CN112641679A

CN112641679A - Microcapsule and preparation method and application thereof

Info

Publication number: CN112641679A
Application number: CN202011599339.XA
Authority: CN
Inventors: 林梦雅; 吴知情; 胡兴国; 胡根华
Original assignee: Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Current assignee: Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Priority date: 2020-12-29
Filing date: 2020-12-29
Publication date: 2021-04-13

Abstract

The invention relates to a microcapsule and a preparation method and application thereof. The microcapsule comprises a core material and a wall material, wherein the core material comprises a secondary fission yeast fermentation product lysate, the wall material comprises sodium alginate and microcrystalline cellulose, and the wall material sodium alginate-microcrystalline cellulose and the core material secondary fission yeast fermentation product lysate are matched with each other, so that the microcapsule has the effects of lasting moisture retention and nourishing. The lipstick containing the microcapsule has excellent moistening feeling, moisturizing degree, lip wrinkle fading effect and relieving effect, and can permanently moisturize and moisten lip skin.

Description

Microcapsule and preparation method and application thereof

Technical Field

The invention belongs to the technical field of cosmetics, relates to a microcapsule, a preparation method and application thereof, and particularly relates to a microcapsule for preparing lip glaze, a preparation method and application thereof.

Background

The lip glaze has good color development capability, can obviously improve the complexion of the face of a user when being coated on the lip, and compared with the traditional lipstick products, the liquid texture of the lip glaze can better provide the feeling of moisturizing, skin-adhering and brightening for people.

The development of the functional lip glaze needs to add a plurality of functional active ingredients with high content, but the active ingredients with high concentration are easy to volatilize, oxidize and deteriorate.

CN110638691A discloses a paint mirror surface color-holding lip glaze and a preparation method thereof, wherein the paint mirror surface color-holding lip glaze comprises, by weight, 20-80% of grease, 0.1-15% of an oil-in-water emulsifier, 0.05-15% of a colorant, 0.5-10% of an oil phase film forming agent and 0.5-20% of a water phase film forming agent, is an oil-in-water type lip product, reduces greasy feeling, improves glossiness and moistening degree, but is difficult to realize lasting moistening and moisture retention.

CN109431956A discloses a matte lip glaze and a preparation process thereof, wherein the matte lip glaze comprises a mixture of undecane and tridecane, an emulsifier, a skin feel regulator, modified mica powder, lauroyl lysine, sunflower seed wax, tocopherol, a first skin conditioner, coconut oil alcohol-caprylate, sodium phytate, an alcohol humectant, sodium chloride, a second skin conditioner and a colorant, is matte in texture, is light and thin after being smeared, has good film-forming property, is not easy to remove makeup and stick to a cup, but has limited moisturizing effect, complex components and irritation problem.

In conclusion, the lip glaze capable of long-term moistening and moisturizing is provided, and has important significance in the field of functional lip glaze.

Disclosure of Invention

Aiming at the defects and actual requirements of the prior art, the invention provides the microcapsule and the preparation method and application thereof, the microcapsule has stable mechanical performance and good wrapping property, can effectively improve the oxidation resistance and the long-acting slow-release capacity of the yeast schizolysis solution, and has the long-acting moisturizing and moistening effects.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the present invention provides a microcapsule comprising a core material comprising a split yeast fermentation product lysate and a wall material comprising sodium alginate and microcrystalline cellulose.

In the invention, the sodium alginate-microcrystalline cellulose is used as a wall material, so that the mechanical property of the microcapsule is more stable, the encapsulation property is better, the oxidation resistance and the long-acting slow-release capacity of the core material schizosaccharomyces cerevisiae fermentation lysate can be effectively improved, the service life of the schizosaccharomyces cerevisiae fermentation lysate can be prolonged, in addition, the microcrystalline cellulose has the water locking capacity, the evaporation of skin moisture can be effectively avoided, the fixation of hydrophilic active ingredients in the schizosaccharomyces cerevisiae fermentation lysate on the skin can be promoted, and the nourishing effect can be prolonged.

The raw materials involved in the invention are common raw materials in the field of cosmetics, and potential safety hazards do not exist.

Preferably, the mass ratio of the core material to the wall material is 1 (2-5), including but not limited to 1:2.2, 1:2.4, 1:2.8, 1:3.2, 1:3.6, 1:3.8, 1:4.2, 1:4.4, 1:4.6 or 1: 4.8.

