CN105664773B - Plane passive type micro-mixer - Google Patents
Plane passive type micro-mixer Download PDFInfo
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- CN105664773B CN105664773B CN201610044013.8A CN201610044013A CN105664773B CN 105664773 B CN105664773 B CN 105664773B CN 201610044013 A CN201610044013 A CN 201610044013A CN 105664773 B CN105664773 B CN 105664773B
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- split channel
- mixed
- mixed cell
- passive type
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3017—Mixing chamber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3034—Micromixers using induced convection or movement in the mixture to mix or move the fluids without mechanical means, e.g. thermodynamic instability, strong gradients, etc.
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3045—Micromixers using turbulence on microscale
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
This application discloses a kind of plane passive type micro-mixer, at least one mixed cell including access road, exit passageway and between access road and exit passageway, each mixed cell includes the first split channel and the second split channel for being used to be shunted liquid respectively；And for the liquid from the first split channel and the second split channel to be carried out to the mixed flow chamber of mixed flow；The mixed flow chamber is connected with the first split channel and the second split channel of adjacent mixed cell, or is connected with exit passageway.The present invention utilizes " coanda " effect, and mixer structure guiding medium produces chaotic advection in convection cavity, significantly improves mixed effect.
Description
Technical field
The present invention relates to micro fluidic chip technical field, more particularly to a kind of plane passive type micro-mixer.
Background technology
Micro-mixer as microfluidic system important component, by its efficiently quickly mixed performance, increasingly
Many is applied to the fields such as bioanalysis, chemical synthesis and clinical trial.When two strands or a plurality of fluids are chemically reacted, need
Realize quick effectively mixing, thus micro-mixer be it is micro-fluidic in important component, due to micro-fluidic chip passage knot
Fluid of the structure in micron dimension, passage is generally in laminar condition, therefore realizes that the quick mixing of fluid under minute yardstick also becomes
Obtain most important.Under different Reynolds numbers, the approach that the fluid in passage is spread by molecule and convection current is mixed is realized
Mixing.Although the former mixing efficiency is high, it needs the incorporation time grown very much under low reynolds number.So real under minute yardstick
The mixing quickly and efficiently of existing fluid is still a challenge.
Mixed process is broadly divided into passive type and active two kinds, and active is that micro-mixer is exerted one's influence by outside
(such as pressure, driven by electroosmosis) controls mixed process, and passive mixing is to be promoted in channel interior by changing structure and shape
Enter mixing.In having designed, micro-mixer uses passive mixing mechanism mostly, also has and active member is added on some chips
Part.Compared to the latter, passive mixing utensil, which has, need not set extras, it is easy to process, the advantage such as easy to use.It is logical at present
Cross optimization channel design, reinforcing chaotic advection turns into the core technology of passive type micro-mixer.
Passive type micro-mixer can realize the chaotic mixing under low reynolds number by the effect such as stretching, folding, dam.But
Such micro-mixer structure is generally slope shape, the three-dimensional structures such as shape, step type is tilted, compared to plane formula blender, its structure
Complex, processing is more difficult.Meanwhile, production cost is higher, is unfavorable for batch production and scale application.
The content of the invention
It is an object of the invention to provide a kind of plane passive type chaotic flow micro-mixer, it has simple in construction, processing
It is easy, mix rapidly and efficiently the features such as.
To achieve the above object, the present invention provides following technical scheme：
A kind of plane passive type micro-mixer, including access road, exit passageway and logical positioned at access road and outlet
At least one mixed cell between road, it is characterised in that：Each mixed cell includes being used to be divided liquid respectively
The first split channel and the second split channel of stream；And for by the liquid from the first split channel and the second split channel
Body carries out the mixed flow chamber of mixed flow；The first split channel and the second split channel of the mixed flow chamber and adjacent mixed cell connect
It is logical, or connected with exit passageway.The present invention utilizes " coanda " effect, and mixer structure guiding medium produces mixed in convection cavity
Ignorant convection current, significantly improves mixed effect." coanda " effect is that fluid has and leaves original flow direction, is changed to protrusion
Body surface flowing tendency.When there is mantle friction between fluid and body surface that it flows through, as long as curvature is less,
Fluid can flow along body surface.
Preferably, the first entrance passage and second that described access road includes connecting with the mixed cell respectively enter
Mouth passage, the width of described first entrance passage is less than the width of described second entrance passage.
Preferably, provided with the baffle plate for slowing down liquid flowing in the second entrance passage.
Preferably, each mixed cell has in a cavity, each described cavity respectively is respectively equipped with a gear
The cavity is separated into first split channel, the second split channel and mixed flow chamber by block, the block, and the mixed flow chamber is formed
In the intersection of first split channel and the second split channel, and positioned at the outlet port of cavity where it.
