CN112741783A - Tablet cosmetic containing ayorelin compound peptide and preparation method thereof - Google Patents
Tablet cosmetic containing ayorelin compound peptide and preparation method thereof Download PDFInfo
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- CN112741783A CN112741783A CN201911054023.XA CN201911054023A CN112741783A CN 112741783 A CN112741783 A CN 112741783A CN 201911054023 A CN201911054023 A CN 201911054023A CN 112741783 A CN112741783 A CN 112741783A
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- archipellin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a tablet cosmetic containing an archipellin composite peptide and a preparation method thereof. Specifically, the tablet cosmetic comprises the active ingredient consisting of the archipellin and the cosmetic peptide with synergistic effect with the archipellin, and a cosmetic matrix. The active components of various polypeptides in the tablet cosmetic can play a synergistic role, thereby achieving the best effects of removing wrinkles and delaying senility. In addition, the tablet cosmetic containing the archipellin composite peptide disclosed by the invention can be directly dissolved in pure water for use, has the characteristics of high dissolving speed and convenience in carrying, and meanwhile, has strong affinity to the skin of a human body and promotes the absorption of active ingredients.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a tablet cosmetic containing an archipelene composite peptide and a preparation method thereof.
Background
As the skin becomes aged, the metabolism of the skin is slowed down and a series of biochemical, histological and physiological changes are generated, and various skin problems are accompanied. One of the most obvious changes is increased wrinkles. Wrinkles are mainly formed by the destruction of collagen and active substances in cell membranes and the oxidation of cells. With the decrease of collagen content in skin, there are also problems of fiber breakage, lipoatrophy, decreased secretion of sweat and sebaceous glands, and the like. With the improvement of living standard of people, more and more people begin to pay attention to skin care, so that it becomes important to find products which have better and safer wrinkle removing and aging delaying effects.
The achirelin is a neurotransmitter inhibiting peptide, has a structure similar to that of SNAP-25, participates in competition for SNAP-25 at a site of a vacuole complex, so that the formation of SNARE is inhibited, the nerve transmission muscle contraction information can be locally blocked, the skin sac nerve conduction is influenced, the muscle can not effectively receive the neurotransmitter, the muscle contraction is weakened, and the aim of smoothing dynamic lines, static lines and fine lines is fulfilled; effectively reorganizes the elasticity of collagen, can increase the activity of elastin, relaxes the lines of the face, and smoothes wrinkles and improves laxity. As an anti-wrinkle component, it is excellent in effect. The wrinkle-removing effect of the achillene can be compared with that of a botulinum toxin type A product on the market, but the achillene is higher in safety, and side effects of pain, erythema, edema, toxin diffusion and the like caused by using the botulinum toxin type A product are avoided, so that the achillene can be used as an active raw material of wrinkle-removing cosmetics.
However, although there are many wrinkle-removing products sold in the market at present, many products usually only contain single polypeptide, and although the effect can also be achieved, the effect needs to be improved, and with the increasing demand of people for the efficacy of cosmetics, the problem that the development of cosmetics which simultaneously act on key sites of multiple ways to repair skin problems and promote the absorption of active ingredients by exerting the synergistic effect of multiple ways among active substances so as to achieve the optimal wrinkle-removing effect is urgently needed to be solved. In addition, because people need to carry cosmetics when going out, wrinkle-removing products in the market are mostly liquid and paste, and are inconvenient to carry, so that the problem that how to make wrinkle-removing products convenient to carry is needed to be solved.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a tablet cosmetic containing the complex peptide of the archipelene and a preparation method thereof. The active components of various polypeptides in the tablet cosmetic can play a synergistic role, thereby achieving the best effects of removing wrinkles and delaying senility. In addition, the tablet cosmetic containing the complex peptide of the ayurrelin disclosed by the invention can be directly dissolved in pure water for use, has the characteristics of high dissolving speed and convenience in carrying, and meanwhile has strong affinity to the skin of a human body and promotes the absorption of active ingredients.
The invention provides a tablet cosmetic containing an archipellin composite peptide, which is characterized by comprising the following components: the cosmetic composition comprises the active ingredients and the cosmetic matrix, wherein the active ingredients consist of the archipellin and the cosmetic peptide with the synergistic effect with the archipellin.
The active ingredients of the tablet cosmetic containing the complex peptide of the achillea are one or more of the achillea, dipeptide-2, palmitoyl hexapeptide-6 and Syn-Hycan.
The tablet cosmetic containing the archipelene composite peptide has the advantages that the mass percentage of the composite peptide active ingredients in the tablet cosmetic is 0.03-1%.
Preferably, the active ingredients of the mixture of the archipellin, the Syn-Hycan and the dipeptide-2 comprise the components in percentage by weight: Syn-Hycan: dipeptide-2 ═ 40% to 50%: 25% -30%: 25% -30%;
preferably, the active ingredients of the mixture of the archipellin, the Syn-Hycan and the palmitoyl hexapeptide-6 comprise the following components in percentage by weight: Syn-Hycan: palmitoyl hexapeptide-6 is 40% -50%: 25% -30%: 25% -30%;
preferably, the active ingredients are a mixture of the archipellin, Syn-Hycan, palmitoyl hexapeptide-6 and dipeptide-2, and the weight percentages of the components are archipellin: Syn-Hycan: palmitoyl hexapeptide-6: dipeptide-2 ═ 40% to 45%: 15% -20%: 15% -20%: 15 to 20 percent.
The tablet cosmetic containing the archipellin composite peptide comprises a cosmetic matrix including sodium carboxymethylcellulose, PEG-4000, sodium hyaluronate, aloe, calcium carboxymethylcellulose and mannitol.
The tablet cosmetic containing the complex peptide of the achillea is prepared by the following steps: weighing the components according to the prescription amount, sieving, selecting particles with proper sizes, and uniformly mixing the particles. And (4) placing the mixed granules into a high-efficiency tabletting device for tabletting. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Drawings
FIG. 1 shows the reduction ratio (%) of wrinkle area.
The specific implementation mode is as follows:
embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention.
Example 1
Weighing the prescribed amount of each component material
Sieving with 60 mesh, 100 mesh, 150 mesh and 200 mesh sieve in sequence, selecting 150 mesh to 60 mesh granules, and mixing the granules uniformly. And tabletting the mixed granules in a high-efficiency tabletting device. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Example 2
Weighing the prescribed amount of each component material
Sieving with 60 mesh, 100 mesh, 150 mesh and 200 mesh sieve in sequence, selecting 150 mesh to 60 mesh granules, and mixing the granules uniformly. And tabletting the mixed granules in a high-efficiency tabletting device. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Example 3
Weighing the prescribed amount of each component material
Sieving with 60 mesh, 100 mesh, 150 mesh and 200 mesh sieve in sequence, selecting 150 mesh to 60 mesh granules, and mixing the granules uniformly. And tabletting the mixed granules in a high-efficiency tabletting device. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Example 4
Weighing the prescribed amount of each component material
Sieving with 60 mesh, 100 mesh, 150 mesh and 200 mesh sieve in sequence, selecting 150 mesh to 60 mesh granules, and mixing the granules uniformly. And tabletting the mixed granules in a high-efficiency tabletting device. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Example 5
Weighing the prescribed amount of each component material
Sieving with 60 mesh, 100 mesh, 150 mesh and 200 mesh sieve in sequence, selecting 150 mesh to 60 mesh granules, and mixing the granules uniformly. And tabletting the mixed granules in a high-efficiency tabletting device. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Example 6
Weighing the prescribed amount of each component material
Sieving with 60 mesh, 100 mesh, 150 mesh and 200 mesh sieve in sequence, selecting 150 mesh to 60 mesh granules, and mixing the granules uniformly. And tabletting the mixed granules in a high-efficiency tabletting device. The weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Example 7 wrinkle removal performance test of the prepared tablet cosmetic containing the archipellin complex peptide.
120 healthy female volunteers were randomly selected and aged between 18 and 55 years. To evaluate examples 1-6, volunteers were randomized into 7 groups of 30 persons each. Six of the volunteers cleaned the facial skin, dried, dissolved the cosmetics of examples 1-6 in pure water, and applied the dissolved liquid cosmetics to the experimental area of the face with the hands. Another group of control groups applied a cosmetic containing only archipelene to the experimental area of the face, once in the morning and once in the evening, and tested the wrinkle area (%) of the experimental area before use and after 90 consecutive days, as shown in table 1. The reduction ratio (%) of the wrinkle area was calculated as shown in fig. 1.
TABLE 1 wrinkle area before and after use
| Example 1 | Before use | 10.15 |
| Day 90 | 6.67 | |
| Example 2 | Before use | 9.68 |
| Day 90 | 6.37 | |
| Example 3 | Before use | 10.21 |
| Day 90 | 6.46 | |
| Example 4 | Before use | 10.38 |
| Day 90 | 6.43 | |
| Example 5 | Before use | 9.78 |
| Day 90 | 6.06 | |
| Example 6 | Before use | 10.13 |
| Day 90 | 6.07 | |
| Control group | Before use | 10.45 |
| Day 90 | 7.76 |
Claims (8)
1. A tablet cosmetic containing an archipellin composite peptide is characterized by comprising the following components: the cosmetic composition comprises the active ingredients and the cosmetic matrix, wherein the active ingredients consist of the archipellin and the cosmetic peptide with the synergistic effect with the archipellin.
2. The tablet cosmetic containing the complex peptide of ayorelin according to claim 1, wherein the cosmetic peptide having a synergistic effect with ayorelin is one or more of dipeptide-2, palmitoyl hexapeptide-6, Syn-Hycan.
3. The tablet cosmetic containing the complex peptide of ayorelin according to claim 1, characterized in that the active ingredient thereof is contained in an amount of 0.03 to 1% by mass of the tablet cosmetic.
4. The tablet cosmetic containing the complex peptide of archipellin according to claim 1, characterized in that the active ingredients are a mixture of archipellin, Syn-Hycan, dipeptide-2, the weight percentages of the ingredients are archipellin: Syn-Hycan: dipeptide-2 ═ 40% to 50%: 25% -30%: 25 to 30 percent.
5. The tablet cosmetic containing the complex peptide of the archipellin according to claim 1, characterized in that the active ingredients are a mixture of archipellin, Syn-Hycan, palmitoyl hexapeptide-6, and the weight percentages of the ingredients are archipellin: Syn-Hycan: palmitoyl hexapeptide-6 is 40% -50%: 25% -30%: 25 to 30 percent.
6. The tablet cosmetic containing the complex peptide of the archipellin according to claim 1, characterized in that the active ingredients are a mixture of archipellin, Syn-Hycan, palmitoyl hexapeptide-6, dipeptide-2, and the weight percentages of the ingredients are archipellin: Syn-Hycan: palmitoyl hexapeptide-6: dipeptide-2 ═ 40% to 45%: 15% -20%: 15% -20%: 15 to 20 percent.
7. The tablet cosmetic containing the archipellin complex peptide as claimed in claim 1, wherein the cosmetic base comprises sodium carboxymethylcellulose, PEG-4000, sodium hyaluronate, aloe, calcium carboxymethylcellulose, mannitol.
8. A method for preparing the tablet cosmetic containing the complex peptide of archipellin of claim 1, characterized in that: weighing the components according to the prescription amount, sieving, selecting particles with proper sizes, and uniformly mixing the particles; placing the mixed granules in a high-efficiency tabletting device, and tabletting; the weight of the tablet cosmetic containing the complex peptide of the archipelene is kept between 160mg and 180 mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911054023.XA CN112741783A (en) | 2019-10-31 | 2019-10-31 | Tablet cosmetic containing ayorelin compound peptide and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911054023.XA CN112741783A (en) | 2019-10-31 | 2019-10-31 | Tablet cosmetic containing ayorelin compound peptide and preparation method thereof |
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| Publication Number | Publication Date |
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| CN112741783A true CN112741783A (en) | 2021-05-04 |
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| CN201911054023.XA Pending CN112741783A (en) | 2019-10-31 | 2019-10-31 | Tablet cosmetic containing ayorelin compound peptide and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110020415A1 (en) * | 2009-07-27 | 2011-01-27 | Audrey Kunin | Composition for treatment of hyperhidrosis |
| US20150157728A1 (en) * | 2008-05-23 | 2015-06-11 | Pankaj Modi | Stabilized and solubilized drug formulation for topical application and transdermal efficacy for cosmetic improvement and methods of formulation |
| CN105380808A (en) * | 2015-11-25 | 2016-03-09 | 陕西艾美雅生物科技有限公司 | Cosmetic substrate, and preparation method and using method thereof |
| CN108158910A (en) * | 2018-03-13 | 2018-06-15 | 艾因特丽（苏州）生物科技有限公司 | A kind of polypeptide compound formulation with senile-resistant efficacy and its preparation method and application |
| CN108852894A (en) * | 2018-06-13 | 2018-11-23 | 浙江湃肽生物有限公司 | It is a kind of for repairing the polypeptides in combination of whitening wrinkle-removing |
| CN109998956A (en) * | 2019-04-15 | 2019-07-12 | 西安尹千容生物科技有限责任公司 | Solid, cosmetic matrix and preparation method thereof |
-
2019
- 2019-10-31 CN CN201911054023.XA patent/CN112741783A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150157728A1 (en) * | 2008-05-23 | 2015-06-11 | Pankaj Modi | Stabilized and solubilized drug formulation for topical application and transdermal efficacy for cosmetic improvement and methods of formulation |
| US20110020415A1 (en) * | 2009-07-27 | 2011-01-27 | Audrey Kunin | Composition for treatment of hyperhidrosis |
| CN105380808A (en) * | 2015-11-25 | 2016-03-09 | 陕西艾美雅生物科技有限公司 | Cosmetic substrate, and preparation method and using method thereof |
| CN108158910A (en) * | 2018-03-13 | 2018-06-15 | 艾因特丽（苏州）生物科技有限公司 | A kind of polypeptide compound formulation with senile-resistant efficacy and its preparation method and application |
| CN108852894A (en) * | 2018-06-13 | 2018-11-23 | 浙江湃肽生物有限公司 | It is a kind of for repairing the polypeptides in combination of whitening wrinkle-removing |
| CN109998956A (en) * | 2019-04-15 | 2019-07-12 | 西安尹千容生物科技有限责任公司 | Solid, cosmetic matrix and preparation method thereof |
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