In a second aspect, the present invention provides a process for producing the microcapsule of the first aspect, the process comprising:

mixing sodium alginate and microcrystalline cellulose to prepare a sodium alginate-microcrystalline cellulose solution, mixing the sodium alginate-microcrystalline cellulose solution and the lysate of the secondary fission yeast fermentation product to obtain a mixed solution, and adding the mixed solution into a calcium chloride solution to obtain the microcapsule.

In a third aspect, the present invention also provides the use of microcapsules according to the first aspect for the preparation of a cosmetic product.

Preferably, the formulation of the cosmetic includes any one of lipstick, lip gloss, or lip gloss.

In a fourth aspect, the present invention provides a lip glaze comprising an emulsifier, an aqueous phase and an oil phase.

The aqueous phase comprises the microcapsules of the first aspect.

Preferably, the mass part of the emulsifier in the lip glaze is 1-10 parts, including but not limited to 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts.

Preferably, the mass part of the water phase in the lip glaze is 10-60 parts, including but not limited to 11 parts, 12 parts, 13 parts, 15 parts, 20 parts, 25 parts, 30 parts, 40 parts, 45 parts, 50 parts, 52 parts, 54 parts, 56 parts or 58 parts.

Preferably, the mass part of the oil phase in the lip glaze is 20-50 parts, including but not limited to 21 parts, 22 parts, 23 parts, 25 parts, 28 parts, 35 parts, 40 parts, 42 parts, 44 parts, 46 parts or 48 parts.

Preferably, the mass part of the microcapsule in the lip glaze is 5-20 parts, including but not limited to 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 16 parts or 18 parts.

Preferably, the emulsifier comprises cetyl polyethylene/polypropylene glycol-10/1 dimethicone and/or lauryl PEG-9 dimethicoxyethyl dimethicone.

Preferably, the aqueous phase further comprises deionized water, glycerol, 1, 3-butanediol, and sodium chloride.

Preferably, the oil phase comprises any one of dimethicone, phenyl silicone, octyldodecanol, or isododecane, or a combination of at least two thereof.

Preferably, the lip glaze further comprises any one or a combination of at least two of a film forming agent, a color paste, a preservative and an antioxidant.

Preferably, the mass part of the film forming agent in the lip glaze is 1-10 parts, including but not limited to 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 8 parts or 9 parts.

Preferably, the mass part of the color paste in the lip glaze is 5-15 parts, including but not limited to 6 parts, 8 parts, 10 parts, 11 parts, 12 parts or 14 parts.

Preferably, the mass part of the preservative in the lip glaze is 0.1-1 part, including but not limited to 0.2 part, 0.4 part, 0.6 part or 0.8 part.

Preferably, the mass part of the antioxidant in the lip glaze is 0.1-1 part, including but not limited to 0.2 part, 0.4 part, 0.6 part or 0.8 part.

Preferably, the lip glaze comprises 1-10 parts by weight of an emulsifier, 20-50 parts by weight of an oil phase, 10-60 parts by weight of a water phase containing the microcapsule according to claim 1 or 2, 1-10 parts by weight of a film forming agent, 5-15 parts by weight of a color paste, 0.1-1 part by weight of a preservative and 0.1-1 part by weight of an antioxidant.

In a fifth aspect, the invention provides a method for preparing the lip glaze of the fourth aspect, wherein the method comprises the following steps:

mixing an emulsifier, a water phase containing the microcapsules of the first aspect, an oil phase, an optional film forming agent, an optional color paste, an optional preservative and an optional antioxidant to obtain the lip glaze.

Preferably, the preparation method comprises the following steps:

(1) mixing sodium alginate and microcrystalline cellulose to prepare a sodium alginate-microcrystalline cellulose solution, mixing the sodium alginate-microcrystalline cellulose solution and the lysate of the secondary cracking yeast fermentation product to obtain a mixed solution, and adding the mixed solution into a calcium chloride solution to obtain a microcapsule;

mixing and heating the microcapsules and optionally deionized water, glycerol, 1, 3-butanediol and sodium chloride to obtain a water phase;

(2) dissolving an optional film forming agent to obtain a film forming agent solution;

mixing an emulsifier, an oil phase and the film forming agent solution and heating to obtain an oil phase mixed solution;

(3) and mixing and heating the water phase and the oil phase mixed solution, then carrying out cooling treatment, and sequentially adding an optional antioxidant, an optional preservative and color paste to obtain the lip glaze.