Preferably, the width of the first described split channel is different with the width of the second described split channel.
Preferably, the described linear passage of the first split channel, the second described split channel is " L " shape passage.
Preferably, the width of the mixed flow chamber is gradually broadened by the first split channel to the second split channel
Preferably, the cross section of the block is right-angled trapezium, rectangle, triangle or its combination.
Preferably, block is set in an identical manner described in each mixed cell.
Preferably, multiple mixed cells are provided between the access road and exit passageway, the plurality of mixed cell includes
The first mixed cell and the second mixed cell being arranged alternately；Block in first mixed cell is mixed with described second
The set-up mode of block in unit is different.
Pipeline is limited in 2D planes by the micro-mixer of the invention, greatlys save space；Because plane is passive micro- mixed
Clutch need not add external device (ED), and structure is relatively simple, process easy, with low cost, be suitable for large-scale production application.
Brief description of the drawings
, below will be to embodiment or existing in order to illustrate more clearly of the embodiment of the present application or technical scheme of the prior art
There is the accompanying drawing used required in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments described in application, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the planar structure schematic diagram of the plane passive type micro-mixer of the embodiment of the present invention one；
Fig. 2 is the planar structure schematic diagram of the plane passive type micro-mixer of the embodiment of the present invention two；
Fig. 3 is the planar structure schematic diagram of the plane passive type micro-mixer of the embodiment of the present invention three；
Fig. 4 is the planar structure schematic diagram of the plane passive type micro-mixer of the embodiment of the present invention four.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, detailed retouch is carried out to the technical scheme in the embodiment of the present invention
State, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the present invention
In embodiment, the every other implementation that those of ordinary skill in the art are obtained on the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
As shown in figure 1, a kind of plane passive type micro-mixer, including access road, exit passageway 7 and logical positioned at entrance
Mixed cell 6 between road and exit passageway 7, mixed cell 6 include being used for the first split channel 3 for being shunted liquid with
And second split channel 4；And for the liquid of the first split channel 3 and the second split channel 4 to be carried out to the mixed flow chamber of mixed flow
5；
Mixed cell 6 herein can be one, and mixed flow chamber 5 is connected with exit passageway 7.
When mixed cell 6 is multiple, mixed flow chamber 5 and the first split channel 3 of adjacent mixed cell 6 and second point
Circulation road 4 is connected, and the mixed flow chamber 5 of last mixed cell is connected with exit passageway 7.
Access road includes first entrance passage 1 and second entrance passage 2, and it is connected with mixed cell 6, and herein first
The cross section of access road and the second entrance passage is rectangular, and first entrance passage 1 can also be with second entrance passage 2
Intersect at a certain angle, angle is 0-180 degree, and especially, first entrance passage 1 is vertical with second entrance passage 2 herein, first
The width of access road 1 is less than the width of described second entrance passage 2.
Each mixed cell 6 has in a cavity, each cavity respectively is respectively equipped with a block 8, and the block 8 is by chamber
Body is separated into first split channel 3, the second split channel 4 and mixed flow chamber 5, and it is logical that mixed flow chamber 5 is formed at first shunting
The intersection of the split channel 4 of road 3 and second, and positioned at the outlet port of cavity where it.
First entrance passage 1 confluxes in intersection, intersection and logical 1 road and second of the first shunting with second entrance passage 2
Split channel 2 is connected, and the width of the first split channel 2 is different from the width of the second split channel 2, herein, the first split channel 2
Width be less than the second split channel 2.First split channel 1 is by separating liquid, the linear passage of the first split channel 1, to protect
Demonstrate,prove the minimum shunt paths of liquid.
Second split channel 2 is shaped as L-shaped, and liquid is come together in mixed flow chamber 5 by broken line shunting.
Operationally, liquid flow direction is the direction shown in Fig. 1 arrow, and two of which medium is respectively by first entrance
Passage 1 and second entrance passage 2 intersect sample introduction, and wherein medium A first entrance passage 1 is by sample introduction, and medium B is by second entrance passage
2 sample introductions；When flowing through intersection, preliminary mixing is realized by molecule diffusion, simultaneously because " coanda " effect (attached wall effect
Should), a part of fluid enters the first split channel 3, and residual fluid continues to flow through the second split channel 4, flowed in mixed flow chamber 5
Body formation chaotic flow, produces whirlpool, enhancing disturbance, so as to reach the purpose quickly mixed.
