CN112704159A - Feed premix for reducing inflammation after delivery of sows and preparation and application thereof - Google Patents
Feed premix for reducing inflammation after delivery of sows and preparation and application thereof Download PDFInfo
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- CN112704159A CN112704159A CN202011297033.9A CN202011297033A CN112704159A CN 112704159 A CN112704159 A CN 112704159A CN 202011297033 A CN202011297033 A CN 202011297033A CN 112704159 A CN112704159 A CN 112704159A
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- parts
- sows
- inflammation
- feed premix
- chlorogenic acid
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
Abstract
The invention relates to a feed premix for reducing inflammation of sows after parturition, and a preparation method and application thereof, wherein the feed premix comprises the following raw material components in parts by weight: 0-18 parts of chlorogenic acid, 28-74 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 0-5 parts of pyrroloquinoline quinone and 10-25 parts of glucose, wherein when the addition amount of the chlorogenic acid and the pyrroloquinoline quinone is 0, the component is not added. Compared with the prior art, the feed additive can effectively reduce the occurrence of postpartum inflammation of sows, prolong the service life of the sows and avoid influencing the later-period production of the sows.
Description
Technical Field
The invention belongs to the technical field of feed additives, and relates to a feed premix for reducing inflammation after delivery of sows and a preparation method thereof.
Background
Due to the improvement of the reproductive performance of the sows and the increase of the number of the farrowing sows, in order to improve the survival rate of the piglets, the nutrition of the sows is better emphasized in the gestation period of the sows, so that the newborn individuals of the piglets are larger, the labor course of the sows is longer when the sows are delivered, the occurrence probability of the inflammation of the birth channels of the sows is easily caused, and the production of the sows at the later stage is influenced.
Disclosure of Invention
The invention aims to provide a feed premix for reducing inflammation of sows after parturition, and preparation and application thereof.
The purpose of the invention can be realized by the following technical scheme:
on one hand, the invention provides a feed premix for reducing inflammation of sows after parturition, which comprises the following raw material components in parts by weight: 0-18 parts of chlorogenic acid, 28-74 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 0-5 parts of pyrroloquinoline quinone and 10-25 parts of glucose. When the addition amount of chlorogenic acid and pyrroloquinoline quinone is 0, the component is not added.
Further, the feed premix comprises the following raw material components in parts by weight: 10-15 parts of chlorogenic acid, 28-74 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 2-4 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
Further, the feed premix comprises the following raw material components in parts by weight: 10-15 parts of chlorogenic acid, 28-40 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 2-4 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
Further, the feed premix comprises the following raw material components in parts by weight: 10-15 parts of chlorogenic acid, 28-40 parts of laminarin, 8-12 parts of resveratrol, 10-20 parts of taurine, 2-4 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
Further, the feed premix comprises the following raw material components in parts by weight: 15 parts of chlorogenic acid, 37 parts of laminarin, 10 parts of resveratrol, 15 parts of taurine, 3 parts of pyrroloquinoline quinone and 20 parts of glucose.
On the other hand, the invention provides a preparation method of the feed premix for reducing the post-partum inflammation of the sow, which comprises the steps of firstly weighing pyrroloquinoline quinone, mixing with laminarin, and then mixing with chlorogenic acid, resveratrol, taurine and glucose to obtain the target product.
Further, the whole preparation process is carried out at room temperature.
In another aspect, the invention provides an application of a feed premix for reducing inflammation after delivery of sows, which is added into basic daily ration to obtain a feed for the antenatal sows.
Furthermore, the addition amount of the feed premix is 3-5% of the mass of the basic ration.
Further, the basic ration is purchased from proud agro biotechnology limited of Hunan.
Compared with the prior art, the immunity of the body is improved through laminarin, the inflammation is reduced through the antibacterial action of chlorogenic acid, the expression of IL-6 and TNF-alpha is regulated and controlled through resveratrol and taurine, the inflammation is inhibited, meanwhile, free radicals in the body are eliminated through the compound pyrroloquinoline quinone, the antioxidant capacity of the body is improved, and finally, the power of the sow during delivery is increased through improving the glucose energy supply of the body, the labor time is shortened, and the inflammation occurrence probability is reduced through comprehensive synergistic effect in multiple aspects.
