7. The micro-hybrid chip of claim 6, wherein: the fourth planar wall (204) and the fifth planar wall (205) form a V-shaped portion for separating the mixing sub-channel (102) and the level amplifying sub-channel (103) from the progressive splitting channel (101).

8. A micro-hybrid chip, comprising: a micro-hybrid chip having a plurality of mixing units (100) as claimed in any one of claims 1 to 7, each mixing unit (100) being arranged in series, the outlet of a composite channel (104) of a preceding mixing unit (100) being adapted to communicate with the inlet of a progressively splitting channel (101) of a succeeding mixing unit (100) in two adjacent mixing units (100).

9. The micro-hybrid chip of claim 8, wherein: the micro-mixing chip is provided with a confluence channel (106) and at least two input ports (107), each input port (107) is communicated to the confluence channel (106), the confluence channel (106) is communicated to the mixing unit (100) arranged at the head, the micro-mixing chip is provided with an output port (108), and the output port (108) is used for flowing out fluid processed by the mixing unit (100) arranged at the tail.

10. A micro-mixing device, characterized by: comprising a substrate chip and a micro-hybrid chip according to any of claims 1 to 9.