Preferably, the heating temperature in the step (1), the step (2) and the step (3) is the same or different, and the heating temperature is 75-85 ℃, including but not limited to 76 ℃, 77 ℃, 78 ℃, 80 ℃, 82 ℃ or 84 ℃.

Preferably, the heating time in step (3) is 2-6 min, including but not limited to 2.3min, 3min, 3.5min, 4min, 4.5min, 5min or 5.5 min.

Preferably, the temperature reduction treatment in step (3) is to reduce the temperature to below 50 ℃, including but not limited to 48 ℃, 45 ℃, 42 ℃, 40 ℃, 35 ℃ or 30 ℃.

As a preferred technical scheme, the preparation method of the lipstick comprises the following steps:

mixing the microcapsule with deionized water, glycerol, 1, 3-butanediol and sodium chloride, and heating to 75-80 ℃ to obtain a water phase;

(2) dissolving a film forming agent in isododecane and mixing to obtain a film forming agent solution;

mixing an emulsifier, an oil phase and the film forming agent solution, and heating to 75-80 ℃ to obtain an oil phase mixed solution;

(3) and mixing the water phase and the oil phase mixed solution, heating at 75-80 ℃ for 2-6 min, then cooling to below 50 ℃, and sequentially adding an antioxidant, a preservative and color paste to obtain the lip glaze.

Compared with the prior art, the invention has at least the following beneficial effects:

(1) in the microcapsule, the wall material sodium alginate-microcrystalline cellulose wraps the core material cracked yeast fermentation product lysate, so that the microcapsule has the effect of slowly releasing active ingredients, and achieves the effects of lasting moisture retention and nourishing; the microcrystalline cellulose can better solidify hydrophilic components in the yeast fermentation lysate of the schizolysis of lips, and further strengthen the nourishing effect of active substances on the skin of the lips;

(2) the lipstick containing the microcapsule has excellent moistening feeling, moisturizing degree, lip wrinkle fading effect and relieving effect, and can permanently moisturize and moisten lip skin.

Detailed Description

For the purpose of facilitating an understanding of the present invention, the present invention will now be described by way of examples. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.

The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.

In the examples of the present invention, the lysate of the yeast fermentation products of the second split yeast was provided by Guangzhou Probiotics technologies, where sodium alginate and microcrystalline cellulose were purchased from Michelin, cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane was purchased from Evonik Operations GmbH, lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane was purchased from Shin-Etsu Silicones Credit Silicone, vitamin E was purchased from Guangzhou Longhui trade Co., Ltd, octyldodecanol was purchased from BASF, isododecane was purchased from Guangzhou cosmetics technologies, dimethicone was purchased from Dow Corning, trimethylsiloxysilicate was purchased from Wacker, 1, 3-butanediol was purchased from Japan celluloid group, glycerin was purchased from Guangzhou chemical Co., Ltd, sodium chloride was purchased from medium salt gold altar salt llc and ethylhexylglycerol was purchased from Schulke & mayr Gmbhd.

Examples 1 to 4

Examples 1-4 provide a lipstick having a formulation (in parts by mass) as shown in table 1.

TABLE 1

The preparation method of the lipstick comprises the following steps:

(1) mixing cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, vitamin E, octyl dodecanol and dimethicone proportionally, stirring, and heating to 80 deg.C to obtain solution A;

(2) mixing isododecane and trimethylsiloxy silicate according to a proportion, and uniformly stirring to obtain a clear solution B;

preparing 1g/100mL sodium alginate solution, adding 1% of nano microcrystalline cellulose by mass, mixing the lysate of the yeast schizolysis product and the sodium alginate solution according to the volume ratio of 1:2, and slowly dripping the mixed solution into 20g/L calcium chloride solution by using a sterile syringe to obtain the microcapsule.

(3) Mixing the microcapsule with deionized water, 1, 3-butanediol, glycerol and sodium chloride according to a proportion, uniformly stirring, and heating to 80 ℃ to obtain a solution C;

(4) introducing the solution C into the solution A, uniformly mixing, and stirring at a high speed for 3min to obtain an emulsion D; when the temperature of the solution D is reduced to 50 ℃, adding the solution B, and uniformly stirring to obtain a solution E;

(5) and adding ethylhexyl glycerol and the color paste into the solution E, and uniformly stirring to obtain the lip glaze.

