CN107376750A - A kind of micro-fluid chip that can be achieved efficiently to mix - Google Patents
A kind of micro-fluid chip that can be achieved efficiently to mix Download PDFInfo
- Publication number
- CN107376750A CN107376750A CN201710655158.6A CN201710655158A CN107376750A CN 107376750 A CN107376750 A CN 107376750A CN 201710655158 A CN201710655158 A CN 201710655158A CN 107376750 A CN107376750 A CN 107376750A
- Authority
- CN
- China
- Prior art keywords
- fluid
- substrate
- passage
- micro
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000012530 fluid Substances 0.000 title claims abstract description 77
- 239000000758 substrate Substances 0.000 claims abstract description 42
- 239000011521 glass Substances 0.000 claims abstract description 8
- 239000005357 flat glass Substances 0.000 abstract description 6
- 239000007788 liquid Substances 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000005259 measurement Methods 0.000 abstract description 2
- 239000011259 mixed solution Substances 0.000 abstract description 2
- 238000013461 design Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
Abstract
A kind of micro-fluid chip that can be achieved efficiently to mix, including substrate, the upper glass plate being covered in above and below substrate, lower sheet glass, the substrate are provided with the passage of different geometries, and the passage includes access road, straight channel and exit passageway；The passage is evenly distributed on substrate.The beneficial effects of the invention are as follows micro-fluid chip uniform force is advantageous to, improves substrate service life and reduce the measurement error caused by substrate deformation；Efficient, the quick mixing of different component liquid can be achieved, obtain well mixed solution.
Description
Technical field
It is more particularly to a kind of to can be achieved the invention belongs to the hybrid technology field of macromolecule, biofluid under minute yardstick
The micro-fluid chip efficiently mixed.
Background technology
At present, although traditional microfluidic chip is widely used, most of microflow controlled biochip and MEMS
(MEMS) field such as biology and medical research and the control of chip lab (Lab-on-chip) is had been used to.It is but most
The conveying and control of one-component microfluid are only used for, mixing efficiency is still had with the mixing of upper fluid for two kinds of components
It is low, the shortcomings that time is long, the needs that a variety of microfluids of scientific experiment requirement quickly mix can not be met.
In Chinese patent literature, Publication No. CN102527280A, entitled " a kind of microring array and micro- reaction dress
Put " patent of invention disclose a kind of technical scheme, including micro-fluidic chip, by the polydimethylsiloxane thin layer for being carved with microchannel
It is bonded and forms with sheet glass, and chip gripper, for clamping the micro-fluidic chip, the fluid channel is led to including two solution inlets
Road and a taphole passage, every passage are formed by a fat pipe and a narrow passage through connection, and three narrow passages are equal
With a hybrid chamber through connection so that three passages are interconnected.Although above-mentioned technical proposal realizes two or more components
Microring array, but exist and mix uneven, incorporation time length, the shortcomings of mixing quality difference.
The content of the invention
In order to solve the above-mentioned technical problem, the present invention provides a kind of micro-fluid chip that can be achieved efficiently to mix, it is therefore an objective to
Meet the well-mixed requirement of multicomponent polymeric fluid, improve mixing quality.
To reach above-mentioned purpose, technical scheme is as follows：
A kind of micro-fluid chip that can be achieved efficiently to mix, including substrate, the upper glass plate being covered in above and below substrate, lower glass
Glass piece, the substrate are provided with the passage of different geometries, and the passage includes access road, straight channel and exit passageway；
The passage is evenly distributed on substrate.
Compared to the prior art, the design that this programme is fully efficiently mixed based on multicomponent fluid, there is provided microfluid core
The passage of plate base, include the passage for the different geometries being evenly distributed on substrate.Passage, which is uniformly arranged on substrate, to be had
Beneficial to micro-fluid chip uniform force, improve substrate service life and reduce the measurement error caused by substrate deformation.It is different
The passage of geometry can realize efficient, the quick mixing of different component liquid, obtain well mixed solution.
Based on such scheme, the present invention is also made that following improvement：
One end is provided with circular arc passage, the access road as fluid A on the substrate；The circular arc passage is radially outwardly extending
Access road of the place provided with fluid B, fluid A, channel B form crown shapes.Pass through circular arc passage and circular arc in this improvement project
The design of outer extension passage, realize that fluid B cuts off to form droplet liquid by fluid A when entering circular arc passage along circular arc tangential line, enter
Enter both straight channels further to be mixed again；Fluid A viscosity is generally greater than fluid B viscosity, the higher fluid of viscosity
It is preferable to the shearing dynamics of the relatively low fluid of viscosity, improve mixing efficiency.
