CN112641891A - Allicin preparation for treating helicobacter pylori and preparation method thereof - Google Patents

Allicin preparation for treating helicobacter pylori and preparation method thereof Download PDF

Info

Publication number
CN112641891A
CN112641891A CN202011174073.4A CN202011174073A CN112641891A CN 112641891 A CN112641891 A CN 112641891A CN 202011174073 A CN202011174073 A CN 202011174073A CN 112641891 A CN112641891 A CN 112641891A
Authority
CN
China
Prior art keywords
parts
allicin
helicobacter pylori
preparation
decoction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011174073.4A
Other languages
Chinese (zh)
Inventor
肖军宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Hongkang Pharmaceutical Technology Co ltd
Original Assignee
Guangzhou Hongkang Pharmaceutical Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Hongkang Pharmaceutical Technology Co ltd filed Critical Guangzhou Hongkang Pharmaceutical Technology Co ltd
Priority to CN202011174073.4A priority Critical patent/CN112641891A/en
Publication of CN112641891A publication Critical patent/CN112641891A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses an allicin preparation for treating helicobacter pylori, which comprises the following components of allicin, coptis chinensis, clove leaves, mint leaves, dandelion, scutellaria baicalensis, malt, liquorice, poria cocos, probiotic powder, codonopsis pilosula and Chinese yam, and has the beneficial effects that: the preparation is prepared by compounding allicin, coptis chinensis, clove leaves, mint leaves, dandelion, scutellaria baicalensis, malt, liquorice, poria cocos, probiotic powder, codonopsis pilosula and Chinese yam, wherein the allicin has higher sensitivity to helicobacter pylori and can not cause drug resistance, the problem of drug resistance of the helicobacter pylori is solved, and the malt has the effects of promoting gastrointestinal motility, helping digestion, resisting colitis, treating acute and chronic hepatitis and the like; clove leaves have a certain inhibiting effect on helicobacter pylori; the dandelion can inhibit the propagation of the helicobacter pylori, has certain efficacy on the treatment of the helicobacter pylori, is safe without side effect, has good treatment effect on patients with chronic gastritis, and has simple operation and high extraction rate of drug effect.