Detailed Description
The present invention will be described in detail with reference to specific examples. The present embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation manner and a specific operation process are given, but the scope of the present invention is not limited to the following embodiments.
In the following examples, unless otherwise specified, all the conventional commercially available raw materials or conventional processing techniques in the art are indicated.
The invention provides a feed premix for reducing inflammation of sows after parturition, which specifically comprises the following components: weighing pyrroloquinoline quinone, mixing with laminarin, and mixing with chlorogenic acid, resveratrol, taurine and glucose to obtain the target product feed premix.
The formulation of each of the raw material components of examples 1-7 is specified in Table 1 below.
TABLE 1
In a specific test, 96 sows with 2-4 pregnancies of 90d LY (Changbai multiplied by about Kyoxia) which are healthy, similar in body condition and similar in mating time and expected delivery period are selected. Sows were randomized in 8 treatment groups: basal diet (lactating sow compound feed 316 produced by proud No. limited, hunan, a placebo group), basal diet + 4% example 1 (experimental group 1), basal diet + 4% example 2 (experimental group 2), basal diet + 4% example 3 (experimental group 3), basal diet + 4% example 4 (experimental group 4), basal diet + 4% example 5 (experimental group 5), basal diet + 4% example 6 (experimental group 6), basal diet + 4% example 7 (experimental group 7), and 12 pigs per group were fed, respectively. Feeding amount is 3.0-3.5 kg/d for 91 d-114 d of gestation, and no feed is fed on the day of farrowing and water is freely drunk. And randomly selecting 20mL of 6 sows in each group on the day of delivery of the sows, taking blood from the anterior vena cava, standing for 1-2 h, centrifuging at 4000r/min for about 15min, taking the supernatant, and respectively filling the supernatant into 1mL centrifuge tubes, and storing in a refrigerator at-20 ℃ to be tested.
And recording and calculating the total farrowing number, the live farrowing number, the healthy farrowing number, the newborn litter weight and the newborn individual weight of each sow.
Determination of inflammatory factors: the concentrations of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha) in the serum of the sows at the day of delivery were determined using an ELISA kit purchased from Nanjing institute of bioengineering.
Data statistics and processing:
all test data are collated by using Excel 2016, a General Linear Model (GLM) program in SPSS17.0 software is used for two-factor variance analysis and significance test, multiple comparisons are carried out by a Duncan method, the difference is not significant when P >0.05 is in a range, the difference is significant when P <0.05 is in a range, and the difference is extremely significant when P <0.01 is in a range.
IL-6 is a cytokine which can induce cells such as T lymphocytes, B lymphocytes and mononuclear macrophages to secrete IL-6 when the organism is infected by pathogen to generate inflammatory reaction, so that the increase of IL-6 indicates that the organism has obvious inflammatory reaction. TNF-alpha is one of tumor necrosis factors, which can cause a plurality of inflammatory reactions of organisms, is mainly produced by cells in the organisms and can cause hemorrhagic necrosis of tumor cells, and if the content of TNF-alpha in the organisms is high, the tumor growth can activate the tumor necrosis factor or the organisms have inflammatory reactions.
TABLE 2 production of each experimental group and control group
TABLE 3 level of postnatal inflammation in each experimental and control group
To sum up, it can be seen that the effect of the experimental group 3 is the best in the case of comparable litter size and healthy birth rate, especially in the aspect of inflammation control, the IL-6 and TNF- α in the experimental group 3 are significantly lower than those in the control group and other experimental groups, and it can be seen that the group 3 has a better anti-inflammatory effect, which indicates that chlorogenic acid, resveratrol and pyrroloquinoline quinone are introduced simultaneously to enhance the anti-inflammatory effect.