Comparative examples 1 to 3

Comparative examples 1 to 3 provide lipsticks which are different from example 4 in the manner of addition of active ingredients, in comparative example 1 in which sodium alginate-microcrystalline cellulose was not added to embed a lysate of yeast bifidus, comparative example 2 in which a solution of a lysate of yeast bifidus which has not been subjected to embedding treatment was added, and comparative example 3 in which a lysate of yeast bifidus which has been embedded with sodium alginate was added.

The formula of the lipstick (in parts by mass) is shown in table 2:

TABLE 2

The method of preparing the lipstick of comparative example 1 includes the steps of:

(3) mixing deionized water, 1, 3-butanediol, glycerol and sodium chloride according to a proportion, uniformly stirring, and heating to 80 ℃ to obtain a solution C;

The method of preparing the lipstick of comparative example 2 includes the steps of:

(3) proportionally mixing the lysate of the fermentation product of the yeast for secondary cracking with deionized water, 1, 3-butanediol, glycerol and sodium chloride, uniformly stirring, and heating to 80 ℃ to obtain a solution C;

The method of preparing the lipstick of comparative example 3 includes the steps of:

preparing 1g/100mL sodium alginate solution, mixing the lysate of the yeast secondary fission fermentation product with the sodium alginate solution according to the volume ratio of 1:2, and slowly dripping the mixed solution into 20g/L calcium chloride solution by using a sterile syringe to obtain the lysate of the yeast secondary fission fermentation product embedded by the sodium alginate.

Test example 1

This test example evaluates the effect of using the lip glaze prepared in examples 1 to 4 and comparative example 1:

and (3) searching 30 female volunteers with deeper lip striae of more than 30 years old, 30 female volunteers with sensitive lips or cheilitis of 20-40 years old and 30 female volunteers with lip glaze using habit of 20-40 years old, and respectively evaluating the lip striae fading degree, the lip soothing and anti-allergy effect and the moisturizing degree of different samples. The products of examples 1 to 4 and comparative example 1 were used for one week for every 6 persons, the full points were 10 points, the average points were taken and compared, and the results of the evaluation of the use effect of examples and comparative examples are shown in table 3.

TABLE 3

Experimental group	Moistening sensation	Moisture retention	Lip line fading effect	Relieving action
					Example 1	6.5	5	3.7	2.2
Example 2	7.1	6	3.8	2.5
					Example 3	7.5	6.5	4	3
Example 4	7.5	7	5	3.5
					Comparative example 1	6	5	3	1.8

As can be seen from table 3, the microcapsules used in examples 1 to 4 had a moisturizing effect score of higher than 6.5, a moisturizing effect score of higher than 5, and at most 7, a lip-lightening effect score of higher than 3.7, and a soothing effect score of higher than 2.2, whereas the microcapsules used in comparative example 1 had no microcapsules, a moisturizing effect score of 6, a moisturizing effect score of 5, a lip-lightening effect score of 3, and a soothing effect score of 1.8, and thus, the microcapsules added to the lip glaze according to the present invention can improve the moisturizing effect, lip-lightening effect, and soothing effect of the lip glaze.

Test example 2

This test example evaluates the moisturizing effect of the lip gloss prepared in example 4 and comparative examples 1 to 3:

30 female volunteers who have the habit of using lip glaze are invited, the ages of the female volunteers are 25-40 years old, and before the product is used, the skin cuticle content of the tested part and the skin cuticle content of the control part of the volunteers are not obviously different, so that the results are comparable.

The experimental method comprises the following steps:

respectively selecting a tested part and a control part on two sides of the lower lip of a volunteer, smearing a sample to be tested on the tested part, and ensuring that the smearing amount is about 5mg/cm²The control area was not coated with any product.

The test indexes and the method are as follows:

the volunteers were asked to refrain from eating or drinking water during the test period, and the moisture content of the epidermis of the test part and the control part was tested before use, at 2h, 4h and 6h after use respectively;

the test was conducted mainly on the moisture content of the skin surface layer, 3 times per test were conducted using a german Comeometer measuring instrument, and the average value was taken to calculate the moisture content difference (moisture content difference ═ moisture content of the test site-moisture content of the control site), and the results are shown in table 4.