Description

Allicin preparation for treating helicobacter pylori and preparation method thereof
The technical field is as follows:
the invention belongs to the technical field of allicin preparations, and particularly relates to an allicin preparation for treating helicobacter pylori and a preparation method thereof.
Background art:
helicobacter pylori is a bacterium that is helicoidal, micro-anaerobic, and has very strict requirements for growth conditions. The first successful separation from the gastric mucosa biopsy tissue of a patient with chronic active gastritis in 1983 is the only microorganism species which is known to exist in the human stomach at present, the helicobacter pylori disease comprises gastritis, peptic ulcer, lymphoproliferative gastric lymphoma and the like caused by helicobacter pylori infection, and about 7 hundred million chronic gastritis patients infected with helicobacter pylori exist in China.
The biggest problem of the existing chronic gastric curative effect is that the helicobacter pylori is resistant to drugs and brings great difficulty to the prevention and treatment of helicobacter pylori infectious diseases, so the invention provides an allicin preparation for treating helicobacter pylori and a preparation method thereof to solve the problems.
The invention content is as follows:
the invention aims to solve the problems, provides an allicin preparation for treating helicobacter pylori and a preparation method thereof, and solves the defect that the biggest problem of the existing chronic gastric curative effect is drug resistance of the helicobacter pylori and great difficulty in preventing and treating helicobacter pylori infectious diseases.
In order to solve the above problems, the present invention provides a technical solution:
an allicin preparation for treating helicobacter pylori comprises allicin, rhizoma Coptidis, folium Caryophylli, folium Menthae, herba Taraxaci, radix Scutellariae, fructus Hordei Germinatus, radix Glycyrrhizae, Poria, probiotic powder, radix Codonopsis and rhizoma Dioscoreae.
As a preferred technical scheme of the invention, the allicin preparation comprises, by weight, 3-8 parts of allicin, 5-10 parts of coptis chinensis, 2-5 parts of clove leaves, 3-7 parts of mint leaves, 5-10 parts of dandelion, 2-5 parts of scutellaria baicalensis, 5-15 parts of malt, 1-5 parts of liquorice, 3-8 parts of poria cocos, 5-7 parts of probiotic powder, 3-6 parts of codonopsis pilosula and 4-7 parts of Chinese yam.
As a preferred technical scheme of the invention, the allicin preparation comprises, by weight, 6 parts of allicin, 8 parts of coptis chinensis, 4 parts of clove leaves, 5 parts of mint leaves, 7 parts of dandelion, 3 parts of scutellaria baicalensis, 11 parts of malt, 2 parts of liquorice, 5 parts of poria cocos, 6 parts of probiotic powder, 5 parts of codonopsis pilosula and 5 parts of Chinese yam.
A method for preparing an allicin preparation for treating helicobacter pylori, the method for preparing the allicin preparation comprises the following steps:
step one, weighing: weighing the garlicin, the coptis chinensis, the clove leaves, the mint leaves, the dandelion, the scutellaria baicalensis, the malt, the liquorice, the poria cocos, the probiotic powder, the codonopsis pilosula and the Chinese yam according to the weight parts of the components of the garlicin preparation for later use;
step two, extraction: mixing the weighed powders of the coptis chinensis, the radix scutellariae, the poria cocos, the mint leaves, the codonopsis pilosula and the Chinese yam, then carrying out reflux purification by using ethanol to obtain an extracting solution, standing, filtering and centrifugally separating the extracting solution to obtain a centrifugally separated mixed supernatant for later use;
step three, primary decoction: putting clove leaves, dandelion, malt and licorice powder into a decocting pot, adding clear water, and separating liquid medicine and medicine residues after decoction to obtain decoction;
step four, secondary decoction: adding the dregs generated by extraction in the step two and the dregs generated by primary decoction into a decocting pot, adding clear water, and separating decoction and dregs to obtain decoction;
step five, boiling: and (3) adding the mixed supernatant obtained in the step (II) and the decoction obtained in the step (III) and the step (IV) into a decocting pot, heating to boil, cooling to below 45 ℃, adding the allicin and the probiotic powder, and uniformly stirring to obtain the allicin preparation for treating the helicobacter pylori.
As a preferred technical scheme of the invention, in the second step, ethanol is refluxed and extracted for 3-4 times, each time of extraction is 100-120 minutes, and the extracting solutions of each time are mixed.