The embodiments described above are described to facilitate an understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (10)
1. The feed premix for reducing inflammation of the parturition sow is characterized by comprising the following raw material components in parts by weight: 0-18 parts of chlorogenic acid, 28-74 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 0-5 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
2. The feed premix for reducing post-partum inflammation of sows as claimed in claim 1, which comprises the following raw materials in parts by weight: 10-15 parts of chlorogenic acid, 28-74 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 2-4 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
3. The feed premix for reducing post-partum inflammation of sows as claimed in claim 1, which comprises the following raw materials in parts by weight: 10-15 parts of chlorogenic acid, 28-40 parts of laminarin, 5-12 parts of resveratrol, 5-20 parts of taurine, 2-4 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
4. The feed premix for reducing post-partum inflammation of sows as claimed in claim 1, which comprises the following raw materials in parts by weight: 10-15 parts of chlorogenic acid, 28-40 parts of laminarin, 8-12 parts of resveratrol, 10-20 parts of taurine, 2-4 parts of pyrroloquinoline quinone and 10-25 parts of glucose.
5. The feed premix for reducing post-partum inflammation of sows as claimed in claim 1, which comprises the following raw materials in parts by weight: 15 parts of chlorogenic acid, 37 parts of laminarin, 10 parts of resveratrol, 15 parts of taurine, 3 parts of pyrroloquinoline quinone and 20 parts of glucose.
6. The method for preparing a feed premix for reducing post partum inflammation of sows as claimed in any of claims 1 to 5, wherein pyrroloquinoline quinone is weighed and mixed with laminarin, and then mixed with chlorogenic acid, resveratrol, taurine and glucose to obtain the target product.
7. The method of claim 6 wherein the entire process is carried out at room temperature.
8. Use of a feed premix for reducing post partum inflammation in sows as claimed in any of claims 1 to 5 which is added to a basal ration to obtain the feed for a gilt in labor.
9. The use of a feed premix for reducing inflammation in sows after parturition as claimed in claim 8, wherein the feed premix is added in an amount of 3-5% by mass of the basal ration.
10. The use of a feed premix for reducing post partum inflammation in sows as claimed in claim 8 wherein said basal ration is purchased from proud biotechnology limited of Hunan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011297033.9A CN112704159A (en) | 2020-11-18 | 2020-11-18 | Feed premix for reducing inflammation after delivery of sows and preparation and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011297033.9A CN112704159A (en) | 2020-11-18 | 2020-11-18 | Feed premix for reducing inflammation after delivery of sows and preparation and application thereof |
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| CN112704159A true CN112704159A (en) | 2021-04-27 |
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| CN202011297033.9A Pending CN112704159A (en) | 2020-11-18 | 2020-11-18 | Feed premix for reducing inflammation after delivery of sows and preparation and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605160A (en) * | 2015-01-20 | 2015-05-13 | 湖南农业大学 | Composition for preventing and treating puerperal endometritis of sow and application of composition |
| CN105192433A (en) * | 2015-11-01 | 2015-12-30 | 刘影 | Special complete formula feed for sows in perinatal period |
| CN106578537A (en) * | 2016-12-30 | 2017-04-26 | 中悦民安（北京）科技发展有限公司 | Lactating sow premixed feed for preventing and treating postpartum inflammation and preparation method thereof |
| CN111053852A (en) * | 2019-12-30 | 2020-04-24 | 江西傲新生物科技有限公司 | Pharmaceutical composition for reducing postpartum inflammation of sow and preparation method thereof |
-
2020
- 2020-11-18 CN CN202011297033.9A patent/CN112704159A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605160A (en) * | 2015-01-20 | 2015-05-13 | 湖南农业大学 | Composition for preventing and treating puerperal endometritis of sow and application of composition |
| CN105192433A (en) * | 2015-11-01 | 2015-12-30 | 刘影 | Special complete formula feed for sows in perinatal period |
| CN106578537A (en) * | 2016-12-30 | 2017-04-26 | 中悦民安（北京）科技发展有限公司 | Lactating sow premixed feed for preventing and treating postpartum inflammation and preparation method thereof |
| CN111053852A (en) * | 2019-12-30 | 2020-04-24 | 江西傲新生物科技有限公司 | Pharmaceutical composition for reducing postpartum inflammation of sow and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 罗亚平: "植物提取物的特性及其在畜禽生产中的应用", 《湖南畜牧兽医》 * |
| 肖俊峰等: "饲粮添加吡咯喹啉醌对围产期母猪繁殖性能和抗氧化功能的影响", 《动物营养学报》 * |
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Application publication date: 20210427 |