The straight channel leading portion is embedded with insert at access road, straight channel posterior segment to be opened up along substrate axis,
Equally distributed concavo-convex concavo-convex passage staggeredly.Using the effect of insert and concavo-convex turning channel to mixed liquor in this improvement project
Body carries out fully efficient mixing.
The access road is on substrate formed symmetrical, or positioned at the side of substrate；According to fluid pressure in this improvement project
Power determines the shape of access road, if combined amount can be significantly reduced because caused by Fluid pressure using runner symmetrical structure more
Internal stress.And combined amount hour pressure is small, using only side unsymmetric structure when internal stress also can less meet to require.
The radially outwardly extending place of circular arc passage is provided with fluid C access road, and fluid B, C-channel are adjacent, fluid A channel
Crown shapes are formed with fluid B, C-channel.This improvement project is designed for the liquid of two or more components, and fluid A can be with
The shearing of convection body B, C is realized, realizes preliminary mixing.
Fluid B inlet passage axis and straight channel axis angle β scopes are 15 ゜ -75 ゜.
The angle α scope of circular arc passage and straight channel is 100 ° of -150 ゜.
The beneficial effects of the invention are as follows the passage of a variety of particular geometry structures, for controlling plurality of liquid component to import
To main channel, and realize cutting, formation, conveying and the mixing of microlayer model；Achievable multicomponent fluid fully efficiently mixes,
Flowing and the mixing situation of microfluid can be further observed by light microscope.
Brief description of the drawings
, below will be to embodiment or existing in order to illustrate more clearly of inventive embodiments or technical scheme of the prior art
The required accompanying drawing used is briefly described in technology description.
Fig. 1 is the top view of the micro-fluid chip of the embodiment of the present invention 1；
Fig. 2 is the A-A sectional views of the micro-fluid chip of the embodiment of the present invention 1；
Fig. 3 is the top view of the micro-fluid chip of the embodiment of the present invention 2；
Fig. 4 is the top view of the micro-fluid chip of the embodiment of the present invention 3；
Fig. 5 is the top view of the micro-fluid chip of the embodiment of the present invention 4；
In figure, 1, substrate；2nd, upper glass plate；3rd, lower sheet glass；4th, access road；5th, straight channel；6th, exit passageway；40-
1st, 40-2, Fluid A Inlet passage；41-1,41-2, Fluid B inlet passage；42-1,42-2, Fluid C Inlet passage；50th, insert；
51st, concavo-convex passage.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes.
Embodiment 1
As shown in Figure 1, 2, it is a kind of to can be achieved the micro-fluid chip that efficiently mixes, including substrate 1, be covered in above and below substrate
Upper glass plate 2, lower sheet glass 3, the substrate 1 be provided with different geometries passage, the passage include access road 4,
Straight channel 5 and exit passageway 6；The passage is uniformly distributed on substrate 1.The entrance logical 4 is on the formed symmetrical of substrate 1, institute
State one end on substrate 1 and be provided with circular arc passage, access road 40-1,40-2 as fluid A；The circular arc passage is radially outwardly extending
Place access road 41-1,41-2 provided with fluid B, fluid A, channel B form crown shapes.The leading portion of straight channel 5 close to enter
Insert 50 is embedded with mouth passage, the posterior segment of straight channel 5 is opens up along substrate axis, equally distributed concavo-convex bumps staggeredly are led to
Road 51；The quantity of insert 50 can select according to specific needs.Fluid B inlet passage axis is with straight channel axis angle β scopes
15゜-75゜.The width range of circular arc passage is 50-200 microns.
Embodiment 2
As shown in figure 3, it is that the radially outwardly extending place of circular arc passage is additionally provided with fluid C entrance and led to the difference of embodiment 1
Road 42-1,42-2, fluid B, C-channel are adjacent, and Fluid C Inlet passage is adjacent with straight channel 5, fluid A channel and fluid B, C-channel
Form crown shapes.Fluid B inlet passage axis and straight channel axis angle β scopes are 15 ゜ -75 ゜, and Fluid C Inlet passage leans on
The nearly side of straight channel and the included angle scope of straight channel axis are 10 ゜ -35 ゜.Runner B, C are adjacent in the present embodiment, runner B, C
It can be connected by circular arc passage, the two position is also interchangeable, and layout type is not limited to the present embodiment.
Embodiment 3
Can be achieved the micro-fluid chip that efficiently mixes as shown in figure 4, a kind of, including substrate 1, be covered in it is upper above and below substrate
Sheet glass 2, lower sheet glass 3, the substrate 1 are provided with the passage of different geometries, and the passage includes access road 4, straight
Passage 5 and exit passageway 6；The passage is uniformly distributed on substrate 1.The entrance logical 4 is located at the side of substrate, the substrate
One end is provided with circular arc passage, the access road 40-1 as fluid A on 1；The radially outwardly extending place of circular arc passage is provided with fluid B
Access road 41-1, fluid A, channel B form half of crown shapes.Circular arc passage inner side edge is the small side of radius with leading directly to
Road meet is circular arc tangential line rather than circular arc.The leading portion of straight channel 5 is embedded with insert 50 at access road, in straight channel 5
Back segment is opens up along substrate axis, equally distributed concavo-convex concavo-convex passage 51 staggeredly；The quantity of insert 50 can be according to specific
Need to select.Fluid B inlet passage axis and straight channel axis angle β scopes are 15 ゜ -75 ゜, and the width range of circular arc passage is
The angle α scope of 50-200 microns, circular arc passage inner side edge and straight channel is 100 ° of -150 ゜
Embodiment 4
As shown in figure 5, it is that the radially outwardly extending place of circular arc passage is additionally provided with entering for fluid C with the difference of embodiment 3
Mouth passage 42-1,42-2, fluid B, C-channel are adjacent, and Fluid C Inlet 42-1 is adjacent with straight channel 5, fluid A channel and fluid B, C
Passage forms half of crown shapes.Fluid B inlet passage axis and straight channel axis angle β scopes are 15 ゜ -75 ゜, and fluid C enters
Mouth passage is 10 ゜ -35 ゜ close to the included angle scope of the side of straight channel and straight channel axis.Runner B, C are adjacent in the present embodiment,
Runner B, C can be also connected by circular arc passage, and the two position is also interchangeable, and layout type is not limited to the present embodiment.
Claims (7)
1. a kind of micro-fluid chip that can be achieved efficiently to mix, including substrate, the upper glass plate being covered in above and below substrate, lower glass
Piece, it is characterised in that：The substrate be provided with different geometries passage, the passage include access road, straight channel and
Exit passageway；The passage is evenly distributed on substrate.
2. micro-fluid chip according to claim 1, it is characterised in that：One end is provided with circular arc passage on the substrate, makees
For fluid A access road；The radially outwardly extending place of circular arc passage is provided with fluid B access road, and fluid A, channel B are formed
Crown shapes.
3. micro-fluid chip according to claim 1, it is characterised in that：The straight channel leading portion is embedding at access road
There is insert, straight channel posterior segment is opens up along substrate axis, equally distributed concavo-convex concavo-convex passage staggeredly.
4. micro-fluid chip according to claim 2, it is characterised in that：The access road on substrate formed symmetrical,
Or positioned at the side of substrate.
5. the micro-fluid chip according to claim 2 or 4, it is characterised in that：The radially outwardly extending place of circular arc passage is set
There is fluid C access road, fluid B, C-channel are adjacent, and fluid A channel forms crown shapes with fluid B, C-channel.
6. micro-fluid chip according to claim 2, it is characterised in that：Fluid B inlet passage axis and straight channel axis
Angle β scopes are 15 ゜ -75 ゜.
7. micro-fluid chip according to claim 4, it is characterised in that：When access road is located at substrate side, circular arc leads to
The angle α scope of road and straight channel is 100 ° of -150 ゜.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710655158.6A CN107376750A (en) | 2017-08-03 | 2017-08-03 | A kind of micro-fluid chip that can be achieved efficiently to mix |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710655158.6A CN107376750A (en) | 2017-08-03 | 2017-08-03 | A kind of micro-fluid chip that can be achieved efficiently to mix |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107376750A true CN107376750A (en) | 2017-11-24 |
Family
ID=60344314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710655158.6A Pending CN107376750A (en) | 2017-08-03 | 2017-08-03 | A kind of micro-fluid chip that can be achieved efficiently to mix |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107376750A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108654490A (en) * | 2018-05-31 | 2018-10-16 | 沈阳工业大学 | One kind being based on chaotic flow microring array chip |
| CN111974290A (en) * | 2020-08-31 | 2020-11-24 | 南京航空航天大学 | Taiji-shaped passive micro mixer |
| WO2021077184A1 (en) * | 2019-10-22 | 2021-04-29 | Instituto De Pesquisas Tecnológicas Do Estado De São Paulo S.A. - Ipt | Microfluidic multiprocessor device and use thereof |
| CN113663573A (en) * | 2020-05-15 | 2021-11-19 | 斯微(上海)生物科技有限公司 | Mixer for particle generation |
| CN113842824A (en) * | 2021-10-15 | 2021-12-28 | 西安交通大学 | Passive micro mixer based on composite side wall microstructure enhanced mixing efficiency |
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Application publication date: 20171124 |