CN112703247A - 毛囊原基、毛囊原基的制造方法、以及毛囊原基中所含的细胞的活化方法 - Google Patents

毛囊原基、毛囊原基的制造方法、以及毛囊原基中所含的细胞的活化方法 Download PDF

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CN112703247A
CN112703247A CN201980059873.0A CN201980059873A CN112703247A CN 112703247 A CN112703247 A CN 112703247A CN 201980059873 A CN201980059873 A CN 201980059873A CN 112703247 A CN112703247 A CN 112703247A
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cells
hair follicle
follicle germ
mesenchymal
stem cells
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CN201980059873.0A
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English (en)
Chinese (zh)
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福田淳二
景山达斗
楯芳树
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Yokohama National University NUC
Kanagawa Institute of Industrial Science and Technology
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Yokohama National University NUC
Kanagawa Institute of Industrial Science and Technology
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C12N5/0628—Hair stem cells; Hair progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1382—Adipose-derived stem cells [ADSC], adipose stromal stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980059873.0A 2018-11-08 2019-10-15 毛囊原基、毛囊原基的制造方法、以及毛囊原基中所含的细胞的活化方法 Pending CN112703247A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018210524A JP7246595B2 (ja) 2018-11-08 2018-11-08 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法
JP2018-210524 2018-11-08
PCT/JP2019/040444 WO2020095631A1 (ja) 2018-11-08 2019-10-15 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法

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CN112703247A true CN112703247A (zh) 2021-04-23

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CN201980059873.0A Pending CN112703247A (zh) 2018-11-08 2019-10-15 毛囊原基、毛囊原基的制造方法、以及毛囊原基中所含的细胞的活化方法

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US (1) US20220041983A1 (https=)
EP (1) EP3878946A4 (https=)
JP (1) JP7246595B2 (https=)
CN (1) CN112703247A (https=)
WO (1) WO2020095631A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7835162B2 (ja) * 2020-11-26 2026-03-25 東ソー株式会社 細胞塊の製造方法
WO2023171395A1 (ja) * 2022-03-09 2023-09-14 株式会社 資生堂 間葉系細胞を含む細胞集団の毛髪再生能を評価する方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106659741A (zh) * 2014-07-07 2017-05-10 米迪波斯特股份有限公司 小尺寸干细胞的毛发生长促进功能及其用途
CN108138133A (zh) * 2015-10-30 2018-06-08 国立大学法人横滨国立大学 再生毛囊原基的集合体的制造方法、含毛囊组织薄片及含毛囊组织薄片的制造方法
US20180271913A1 (en) * 2017-03-21 2018-09-27 National Cheng Kung University Pharmaceutical compositions for promoting hair follicle regeneration and methods for preparing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2641528T3 (es) 2006-06-27 2017-11-10 Shiseido Company, Limited Masa celular capaz de servir como estructura de tipo órgano primitivo compuesta por una diversidad de tipos de células de origen somático
US8017390B2 (en) * 2007-07-20 2011-09-13 Dongguk University Industry-Academic Cooperation Foundation Method for the preparation of dermal papilla tissue employing mesenchymal stem cells
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106659741A (zh) * 2014-07-07 2017-05-10 米迪波斯特股份有限公司 小尺寸干细胞的毛发生长促进功能及其用途
CN108138133A (zh) * 2015-10-30 2018-06-08 国立大学法人横滨国立大学 再生毛囊原基的集合体的制造方法、含毛囊组织薄片及含毛囊组织薄片的制造方法
US20180271913A1 (en) * 2017-03-21 2018-09-27 National Cheng Kung University Pharmaceutical compositions for promoting hair follicle regeneration and methods for preparing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
伍津津: "毛囊干细胞与组织工程研究进展", 《中国医学文摘(皮肤科学)》 *
宾志文等: "小鼠毛囊来源间充质干细胞体外诱导成软骨的细胞标记物", 《中国组织工程研究》 *

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Publication number Publication date
EP3878946A4 (en) 2022-07-27
JP7246595B2 (ja) 2023-03-28
JP2020074718A (ja) 2020-05-21
WO2020095631A1 (ja) 2020-05-14
US20220041983A1 (en) 2022-02-10
EP3878946A1 (en) 2021-09-15

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Application publication date: 20210423