TABLE 4

Group of	Before use	2h	4h	6h
					Example 4	1.79	13.87	23.03	28.88
Comparative example 1	1.13	1.88	0.63	1.47
					Comparative example 2	-0.80	14.33	11.78	9.23
Comparative example 3	1.66	10.98	17.93	23.82

The results are shown in table 4, the lip glaze is prepared by using the microcapsule (sodium alginate-microcrystalline cellulose embedded split yeast fermentation product lysate) in example 4, the difference between the skin surface water content of the tested part and the skin surface water content of the control part after 6 hours of use by the volunteer is 28.88, which shows that the skin surface water content of the tested part is obviously higher than that of the control part, namely, the lip glaze prepared in example 5 has excellent long-acting moisturizing effect, compared with the lip glaze prepared in comparative example 1 without adding the microcapsule, comparative example 2 with only adding the split yeast fermentation product lysate, comparative example 3 with only adding sodium alginate to embed the split yeast fermentation product lysate, the moisturizing effect of the three is poor, and in addition, the moisturizing effect of the lip glaze prepared in comparative example 3 is obviously better than that of the lip glaze prepared in comparative example 2.

The comprehensive results show that the sodium alginate-microcrystalline cellulose embedded secondary fission yeast fermentation product lysate is adopted in the microcapsule, so that the long-acting moisturizing effect can be effectively improved.

The applicant states that the present invention is illustrated by the above examples to show the detailed process equipment and process flow of the present invention, but the present invention is not limited to the above detailed process equipment and process flow, i.e. it does not mean that the present invention must rely on the above detailed process equipment and process flow to be implemented. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims

1. A microcapsule, comprising a core material and a wall material;

the core material comprises a split yeast fermentation product lysate;

the wall material comprises sodium alginate and microcrystalline cellulose.

2. The microcapsule according to claim 1, wherein the mass ratio of the core material to the wall material is 1 (2-5).

3. A process for the preparation of microcapsules according to claim 1 or 2, characterized in that it comprises:

4. Use of microcapsules according to claim 1 or 2 for the preparation of a cosmetic product;

5. A lip glaze, which is characterized by comprising an emulsifier, a water phase and an oil phase;

the aqueous phase comprises microcapsules according to claim 1 or 2.

6. The lip glaze according to claim 5, wherein the mass part of the emulsifier in the lip glaze is 1-10 parts;

preferably, the mass part of the water phase in the lip glaze is 10-60 parts;

preferably, the mass part of the oil phase in the lip glaze is 20-50 parts;

preferably, the mass part of the microcapsule in the lip glaze is 5-20;

preferably, the emulsifier comprises cetyl polyethylene/polypropylene glycol-10/1 dimethicone and/or lauryl PEG-9 dimethicoxyethyl dimethicone;

preferably, the aqueous phase further comprises deionized water, glycerol, 1, 3-butanediol, and sodium chloride;

preferably, the oil phase comprises any one of or a combination of at least two of dimethicone, phenyl silicone, octyldodecanol, or isododecane;

preferably, the lip glaze further comprises any one or a combination of at least two of a film forming agent, a color paste, a preservative and an antioxidant;

preferably, the mass part of the film forming agent in the lip glaze is 1-10 parts;

preferably, the mass part of the color paste in the lip glaze is 5-15 parts;

preferably, the mass part of the preservative in the lip glaze is 0.1-1;

preferably, the mass part of the antioxidant in the lip glaze is 0.1-1 part.

7. The lip glaze according to claim 5 or 6, wherein the lip glaze comprises 1-10 parts by mass of an emulsifier, 20-50 parts by mass of an oil phase, 10-60 parts by mass of a water phase containing the microcapsules according to claim 1 or 2, 1-10 parts by mass of a film forming agent, 5-15 parts by mass of a color paste, 0.1-1 part by mass of a preservative and 0.1-1 part by mass of an antioxidant.

8. A process for the preparation of a lip glaze according to any one of claims 5 to 7, characterized in that it comprises:

mixing an emulsifier, an aqueous phase containing microcapsules according to claim 1 or 2, an oil phase, an optional film-forming agent, an optional color paste, an optional preservative and an optional antioxidant to obtain the lip glaze;

preferably, the preparation method comprises the following steps:

9. The method according to claim 8, wherein the heating temperature in the step (1), the step (2) and the step (3) is the same or different, and the heating temperature is 75-85 ℃;

preferably, the heating time in the step (3) is 2-6 min;

preferably, the temperature reduction treatment in the step (3) is to reduce the temperature to below 50 ℃.

10. The method for preparing according to claim 8 or 9, characterized in that it comprises the steps of: