CN112714769A - Ror-1特异性嵌合抗原受体及其用途 - Google Patents
Ror-1特异性嵌合抗原受体及其用途 Download PDFInfo
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- CN112714769A CN112714769A CN201980059126.7A CN201980059126A CN112714769A CN 112714769 A CN112714769 A CN 112714769A CN 201980059126 A CN201980059126 A CN 201980059126A CN 112714769 A CN112714769 A CN 112714769A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
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- Chemical & Material Sciences (AREA)
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- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696075P | 2018-07-10 | 2018-07-10 | |
| US62/696,075 | 2018-07-10 | ||
| PCT/US2019/041213 WO2020014366A1 (en) | 2018-07-10 | 2019-07-10 | Ror-1 specific chimeric antigen receptors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112714769A true CN112714769A (zh) | 2021-04-27 |
Family
ID=69141807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980059126.7A Pending CN112714769A (zh) | 2018-07-10 | 2019-07-10 | Ror-1特异性嵌合抗原受体及其用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12275772B2 (enExample) |
| EP (1) | EP3820484A4 (enExample) |
| JP (2) | JP2021530217A (enExample) |
| KR (1) | KR20210043562A (enExample) |
| CN (1) | CN112714769A (enExample) |
| AU (1) | AU2019301147A1 (enExample) |
| CA (1) | CA3105816A1 (enExample) |
| IL (1) | IL280029A (enExample) |
| SG (1) | SG11202100205UA (enExample) |
| WO (1) | WO2020014366A1 (enExample) |
| ZA (1) | ZA202100391B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116284246A (zh) * | 2022-12-12 | 2023-06-23 | 江苏三联生物工程股份有限公司 | 信号肽、核酸片段、重组表达载体、宿主细胞及其应用 |
| CN119233991A (zh) * | 2022-05-24 | 2024-12-31 | 卡里布生物科学公司 | 抗ror1抗体和ror1靶向性经工程化的细胞 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| JP2021500882A (ja) * | 2017-10-18 | 2021-01-14 | プレシゲン,インコーポレイテッド | スペーサーを含むポリペプチド組成物 |
| AU2019301147A1 (en) | 2018-07-10 | 2021-01-21 | Precigen, Inc. | ROR-1 specific chimeric antigen receptors and uses thereof |
| JP7632868B2 (ja) * | 2018-10-26 | 2025-02-19 | 国立大学法人信州大学 | 高効率な遺伝子改変細胞の作製方法 |
| EP4028413A1 (en) | 2019-09-10 | 2022-07-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| WO2021189008A1 (en) | 2020-03-20 | 2021-09-23 | Lyell Immunopharma, Inc. | Novel recombinant cell surface markers |
| WO2021191870A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| CN113584083A (zh) * | 2020-04-30 | 2021-11-02 | 深圳市深研生物科技有限公司 | 用于逆转录病毒载体的生产细胞和包装细胞及其制备方法 |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| EP4240405A1 (en) | 2020-11-05 | 2023-09-13 | Mendus B.V. | Use of tumor-independent antigens in immunotherapies |
| WO2022143928A1 (zh) * | 2020-12-31 | 2022-07-07 | 亘喜生物科技(上海)有限公司 | 膜融合蛋白及其在免疫细胞中的应用 |
| CA3204211A1 (en) * | 2021-01-11 | 2022-07-14 | Helen SABZEVARI | Chimeric receptor therapy |
| KR20230135075A (ko) | 2021-01-22 | 2023-09-22 | 멘두스 비.브이. | 종양 백신접종 방법 |
| AU2022212307A1 (en) * | 2021-02-01 | 2023-08-17 | The Regents Of The University Of California | Treatment of neuroendocrine cancers |
| WO2022182891A1 (en) | 2021-02-25 | 2022-09-01 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| JP2024508597A (ja) * | 2021-03-09 | 2024-02-28 | 四川科倫博泰生物医薬股▲フン▼有限公司 | Ror1結合タンパク質及びその用途 |
| IL310901A (en) * | 2021-08-18 | 2024-04-01 | Univ Pennsylvania | Compositions and methods for chimeric antigen receptors specific to b cell receptors |
| JP2024540099A (ja) | 2021-10-28 | 2024-10-31 | ライエル・イミュノファーマ・インコーポレイテッド | Ror1結合タンパク質を発現する細胞を培養する方法 |
| WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| CN118206620A (zh) * | 2022-12-09 | 2024-06-18 | 上海细胞治疗集团股份有限公司 | 一种多肽标签及其应用 |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025194140A1 (en) * | 2024-03-15 | 2025-09-18 | Port Therapeutics, Inc. | Thermally controlled gene expression and uses thereof |
| WO2025217398A1 (en) | 2024-04-10 | 2025-10-16 | Lyell Immunopharma, Inc. | Methods for culturing cells with improved culture medium |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
Citations (2)
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| CN106922148A (zh) * | 2014-07-29 | 2017-07-04 | 瑟勒提斯公司 | 用于癌症免疫疗法的ror1(ntrkr1)特异性的嵌合抗原受体 |
| CN107428833A (zh) * | 2015-01-16 | 2017-12-01 | 朱诺治疗学股份有限公司 | Ror1特异性抗体和嵌合抗原受体 |
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| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
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| CA2296093A1 (en) | 1997-07-10 | 1999-01-21 | The Salk Institute For Biological Studies | Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression |
| US6333318B1 (en) | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
| WO2011159847A2 (en) * | 2010-06-15 | 2011-12-22 | The Regents Of The University Of California | Receptor tyrosine kinase-like orphan receptor 1 (ror1) single chain fv antibody fragment conjugates and methods of use thereof |
| EP3828205A1 (en) * | 2010-10-01 | 2021-06-02 | Oxford BioTherapeutics Ltd | Anti-ror1 antibodies |
| WO2012097313A2 (en) * | 2011-01-14 | 2012-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| WO2012122025A2 (en) * | 2011-03-04 | 2012-09-13 | Intrexon Corporation | Vectors conditionally expressing protein |
| KR102086874B1 (ko) * | 2012-04-11 | 2020-03-10 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 |
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| EP2997134B1 (en) | 2013-05-14 | 2020-06-24 | Board of Regents, The University of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| US20160311879A1 (en) | 2013-12-18 | 2016-10-27 | Intrexon Corporation | Single chain il-12 nucleic acids, polypeptides, and uses thereof |
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| JP2018521004A (ja) * | 2015-05-18 | 2018-08-02 | ユーリカ セラピューティックス, インコーポレイテッド | 抗ror1キメラ抗原受容体 |
| WO2017062953A1 (en) | 2015-10-10 | 2017-04-13 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| EP4094780A3 (en) | 2016-02-12 | 2023-02-08 | University of Massachusetts | Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization |
| AU2017244108B2 (en) * | 2016-03-29 | 2021-03-18 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| AU2017279548B2 (en) * | 2016-06-08 | 2024-08-08 | Precigen, Inc. | CD33 specific chimeric antigen receptors |
| EP3548047A4 (en) * | 2016-11-30 | 2020-07-01 | Intrexon Corporation | ADMINISTRATION OF STEROIDS AND IMMUNOTHERAPY |
| EP3551197B1 (en) * | 2016-12-12 | 2023-11-22 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| SG11201906213UA (en) * | 2017-01-10 | 2019-08-27 | Intrexon Corp | Modulating expression of polypeptides via new gene switch expression systems |
| US11118168B2 (en) | 2017-06-07 | 2021-09-14 | Precigen, Inc. | Expression of novel cell tags |
| JP2021500882A (ja) | 2017-10-18 | 2021-01-14 | プレシゲン,インコーポレイテッド | スペーサーを含むポリペプチド組成物 |
| AU2019244479B2 (en) | 2018-03-30 | 2024-12-19 | Les Hopitaux Universitaires De Geneve | Micro RNA expression constructs and uses thereof |
| AU2019301147A1 (en) | 2018-07-10 | 2021-01-21 | Precigen, Inc. | ROR-1 specific chimeric antigen receptors and uses thereof |
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2019
- 2019-07-10 AU AU2019301147A patent/AU2019301147A1/en active Pending
- 2019-07-10 EP EP19833113.4A patent/EP3820484A4/en active Pending
- 2019-07-10 CN CN201980059126.7A patent/CN112714769A/zh active Pending
- 2019-07-10 WO PCT/US2019/041213 patent/WO2020014366A1/en not_active Ceased
- 2019-07-10 KR KR1020217002650A patent/KR20210043562A/ko active Pending
- 2019-07-10 CA CA3105816A patent/CA3105816A1/en active Pending
- 2019-07-10 JP JP2021500519A patent/JP2021530217A/ja active Pending
- 2019-07-10 SG SG11202100205UA patent/SG11202100205UA/en unknown
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2021
- 2021-01-07 IL IL280029A patent/IL280029A/en unknown
- 2021-01-07 US US17/143,386 patent/US12275772B2/en active Active
- 2021-01-19 ZA ZA2021/00391A patent/ZA202100391B/en unknown
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2024
- 2024-02-16 JP JP2024022330A patent/JP2024073449A/ja active Pending
Patent Citations (2)
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| CN106922148A (zh) * | 2014-07-29 | 2017-07-04 | 瑟勒提斯公司 | 用于癌症免疫疗法的ror1(ntrkr1)特异性的嵌合抗原受体 |
| CN107428833A (zh) * | 2015-01-16 | 2017-12-01 | 朱诺治疗学股份有限公司 | Ror1特异性抗体和嵌合抗原受体 |
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| CN119233991A (zh) * | 2022-05-24 | 2024-12-31 | 卡里布生物科学公司 | 抗ror1抗体和ror1靶向性经工程化的细胞 |
| CN116284246A (zh) * | 2022-12-12 | 2023-06-23 | 江苏三联生物工程股份有限公司 | 信号肽、核酸片段、重组表达载体、宿主细胞及其应用 |
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| Publication number | Publication date |
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| SG11202100205UA (en) | 2021-02-25 |
| ZA202100391B (en) | 2025-05-28 |
| CA3105816A1 (en) | 2020-01-16 |
| JP2024073449A (ja) | 2024-05-29 |
| KR20210043562A (ko) | 2021-04-21 |
| EP3820484A1 (en) | 2021-05-19 |
| IL280029A (en) | 2021-03-01 |
| AU2019301147A1 (en) | 2021-01-21 |
| EP3820484A4 (en) | 2022-05-04 |
| JP2021530217A (ja) | 2021-11-11 |
| US12275772B2 (en) | 2025-04-15 |
| US20210177902A1 (en) | 2021-06-17 |
| WO2020014366A1 (en) | 2020-01-16 |
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