As a preferred technical scheme of the invention, the first decoction in the third step comprises a strong fire stage and a slow fire stage, clove leaves, dandelion, malt and licorice powder are placed into a decocting pot, firstly, clear water is added for soaking for 15-20 minutes, then, the mixture is boiled with strong fire, and then, the mixture is decocted with slow fire after being boiled, and the mixture is decocted with slow fire for 60-90 minutes.
As a preferable technical scheme of the invention, 70% ethanol is adopted for reflux extraction in the second step.
As a preferable technical scheme of the invention, the decoction dregs generated by decoction in the fourth step are dried in the sun.
The invention has the beneficial effects that:
compared with the traditional preparation for treating helicobacter pylori, the preparation is prepared by compounding allicin, coptis chinensis, clove leaves, mint leaves, dandelion, scutellaria baicalensis, malt, liquorice, poria cocos, probiotic powder, codonopsis pilosula and Chinese yam, wherein the allicin has higher sensitivity to the helicobacter pylori, does not cause drug resistance, solves the problem of drug resistance of the helicobacter pylori, is safe and free of side effects, has a good treatment effect on patients with chronic gastritis, and is simple to operate and high in drug effect extraction rate;
the coptis chinensis is taken as a root and has the effects of purging fire and removing toxicity, and the used berberine is mainly extracted from the root and stem of the coptis chinensis and is very effective for acute bacillary dysentery, acute colitis and acute conjunctivitis;
the probiotic powder is beneficial to human health, can maintain the health balance of intestinal tracts, mainly comprises bifidobacterium and lactobacillus, has the functions of intestinal tract health care and immunity enhancement, and can reduce the reproduction of helicobacter pylori in the stomach by a product obtained by probiotic fermentation, thereby reducing the risk of gastritis and gastric ulcer;
the malt has the functions of promoting gastrointestinal motility, helping digestion, resisting colitis, treating acute and chronic hepatitis and the like;
poria has effects in invigorating spleen and stomach;
clove leaves have a certain inhibiting effect on helicobacter pylori;
the herba Taraxaci has effects of promoting diuresis, improving eyesight, clearing heat and detoxicating, resisting bacteria and inflammation, relieving swelling and pain, etc., can inhibit reproduction of helicobacter pylori, and has certain effect on treatment of helicobacter pylori.
Description of the drawings:
for ease of illustration, the invention is described in detail by the following detailed description and the accompanying drawings.
FIG. 1 is a flow chart of the preparation of allicin preparation of the present invention.
The specific implementation mode is as follows:
as shown in fig. 1, the following technical solutions are adopted in the present embodiment:
example 1 an allicin preparation for the treatment of helicobacter pylori, which comprises allicin, coptis root, clove leaf, mint leaf, dandelion, scutellaria baicalensis, malt, liquorice, poria cocos, probiotic powder, codonopsis pilosula and Chinese yam.
The allicin preparation comprises, by weight, 3-8 parts of allicin, 5-10 parts of coptis chinensis, 2-5 parts of clove leaves, 3-7 parts of mint leaves, 5-10 parts of dandelion, 2-5 parts of scutellaria baicalensis, 5-15 parts of malt, 1-5 parts of liquorice, 3-8 parts of poria cocos, 5-7 parts of probiotic powder, 3-6 parts of codonopsis pilosula and 4-7 parts of Chinese yam.
The allicin preparation comprises, by weight, 6 parts of allicin, 8 parts of coptis chinensis, 4 parts of clove leaves, 5 parts of mint leaves, 7 parts of dandelion, 3 parts of scutellaria baicalensis, 11 parts of malt, 2 parts of liquorice, 5 parts of poria cocos, 6 parts of probiotic powder, 5 parts of codonopsis pilosula and 5 parts of Chinese yam.
A method for preparing an allicin preparation for treating helicobacter pylori, the method for preparing the allicin preparation comprises the following steps:
step one, weighing: weighing the garlicin, the coptis chinensis, the clove leaves, the mint leaves, the dandelion, the scutellaria baicalensis, the malt, the liquorice, the poria cocos, the probiotic powder, the codonopsis pilosula and the Chinese yam according to the weight parts of the components of the garlicin preparation for later use;
step two, extraction: mixing the weighed powders of the coptis chinensis, the radix scutellariae, the poria cocos, the mint leaves, the codonopsis pilosula and the Chinese yam, then carrying out reflux purification by using ethanol to obtain an extracting solution, standing, filtering and centrifugally separating the extracting solution to obtain a centrifugally separated mixed supernatant for later use;
step three, primary decoction: putting clove leaves, dandelion, malt and licorice powder into a decocting pot, adding clear water, and separating liquid medicine and medicine residues after decoction to obtain decoction;
step four, secondary decoction: adding the dregs generated by extraction in the step two and the dregs generated by primary decoction into a decocting pot, adding clear water, and separating decoction and dregs to obtain decoction;
step five, boiling: and (3) adding the mixed supernatant obtained in the step (II) and the decoction obtained in the step (III) and the step (IV) into a decocting pot, heating to boil, cooling to below 45 ℃, adding the allicin and the probiotic powder, and uniformly stirring to obtain the allicin preparation for treating the helicobacter pylori.
Wherein, the ethanol reflux extraction in the second step is performed for 3 to 4 times, each time of extraction lasts for 120 minutes, and the extracting solutions of each time are mixed.
Wherein, the first decoction in the third step comprises a strong fire stage and a slow fire stage, the clove leaves, the dandelion, the malt and the licorice powder are placed into a decocting pot, firstly, clear water is added for soaking for 15-20 minutes, then, the mixture is boiled by strong fire, and is decocted by slow fire after being boiled, and the mixture is decocted by slow fire for 60-90 minutes.
Wherein, 70% ethanol is adopted for reflux extraction in the second step.
Wherein, the decoction dregs generated by the decoction in the fourth step are dried in the sun.
Example 2: an allicin preparation for treating helicobacter pylori comprises allicin, rhizoma Coptidis, folium Caryophylli, folium Menthae, herba Taraxaci, radix Scutellariae, fructus Hordei Germinatus, radix Glycyrrhizae, Poria, probiotic powder, radix Codonopsis and rhizoma Dioscoreae.
The allicin preparation comprises, by weight, 3-8 parts of allicin, 5-10 parts of coptis chinensis, 2-5 parts of clove leaves, 3-7 parts of mint leaves, 5-10 parts of dandelion, 2-5 parts of scutellaria baicalensis, 5-15 parts of malt, 1-5 parts of liquorice, 3-8 parts of poria cocos, 5-7 parts of probiotic powder, 3-6 parts of codonopsis pilosula and 4-7 parts of Chinese yam.
The allicin preparation comprises, by weight, 5 parts of allicin, 7 parts of coptis chinensis, 3 parts of clove leaves, 7 parts of mint leaves, 8 parts of dandelion, 5 parts of scutellaria baicalensis, 8 parts of malt, 4 parts of liquorice, 8 parts of poria cocos, 5 parts of probiotic powder, 4 parts of codonopsis pilosula and 7 parts of Chinese yam.
A method for preparing an allicin preparation for treating helicobacter pylori, the method for preparing the allicin preparation comprises the following steps:
step one, weighing: weighing the garlicin, the coptis chinensis, the clove leaves, the mint leaves, the dandelion, the scutellaria baicalensis, the malt, the liquorice, the poria cocos, the probiotic powder, the codonopsis pilosula and the Chinese yam according to the weight parts of the components of the garlicin preparation for later use;
step two, extraction: mixing the weighed powders of the coptis chinensis, the radix scutellariae, the poria cocos, the mint leaves, the codonopsis pilosula and the Chinese yam, then carrying out reflux purification by using ethanol to obtain an extracting solution, standing, filtering and centrifugally separating the extracting solution to obtain a centrifugally separated mixed supernatant for later use;
step three, primary decoction: putting clove leaves, dandelion, malt and licorice powder into a decocting pot, adding clear water, and separating liquid medicine and medicine residues after decoction to obtain decoction;
step four, secondary decoction: adding the dregs generated by extraction in the step two and the dregs generated by primary decoction into a decocting pot, adding clear water, and separating decoction and dregs to obtain decoction;
step five, boiling: and (3) adding the mixed supernatant obtained in the step (II) and the decoction obtained in the step (III) and the step (IV) into a decocting pot, heating to boil, cooling to below 45 ℃, adding the allicin and the probiotic powder, and uniformly stirring to obtain the allicin preparation for treating the helicobacter pylori.
Wherein, the ethanol reflux extraction in the second step is performed for 3 to 4 times, each time of extraction lasts for 120 minutes, and the extracting solutions of each time are mixed.