Embodiment one
As shown in figure 1, a kind of plane passive type micro-mixer, first entrance passage is transversal with the second entrance passage
Face is rectangular, and first entrance passage 1 is vertical with second entrance passage 2, confluxes in the intersection of mixed cell 6, mixing herein
The cavity that unit 6 is surrounded by quadrangle side wall, there is block 8 in mixed cell 6, and mixed cell 6 is separated to form into by block 8
First split channel 3, the second split channel 4 and mixed flow chamber 5, the first split channel 3 and the second split channel 4 and mixed cell 6
Intersection connection, mixed flow chamber 5 connects with the first split channel 3 and the second split channel 4 of adjacent mixed cell.And positioned at mixed
Flow the exit of chamber 5.
The cross section of block 8 herein is right-angled trapezium, and the shape of its mixed flow chamber 5 and block 8 for being separated to form matches,
Mixed flow chamber 5 is a ladder cavity, and the width of mixed flow chamber is gradually broadened by the first split channel to the second split channel.
The shape of block 8 is the same in each mixed cell 6, and its exhaust position and direction in mixed cell
It is identical.
Embodiment two
As shown in Fig. 2 the present embodiment two is substantially similar to be the same as Example one, but from unlike embodiment one, each mixing
The shape for closing block 8 in unit 6 is the same, and mixed cell 6 includes the first mixed cell and second for alternating arrangement
Mixed cell；Block in first mixed cell is different from the set-up mode of the block in second mixed cell.Certainly,
Can be that orientation is random, as long as meeting the mixed flow chamber 5 of mixed cell 6 and the first shunting in adjacent mixed cell 6
Passage 3 is connected with the second split channel 4, and positioned at the exit of mixed cell 6.
Embodiment three
As shown in figure 3, the present embodiment three is substantially similar to be the same as Example one, but from unlike embodiment one, having herein
The cross section of a little blocks 8 is right-angled trapezium, and the cross section of some blocks 8 is square, its mixed flow chamber 5 and block for being separated to form
8 shape matches, and when the cross section of block 8 is right-angled trapezium, mixed flow chamber 5 is a ladder cavity, the width of mixed flow cavity
Degree is gradually broadened by the first split channel to the second split channel.When square is in the cross section of block 8, mixed flow chamber 5 is one
Individual rectangular enclosure, the width of mixed flow cavity 5 is wide.
The shape of block 8 is different in each mixed cell 6, and the cross section of block 8 is in first mixed cell
The cross section of block 8 is right-angled trapezium, the block 8 in remaining mixed cell 6 in right-angled trapezium, second mixed cell 6
Cross section is square.The setting side of block of the block 8 in the first mixed cell and the block in second mixed cell
Formula is different.As long as meeting the 5 of mixed cell 6 with the first split channel 3 in adjacent mixed cell 6 and the second split channel 4 to connect
It is logical.
Example IV
As shown in figure 4, in the present embodiment, block 8 is shaped as trapezoidal or triangle, is provided with wider passage
Baffle plate 9, the baffle plate 9 causes fluid to be stopped in cavity and carries out mixed flow mixing by stopping.
Finally, in addition it is also necessary to explanation, term " wrap and include ", "comprising" or its any other variant are intended to non-row
His property is included, so that process, method, article or equipment including a series of key elements not only include those key elements, and
And also including other key elements being not expressly set out, or also include for this process, method, article or equipment institute inherently
Key element.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation make a distinction with another entity or operation, and not necessarily require or imply these entities or deposited between operating
In any this actual relation or order.Moreover, term " comprising ", "comprising" or its any other variant are intended to
Nonexcludability is included, so that process, method, article or equipment including a series of key elements not only will including those
Element, but also other key elements including being not expressly set out, or also include being this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element limited by sentence "including a ...", it is not excluded that
Also there is other identical element in process, method, article or equipment including the key element.
Described above is only the embodiment of the application, it is noted that for the ordinary skill people of the art
For member, on the premise of the application principle is not departed from, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as the protection domain of the application.
Claims (9)
1. a kind of plane passive type micro-mixer, including access road, exit passageway and positioned at access road and exit passageway
Between at least one mixed cell, it is characterised in that：Each mixed cell includes being used to be shunted liquid respectively
The first split channel and the second split channel；And for by the liquid from the first split channel and the second split channel
Carry out the mixed flow chamber of mixed flow；The first split channel and the second split channel of the mixed flow chamber and adjacent mixed cell connect
It is logical, or connect with exit passageway, described access road including the first entrance passage that is connected respectively with the mixed cell and
Second entrance passage, the width of described first entrance passage is less than the width of described second entrance passage.
2. plane passive type micro-mixer according to claim 1, it is characterised in that：It is provided with the second entrance passage
Slow down the baffle plate of liquid flowing.
3. plane passive type micro-mixer according to claim 1, it is characterised in that：Each mixed cell has respectively
There is a cavity, a block is respectively equipped with each described cavity, the cavity is separated into first shunting by the block
Passage, the second split channel and mixed flow chamber, the mixed flow chamber are formed at the friendship of first split channel and the second split channel
At remittance, and positioned at the outlet port of cavity where it.
4. plane passive type micro-mixer according to claim 3, it is characterised in that：The width of the first described split channel
Degree is different with the width of the second described split channel.
5. plane passive type micro-mixer according to claim 3, it is characterised in that：The first described split channel is in straight
Line passage, the second described split channel is " L " shape passage.
6. plane passive type micro-mixer according to claim 3, it is characterised in that：The width of the mixed flow chamber is by first
Split channel to the second split channel gradually broadens.
7. plane passive type micro-mixer according to claim 3, it is characterised in that：The cross section of the block is right angle
Trapezoidal, rectangle, triangle or its combination.
8. plane passive type micro-mixer according to claim 3, it is characterised in that：Block described in each mixed cell
Set in an identical manner.
9. plane passive type micro-mixer according to claim 3, it is characterised in that：The access road and exit passageway
Between be provided with multiple mixed cells, the plurality of mixed cell includes the first mixed cell for being arranged alternately and the second mixing is single
Member；Block in first mixed cell is different from the set-up mode of the block in second mixed cell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610044013.8A CN105664773B (en) | 2016-01-22 | 2016-01-22 | Plane passive type micro-mixer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610044013.8A CN105664773B (en) | 2016-01-22 | 2016-01-22 | Plane passive type micro-mixer |
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| CN105664773A CN105664773A (en) | 2016-06-15 |
| CN105664773B true CN105664773B (en) | 2017-09-19 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106268471B (en) * | 2016-08-05 | 2019-02-05 | 江苏大学 | A kind of reducing elbow tandem micro-mixer |
| CN106268472B (en) * | 2016-08-26 | 2018-11-20 | 苏州含光微纳科技有限公司 | A kind of inverted V-shaped multistage mixing array structure for passive micro-mixer |
| TWI634320B (en) * | 2017-06-23 | 2018-09-01 | 國立彰化師範大學 | Microchannel reaction tutorial device |
| CN107376750A (en) * | 2017-08-03 | 2017-11-24 | 青岛科技大学 | A kind of micro-fluid chip that can be achieved efficiently to mix |
| CN113663573A (en) * | 2020-05-15 | 2021-11-19 | 斯微(上海)生物科技有限公司 | Mixer for particle generation |
| CN111773987B (en) * | 2020-07-06 | 2021-10-15 | 中南大学 | Passive micro-mixer for chemiluminescence detection and application method thereof |
| CN112206695B (en) * | 2020-09-16 | 2021-11-19 | 复旦大学 | Multi-layer structure micro-channel mixer and fluid mixing method thereof |
| CN112755867B (en) * | 2020-12-17 | 2022-09-06 | 广东省医疗器械研究所 | Micro-mixing chip and micro-mixing device |
| CN114053920B (en) * | 2021-11-17 | 2023-03-14 | 锦州镁赫化学科技有限公司 | Micro mixer |
| JP2024042541A (en) * | 2022-09-15 | 2024-03-28 | 株式会社東芝 | Flow channel structure and method for producing lipid particles |
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| CN201959734U (en) * | 2011-02-28 | 2011-09-07 | 北京工业大学 | Micro-mixer adopting asymmetric separating reconstructing fan-shaped cavity structure |
| CN104138728A (en) * | 2014-04-17 | 2014-11-12 | 西北工业大学 | Split and recombined passive micromixer with bridge-type structure |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4792664B2 (en) * | 2001-06-15 | 2011-10-12 | コニカミノルタホールディングス株式会社 | Mixing method, mixing mechanism, micromixer and microchip having the mixing mechanism |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201959734U (en) * | 2011-02-28 | 2011-09-07 | 北京工业大学 | Micro-mixer adopting asymmetric separating reconstructing fan-shaped cavity structure |
| CN104138728A (en) * | 2014-04-17 | 2014-11-12 | 西北工业大学 | Split and recombined passive micromixer with bridge-type structure |
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Address after: 215000 No. 128, Fang Zhou road, Suzhou Industrial Park, Jiangsu, China Patentee after: SUZHOU WENHAO MICROFLUIDIC TECHNOLOGY Co.,Ltd. Address before: 215808 No. 128, Fang Zhou road, Suzhou Industrial Park, Jiangsu, China Patentee before: SUZHOU WENHAO CHIP TECHNOLOGY Co.,Ltd. |