Wherein, the first decoction in the third step comprises a strong fire stage and a slow fire stage, the clove leaves, the dandelion, the malt and the licorice powder are placed into a decocting pot, firstly, clear water is added for soaking for 15-20 minutes, then, the mixture is boiled by strong fire, and is decocted by slow fire after being boiled, and the mixture is decocted by slow fire for 60-90 minutes.
Wherein, 70% ethanol is adopted for reflux extraction in the second step.
Wherein, the decoction dregs generated by decoction in the fourth step are dried in the sun, and the decoction dregs can be used for planting, fertilizing and the like for reutilization.
Specifically, the method comprises the following steps: an allicin preparation for treating helicobacter pylori and a preparation method thereof, when in use, the powder of allicin, coptis chinensis, clove leaves, mint leaves, dandelion, scutellaria baicalensis, malt, liquorice, poria cocos, probiotic powder, codonopsis pilosula and Chinese yam are weighed according to the weight parts of the components of the allicin preparation, the powder of the coptis chinensis, the scutellaria baicalensis, the poria cocos, the mint leaves, the codonopsis pilosula and the Chinese yam are mixed, then ethanol is used for reflux purification, the ethanol is used for reflux extraction for 3-4 times, each time 100 times of extraction is carried out for 120 minutes, each time of extraction is mixed to obtain an extraction solution, the extraction solution is stood, filtered and centrifugally separated to obtain mixed supernatant after centrifugal separation, the same extraction mode is adopted, the allicin powder is subjected to reflux extraction through the ethanol, the extraction solution is stood, filtered and centrifugally separated to obtain the garlicin supernatant after centrifugal separation, the clove leaves, the mint leaves and the Chinese yam are, Putting dandelion, malt and licorice powder into a boiling pot, adding clear water for soaking for 15-20 minutes, then boiling with strong fire, adjusting to slow fire for boiling, decocting with slow fire for 60-90 minutes, separating decoction liquid and decoction dregs to obtain decoction liquid, adding the decoction dregs extracted in the step two and the decoction dregs generated in the first decoction into the boiling pot, adding clear water, separating the decoction liquid and the decoction dregs after decoction to obtain the decoction liquid, finally adding the mixed supernatant obtained in the step two and the decoction liquid obtained in the step three and the step four into the boiling pot, heating to boiling, cooling to below 45 ℃, adding garlicin and probiotic powder, and stirring uniformly to obtain the garlicin preparation for treating helicobacter pylori The composition is prepared by compounding probiotic powder, codonopsis pilosula and Chinese yam, wherein allicin has higher sensitivity to helicobacter pylori and does not cause drug resistance, the problem of drug resistance of the helicobacter pylori is solved, the coptis chinensis is taken as a root and has the effects of purging intense heat and removing toxicity, and the used berberine is mainly extracted from the root and stem of the coptis chinensis and is very effective to acute bacillary dysentery, acute colitis and acute conjunctivitis; the probiotic powder is beneficial to human health, can maintain the health balance of intestinal tracts, mainly comprises bifidobacterium and lactobacillus, has the functions of intestinal tract health care and immunity enhancement, and can reduce the reproduction of helicobacter pylori in the stomach by a product obtained by probiotic fermentation, thereby reducing the risk of gastritis and gastric ulcer; the malt has the functions of promoting gastrointestinal motility, helping digestion, resisting colitis, treating acute and chronic hepatitis and the like; poria has effects in invigorating spleen and stomach; clove leaves have a certain inhibiting effect on helicobacter pylori; the dandelion has the effects of promoting urination, improving eyesight, clearing heat and removing toxicity, resisting bacteria and diminishing inflammation, reducing swelling and relieving pain and the like, can inhibit the propagation of the helicobacter pylori, and has certain efficacy on the treatment of the helicobacter pylori, so the allicin preparation is safe and has no side effect, the treatment effect on patients with chronic gastritis is good, the preparation method is simple to operate, and the extraction rate of the drug effect is high.
While there have been shown and described what are at present considered to be the fundamental principles of the invention and its essential features and advantages, it will be understood by those skilled in the art that the invention is not limited by the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents.

Claims (8)

1. An allicin preparation for treating helicobacter pylori, which is characterized in that: the allicin preparation comprises allicin, Coptidis rhizoma, folium Caryophylli, folium Menthae, herba Taraxaci, Scutellariae radix, fructus Hordei Germinatus, Glycyrrhrizae radix, Poria, probiotic bacteria powder, radix Codonopsis and rhizoma Dioscoreae.
2. The allicin preparation for the treatment of helicobacter pylori according to claim 1, wherein: the allicin preparation comprises, by weight, 3-8 parts of allicin, 5-10 parts of coptis chinensis, 2-5 parts of clove leaves, 3-7 parts of mint leaves, 5-10 parts of dandelion, 2-5 parts of scutellaria baicalensis, 5-15 parts of malt, 1-5 parts of liquorice, 3-8 parts of poria cocos, 5-7 parts of probiotic powder, 3-6 parts of codonopsis pilosula and 4-7 parts of Chinese yam.
3. The allicin preparation for the treatment of helicobacter pylori according to claim 2, wherein: the allicin preparation comprises, by weight, 6 parts of allicin, 8 parts of coptis chinensis, 4 parts of clove leaves, 5 parts of mint leaves, 7 parts of dandelion, 3 parts of scutellaria baicalensis, 11 parts of malt, 2 parts of liquorice, 5 parts of poria cocos, 6 parts of probiotic powder, 5 parts of codonopsis pilosula and 5 parts of Chinese yam.
4. A preparation method of an allicin preparation for treating helicobacter pylori is characterized by comprising the following steps: the preparation method of the allicin preparation comprises the following steps:
step one, weighing: weighing the garlicin, the coptis chinensis, the clove leaves, the mint leaves, the dandelion, the scutellaria baicalensis, the malt, the liquorice, the poria cocos, the probiotic powder, the codonopsis pilosula and the Chinese yam according to the weight parts of the components of the garlicin preparation for later use;
step two, extraction: mixing the weighed powders of the coptis chinensis, the radix scutellariae, the poria cocos, the mint leaves, the codonopsis pilosula and the Chinese yam, then carrying out reflux purification by using ethanol to obtain an extracting solution, standing, filtering and centrifugally separating the extracting solution to obtain a centrifugally separated mixed supernatant for later use;
step three, primary decoction: putting clove leaves, dandelion, malt and licorice powder into a decocting pot, adding clear water, and separating liquid medicine and medicine residues after decoction to obtain decoction;
step four, secondary decoction: adding the dregs generated by extraction in the step two and the dregs generated by primary decoction into a decocting pot, adding clear water, and separating decoction and dregs to obtain decoction;
step five, boiling: and (3) adding the mixed supernatant obtained in the step (II) and the decoction obtained in the step (III) and the step (IV) into a decocting pot, heating to boil, cooling to below 45 ℃, adding the allicin and the probiotic powder, and uniformly stirring to obtain the allicin preparation for treating the helicobacter pylori.
5. The method for preparing an allicin preparation for the treatment of helicobacter pylori according to claim 4, wherein: and in the second step, ethanol is refluxed and extracted for 3-4 times, each time of extraction is 100-120 minutes, and the extracting solutions of each time are mixed.
6. The method for preparing an allicin preparation for the treatment of helicobacter pylori according to claim 4, wherein: the first decoction in the third step comprises a strong fire stage and a slow fire stage, the clove leaves, the dandelion, the malt and the licorice powder are placed into a decocting pot, firstly, clear water is added for soaking for 15-20 minutes, then, the boiling is carried out by strong fire, the boiling is carried out, then, the slow fire is adjusted to be decocted, and the slow fire is decocted for 60-90 minutes.
7. The method for preparing an allicin preparation for the treatment of helicobacter pylori according to claim 5, wherein: and in the second step, 70% ethanol is adopted for reflux extraction.
8. The method for preparing an allicin preparation for the treatment of helicobacter pylori according to claim 4, wherein: and drying the decoction dregs generated by decoction in the fourth step in the sun.
CN202011174073.4A 2021-03-03 2021-03-03 Allicin preparation for treating helicobacter pylori and preparation method thereof Pending CN112641891A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011174073.4A CN112641891A (en) 2021-03-03 2021-03-03 Allicin preparation for treating helicobacter pylori and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011174073.4A CN112641891A (en) 2021-03-03 2021-03-03 Allicin preparation for treating helicobacter pylori and preparation method thereof

Publications (1)

Publication Number Publication Date
CN112641891A true CN112641891A (en) 2021-04-13

Family

ID=75346862

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011174073.4A Pending CN112641891A (en) 2021-03-03 2021-03-03 Allicin preparation for treating helicobacter pylori and preparation method thereof

Country Status (1)

Country Link
CN (1) CN112641891A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112316123A (en) * 2020-12-03 2021-02-05 滁州向日葵药业有限公司 Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112316123A (en) * 2020-12-03 2021-02-05 滁州向日葵药业有限公司 Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙文伟等: "慢性胃炎患者四君子汤治疗对T细胞亚群的影响", 《放射免疫学杂志》 *
陈济民等: "健脾清热法治疗幽门螺杆菌感染70例临床观察", 《浙江中医药大学学报》 *

Similar Documents

Publication Publication Date Title
CN101411782B (en) Pharmaceutical composition for treating acute pharyngitis and preparation method thereof
CN101439164A (en) Preparation method of traditional Chinese medicine for treating excessive-fire type aphtha
CN111991535A (en) Traditional Chinese medicine extract with function of treating Hp-related gastritis and preparation method and application thereof
CN104306679A (en) Chinese herb agentia for treating epidemic cerebrospinal meningitis and preparation method thereof
CN112641891A (en) Allicin preparation for treating helicobacter pylori and preparation method thereof
CN114601906A (en) Jiulongqing enzyme probiotic oral liquid for treating digestive system diseases and preparation method and application thereof
CN104056242A (en) Traditional Chinese medicine composition for treating acute cholecystitis and preparation method thereof
CN114558074A (en) Traditional Chinese medicine composition for treating metabolic-related fatty liver disease and preparation method and application thereof
CN109172729B (en) Lung-clearing paste and preparation method thereof
CN113797294A (en) Medicine composition for treating atrophic gastritis and preparation method thereof
CN107898887B (en) Traditional Chinese medicine for treating helicobacter pylori
CN111471562A (en) Motherwort wine and preparation method thereof
CN105169327B (en) A kind of pharmaceutical composition and preparation method thereof for treating porcine diarrhea disease
CN115998824B (en) Traditional Chinese medicine composition for clearing damp and detoxicating, and preparation method and application thereof
CN116712523B (en) Composition for treating middle deficiency and qi reversal reflux esophagitis and preparation method thereof
CN105617197A (en) Traditional Chinese medicine composition for treating chronic renal failure of dogs as well as preparation method and application of traditional Chinese medicine composition
CN104524283A (en) Use of traditional Chinese medicine composition for preparing medicine for treating chronic gastritis
CN105343797A (en) Traditional Chinese medicine composition for curing stomach illness and preparation method thereof
CN111888416A (en) Traditional Chinese medicine composition for treating chronic non-atrophic gastritis and application thereof
CN115282242A (en) Traditional Chinese medicine composition for treating children mesenteric lymphadenitis
CN104721670A (en) TCM (traditional Chinese medicine) composition for treating Laryngopharyngitis and preparing method thereof
CN105055806A (en) Medicinal preparation for treating diarrhea
CN117180396A (en) Traditional Chinese medicine composition for treating anxiety and depression with acid regurgitation and heart burning and application thereof
CN114569690A (en) Traditional Chinese medicine composition for treating helicobacter pylori infectious gastritis
CN111557390A (en) Prevention and treatment type pure traditional Chinese medicine livestock and poultry feed additive composition

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210413

RJ01 Rejection of invention patent application after publication